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Volumn 19, Issue 11, 2010, Pages 1321-1338

Tumor vasculature as target for therapeutic intervention

Author keywords

angiogenesis; cancer; tumor vasculature; vascular active agents; vascular disrupting agents; vascular normalization

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; 6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AFLIBERCEPT; AG 0137; ANGINEX; ANGIOPOIETIN; AXITINIB; BASIC FIBROBLAST GROWTH FACTOR; BAY 57 9352; BEVACIZUMAB; CEDIRANIB; CILENGITIDE; COMBRETASTATIN A1 PHOSPHATE; COMBRETASTATIN A4 PHOSPHATE; CYTOKINE; DENIBULIN; INTEGRIN; MONOCLONAL ANTIBODY IMC 1C11; MONOCLONAL ANTIBODY LM 609; N ACETYLCOLCHINOL PHOSPHATE; N ACETYLPROLYLHISTIDYLSERYLCYSTEINYLASPARAGINE AMIDE; PLACENTAL GROWTH FACTOR; SEMAXANIB; SERINE 2 METHOXY 5 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]ANILIDE; SORAFENIB; SUNITINIB; TRANSFORMING GROWTH FACTOR; TW 152 F; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN; VATALANIB; VOLOCIXIMAB;

EID: 77958478041     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.2010.524204     Document Type: Review
Times cited : (22)

References (185)
  • 1
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990. 61. 5. 759-67.
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-67
    • Fearon, E.R.1    Vogelstein, B.2
  • 2
    • 38749114995 scopus 로고    scopus 로고
    • Oncogenes and cancer
    • Croce CM. Oncogenes and cancer. N Engl J Med 2008;358(5):502-11
    • (2008) N Engl J Med , vol.358 , Issue.5 , pp. 502-11
    • Croce, C.M.1
  • 3
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407(6801):249-57
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-57
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003;9(6):653-60
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 653-60
    • Carmeliet, P.1
  • 5
    • 36148937125 scopus 로고    scopus 로고
    • Tumour vascularization: Sprouting angiogenesis and beyond
    • Hillen F, Griffioen AW. Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev 2007;26(3-4):489-502
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.3-4 , pp. 489-502
    • Hillen, F.1    Griffioen, A.W.2
  • 6
    • 72449192192 scopus 로고    scopus 로고
    • Antiangiogenesis therapy might have the unintended effect of promoting tumor metastasis by increasing an alternative circulatory system
    • Qu B, Guo L, Ma J, Lv Y. Antiangiogenesis therapy might have the unintended effect of promoting tumor metastasis by increasing an alternative circulatory system. Med Hypotheses 2010;74(2):360-1
    • (2010) Med Hypotheses , vol.74 , Issue.2 , pp. 360-1
    • Qu, B.1    Guo, L.2    Ma, J.3    Lv, Y.4
  • 7
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A, et al. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103(2):159-65
    • (1999) J Clin Invest , vol.103 , Issue.2 , pp. 159-65
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3
  • 8
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • Baluk P, Hashizume H, McDonald DM. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 2005;15(1):102-11
    • (2005) Curr Opin Genet Dev , vol.15 , Issue.1 , pp. 102-11
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 9
    • 20344367537 scopus 로고    scopus 로고
    • Tumour vascular targeting
    • Neri D, Bicknell R. Tumour vascular targeting. Nat Rev Cancer 2005;5(6):436-46
    • (2005) Nat Rev Cancer , vol.5 , Issue.6 , pp. 436-46
    • Neri, D.1    Bicknell, R.2
  • 10
    • 0026089377 scopus 로고
    • Microvascular architecture in a mammary carcinoma: Branching patterns and vessel dimensions
    • Less JR, Skalak TC, Sevick EM, Jain RK. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res 1991;51(1):265-73
    • (1991) Cancer Res , vol.51 , Issue.1 , pp. 265-73
    • Less, J.R.1    Skalak, T.C.2    Sevick, E.M.3    Jain, R.K.4
  • 11
    • 7044233257 scopus 로고    scopus 로고
    • Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy
    • Tozer GM, Ameer-Beg SM, Baker J, et al. Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy. Adv Drug Deliv Rev 2005;57(1):135-52
    • (2005) Adv Drug Deliv Rev , vol.57 , Issue.1 , pp. 135-52
    • Tozer, G.M.1    Ameer-Beg, S.M.2    Baker, J.3
  • 12
    • 0034660890 scopus 로고    scopus 로고
    • Fractals and cancer
    • Baish JW, Jain RK. Fractals and cancer. Cancer Res 2000;60(14):3683-8
    • (2000) Cancer Res , vol.60 , Issue.14 , pp. 3683-8
    • Baish, J.W.1    Jain, R.K.2
  • 13
    • 0033839080 scopus 로고    scopus 로고
    • Openings between defective endothelial cells explain tumor vessel leakiness
    • Hashizume H, Baluk P, Morikawa S, et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol 2000;156(4):1363-80
    • (2000) Am J Pathol , vol.156 , Issue.4 , pp. 1363-80
    • Hashizume, H.1    Baluk, P.2    Morikawa, S.3
  • 14
    • 0034531951 scopus 로고    scopus 로고
    • Endothelial cells of tumor vessels: Abnormal but not absent
    • McDonald DM, Foss AJ. Endothelial cells of tumor vessels: abnormal but not absent. Cancer Metastasis Rev 2000;19(1-2):109-20
    • (2000) Cancer Metastasis Rev , vol.19 , Issue.1-2 , pp. 109-20
    • McDonald, D.M.1    Foss, A.J.2
  • 15
    • 0032516078 scopus 로고    scopus 로고
    • Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
    • Hobbs SK, Monsky WL, Yuan F, et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci USA 1998;95(8):4607-12
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.8 , pp. 4607-12
    • Hobbs, S.K.1    Monsky, W.L.2    Yuan, F.3
  • 16
    • 0036548794 scopus 로고    scopus 로고
    • Dissecting tumour pathophysiology using intravital microscopy
    • Jain RK, Munn LL, Fukumura D. Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer 2002;2(4):266-76
    • (2002) Nat Rev Cancer , vol.2 , Issue.4 , pp. 266-76
    • Jain, R.K.1    Munn, L.L.2    Fukumura, D.3
  • 17
    • 0036488496 scopus 로고    scopus 로고
    • Specialization of tumour vasculature
    • Ruoslahti E. Specialization of tumour vasculature. Nat Rev Cancer 2002;2(2):83-90
    • (2002) Nat Rev Cancer , vol.2 , Issue.2 , pp. 83-90
    • Ruoslahti, E.1
  • 18
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005;438(7070):932-6
    • (2005) Nature , vol.438 , Issue.7070 , pp. 932-6
    • Carmeliet, P.1
  • 19
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285(21):1182-6
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-6
    • Folkman, J.1
  • 20
    • 0025204095 scopus 로고
    • Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
    • Ingber D, Fujita T, Kishimoto S, et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 1990;348(6301):555-7
    • (1990) Nature , vol.348 , Issue.6301 , pp. 555-7
    • Ingber, D.1    Fujita, T.2    Kishimoto, S.3
  • 21
    • 34249822498 scopus 로고    scopus 로고
    • Genes that distinguish physiological and pathological angiogenesis
    • Seaman S, Stevens J, Yang MY, et al. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 2007;11(6):539-54
    • (2007) Cancer Cell , vol.11 , Issue.6 , pp. 539-54
    • Seaman, S.1    Stevens, J.2    Yang, M.Y.3
  • 22
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes? Bipolar effects of the tumour stroma in cancer
    • Mueller MM, Fusenig NE. Friends or foes? Bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 2004;4(11):839-49
    • (2004) Nat Rev Cancer , vol.4 , Issue.11 , pp. 839-49
    • Mueller, M.M.1    Fusenig, N.E.2
  • 23
