Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 10, 2008, Pages 1400-1405

  Yang, Qingang ^a   Chen, Lili ^a   He, Xuchang ^a   Gao, Zhenting ^b   Shen, Xu ^a   Bai, Donglu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cinanserin analog; Fluorescence resonance energy transfer based assay; Inhibitor; SARS coronavirus 3CL protease

Indexed keywords

2 (2 PHENOXYETHYLTHIO)BENZENAMINE; 2 (3 METHOXYPROPYLTHIO)BENZENAMINE; 2 (4 METHOXYBUTYLTHIO)BENZENAMINE; 2 [2 (2 N METHYLPYRROLIDYL)ETHYLTHIO]BENZENAMINE; BENZYL N 2 (3 DIMETHYLAMINOPROPYLTHIO)PHENYLCARBAMATE; CINANSERIN; CINANSERIN DERIVATIVE; N (2 ALLYLTHIOPHENYL)CINNAMIDE; N (2 BENZYLTHIOPHENYL)CINNAMIDE; N (2 CARBOMETHOXYETHYLTHIOPHENYL)CINNAMIDE; N (2 CINNAMOYLTHIOPHENYL)CINNAMIDE; N [2 (2 CYANOCINNAMOYLTHIO)PHENYL] 2 CYANOCINNAMIDE; N [2 (2 N METHYLPYRROLIDYLETHYLTHIO)PHENYL]CINNAMIDE; N [2 (2 PYRIDYLMETHYLTHIO)PHENYL]CINNAMIDE; N [2 (3 DIMETHYLAMINOPROPYLTHIO)PHENYL] 2 CYANOCINNAMIDE; N [2 (3 DIMETHYLAMINOPROPYLTHIO)PHENYL] 2 PHENYLCINNAMIDE; N [2 (3 DIMETHYLAMINOPROPYLTHIO)PHENYL] 3 PHENYLPROPANAMIDE; N [2 (3 DIMETHYLAMINOPROPYLTHIO)PHENYL] 4 METHYLBENZENESULFONAMIDE; N [2 (3 DIMETHYLAMINOPROPYLTHIO)PHENYL] 4 PHENYLBENZAMIDE; N [2 (3 DIMETHYLAMINOPROPYLTHIO)PHENYL]BENZAMIDE; N [2 (3 DIMETHYLAMINOPROPYLTHIO)PHENYL]PHENYLACETAMIDE; N [2 (3 METHOXYPROPYLTHIO)PHENYL]CINNAMIDE; N [2 (3 PYRIDYLMETHYLTHIO)PHENYL]CINNAMIDE; N [2 (4 METHOXYBUTYLTHIO)PHENYL]CINNAMIDE; N [2 (4 NITROBENZYLTHIO)PHENYL]CINNAMIDE; N [2 (4 PYRIDYLMETHYLTHIO)PHENYL]CINNAMIDE; N [2 (PHENETHYLTHIO)PHENYL]CINNAMIDE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; IC 50; NONHUMAN; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME;

ANTIVIRAL AGENTS; CINANSERIN; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; FLUORESCENCE RESONANCE ENERGY TRANSFER; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEASE INHIBITORS; SARS VIRUS; SEROTONIN ANTAGONISTS; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 54349125060     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.1400     Document Type: Article

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