Polyprotein cleavage mechanism of SARS CoV M pro and chemical modification of the octapeptide

Peptides

Volumn 25, Issue 11, 2004, Pages 1857-1864

  Du, Qi Shi ^a,b   Wang, Shu Qing ^a   Zhu, Yu ^a   Wei, Dong Qing ^a,b,c   Guo, Hong ^d   Sirois, Suzanne ^b   Chou, Kuo Chen ^a,e,f  

^a TIANJIN NORMAL UNIVERSITY   (China)

^b Institut Technologique de Montreal   (Canada)

^c Gina Cody School of Engineering and Computer Science   (Canada)

^d UNIVERSITY OF TENNESSEE   (United States)

^e SHANGHAI JIAO TONG UNIVERSITY   (China)

^f GORDON LIFE SCIENCE INSTITUTE   (United States)

Author keywords

Coronavirus main proteinase; Distorted key theory; Drug design; Inhibitor; KZ7088; Octapeptide; SARS

Indexed keywords

ALANYLVALYLLEUCYLGLUTAMYLSERYLGLYCYLPHENYLALANYLARGININE; CARBONYL DERIVATIVE; CYSTEINE; GLUTAMINE; HISTIDINE; OCTAPEPTIDE; POLYPROTEIN; PROTEINASE; SERINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CATALYSIS; CHEMICAL BOND; DENSITY; ELECTRON; ENZYME ACTIVE SITE; MOLECULAR MECHANICS; POLARIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; QUANTUM MECHANICS; SARS CORONAVIRUS; SOLID; SURFACE CHARGE; THEORY;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; CYSTEINE; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; ELECTROSTATICS; GLUTAMINE; HISTIDINE; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; QUANTUM THEORY; SARS VIRUS; SERINE; SEVERE ACUTE RESPIRATORY SYNDROME;

CORONAVIRUS;

EID: 6344236941     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2004.06.018     Document Type: Article

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