    • 0030051051 scopus 로고    scopus 로고
    • Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction
    • Ronnov-Jessen L, Petersen OW, Bissell MJ. Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 1996;76(1):69-125
    • (1996) Physiol Rev , vol.76 , Issue.1 , pp. 69-125
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Bissell, M.J.3
  • 24
    • 0037805549 scopus 로고    scopus 로고
    • Basement membranes: Structure, assembly and role in tumour angiogenesis
    • Kalluri R. Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 2003;3(6):422-33
    • (2003) Nat Rev Cancer , vol.3 , Issue.6 , pp. 422-33
    • Kalluri, R.1
  • 25
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • Morikawa S, Baluk P, Kaidoh T, et al. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 2002;160(3):985-1000
    • (2002) Am J Pathol , vol.160 , Issue.3 , pp. 985-1000
    • Morikawa, S.1    Baluk, P.2    Kaidoh, T.3
  • 26
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006;6(5):392-401
    • (2006) Nat Rev Cancer , vol.6 , Issue.5 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 27
    • 61449187403 scopus 로고    scopus 로고
    • Origin of carcinoma associated fibroblasts
    • Haviv I, Polyak K, Qiu W, et al. Origin of carcinoma associated fibroblasts. Cell Cycle 2009;8(4):589-95
    • (2009) Cell Cycle , vol.8 , Issue.4 , pp. 589-95
    • Haviv, I.1    Polyak, K.2    Qiu, W.3
  • 29
    • 47849098044 scopus 로고    scopus 로고
    • Inflammation: Gearing the journey to cancer
    • Kundu JK, Surh YJ. Inflammation: gearing the journey to cancer. Mutat Res 2008;659(1-2):15-30
    • (2008) Mutat Res , vol.659 , Issue.1-2 , pp. 15-30
    • Kundu, J.K.1    Surh, Y.J.2
  • 30
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006;124(2):263-6
    • (2006) Cell , vol.124 , Issue.2 , pp. 263-6
    • Condeelis, J.1    Pollard, J.W.2
  • 31
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006;66(2):605-12
    • (2006) Cancer Res , vol.66 , Issue.2 , pp. 605-12
    • Lewis, C.E.1    Pollard, J.W.2
  • 32
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307(5706):58-62
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 33
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain RK. Molecular regulation of vessel maturation. Nat Med 2003;9(6):685-93
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 685-93
    • Jain, R.K.1
  • 34
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3(6):401-10
    • (2003) Nat Rev Cancer , vol.3 , Issue.6 , pp. 401-10
    • Bergers, G.1    Benjamin, L.E.2
  • 35
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9(6):669-76
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 669-76
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 36
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 2005;69(Suppl 3):4-10
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 4-10
    • Carmeliet, P.1
  • 37
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23(5):1011-27
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1011-27
    • Hicklin, D.J.1    Ellis, L.M.2
  • 38
    • 0030641090 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A multifunctional angiogenic cytokine
    • Brown LF, Detmar M, Claffey K, et al. Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine. Exs 1997;79:233-69
    • (1997) Exs , vol.79 , pp. 233-69
    • Brown, L.F.1    Detmar, M.2    Claffey, K.3
  • 39
    • 0034662621 scopus 로고    scopus 로고
    • Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy
    • Hansen-Algenstaedt N, Stoll BR, Padera TP, et al. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res 2000;60(16):4556-60
    • (2000) Cancer Res , vol.60 , Issue.16 , pp. 4556-60
    • Hansen-Algenstaedt, N.1    Stoll, B.R.2    Padera, T.P.3
  • 40
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M, LeJeune S, Scott PA, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997;57(5):963-9
    • (1997) Cancer Res , vol.57 , Issue.5 , pp. 963-9
    • Relf, M.1    Lejeune, S.2    Scott, P.A.3
  • 41
    • 0033121275 scopus 로고    scopus 로고
    • The role of alpha-v integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
    • Eliceiri BP, Cheresh DA. The role of alpha-v integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest 1999;103(9):1227-30
    • (1999) J Clin Invest , vol.103 , Issue.9 , pp. 1227-30
    • Eliceiri, B.P.1    Cheresh, D.A.2
  • 42
    • 0031745571 scopus 로고    scopus 로고
    • Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
    • Aplin AE, Howe A, Alahari SK, Juliano RL. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev 1998;50(2):197-263
    • (1998) Pharmacol Rev , vol.50 , Issue.2 , pp. 197-263
    • Aplin, A.E.1    Howe, A.2    Alahari, S.K.3    Juliano, R.L.4
  • 43
    • 0026631151 scopus 로고
    • Involvement of integrin alpha v gene expression in human melanoma tumorigenicity
    • Felding-Habermann B, Mueller BM, Romerdahl CA, Cheresh DA. Involvement of integrin alpha V gene expression in human melanoma tumorigenicity. J Clin Invest 1992;89(6):2018-22
    • (1992) J Clin Invest , vol.89 , Issue.6 , pp. 2018-22
    • Felding-Habermann, B.1    Mueller, B.M.2    Romerdahl, C.A.3    Cheresh, D.A.4
  • 45
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994;264(5158):569-71
    • (1994) Science , vol.264 , Issue.5158 , pp. 569-71
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 46
    • 0038376001 scopus 로고    scopus 로고
    • Imaging of angiogenesis: From microscope to clinic
    • McDonald DM, Choyke PL. Imaging of angiogenesis: from microscope to clinic Nat Med 2003;9(6):713-25
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 713-25
    • McDonald, D.M.1    Choyke, P.L.2
  • 47
    • 0028972105 scopus 로고
    • Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin
    • Brooks PC, Stromblad S, Klemke R, et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest 1995;96(4):1815-22
    • (1995) J Clin Invest , vol.96 , Issue.4 , pp. 1815-22
    • Brooks, P.C.1    Stromblad, S.2    Klemke, R.3
  • 48
    • 0028670833 scopus 로고
    • Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks PC, Montgomery AM, Rosenfeld M, et al. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994;79(7):1157-64
    • (1994) Cell , vol.79 , Issue.7 , pp. 1157-64
    • Brooks, P.C.1    Montgomery, A.M.2    Rosenfeld, M.3
  • 49
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha vintegrins
    • Bader BL, Rayburn H, Crowley D, Hynes RO. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha vintegrins. Cell 1998;95(4):507-19
    • (1998) Cell , vol.95 , Issue.4 , pp. 507-19
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 50
    • 20144379162 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis
    • Nyberg P, Xie L, Kalluri R Endogenous inhibitors of angiogenesis. Cancer Res 2005;65(10):3967-79
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 3967-79
    • Nyberg, P.1    Xie, L.2    Kalluri, R.3
  • 51
    • 10344258050 scopus 로고    scopus 로고
    • The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesis
    • Sund M, Xie L, Kalluri R. The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesis. APMIS 2004;112(7-8):450-62
    • (2004) APMIS , vol.112 , Issue.7-8 , pp. 450-62
    • Sund, M.1    Xie, L.2    Kalluri, R.3
  • 52
    • 61649113720 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis A historical review
    • Ribatti D. Endogenous inhibitors of angiogenesis A historical review. Leuk Res 2009;33(5):638-44
    • (2009) Leuk Res , vol.33 , Issue.5 , pp. 638-44
    • Ribatti, D.1
  • 53
    • 0025093973 scopus 로고
    • Vascular attack as a therapeutic strategy for cancer
    • Denekamp J. Vascular attack as a therapeutic strategy for cancer. Cancer Metastasis Rev 1990;9(3):267-82
    • (1990) Cancer Metastasis Rev , vol.9 , Issue.3 , pp. 267-82
    • Denekamp, J.1
  • 54
    • 0020081554 scopus 로고
    • Endothelial cell proliferation as a novel approach to targeting tumour therapy
    • Denekamp J. Endothelial cell proliferation as a novel approach to targeting tumour therapy. Br J Cancer 1982;45(1):136-9
    • (1982) Br J Cancer , vol.45 , Issue.1 , pp. 136-9
    • Denekamp, J.1
  • 55
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438(7070):967-74
    • (2005) Nature , vol.438 , Issue.7070 , pp. 967-74
    • Ferrara, N.1    Kerbel, R.S.2
  • 56
    • 0035525207 scopus 로고    scopus 로고
    • Angiogenesis inhibition in solid tumors
    • Rosen LS. Angiogenesis inhibition in solid tumors. Cancer J 2001;7(Suppl 3):S120-8
    • (2001) Cancer J , vol.7 , Issue.SUPPL. 3
    • Rosen, L.S.1
  • 57
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4(6):423-36
    • (2004) Nat Rev Cancer , vol.4 , Issue.6 , pp. 423-36
    • Kerbel, R.S.1    Kamen, B.A.2
  • 58
    • 0014936304 scopus 로고
    • Inhibition of metastatic spread by I.C.R F. 159: Selective deletion of a malignant characteristic
    • Salsbury AJ, Burrage K, Hellmann K. Inhibition of metastatic spread by I.C.R. F. 159: selective deletion of a malignant characteristic Br Med J 1970;4(5731):344-6
    • (1970) Br Med J , vol.4 , Issue.5731 , pp. 344-6
    • Salsbury, A.J.1    Burrage, K.2    Hellmann, K.3
  • 59
    • 0015493534 scopus 로고
    • Metastases and the normalization of tumour blood vessels by ICRF 159:A new type of drug action
    • Le Serve AW, Hellmann K. Metastases and the normalization of tumour blood vessels by ICRF 159:a new type of drug action. Br Med J 1972;1(5800):597-601
    • (1972) Br Med J , vol.1 , Issue.5800 , pp. 597-601
    • Le Serve, A.W.1    Hellmann, K.2
  • 60
    • 0037247791 scopus 로고    scopus 로고
    • Dynamics of tumour angiogenesis: Effect of razoxane-induced growth rate slowdown
    • Hellmann K. Dynamics of tumour angiogenesis: effect of razoxane-induced growth rate slowdown. Clin Exp Metastasis 2003;20(2):95-102
    • (2003) Clin Exp Metastasis , vol.20 , Issue.2 , pp. 95-102
    • Hellmann, K.1
  • 61
    • 0037939726 scopus 로고    scopus 로고
    • Vasocrine' formation of tumor cell-lined vascular spaces: Implications for rational design of antiangiogenic therapies
    • Rybak SM, Sanovich E, Hollingshead MG, et al. 'Vasocrine' formation of tumor cell-lined vascular spaces: implications for rational design of antiangiogenic therapies. Cancer Res 2003;63(11):2812-19
    • (2003) Cancer Res , vol.63 , Issue.11 , pp. 2812-19
    • Rybak, S.M.1    Sanovich, E.2    Hollingshead, M.G.3
  • 62
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001;7(9):987-9
    • (2001) Nat Med , vol.7 , Issue.9 , pp. 987-9
    • Jain, R.K.1
  • 63
    • 0038235987 scopus 로고    scopus 로고
    • Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
    • Wildiers H, Guetens G, De Boeck G, et al. Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer 2003;88(12):1979-86
    • (2003) Br J Cancer , vol.88 , Issue.12 , pp. 1979-86
    • Wildiers, H.1    Guetens, G.2    De Boeck, G.3
  • 64
    • 0034306974 scopus 로고    scopus 로고
    • Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
    • Lee CG, Heijn M, di Tomaso E, et al. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 2000;60(19):5565-70
    • (2000) Cancer Res , vol.60 , Issue.19 , pp. 5565-70
    • Lee, C.G.1    Heijn, M.2    Di Tomaso, E.3
  • 65
    • 34249689557 scopus 로고    scopus 로고
    • VEGF-targeted cancer therapy strategies: Current progress, hurdles and future prospects
    • Duda DG, Batchelor TT, Willett CG, Jain RK. VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. Trends Mol Med 2007;13(6):223-30
    • (2007) Trends Mol Med , vol.13 , Issue.6 , pp. 223-30
    • Duda, D.G.1    Batchelor, T.T.2    Willett, C.G.3    Jain, R.K.4
  • 66
    • 34248372373 scopus 로고    scopus 로고
    • Rationale and clinical results of multi-target treatments in oncology
    • Sartore-Bianchi A, Ricotta R, Cerea G, et al. Rationale and clinical results of multi-target treatments in oncology. Int J Biol Markers 2007;22(1 Suppl 4):S77-87
    • (2007) Int J Biol Markers , vol.22 , Issue.1 SUPPL. 4
    • Sartore-Bianchi, A.1    Ricotta, R.2    Cerea, G.3
  • 67
    • 34247847960 scopus 로고    scopus 로고
    • Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer
    • Willett CG, Duda DG, di Tomaso E, et al. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol 2007;4(5):316-21
    • (2007) Nat Clin Pract Oncol , vol.4 , Issue.5 , pp. 316-21
    • Willett, C.G.1    Duda, D.G.2    Di Tomaso, E.3
  • 68
    • 78651031713 scopus 로고
    • Chemotherapy of cancer: Regional perfusion utilizing an extracorporeal circuit
    • Creech O Jr, Krementz ET, Ryan RF, Winblad JN. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg 1958;148(4):616-32
    • (1958) Ann Surg , vol.148 , Issue.4 , pp. 616-32
    • Creech Jr., O.1    Krementz, E.T.2    Ryan, R.F.3    Winblad, J.N.4
  • 69
    • 0023885868 scopus 로고
    • Regional perfusion treatment with melphalan for melanoma in a limb: An evaluation of drug kinetics
    • Benckhuijsen C, Kroon BB, van Geel AN, Wieberdink J. Regional perfusion treatment with melphalan for melanoma in a limb: an evaluation of drug kinetics. Eur J Surg Oncol 1988;14(2):157-63
    • (1988) Eur J Surg Oncol , vol.14 , Issue.2 , pp. 157-63
    • Benckhuijsen, C.1    Kroon, B.B.2    Van Geel, A.N.3    Wieberdink, J.4
  • 70
    • 0026717674 scopus 로고
    • The pathophysiology of tumor necrosis factors
    • Vassalli P. The pathophysiology of tumor necrosis factors. Annu Rev Immunol 1992;10:411-52
    • (1992) Annu Rev Immunol , vol.10 , pp. 411-52
    • Vassalli, P.1
  • 71
    • 0023877120 scopus 로고
    • Toxic effect of tumor necrosis factor on tumor vasculature in mice
    • Watanabe N, Niitsu Y, Umeno H, et al. Toxic effect of tumor necrosis factor on tumor vasculature in mice. Cancer Res 1988;48(8):2179-83
    • (1988) Cancer Res , vol.48 , Issue.8 , pp. 2179-83
    • Watanabe, N.1    Niitsu, Y.2    Umeno, H.3
  • 72
    • 0033836614 scopus 로고    scopus 로고
    • Low-dose tumor necrosis factor-alpha augments antitumor activity of stealth liposomal doxorubicin (DOXIL) in soft tissue sarcoma-bearing rats
    • Ten Hagen TL, Van Der Veen AH, Nooijen PT, et al. Low-dose tumor necrosis factor-alpha augments antitumor activity of stealth liposomal doxorubicin (DOXIL) in soft tissue sarcoma-bearing rats. Int J Cancer 2000;87(6):829-37
    • (2000) Int J Cancer , vol.87 , Issue.6 , pp. 829-37
    • Ten Hagen, T.L.1    Van Der Veen, A.H.2    Nooijen, P.T.3
  • 73
    • 35148831186 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha mediates homogeneous distribution of liposomes in murine melanoma that contributes to a better tumor response
    • Seynhaeve AL, Hoving S, Schipper D, et al. Tumor necrosis factor alpha mediates homogeneous distribution of liposomes in murine melanoma that contributes to a better tumor response. Cancer Res 2007;67(19):9455-62
    • (2007) Cancer Res , vol.67 , Issue.19 , pp. 9455-62
