Regulation of hypoxic pulmonary vasoconstriction: Basic mechanisms

European Respiratory Journal

Volumn 32, Issue 6, 2008, Pages 1639-1651

  Sommer, N ^a   Dietrich, A ^b   Schermuly, R T ^a   Ghofrani, H A ^a   Gudermann, T ^b   Schulz, R ^a   Seeger, W ^a   Grimminger, F ^a   Weissmann, N ^a  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Hypoxia; Hypoxic pulmonary vasoconstriction; Lung; Oxygen; Oxygen sensing

Indexed keywords

CALCIUM; CALCIUM CHANNEL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; VOLTAGE GATED POTASSIUM CHANNEL;

CALCIUM CELL LEVEL; CONFERENCE PAPER; DISEASE EXACERBATION; EFFECTOR CELL; GAS EXCHANGE; HUMAN; HYPOXIA; HYPOXIC LUNG VASOCONSTRICTION; LUNG ALVEOLUS; MITOCHONDRION; NONHUMAN; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANOXIA; CALCIUM; CALCIUM CHANNELS, L-TYPE; CAPILLARIES; HUMANS; MODELS, BIOLOGICAL; NADPH OXIDASE; OXIDATION-REDUCTION; OXYGEN; PRESSURE; PULMONARY ARTERY; PULMONARY CIRCULATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 58849142043     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00013908     Document Type: Conference Paper

References (154)

1. Marshall BE, Marshall C, Benumof J, Saidman LJ. Hypoxic pulmonary vasoconstriction in dogs: effects of lung segment size and oxygen tension. J Appl Physiol 1981; 51: 1543-1551.
2. Orchard CH, Sanchez de Leon R, Sykes MK. The relationship between hypoxic pulmonary vasoconstriction and arterial oxygen tension in the intact dog. J Physiol 1983; 338: 61-74.
3. Naeije R, Brimioulle S. Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure. Crit Care 2001; 5: 67-71.
4. Carter EP, Hartsfield CL, Miyazono M, Jakkula M, Morris KG Jr, McMurtry IF. Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Am J Physiol Lung Cell Mol Physiol 2002; 283: 346-353.
5. Marshall BE. Hypoxic pulmonary vasoconstriction. Acta Anaesthesiol Scand Suppl 1990; 94: 37-41.
6. Weir EK. Does normoxic pulmonary vasodilatation rather than hypoxic vasoconstriction account for the pulmonary pressor response to hypoxia? Lancet 1978; 1: 476-477.
7. Weissmann N, Akkayagil E, Quanz K, et al. Basic features of hypoxic pulmonary vasoconstriction in mice. Respir Physiol Neurobiol 2004; 139: 191-202.
8. Weissmann N, Grimminger F, Walmrath D, Seeger W. Hypoxic vasoconstriction in buffer-perfused rabbit lungs. Respir Physiol 1995; 100: 159-169.
9. Lindgren L, Marshall C, Marshall BE. Hypoxic pulmonary vasoconstriction in isolated rat lungs perfused with perfluorocarbon emulsion. Acta Physiol Scand 1985; 123: 335-338.
10. Peake MD, Harabin AL, Brennan NJ, Sylvester JT. Steady-state vascular responses to graded hypoxia in isolated lungs of five species. J Appl Physiol 1981; 51: 1214-1219.
11. Skovgaard N, Abe AS, Andrade DV, Wang T. Hypoxic pulmonary vasoconstriction in reptiles: a comparative study of four species with different lung structures and pulmonary blood pressures. Am J Physiol Regul Integr Comp Physiol 2005; 289: 1280-1288.
12. Olson KR, Russell MJ, Forster ME. Hypoxic vasoconstriction of cyclostome systemic vessels: the antecedent of hypoxic pulmonary vasoconstriction? Am J Physiol Regul Integr Comp Physiol 2001; 280: 198-206.
13. Plumier L. La circulation pulmonaire chez le chien [Pulmonary circulation in the dog]. Arch Int Physiol 1904; 1: 176-213.
14. Bradford JR, Dean HP. The pulmonary circulation. J Physiol (Lond) 1894; 16: 34-96.
15. Von Euler US, Liljestrand G. Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 1946; 12: 301-320.
16. Motley HL, Cournand A, Werko L, Himmelstein A, Dresdale D. The influence of short periods of induced acute anoxia upon pulmonary arterial pressure in man. Am J Physiol 1947; 150: 315-320.
17. Sylvester JT, Gottlieb JE, Rock P, Wetzel RC. Acute hypoxic responses. In: Bergofsky EF, ed. Abnormal Pulmonary Circulation. New York, Churchill-Livingstone, 1986; pp. 127-165.
18. 2 tensions upon the resistance of pulmonary blood vessels. Am J Physiol 1953; 172: 211-220.
19. Fishman AP. Hypoxia on the pulmonary circulation. How and where it acts. Circ Res 1976; 38: 221-231.
20. Cutaia M, Rounds S. Hypoxic pulmonary vasoconstriction. Physiologic significance, mechanism, and clinical relevance. Chest 1990; 97: 706-718.
21. Davis MJ, Joyner WL, Gilmore JP. Microvascular pressure distribution and responses of pulmonary allografts and cheek pouch arterioles in the hamster to oxygen. Circ Res 1981; 49: 125-132.
22. Hillier SC, Graham JA, Hanger CC, Godbey PS, Glenny RW, Wagner WW Jr. Hypoxic vasoconstriction in pulmonary arterioles and venules. J Appl Physiol 1997; 82: 1084-1090.
23. Staub NC. Site of hypoxic pulmonary vasoconstriction. Chest 1985; 88: Suppl. 4, S240-S245.
24. Kato M, Staub NC. Response of small pulmonary arteries to unilobar hypoxia and hypercapnia. Circ Res 1966; 19: 426-440.
25. Dawson CA, Grimm DJ, Linehan JH. Influence of hypoxia on the longitudinal distribution of pulmonary vascular resistance. J Appl Physiol 1978; 44: 493-498.
26. Murray TR, Chen L, Marshall BE, Macarak EJ. Hypoxic contraction of cultured pulmonary vascular smooth muscle cells. Am J Respir Cell Mol Biol 1990; 3: 457-465.
27. Madden JA, Vadula MS, Kurup VP. Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells. Am J Physiol 1992; 263: 384-393.
28. Liu Q, Sham JS, Shimoda LA, Sylvester JT. Hypoxic constriction of porcine distal pulmonary arteries: endothelium and endothelin dependence. Am J Physiol Lung Cell Mol Physiol 2001; 280: 856-865.
29. Aaronson PI, Robertson TP, Ward JP. Endothelium-derived mediators and hypoxic pulmonary vasoconstriction. Respir Physiol Neurobiol 2002; 132: 107-120.
30. Weir EK, Olschewski A. Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia. Cardiovasc Res 2006; 71: 630-641.
31. 2+-dependent action potentials in small pulmonary arteries of the cat. J Appl Physiol 1985; 59: 1389-1393.
32. Savineau JP, Gonzalez de la Fuente P, Marthan R. Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries. Respir Physiol 1995; 99: 191-198.
33. Ohe M, Ogata M, Shirato K, Takishima T. Effects of verapamil and BAY K 8644 on the hypoxic contraction of the isolated human pulmonary artery. Tohoku J Exp Med 1989; 157: 81-82.
34. Tucker A, McMurtry IF, Grover RF, Reeves JT. Attenuation of hypoxic pulmonary vasoconstriction by verapamil in intact dogs. Proc Soc Exp Biol Med 1976; 151: 611-614.
35. 2+ and nonselective cation channels. Am J Physiol Lung Cell Mol Physiol 2005; 289: L5-L13.
36. 2+ entry. Am J Physiol Lung Cell Mol Physiol 2005; 288: L1059-L1069.
37. Ward JP, Robertson TP, Aaronson PI. Capacitative calcium entry: a central role in hypoxic pulmonary vasoconstriction? Am J Physiol Lung Cell Mol Physiol 2005; 289: 2-4.
38. Yuan XJ, Goldman WF, Tod ML, Rubin LJ, Blaustein MP. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am J Physiol 1993; 264: 116-123.
39. Post JM, Hume JR, Archer SL, Weir EK. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol 1992; 262: 882-890.
40. Hasunuma K, Rodman DM, McMurtry IF. Effects of K+ channel blockers on vascular tone in the perfused rat lung. Am Rev Respir Dis 1991; 144: 884-887.
41. Patel AJ, Lazdunski M, Honore E. Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. Embo J 1997; 16: 6615-6625.
42. Hulme JT, Coppock EA, Felipe A, Martens JR, Tamkun MM. Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Circ Res 1999; 85: 489-497.
43. Archer SL, Souil E, Dinh-Xuan AT, et al. Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J Clin Invest 1998; 101: 2319-2330.
44. Archer SL, London B, Hampl V, et al. Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. FASEB J 2001; 15: 1801-1803.
45. Reeve HL, Weir EK, Nelson DP, Peterson DA, Archer SL. Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue. Exp Physiol 1995; 80: 825-834.
46. Weir EK, Hong Z, Porter VA, Reeve HL. Redox signalling in oxygen sensing by vessels. Respir Physiol Neurobiol 2002; 132: 121-130.
47. Park MK, Bae YM, Lee SH, Ho WK, Earm YE. Modulation of voltage-dependent K+ channel by redox potential in pulmonary and ear arterial smooth muscle cells of the rabbit. Pflugers Arch 1997; 434: 764-771.
48. Olschewski A, Hong Z, Peterson DA, Nelson DP, Porter VA, Weir EK. Opposite effects of redox status on membrane potential, cytosolic calcium, and tone in pulmonary arteries and ductus arteriosus. Am J Physiol Lung Cell Mol Physiol 2004; 286: 15-22.
49. 2+ conductances in pulmonary artery cells. Am J Physiol 1994; 267: L52-L63.
50. 2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res 2004; 95: 496-505.
51. Yu Y, Fantozzi I, Remillard CV, et al. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 2004; 101: 13861-13866.
52. Ng LC, Wilson SM, Hume JR. Mobilization of sarcoplasmic reticulum stores by hypoxia leads to consequent activation of capacitative Ca2+ entry in isolated canine pulmonary arterial smooth muscle cells. J Physiol 2005; 563: 409-419.
53. Snetkov VA, Aaronson PI, Ward JP, Knock GA, Robertson TP. Capacitative calcium entry as a pulmonary specific vasoconstrictor mechanism in small muscular arteries of the rat. Br J Pharmacol 2003; 140: 97-106.
54. Weissmann N, Dietrich A, Fuchs B, et al. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci USA 2006; 103: 19093-19098.
55. 2+]i inhibition of K+ channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization. Circ Res 1995; 77: 131-139.
56. 2+ release from intracellular stores is an initial step in hypoxic pulmonary vasoconstriction of rat pulmonary artery resistance vessels. Circulation 1997; 96: 3647-3654.
57. 2+ release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. J Appl Physiol 2002; 92: 527-534.
58. 2+ release in hypoxic vasoconstriction of canine pulmonary artery. Br J Pharmacol 1997; 122: 21-30.
59. 2+]i rise in rabbit pulmonary arterial smooth muscle cells. Life Sci 2002; 70: 2321-2333.
60. Dipp M, Nye PC, Evans AM. Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle. Am J Physiol Lung Cell Mol Physiol 2001; 281: 318-325.
61. 2+ release mechanism. J Biol Chem 1997; 272: 7069-7077.
62. Du W, Frazier M, McMahon TJ, Eu JP. Redox activation of intracellular calcium release channels (ryanodine receptors) in the sustained phase of hypoxia-induced pulmonary vasoconstriction. Chest 2005; 128: Suppl. 6, S556-S558.
63. Favero TG, Zable AC, Abramson JJ. Hydrogen peroxide stimulates the Ca2+ release channel from skeletal muscle sarcoplasmic reticulum. J Biol Chem 1995; 270: 25557-25563.
64. Wilson HL, Dipp M, Thomas JM, Lad C, Galione A, Evans AM. Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction. J Biol Chem 2001; 276: 11180-11188.
65. Kaplin AI, Snyder SH, Linden DJ. Reduced nicotinamide adenine dinucleotide-selective stimulation of inositol 1,4,5-trisphosphate receptors mediates hypoxic mobilization of calcium. J Neurosci 1996; 16: 2002-2011.
66. Robertson TP, Dipp M, Ward JP, Aaronson PI, Evans AM. Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat. Br J Pharmacol 2000; 131: 5-9.
