Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats

Journal of Hypertension

Volumn 25, Issue 8, 2007, Pages 1687-1697

  Hilgers, Rob H P ^a   Todd Jr , Joseph ^a   Webb, R Clinton ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Angiotensin II; Calcium sensitization; Hypertension; Mesenteric artery; Rho kinase

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANGIOTENSIN II; CALCIUM; CALYCULIN A; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MYOSIN LIGHT CHAIN PHOSPHATASE; NORADRENALIN; PDZ PROTEIN; PHENYLEPHRINE; POTASSIUM ION; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY RESISTANCE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DEPOLARIZATION; ENDOTHELIUM; ENZYME ACTIVITY; ENZYME SUBUNIT; HYPERTENSION; IMMUNOPRECIPITATION; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

EID: 34447318332     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32816f778d     Document Type: Article

References (33)

1. Somlyo AP, Somlyo AV. Signal transduction and regulation smooth muscle. Nature 1994; 372:231-236.
2. Hilgers RH, Webb RC. Molecular aspects of arterial smooth muscle contraction: focus on Rho. Exp Biol Med (Maywood) 2005; 230:829-835.
3. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997; 389:990-994.
4. Jackson EK, Andresen BT, Seasholtz TM, Zhu C, Romero GG. Enhanced activation of RhoA by angiotensin II in SHR preglomerular microvascular smooth muscle cells. J Cardiovasc Pharmacol 2005; 45:283-285.
5. Ying Z, Jin L, Palmer T, Webb RC. Angiotensin II up-regulates the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF), a regulator of G protein signaling domain-containing RhoGEF, in vascular smooth muscle cells. Mol Pharmacol 2006; 69:932-940.
6. Schmidt A, Hall A. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 2002; 16:1587-1609.
7. Leung T, Chen XQ, Manser E, Lim L. The p. 160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol 1996; 16:1513-1527.
8. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho kinase). Science 1996; 273:245-248.
9. Lee DL, Webb RC, Jin L. Hypertension and RhoA/Rho kinase signaling in the vasculature: highlights from the recent literature. Hypertension 2004; 44:796-799.
10. Weber DS, Webb RC. Enhanced relaxation to the Rho kinase inhibitor Y-27632 in mesenteric arteries from mineralocorticoid hypertensive rats. Pharmacology 2001; 63:129-133.
11. Mukai Y, Shimokawa H, Matoba T, Kandabashi T, Satoh S, Hiroki J, et al. Involvement of Rho kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J 2001; 15:1062-1064.
12. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000; 522:177-185.
13. Bohr DF, Dominiczak AF, Webb RC. Pathophysiology of the vasculature in hypertension. Hypertension 1991; 18:69-75.
14. Mulvany MJ, Aalkjaer C. Structure and function of small arteries. Physiol Rev 1990; 70:921-961.
15. Jin L, Ying Z, Hilgers RH, Yin J, Zhao X, Imig JD, Webb RC. Increased RhoA/Rho kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats. J Pharmacol Exp Ther 2006; 318:288-295.
16. Yamakawa T, Tanaka S, Numaguchi K, Yamakawa Y, Motley ED, Ichihara S, Inagami T. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension 2000; 35:313-318.
17. Moriki N, Ito M, Setoh T, Kureishi Y, Okamoto R, Nakakuki T, et al. RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. Hypertens Res 2004; 27:263-270.
18. Bi D, Nishimura J, Niiro N, Hirano K, Kanaide H. Contractile properties of the cultured vascular smooth muscle cells: the crucial role played by RhoA in the regulation of contractility. Circ Res 2005; 96:890-897.
19. Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, et al. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 2003; 92:411-418.
20. Ying Z, Jin L, Dorrance AM, Webb RC. Increased expression of mRNA for regulator of G protein signaling domain-containing Rho guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive rats. Am J Hypertens 2004; 17:981-985.
21. Bian K, Bukoski RD. Myofilament calcium sensitivity of normotensive and hypertensive resistance arteries. Hypertension 1995; 25:110-116.
22. Bolz SS, Vogel L, Sollinger D, Derwand R, de Wit C, Loirand G, Pohl U. Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. Circulation 2003; 107:3081-3087.
23. Shaw LM, Ohanian J, Heagerty AM. Calcium sensitivity and agonist-induced calcium sensitization in small arteries of young and adult spontaneously hypertensive rats. Hypertension 1997; 30:442-448.
24. 2+-sensitization of coronary artery contraction in genetically hypertensive rats: evidence for altered signal transduction in the coronary smooth muscle cells. J Clin Invest 1994; 94:1397-1403.
25. Fukui T, Ishizaka N, Rajagopalan S, Laursen JB, Capers IVQ, Taylor WR, et al. P22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. J Biol Chem 1996; 271:23317- 23321.
26. Daigle C, Martens FMAC, Girardot D, Dao HH, Touyz RM, Moreau P. Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo. BMC Cardiovasc Disord 2004; 10:4-6.
27. 13 in receptor-mediated stress fiber formation. J Biol Chem 1999; 274:17901-17907.
28. Fukumoto S, Chikumi H, Gutkind JS. RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho. Oncogene 2001; 20:1661-1668.
29. Booden MA, Siderovski DP, Der CJ. Leukemia-associated Rho guanine nucleotide exchange factor promotes Gαq-coupled activation of RhoA. Mol Cell Biol 2002; 22:4053-4061.
30. Olesky A, Opalinski L, Derewenda U, Derewenda ZS, Otlewski J. The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF. J Biol Chem 2006; 281:32891-32897.
31. 2+. Circ Res 2001; 88:1283-1290.
32. 2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697. Biochem J 2005; 389:763-774.
33. Nagumo H, Sasaki Y, Ono Y, Okamoto H, Seto M, Takuwa Y. Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. Am J Physiol 2000; 278:C57-C65.