    • Seynhaeve, A.L.1    Hoving, S.2    Schipper, D.3
  • 74
    • 0035674528 scopus 로고    scopus 로고
    • Liposome-encapsulated tumor necrosis factor-alpha enhances the effects of radiation against human colon tumor xenografts
    • Kim DW, Andres ML, Li J, et al. Liposome-encapsulated tumor necrosis factor-alpha enhances the effects of radiation against human colon tumor xenografts. J Interferon Cytokine Res 2001;21(11):885-97
    • (2001) J Interferon Cytokine Res , vol.21 , Issue.11 , pp. 885-97
    • Kim, D.W.1    Andres, M.L.2    Li, J.3
  • 75
    • 33748473423 scopus 로고    scopus 로고
    • Early destruction of tumor vasculature in tumor necrosis factor-alpha-based isolated limb perfusion is responsible for tumor response
    • Hoving S, Seynhaeve AL, van Tiel ST, et al. Early destruction of tumor vasculature in tumor necrosis factor-alpha-based isolated limb perfusion is responsible for tumor response. Anticancer Drugs 2006;17(8):949-59
    • (2006) Anticancer Drugs , vol.17 , Issue.8 , pp. 949-59
    • Hoving, S.1    Seynhaeve, A.L.2    Van Tiel, S.T.3
  • 76
    • 7944228473 scopus 로고    scopus 로고
    • Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: Preclinical studies
    • Brunstein F, Hoving S, Seynhaeve AL, et al. Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: preclinical studies. J Natl Cancer Inst 2004;96(21):1603-10
    • (2004) J Natl Cancer Inst , vol.96 , Issue.21 , pp. 1603-10
    • Brunstein, F.1    Hoving, S.2    Seynhaeve, A.L.3
  • 77
    • 20144380062 scopus 로고    scopus 로고
    • Synergistic antitumor response of interleukin 2 with melphalan in isolated limb perfusion in soft tissue sarcoma-bearing rats
    • Hoving S, Brunstein F, aan de Wiel-Ambagtsheer G, et al. Synergistic antitumor response of interleukin 2 with melphalan in isolated limb perfusion in soft tissue sarcoma-bearing rats. Cancer Res 2005;65(10):4300-8
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 4300-8
    • Hoving, S.1    Brunstein, F.2    Aan De Wiel-Ambagtsheer, G.3
  • 78
    • 33845629436 scopus 로고    scopus 로고
    • Isolated limb perfusion with melphalan and tumor necrosis factor alpha for advanced melanoma and soft-tissue sarcoma
    • Hayes AJ, Neuhaus SJ, Clark MA, Thomas JM. Isolated limb perfusion with melphalan and tumor necrosis factor alpha for advanced melanoma and soft-tissue sarcoma. Ann Surg Oncol 2007;14(1):230-8
    • (2007) Ann Surg Oncol , vol.14 , Issue.1 , pp. 230-8
    • Hayes, A.J.1    Neuhaus, S.J.2    Clark, M.A.3    Thomas, J.M.4
  • 79
    • 32844472410 scopus 로고    scopus 로고
    • Technology insight: Utility of TNF-alpha-based isolated limb perfusion to avoid amputation of irresectable tumors of the extremities
    • Grunhagen DJ, de Wilt JH, ten Hagen TL, Eggermont AM. Technology insight: utility of TNF-alpha-based isolated limb perfusion to avoid amputation of irresectable tumors of the extremities. Nat Clin Pract Oncol 2006;3(2):94-103
    • (2006) Nat Clin Pract Oncol , vol.3 , Issue.2 , pp. 94-103
    • Grunhagen, D.J.1    De Wilt, J.H.2    Ten Hagen, T.L.3    Eggermont, A.M.4
  • 80
    • 44949120836 scopus 로고    scopus 로고
    • Isolated limb perfusion with melphalan and TNF-alpha in the treatment of extremity sarcoma
    • Verhoef C, de Wilt JH, Grunhagen DJ, et al. Isolated limb perfusion with melphalan and TNF-alpha in the treatment of extremity sarcoma. Curr Treat Options Oncol 2007;8(6):417-27
    • (2007) Curr Treat Options Oncol , vol.8 , Issue.6 , pp. 417-27
    • Verhoef, C.1    De Wilt, J.H.2    Grunhagen, D.J.3
  • 82
    • 0021686169 scopus 로고
    • Dynamic instability of microtubule growth
    • Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature 1984;312(5991):237-42
    • (1984) Nature , vol.312 , Issue.5991 , pp. 237-42
    • Mitchison, T.1    Kirschner, M.2
  • 83
    • 1642564595 scopus 로고    scopus 로고
    • Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho
    • Bayless KJ, Davis GE. Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho. J Biol Chem 2004;279(12):11686-95
    • (2004) J Biol Chem , vol.279 , Issue.12 , pp. 11686-95
    • Bayless, K.J.1    Davis, G.E.2
  • 84
    • 0037085753 scopus 로고    scopus 로고
    • The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
    • Kanthou C, Tozer GM. The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. Blood 2002;99(6):2060-9
    • (2002) Blood , vol.99 , Issue.6 , pp. 2060-9
    • Kanthou, C.1    Tozer, G.M.2
  • 85
    • 36749043820 scopus 로고    scopus 로고
    • Tumour targeting by microtubule-depolymerizing vascular disrupting agents
    • Kanthou C, Tozer GM. Tumour targeting by microtubule-depolymerizing vascular disrupting agents. Expert Opin Ther Targets 2007;11(11):1443-57
    • (2007) Expert Opin Ther Targets , vol.11 , Issue.11 , pp. 1443-57
    • Kanthou, C.1    Tozer, G.M.2
  • 86
    • 0036278972 scopus 로고    scopus 로고
    • Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models
    • Blakey DC, Westwood FR, Walker M, et al. Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models. Clin Cancer Res 2002;8(6):1974-83
    • (2002) Clin Cancer Res , vol.8 , Issue.6 , pp. 1974-83
    • Blakey, D.C.1    Westwood, F.R.2    Walker, M.3
  • 87
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004;10(2):415-27
    • (2004) Clin Cancer Res , vol.10 , Issue.2 , pp. 415-27
    • Thorpe, P.E.1
  • 88
    • 0037373826 scopus 로고    scopus 로고
    • Blakey DC the first international conference on vascular targeting: Meeting overview
    • Thorpe PE, Chaplin DJ, Blakey DC The first international conference on vascular targeting: meeting overview. Cancer Res 2003;63(5):1144-7
    • (2003) Cancer Res , vol.63 , Issue.5 , pp. 1144-7
    • Thorpe, P.E.1    Chaplin, D.J.2
  • 89
    • 0036569804 scopus 로고    scopus 로고
    • Enhancement of radiation therapy by the novel vascular targeting agent ZD6126
    • Siemann DW, Rojiani AM. Enhancement of radiation therapy by the novel vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys 2002;53(1):164-71
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , Issue.1 , pp. 164-71
    • Siemann, D.W.1    Rojiani, A.M.2
  • 90
    • 0036891109 scopus 로고    scopus 로고
    • Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126
    • Siemann DW, Rojiani AM. Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys 2002;54(5):1512-17
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , Issue.5 , pp. 1512-17
    • Siemann, D.W.1    Rojiani, A.M.2
  • 91
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
    • Siemann DW, Mercer E, Lepler S, Rojiani AM. Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy. Int J Cancer 2002;99(1):1-6
    • (2002) Int J Cancer , vol.99 , Issue.1 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rojiani, A.M.4
  • 92
    • 34948862788 scopus 로고    scopus 로고
    • Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel
    • Martinelli M, Bonezzi K, Riccardi E, et al. Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel. Br J Cancer 2007;97(7):888-94
    • (2007) Br J Cancer , vol.97 , Issue.7 , pp. 888-94
    • Martinelli, M.1    Bonezzi, K.2    Riccardi, E.3
  • 93
    • 4744355086 scopus 로고    scopus 로고
    • Combination of the vascular targeting agent ZD6126 with boron neutron capture therapy
    • Masunaga S, Sakurai Y, Suzuki M, et al. Combination of the vascular targeting agent ZD6126 with boron neutron capture therapy. Int J Radiat Oncol Biol Phys 2004;60(3):920-7
    • (2004) Int J Radiat Oncol Biol Phys , vol.60 , Issue.3 , pp. 920-7
    • Masunaga, S.1    Sakurai, Y.2    Suzuki, M.3
  • 94
    • 0142155561 scopus 로고    scopus 로고
    • Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response
    • Horsman MR, Murata R. Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response. Int J Radiat Oncol Biol Phys 2003;57(4):1047-55
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , Issue.4 , pp. 1047-55
    • Horsman, M.R.1    Murata, R.2
  • 95
    • 20344394640 scopus 로고    scopus 로고
    • The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors
    • Siemann DW, Rojiani AM. The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors. Int J Radiat Oncol Biol Phys 2005;62(3):846-53
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , Issue.3 , pp. 846-53
    • Siemann, D.W.1    Rojiani, A.M.2
  • 96
    • 70350002279 scopus 로고    scopus 로고
    • Adverse effects of anticancer agents that target the VEGF pathway
    • Chen HX, Cleck JN. Adverse effects of anticancer agents that target the VEGF pathway. Nat Rev Clin Oncol 2009;6(8):465-77
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.8 , pp. 465-77
    • Chen, H.X.1    Cleck, J.N.2
  • 97
    • 33645732100 scopus 로고    scopus 로고
    • Phase i clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors
    • Beerepoot LV, Radema SA, Witteveen EO, et al. Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors. J Clin Oncol 2006;24(10):1491-8
    • (2006) J Clin Oncol , vol.24 , Issue.10 , pp. 1491-8
    • Beerepoot, L.V.1    Radema, S.A.2    Witteveen, E.O.3
  • 98
    • 77949494504 scopus 로고    scopus 로고
    • Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma
    • Helfrich I, Scheffrahn I, Bartling S, et al. Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma. J Exp Med 2010;207(3):491-503
    • (2010) J Exp Med , vol.207 , Issue.3 , pp. 491-503
    • Helfrich, I.1    Scheffrahn, I.2    Bartling, S.3
  • 99
    • 34047092739 scopus 로고    scopus 로고
    • How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor
    • Luckner SR, Klotzsche M, Berens C, et al. How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor. J Mol Biol 2007;368(3):780-90
    • (2007) J Mol Biol , vol.368 , Issue.3 , pp. 780-90
    • Luckner, S.R.1    Klotzsche, M.2    Berens, C.3
  • 100
    • 0037106261 scopus 로고    scopus 로고
    • Phase i study of recombinant human endostatin in patients with advanced solid tumors
    • Herbst RS, Hess KR, Tran HT, et al. Phase I study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol 2002;20(18):3792-803
    • (2002) J Clin Oncol , vol.20 , Issue.18 , pp. 3792-803
    • Herbst, R.S.1    Hess, K.R.2    Tran, H.T.3
  • 101
    • 0037440123 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors
    • Thomas JP, Arzoomanian RZ, Alberti D, et al. Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol 2003;21(2):223-31
    • (2003) J Clin Oncol , vol.21 , Issue.2 , pp. 223-31
    • Thomas, J.P.1    Arzoomanian, R.Z.2    Alberti, D.3
  • 102
    • 33747072903 scopus 로고    scopus 로고
    • Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors
    • Kulke MH, Bergsland EK, Ryan DP, et al. Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors. J Clin Oncol 2006;24(22):3555-61
    • (2006) J Clin Oncol , vol.24 , Issue.22 , pp. 3555-61
    • Kulke, M.H.1    Bergsland, E.K.2    Ryan, D.P.3
  • 103
    • 0034283571 scopus 로고    scopus 로고
    • Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity
    • Sasaki T, Larsson H, Tisi D, et al. Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity. J Mol Biol 2000;301(5):1179-90
    • (2000) J Mol Biol , vol.301 , Issue.5 , pp. 1179-90
    • Sasaki, T.1    Larsson, H.2    Tisi, D.3
  • 104
    • 0034647922 scopus 로고    scopus 로고
    • Distinct antitumor properties of a type IV collagen domain derived from basement membrane
    • Maeshima Y, Colorado PC, Torre A, et al. Distinct antitumor properties of a type IV collagen domain derived from basement membrane. J Biol Chem 2000;275(28):21340-8
    • (2000) J Biol Chem , vol.275 , Issue.28 , pp. 21340-8
    • Maeshima, Y.1    Colorado, P.C.2    Torre, A.3
  • 105
    • 4444353257 scopus 로고    scopus 로고
    • Tumor progression: The effects ofthrombospondin-1 and-2
    • Lawler J, Detmar M. Tumor progression: the effects ofthrombospondin-1 and-2. Int J Biochem Cell Biol 2004;36(6):1038-45
    • (2004) Int J Biochem Cell Biol , vol.36 , Issue.6 , pp. 1038-45
    • Lawler, J.1    Detmar, M.2
  • 106
    • 24644508961 scopus 로고    scopus 로고
    • Phase i safety, pharmacokinetic, and pharmacodynamic study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced cancer
    • Hoekstra R, de Vos FY, Eskens FA, et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced cancer. J Clin Oncol 2005;23(22):5188-97
    • (2005) J Clin Oncol , vol.23 , Issue.22 , pp. 5188-97
    • Hoekstra, R.1    De Vos, F.Y.2    Eskens, F.A.3
  • 107
    • 57149111052 scopus 로고    scopus 로고
    • Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma
    • Baker LH, Rowinsky EK, Mendelson D, et al. Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma. J Clin Oncol 2008;26(34):5583-8
    • (2008) J Clin Oncol , vol.26 , Issue.34 , pp. 5583-8
    • Baker, L.H.1    Rowinsky, E.K.2    Mendelson, D.3
  • 108
    • 0034194237 scopus 로고    scopus 로고
    • Anti-angiogenic cues from vascular basement membrane collagen
    • Colorado PC, Torre A, Kamphaus G, et al. Anti-angiogenic cues from vascular basement membrane collagen. Cancer Res 2000;60(9):2520-6
    • (2000) Cancer Res , vol.60 , Issue.9 , pp. 2520-6
    • Colorado, P.C.1    Torre, A.2    Kamphaus, G.3
  • 109
    • 0033979905 scopus 로고    scopus 로고
    • Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth
    • Kamphaus GD, Colorado PC, Panka DJ, et al. Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. J Biol Chem 2000;275(2):1209-15
    • (2000) J Biol Chem , vol.275 , Issue.2 , pp. 1209-15
    • Kamphaus, G.D.1    Colorado, P.C.2    Panka, D.J.3
  • 110
    • 0037423391 scopus 로고    scopus 로고
    • Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan
    • Mongiat M, Sweeney SM, San Antonio JD, et al. Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J Biol Chem 2003;278(6):4238-49
    • (2003) J Biol Chem , vol.278 , Issue.6 , pp. 4238-49
    • Mongiat, M.1    Sweeney, S.M.2    San Antonio, J.D.3
  • 111
    • 0022438854 scopus 로고
    • Interferon treatment of human neoplasia
    • Strander H. Interferon treatment of human neoplasia. Adv Cancer Res 1986;46:1-265
    • (1986) Adv Cancer Res , vol.46 , pp. 1-265
    • Strander, H.1
  • 112
    • 0033538517 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
    • Dawson DW, Volpert OV, Gillis P, et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999;285(5425):245-8
    • (1999) Science , vol.285 , Issue.5425 , pp. 245-8
    • Dawson, D.W.1    Volpert, O.V.2    Gillis, P.3
  • 113
    • 29844452745 scopus 로고    scopus 로고
    • Recombinant human angiostatin (rhAngiostatin) in combination with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer: A phase II study from Indiana University
    • Kurup A, Lin CW, Murry DJ, et al. Recombinant human angiostatin (rhAngiostatin) in combination with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer: a phase II study from Indiana University. Ann Oncol 2006;17(1):97-103
    • (2006) Ann Oncol , vol.17 , Issue.1 , pp. 97-103
    • Kurup, A.1    Lin, C.W.2    Murry, D.J.3
  • 114
    • 0033578910 scopus 로고    scopus 로고
    • Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
    • O'Reilly MS, Pirie-Shepherd S, Lane WS, Folkman J. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science 1999;285(5435):1926-8
    • (1999) Science , vol.285 , Issue.5435 , pp. 1926-8
    • O'Reilly, M.S.1    Pirie-Shepherd, S.2    Lane, W.S.3    Folkman, J.4
  • 115
    • 0032582635 scopus 로고    scopus 로고
    • Prothrombin kringle-2 domain has a growth inhibitory activity against basic fibroblast growth factor-stimulated capillary endothelial cells
    • Lee TH, Rhim T, Kim SS. Prothrombin kringle-2 domain has a growth inhibitory activity against basic fibroblast growth factor-stimulated capillary endothelial cells. J Biol Chem 1998;273(44):28805-12
    • (1998) J Biol Chem , vol.273 , Issue.44 , pp. 28805-12
    • Lee, T.H.1    Rhim, T.2    Kim, S.S.3
  • 116
    • 0025166396 scopus 로고
    • Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides
    • Maione TE, Gray GS, Petro J, et al. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 1990;247(4938):77-9
    • (1990) Science , vol.247 , Issue.4938 , pp. 77-9
    • Maione, T.E.1    Gray, G.S.2    Petro, J.3
  • 117
    • 0032830403 scopus 로고    scopus 로고
    • Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo
    • Hayami T, Shukunami C, Mitsui K, et al. Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo. FEBS Lett 1999;458(3):436-40
    • (1999) FEBS Lett , vol.458 , Issue.3 , pp. 436-40
    • Hayami, T.1    Shukunami, C.2    Mitsui, K.3
  • 118
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002;295(5564):2387-92
    • (2002) Science , vol.295 , Issue.5564 , pp. 2387-92
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 119
    • 33750483598 scopus 로고    scopus 로고
    • Phase i safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer
    • James J, Murry DJ, Treston AM, et al. Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. Invest New Drugs 2007;25(1):41-8
    • (2007) Invest New Drugs , vol.25 , Issue.1 , pp. 41-8
    • James, J.1    Murry, D.J.2    Treston, A.M.3
  • 120
    • 35948946128 scopus 로고    scopus 로고
    • Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma
    • Rajkumar SV, Richardson PG, Lacy MQ, et al. Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma. Clin Cancer Res 2007;13(20):6162-7
    • (2007) Clin Cancer Res , vol.13 , Issue.20 , pp. 6162-7
    • Rajkumar, S.V.1    Richardson, P.G.2    Lacy, M.Q.3
  • 121
    • 0032445492 scopus 로고    scopus 로고
    • Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth
    • Pike SE, Yao L, Jones KD, et al. Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J Exp Med 1998;188(12):2349-56
    • (1998) J Exp Med , vol.188 , Issue.12 , pp. 2349-56
    • Pike, S.E.1    Yao, L.2    Jones, K.D.3
  • 122
    • 33845358271 scopus 로고    scopus 로고
    • A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma
    • Mita MM, Rowinsky EK, Forero L, et al. A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma. Cancer Chemother Pharmacol 2007;59(2):165-74
    • (2007) Cancer Chemother Pharmacol , vol.59 , Issue.2 , pp. 165-74
    • Mita, M.M.1    Rowinsky, E.K.2    Forero, L.3
  • 123
    • 3142774878 scopus 로고    scopus 로고
    • AEE788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity
    • Traxler P, Allegrini PR, Brandt R, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 2004;64(14):4931-41
    • (2004) Cancer Res , vol.64 , Issue.14 , pp. 4931-41
    • Traxler, P.1    Allegrini, P.R.2    Brandt, R.3
  • 124
    • 0141993064 scopus 로고    scopus 로고
    • A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia
    • Fiedler W, Mesters R, Tinnefeld H, et al. A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood 2003;102(8):2763-7
    • (2003) Blood , vol.102 , Issue.8 , pp. 2763-7
    • Fiedler, W.1    Mesters, R.2    Tinnefeld, H.3
  • 125
  • 126
    • 39749191543 scopus 로고    scopus 로고
    • Phase i clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012
    • MacDonald TJ, Stewart CF, Kocak M, et al. Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012. J Clin Oncol 2008;26(6):919-24
    • (2008) J Clin Oncol , vol.26 , Issue.6 , pp. 919-24
    • MacDonald, T.J.1    Stewart, C.F.2    Kocak, M.3
  • 127
    • 57149108506 scopus 로고    scopus 로고
    • Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme
    • Reardon DA, Fink KL, Mikkelsen T, et al. Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol 2008;26(34):5610-17
    • (2008) J Clin Oncol , vol.26 , Issue.34 , pp. 5610-17
    • Reardon, D.A.1    Fink, K.L.2    Mikkelsen, T.3
  • 129
    • 33745240059 scopus 로고    scopus 로고
    • Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours
    • Cianfrocca ME, Kimmel KA, Gallo J, et al. Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours. Br J Cancer 2006;94(11):1621-6
    • (2006) Br J Cancer , vol.94 , Issue.11 , pp. 1621-6
    • Cianfrocca, M.E.1    Kimmel, K.A.2    Gallo, J.3
  • 130
    • 61349149253 scopus 로고    scopus 로고
    • Phase III trial of FOLFOX plus bevacizumab or cediranib (AZD2171) as first-line treatment of patients with metastatic colorectal cancer: HORIZON III
    • Robertson JD, Botwood NA, Rothenberg ML, Schmoll HJ. Phase III trial of FOLFOX plus bevacizumab or cediranib (AZD2171) as first-line treatment of patients with metastatic colorectal cancer: HORIZON III. Clin Colorectal Cancer 2009;8(1):59-60
    • (2009) Clin Colorectal Cancer , vol.8 , Issue.1 , pp. 59-60
    • Robertson, J.D.1    Botwood, N.A.2    Rothenberg, M.L.3    Schmoll, H.J.4
  • 131
    • 56749102822 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • Heymach JV, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008;26(33):5407-15
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5407-15
    • Heymach, J.V.1    Paz-Ares, L.2    De Braud, F.3
  • 132
    • 61449202998 scopus 로고    scopus 로고
    • The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
    • Hurwitz HI, Yi J, Ince W, et al. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist 2009;14(1):22-8
    • (2009) Oncologist , vol.14 , Issue.1 , pp. 22-8
    • Hurwitz, H.I.1    Yi, J.2    Ince, W.3
  • 133
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009;27(8):1227-34
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1227-34
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3
  • 134
    • 33750360895 scopus 로고    scopus 로고
    • Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: Theory and clinical practice
    • Willett CG, Kozin SV, Duda DG, et al. Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice. Semin Oncol 2006;33(5 Suppl 10):S35-40
    • (2006) Semin Oncol , vol.33 , Issue.5 SUPPL. 10
    • Willett, C.G.1    Kozin, S.V.2    Duda, D.G.3
  • 135
    • 20044381863 scopus 로고    scopus 로고
    • Phase i investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer
    • Jayson GC, Mulatero C, Ranson M, et al. Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer. Eur J Cancer 2005;41(4):555-63
    • (2005) Eur J Cancer , vol.41 , Issue.4 , pp. 555-63
    • Jayson, G.C.1    Mulatero, C.2    Ranson, M.3
  • 136
    • 0037386937 scopus 로고    scopus 로고
    • A phase i study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma
    • Posey JA, Ng TC, Yang B, et al. A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma. Clin Cancer Res 2003;9(4):1323-32
    • (2003) Clin Cancer Res , vol.9 , Issue.4 , pp. 1323-32
    • Posey, J.A.1    Ng, T.C.2    Yang, B.3
  • 137
    • 27144531609 scopus 로고    scopus 로고
    • Technology evaluation: VEGF Trap (cancer), Regeneron/sanofi-aventis
    • Lau SC, Rosa DD, Jayson G. Technology evaluation: VEGF Trap (cancer), Regeneron/sanofi-aventis. Curr Opin Mol Ther 2005;7(5):493-501
    • (2005) Curr Opin Mol Ther , vol.7 , Issue.5 , pp. 493-501
    • Lau, S.C.1    Rosa, D.D.2    Jayson, G.3
  • 138
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
    • Cohen EE, Rosen LS, Vokes EE, et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol 2008;26(29):4708-13
    • (2008) J Clin Oncol , vol.26 , Issue.29 , pp. 4708-13
    • Cohen, E.E.1    Rosen, L.S.2    Vokes, E.E.3
  • 139
    • 27744563296 scopus 로고    scopus 로고
    • Phase i trial of a monoclonal antibody specific for alpha-v-beta-3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion
    • McNeel DG, Eickhoff J, Lee FT, et al. Phase I trial of a monoclonal antibody specific for alpha-v-beta-3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion. Clin Cancer Res 2005;11(21):7851-60
    • (2005) Clin Cancer Res , vol.11 , Issue.21 , pp. 7851-60
    • McNeel, D.G.1    Eickhoff, J.2    Lee, F.T.3
  • 140
    • 38149098569 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alpha-v-beta-3 integrin receptor, in patients with advanced solid tumors
    • Delbaldo C, Raymond E, Vera K, et al. Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alpha-v-beta-3 integrin receptor, in patients with advanced solid tumors. Invest New Drugs 2008;26(1):35-43
    • (2008) Invest New Drugs , vol.26 , Issue.1 , pp. 35-43
    • Delbaldo, C.1    Raymond, E.2    Vera, K.3
  • 141
    • 0033866240 scopus 로고    scopus 로고
    • In vivo therapy of malignant melanoma by means of antagonists of alpha-v integrins
    • Mitjans F, Meyer T, Fittschen C, et al. In vivo therapy of malignant melanoma by means of antagonists of alpha-v integrins. Int J Cancer 2000;87(5):716-23
    • (2000) Int J Cancer , vol.87 , Issue.5 , pp. 716-23
    • Mitjans, F.1    Meyer, T.2    Fittschen, C.3
  • 142
    • 59449094255 scopus 로고    scopus 로고
    • Volociximab, a chimeric monoclonal antibody that specifically binds alph-5-beta-1 integrin: A phase I, pharmacokinetic, and biological correlative study
    • Ricart AD, Tolcher AW, Liu G, et al. Volociximab, a chimeric monoclonal antibody that specifically binds alph-5-beta-1 integrin: a phase I, pharmacokinetic, and biological correlative study. Clin Cancer Res 2008;14(23):7924-9
    • (2008) Clin Cancer Res , vol.14 , Issue.23 , pp. 7924-9
    • Ricart, A.D.1    Tolcher, A.W.2    Liu, G.3
  • 143
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • Ridgway J, Zhang G, Wu Y, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006;444(7122):1083-7
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1083-7
    • Ridgway, J.1    Zhang, G.2    Wu, Y.3
  • 144
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356(2):115-24
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 115-24
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 145
    • 50949108994 scopus 로고    scopus 로고
    • Isolated limb perfusion with tumor necrosis factor and melphalan for non-resectable soft tissue sarcomas: Long-term results on efficacy and limb salvage in a selected group of patients
    • Cherix S, Speiser M, Matter M, et al. Isolated limb perfusion with tumor necrosis factor and melphalan for non-resectable soft tissue sarcomas: long-term results on efficacy and limb salvage in a selected group of patients. J Surg Oncol 2008;98(3):148-55
    • (2008) J Surg Oncol , vol.98 , Issue.3 , pp. 148-55
    • Cherix, S.1    Speiser, M.2    Matter, M.3
  • 146
    • 40549107085 scopus 로고    scopus 로고
    • TNF-based isolated limb perfusion followed by consolidation biotherapy with systemic low-dose interferon alpha 2b in patients with in-transit melanoma metastases: A pilot trial
    • Rossi CR, Russano F, Mocellin S, et al. TNF-based isolated limb perfusion followed by consolidation biotherapy with systemic low-dose interferon alpha 2b in patients with in-transit melanoma metastases: a pilot trial. Ann Surg Oncol 2008;15(4):1218-23
    • (2008) Ann Surg Oncol , vol.15 , Issue.4 , pp. 1218-23
    • Rossi, C.R.1    Russano, F.2    Mocellin, S.3
  • 147
    • 37849009384 scopus 로고    scopus 로고
    • Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate
    • Joensuu H, De Braud F, Coco P, et al. Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate. Ann Oncol 2008;19(1):173-7
    • (2008) Ann Oncol , vol.19 , Issue.1 , pp. 173-7
    • Joensuu, H.1    De Braud, F.2    Coco, P.3
  • 148
    • 33845615922 scopus 로고    scopus 로고
    • Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery
    • Brunstein F, Rens J, van Tiel ST, et al. Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery. Br J Cancer 2006;95(12):1663-9
    • (2006) Br J Cancer , vol.95 , Issue.12 , pp. 1663-9
    • Brunstein, F.1    Rens, J.2    Van Tiel, S.T.3
  • 149
    • 33846629479 scopus 로고    scopus 로고
    • Synergistic antitumor effects of histamine plus melphalan in isolated hepatic perfusion for liver metastases
    • Brunstein F, Eggermont AM, de Wiel-Ambagtsheer G, et al. Synergistic antitumor effects of histamine plus melphalan in isolated hepatic perfusion for liver metastases. Ann Surg Oncol 2007;14(2):795-801
    • (2007) Ann Surg Oncol , vol.14 , Issue.2 , pp. 795-801
    • Brunstein, F.1    Eggermont, A.M.2    De Wiel-Ambagtsheer, G.3
  • 151
    • 40549125995 scopus 로고    scopus 로고
    • Phase i clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors
    • LoRusso PM, Gadgeel SM, WozniakA, et al. Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors. Invest New Drugs 2008;26(2):159-67
    • (2008) Invest New Drugs , vol.26 , Issue.2 , pp. 159-67
    • Lorusso, P.M.1    Gadgeel, S.M.2    Wozniak, A.3
  • 152
    • 0042386700 scopus 로고    scopus 로고
    • Phase i clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
    • Rustin GJ, Galbraith SM, Anderson H, et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol 2003;21(15):2815-22
    • (2003) J Clin Oncol , vol.21 , Issue.15 , pp. 2815-22
    • Rustin, G.J.1    Galbraith, S.M.2    Anderson, H.3
  • 153
    • 33745135802 scopus 로고    scopus 로고
    • Current development status of small-molecule vascular disrupting agents
    • Chaplin DJ, Horsman MR, Siemann DW. Current development status of small-molecule vascular disrupting agents. Curr Opin Investig Drugs 2006;7(6):522-8
    • (2006) Curr Opin Investig Drugs , vol.7 , Issue.6 , pp. 522-8
    • Chaplin, D.J.1    Horsman, M.R.2    Siemann, D.W.3
  • 154
    • 0142121501 scopus 로고    scopus 로고
    • Differential relationship between changes in tumour size and microcirculatory functions induced by therapy with an antivascular drug and with cytotoxic drugs. implications for the evaluation of therapeutic efficacy of AC7700 (AVE8062)
    • Hori K, Saito S, Sato Y, et al. Differential relationship between changes in tumour size and microcirculatory functions induced by therapy with an antivascular drug and with cytotoxic drugs. implications for the evaluation of therapeutic efficacy of AC7700 (AVE8062). Eur J Cancer 2003;39(13):1957-66
    • (2003) Eur J Cancer , vol.39 , Issue.13 , pp. 1957-66