67. Wang Z, Lanner MC, Jin N, Swartz D, Li L, Rhoades RA. Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells: role of Rho-kinase. Am J Respir Cell Mol Biol 2003; 29: 465-471.
68. Wojciak-Stothard B, Tsang LY, Paleolog E, Hall SM, Haworth SG. Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2006; 290: L1173-L1182.
69. Robertson TP. Point: release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction. J Appl Physiol 2007; 102: 2071-2072.
70. Bennie RE, Packer CS, Powell DR, Jin N, Rhoades RA. Biphasic contractile response of pulmonary artery to hypoxia. Am J Physiol 1991; 261: 156-163.
71. Marshall C, Marshall BE. Hypoxic pulmonary vasoconstriction is not endothelium dependent. Proc Soc Exp Biol Med 1992; 201: 267-270.
72. Leach RM, Robertson TP, Twort CH, Ward JP. Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries. Am J Physiol 1994; 266: 223-231.
73. Ward JP, Knock GA, Snetkov VA, Aaronson PI. Protein kinases in vascular smooth muscle tone-role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction. Pharmacol Ther 2004; 104: 207-231.
74. Wolin MS. Interactions of oxidants with vascular signalling systems. Arterioscler Thromb Vasc Biol 2000; 20: 1430-1442.
75. Sylvester JT. Hypoxic pulmonary vasoconstriction: a radical view. Circ Res 2001; 88: 1228-1230.
76. Sham JS. Hypoxic pulmonary vasoconstriction: ups and downs of reactive oxygen species. Circ Res 2002; 91: 649-651.
77. Waypa GB, Schumacker PT. Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing. J Appl Physiol 2005; 98: 404-414.
78. Moudgil R, Michelakis ED, Archer SL. Hypoxic pulmonary vasoconstriction. J Appl Physiol 2005; 98: 390-403.
79. Ward JP. Point: hypoxic pulmonary vasoconstriction is mediated by increased production of reactive oxygen species. J Appl Physiol 2006; 101: 993-995.
80. Wilhelm J, Herget J. Role of ion fluxes in hydrogen peroxide pulmonary vasoconstriction. Physiol Res 1995; 44: 31-37.
81. 2-induced contractions of pulmonary arteries. Am J Physiol 1993; 264: H1542-H1547.
82. Jones RD, Thompson JS, Morice AH. The effect of hydrogen peroxide on hypoxia, prostaglandin F2 alpha and potassium chloride induced contractions in isolated rat pulmonary arteries. Pulm Pharmacol Ther 1997; 10: 37-42.
83. Weir EK, Eaton JW, Chesler E. Redox status and pulmonary vascular reactivity. Chest 1985; 88: Suppl. 4, S249-S52.
84. Waypa GB, Chandel NS, Schumacker PT. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res 2001; 88: 1259-1266.
85. Weissmann N, Grimminger F, Voswinckel R, Conzen J, Seeger W. Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs. Am J Physiol 1998; 274: 721-727.
86. Paky A, Michael JR, Burke-Wolin TM, Wolin MS, Gurtner GH. Endogenous production of superoxide by rabbit lungs: effects of hypoxia or metabolic inhibitors. J Appl Physiol 1993; 74: 2868-2874.
87. Waypa GB, Guzy R, Mungai PT, et al. Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells. Circ Res 2006; 99: 970-978.
88. 2 radicals and pulmonary vascular reactivity in rat lung. J Appl Physiol 1989; 67: 1903-1911.
89. 2 sensor in rat pulmonary vasculature. Circ Res 1993; 73: 1100-1112.
90. Weissmann N, Vogels H, Schermuly RT, et al. Measurement of exhaled hydrogen peroxide from rabbit lungs. Biol Chem 2004; 385: 259-264.
91. Weissmann N, Kuzkaya N, Fuchs B, et al. Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy. Respir Res 2005; 6: 86.
92. Michelakis ED, Hampl V, Nsair A, et al. Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ Res 2002; 90: 1307-1315.
93. Paddenberg R, Ishaq B, Goldenberg A, et al. Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol 2003; 284: 710-719.
94. Liu JQ, Sham JS, Shimoda LA, Kuppusamy P, Sylvester JT. Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2003; 285: 322-333.
95. Bonnet S, Michelakis ED, Porter CJ, et al. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 2006; 113: 2630-2641.
96. 2 sensor. Am J Physiol 1994; 267: 823-831.
97. Marshall C, Mamary AJ, Verhoeven AJ, Marshall BE. Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. Am J Respir Cell Mol Biol 1996; 15: 633-644.
98. Killilea DW, Hester R, Balczon R, Babal P, Gillespie MN. Free radical production in hypoxic pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2000; 279: 408-412.
99. Mehta JP, Li CJ, Guardiola J, Cabrera JA, Weir KE, Eaton JW. Generation of oxidants by hypoxic human pulmonary and coronary smooth muscle cells. Chest 2008; 133: 1410-1414.
100. 2 sensors, and controversies. News Physiol Sci 2002; 17: 131-137.
101. Oeckler RA, Kaminski PM, Wolin MS. Stretch enhances contraction of bovine coronary arteries via an NAD(P)H oxidase-mediated activation of the extracellular signal-regulated kinase mitogen-activated protein kinase cascade. Circ Res 2003; 92: 23-31.
102. Staniek K, Nohl H. Are mitochondria a permanent source of reactive oxygen species? Biochim Biophys Acta 2000; 1460: 268-275.
103. Weissmann N, Zeller S, Schafer RU, et al. Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction. Am J Respir Cell Mol Biol 2006; 34: 505-513.
104. 2+ channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respir Physiol Neurobiol 2006; 151: 192-208.
105. Sylvester JT, Harabin AL, Peake MD, Frank RS. Vasodilator and constrictor responses to hypoxia in isolated pig lungs. J Appl Physiol 1980; 49: 820-825.
106. Salvaterra CG, Goldman WF. Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytes. Am J Physiol 1993; 264: 323-328.
107. Waypa GB, Marks JD, Mack MM, Boriboun C, Mungai PT, Schumacker PT. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res 2002; 91: 719-726.
108. Rounds S, McMurtry IF. Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs. Circ Res 1981; 48: 393-400.
109. Weissmann N, Ebert N, Ahrens M, et al. Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs. Am J Respir Cell Mol Biol 2003; 29: 721-732.
110. 2-sensor in resistance artery smooth muscle cells. J Mol Cell Cardiol 2004; 37: 1119-1136.
111. Bell EL, Emerling BM, Chandel NS. Mitochondrial regulation of oxygen sensing. Mitochondrion 2005; 5: 322-332.
112. Buescher PC, Pearse DB, Pillai RP, Litt MC, Mitchell MC, Sylvester JT. Energy state and vasomotor tone in hypoxic pig lungs. J Appl Physiol 1991; 70: 1874-1881.
113. 2 and PCO. Am J Physiol 1981; 241: E47-E50.
114. Leach RM, Hill HS, Snetkov VA, Ward JP. Hypoxia, energy state and pulmonary vasomotor tone. Respir Physiol Neurobiol 2002; 132: 55-67.
115. 2-sensing cells? J Biol Chem 2005; 280: 41504-41511.
116. Leach RM, Sheehan DW, Chacko VP, Sylvester JT. Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries. Am J Physiol Lung Cell Mol Physiol 2000; 278: 294-304.
117. Shigemori K, Ishizaki T, Matsukawa S, Sakai A, Nakai T, Miyabo S. Adenine nucleotides via activation of ATP-sensitive K+ channels modulate hypoxic response in rat pulmonary artery. Am J Physiol 1996; 270: 803-809.
118. Wiener CM, Dunn A, Sylvester JT. ATP-dependent K+ channels modulate vasoconstrictor responses to severe hypoxia in isolated ferret lungs. J Clin Invest 1991; 88: 500-504.
119. Leach RM, Hill HM, Snetkov VA, Robertson TP, Ward JP. Divergent roles of glycolysis and themitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor. J Physiol 2001; 536: 211-224.
120. Wanstall JC, O'Brien E. In vitro hypoxia on rat pulmonary artery: effects on contractions to spasmogens and role of KATP channels. Eur J Pharmacol 1996; 303: 71-78.
121. Paddenberg R, Konig P, Faulhammer P, Goldenberg A, Pfeil U, Kummer W. Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices. Respir Res 2006; 7: 93.
122. Guzy RD, Hoyos B, Robin E, et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 2005; 1: 401-408.
123. Weir EK, Archer SL. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J 1995; 9: 183-189.
124. Guzy RD, Schumacker PT. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp Physiol 2006; 91: 807-819.
125. Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 2004; 287: 817-833.
126. Andrukhiv A, Costa AD, West IC, Garlid KD. Opening mitoKATP increases superoxide generation from complex I of the electron transport chain. Am J Physiol Heart Circ Physiol 2006; 291: H2067-H2074.
127. - currents are activated by metabolic inhibition in rat pulmonary artery smooth muscle cells. Am J Physiol 1997; 273: 520-530.
128. 2+] in rat pulmonary artery smooth muscle cells. J Physiol 1999; 516: 139-147.
129. Duchen MR. Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J Physiol 1999; 516: 1-17.
130. Kang TM, Park MK, Uhm DY. Effects of hypoxia and mitochondrial inhibition on the capacitative calcium entry in rabbit pulmonary arterial smooth muscle cells. Life Sci 2003; 72: 1467-1479.
131. Lassegue B, Clempus RE. Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol 2003; 285: 277-297.
132. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000; 86: 494-501.
133. Bokoch GM, Knaus UG. NADPH oxidases: not just for leukocytes anymore! Trends Biochem Sci 2003; 28: 502-508.
134. Shmelzer Z, Haddad N, Admon E, et al. Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes. J Cell Biol 2003; 162: 683-692.
135. Weissmann N, Voswinckel R, Hardebusch T, et al. Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction. Am J Physiol 1999; 276: 90-95.
136. Matsuzaki I, Chatterjee S, Debolt K, Manevich Y, Zhang Q, Fisher AB. Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction. Am J Physiol Heart Circ Physiol 2005; 288: 336-343.
137. Petheo GL, Demaurex N. Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase. Biochem J 2005; 388: 485-491.
138. Henderson LM, Chappell JB, Jones OT. The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem J 1987; 246: 325-329.
139. Jones RD, Hancock JT, Morice AH. NADPH oxidase: a universal oxygen sensor? Free Radic Biol Med 2000; 29: 416-424.
140. Mohazzab KM, Wolin MS. Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle. Am J Physiol 1994; 267: 815-822.
141. Gabig TG, Bearman SI, Babior BM. Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood 1979; 53: 1133-1139.
142. Thomas HM3, Carson RC, Fried ED, Novitch RS. Inhibition of hypoxic pulmonary vasoconstriction by diphenyleneiodonium. Biochem Pharmacol 1991; 42: 9-12.
143. Grimminger F, Weissmann N, Spriestersbach R, Becker E, Rosseau S, Seeger W. Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs. Am J Physiol 1995; 268: 747-752.
144. Majander A, Finel M, Wikstrom M. Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I). J Biol Chem 1994; 269: 21037-21042.
145. Weir EK, Reeve HL, Cornfield DN, Tristani-Firouzi M, Peterson DA, Archer SL. Diversity of response in vascular smooth muscle cells to changes in oxygen tension. Kidney Int 1997; 51: 462-466.
146. Jones RD, Thompson JS, Morice AH. The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries. Physiol Res 2000; 49: 587-596.
147. Weissmann N, Tadic A, Hanze J, et al. Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)? Am J Physiol Lung Cell Mol Physiol 2000; 279: 683-690.
148. Ichinose F, Ullrich R, Sapirstein A, et al. Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction. J Clin Invest 2002; 109: 1493-1500.
149. 2 sensing is preserved inmice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci USA 1999; 96: 7944-7949.
150. 2 sensors and O2-sensitive potassium channels in the pulmonary circulation. Adv Exp Med Biol 2000; 475: 219-240.
151. Michelakis ED, McMurtry MS, Wu XC, et al. Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation 2002; 105: 244-250.
152. Aaronson PI. Hypoxic pulmonary vasoconstriction is/is not mediated by increased production of reactive oxygen species. J Appl Physiol 2006; 101: 1000-1005.
153. 2+ signaling. Am J Physiol Cell Physiol 2006; 291: C1082-C1088.
154. Duszynski J, Koziel R, Brutkowski W, Szczepanowska J, Zablocki K. The regulatory role of mitochondria in capacitative calcium entry. Biochim Biophys Acta 2006; 1757: 380-387.