Letters to the editor: TNF-α is not the cause of fatty liver disease in obese diabetic mice

Nature Medicine

Volumn 7, Issue 1, 2001, Pages 2-3

  Memon, R A ^a   Grunfeld, C ^a   Feingold, K R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LEPTIN; METFORMIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LETTER; LIPID LIVER LEVEL; LIVER FATTY DEGENERATION; LIVER MITOCHONDRION; MOUSE; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; FATTY LIVER; LIPID METABOLISM; LIVER; METABOLISM; NOTE; PHYSIOLOGY;

ANIMALIA;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; FATTY LIVER; LIPID METABOLISM; LIVER; MICE; OBESITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035131872     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/83316     Document Type: Letter

References (15)

1. Metformin reverse fatty liver disease in obese, leptin-deficient mice
2. Protection from obesity-induced insulin resistance in mice lacking TNF-α function
3. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α mediated insulin resistance in genetic obesity
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5. Obesity increases sensitivity to endotoxin liver injury: Implications for pathogenesis of steatohepatitis
6. Nonalcoholic fatty liver disease: A spectrum of clinical pathological severity
7. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
8. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear-κB: Studies with isolated mitochondria and rat hepatocytes
9. Mitochondrial adaptations to obesity-related oxidant stress
10. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
11. Kupffer cells are a dominant type of uncoupling protein-2 expression in rat liver
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13. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice
14. Role of uncoupled and non-coupled oxidations in the maintenance of safely low levels of oxygen and its one electron reductants
15. Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest