Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/βPIX/Rac-1 pathway

Hypertension

Volumn 54, Issue 5, 2009, Pages 1028-1034

  Vecchione, Carmine ^a   Carnevale, Daniela ^a   Di Pardo, Alba ^a   Gentile, Maria Teresa ^a   Damato, Antonio ^a   Cocozza, Germana ^a   Antenucci, Giovanna ^a   Mascio, Giada ^a   Bettarini, Umberto ^a   Landolfi, Alessandro ^a   Iorio, Luca ^a   Maffei, Angelo ^a   Lembo, Giuseppe ^a,b  

^a IRCCS NEUROMED   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Endothelial dysfunction; High pressure; Integrin signaling; Mechanotransduction; Oxidative stress

Indexed keywords

GUANINE DERIVATIVE; INTEGRIN LINKED KINASE; INTEGRIN LINKED KINASE 1; PAXILLIN; PROTEIN BETA PIX; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; SUPEROXIDE; UNCLASSIFIED DRUG; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MONITORING; CAROTID ARTERY; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART DISEASE; HEART FUNCTION; HYPERTENSION; MALE; MECHANICAL STRESS; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRESSURE GRADIENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR TISSUE; VASODILATATION; BLOOD VESSEL; DRUG EFFECT; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

BLOOD VESSELS; CAROTID ARTERIES; ENDOTHELIUM, VASCULAR; HUMANS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PAXILLIN; PROTEIN-SERINE-THREONINE KINASES; RAC1 GTP-BINDING PROTEIN; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 70449725149     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.109.136572     Document Type: Article

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