    • Hori, K.1    Saito, S.2    Sato, Y.3
  • 155
    • 1642283508 scopus 로고    scopus 로고
    • Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate
    • Kirwan IG, Loadman PM, Swaine DJ, et al. Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate. Clin Cancer Res 2004;10(4): 1446-53
    • (2004) Clin Cancer Res , vol.10 , Issue.4 , pp. 1446-53
    • Kirwan, I.G.1    Loadman, P.M.2    Swaine, D.J.3
  • 156
    • 57449103348 scopus 로고    scopus 로고
    • Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, Von Pawel J, Reck M, et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Br J Cancer 2008;99(12):2006-12
    • (2008) Br J Cancer , vol.99 , Issue.12 , pp. 2006-12
    • McKeage, M.J.1    Von Pawel, J.2    Reck, M.3
  • 157
    • 52949103358 scopus 로고    scopus 로고
    • ASA 404: Update on drug development
    • Rehman F, Rustin G. ASA404: update on drug development. Expert Opin Investig Drugs 2008;17(10):1547-51
    • (2008) Expert Opin Investig Drugs , vol.17 , Issue.10 , pp. 1547-51
    • Rehman, F.1    Rustin, G.2
  • 158
    • 34248159068 scopus 로고    scopus 로고
    • Small molecule vascular disrupting agents: Potential new drugs for cancer treatment
    • Cai SX. Small molecule vascular disrupting agents: potential new drugs for cancer treatment. Recent Pat Anticancer Drug Discov 2007;2(1):79-101
    • (2007) Recent Pat Anticancer Drug Discov , vol.2 , Issue.1 , pp. 79-101
    • Cai, S.X.1
  • 159
    • 33748372759 scopus 로고    scopus 로고
    • A phase 1 study ofABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors
    • Fox E, Maris JM, Widemann BC, et al. A phase 1 study ofABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors. Clin Cancer Res 2006;12(16):4882-7
    • (2006) Clin Cancer Res , vol.12 , Issue.16 , pp. 4882-7
    • Fox, E.1    Maris, J.M.2    Widemann, B.C.3
  • 160
    • 44649138596 scopus 로고    scopus 로고
    • A phase II study ofABT-751 in patients with advanced non-small cell lung cancer
    • Mauer AM, Cohen EE, Ma PC, et al. A phase II study ofABT-751 in patients with advanced non-small cell lung cancer. J Thorac Oncol 2008;3(6):631-6
    • (2008) J Thorac Oncol , vol.3 , Issue.6 , pp. 631-6
    • Mauer, A.M.1    Cohen, E.E.2    Ma, P.C.3
  • 161
    • 58549093199 scopus 로고    scopus 로고
    • Phase i study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks
    • Yamamoto N, Andoh M, Kawahara M, et al. Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks. Cancer Sci 2009;100(2):316-21
    • (2009) Cancer Sci , vol.100 , Issue.2 , pp. 316-21
    • Yamamoto, N.1    Andoh, M.2    Kawahara, M.3
  • 162
    • 33845582571 scopus 로고    scopus 로고
    • Phase II study of intravenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy
    • Patel S, Keohan ML, Saif MW, et al. Phase II study of intravenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy. Cancer 2006;107(12):2881-7
    • (2006) Cancer , vol.107 , Issue.12 , pp. 2881-7
    • Patel, S.1    Keohan, M.L.2    Saif, M.W.3
  • 163
    • 0010712792 scopus 로고    scopus 로고
    • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
    • Brooks PC, Silletti S, von Schalscha TL, et al. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 1998;92(3):391-400
    • (1998) Cell , vol.92 , Issue.3 , pp. 391-400
    • Brooks, P.C.1    Silletti, S.2    Von Schalscha, T.L.3
  • 164
    • 0036098835 scopus 로고    scopus 로고
    • Roles of prolactin and related members of the prolactin/growth hormone/placental lactogen family in angiogenesis
    • Corbacho AM, Martinez De La Escalera G, Clapp C. Roles of prolactin and related members of the prolactin/growth hormone/placental lactogen family in angiogenesis. J Endocrinol 2002;173(2):219-38
    • (2002) J Endocrinol , vol.173 , Issue.2 , pp. 219-38
    • Corbacho, A.M.1    Martinez De La Escalera, G.2    Clapp, C.3
  • 165
    • 13044311402 scopus 로고    scopus 로고
    • Troponin i is present in human cartilage and inhibits angiogenesis
    • Moses MA, Wiederschain D, Wu I, et al. Troponin I is present in human cartilage and inhibits angiogenesis. Proc Natl Acad Sci USA 1999;96(6):2645-50
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.6 , pp. 2645-50
    • Moses, M.A.1    Wiederschain, D.2    Wu, I.3
  • 166
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007;11(1):83-95
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    Di Tomaso, E.3
  • 167
    • 55949122477 scopus 로고    scopus 로고
    • Phase i dose escalation study of telatinib (BAY 57-9352) in patients with advanced solid tumours
    • Strumberg D, Schultheis B, Adamietz IA, et al. Phase I dose escalation study of telatinib (BAY 57-9352) in patients with advanced solid tumours. Br J Cancer 2008;99(10):1579-85
    • (2008) Br J Cancer , vol.99 , Issue.10 , pp. 1579-85
    • Strumberg, D.1    Schultheis, B.2    Adamietz, I.A.3
  • 168
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10(1):25-34
    • (2009) Lancet Oncol , vol.10 , Issue.1 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 169
    • 0037041644 scopus 로고    scopus 로고
    • Isolated limb perfusion with actinomycin D and TNF-alpha results in improved tumour response in soft-tissue sarcoma-bearing rats but is accompanied by severe local toxicity
    • Seynhaeve AL, de Wilt JH, van Tiel ST, et al. Isolated limb perfusion with actinomycin D and TNF-alpha results in improved tumour response in soft-tissue sarcoma-bearing rats but is accompanied by severe local toxicity. Br J Cancer 2002;86(7):1174-9
    • (2002) Br J Cancer , vol.86 , Issue.7 , pp. 1174-9
    • Seynhaeve, A.L.1    De Wilt, J.H.2    Van Tiel, S.T.3
  • 170
    • 2642570969 scopus 로고    scopus 로고
    • Lack of efficacy of Doxil in TNF-alpha-based isolated limb perfusion in sarcoma-bearing rats
    • Ten Hagen TL, Hoving S, Ambagtsheer G, et al. Lack of efficacy of Doxil in TNF-alpha-based isolated limb perfusion in sarcoma-bearing rats. Br J Cancer 2004;90(9):1830-2
    • (2004) Br J Cancer , vol.90 , Issue.9 , pp. 1830-2
    • Ten Hagen, T.L.1    Hoving, S.2    Ambagtsheer, G.3
  • 171
    • 0033922618 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha augments tumor effects in isolated hepatic perfusion with melphalan in a rat sarcoma model
    • van Ijken MG, van Etten B, de Wilt JH, et al. Tumor necrosis factor-alpha augments tumor effects in isolated hepatic perfusion with melphalan in a rat sarcoma model. J Immunother 2000;23(4):449-55
    • (2000) J Immunother , vol.23 , Issue.4 , pp. 449-55
    • Van Ijken, M.G.1    Van Etten, B.2    De Wilt, J.H.3
  • 172
    • 0023905489 scopus 로고
    • Anti-tumor activity of recombinant tumor necrosis factor on mouse fibrosarcoma in vivo and in vitro
    • Tomazic VJ, Farha M, Loftus A, Elias EG. Anti-tumor activity of recombinant tumor necrosis factor on mouse fibrosarcoma in vivo and in vitro. J Immunol 1988;140(11):4056-61
    • (1988) J Immunol , vol.140 , Issue.11 , pp. 4056-61
    • Tomazic, V.J.1    Farha, M.2    Loftus, A.3    Elias, E.G.4
  • 173
    • 1342288382 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics
    • Brouckaert P, Takahashi N, van Tiel ST, et al. Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics. Int J Cancer 2004;109(3):442-8
    • (2004) Int J Cancer , vol.109 , Issue.3 , pp. 442-8
    • Brouckaert, P.1    Takahashi, N.2    Van Tiel, S.T.3
  • 174
    • 20844448538 scopus 로고    scopus 로고
    • Addition of low-dose tumor necrosis factor-alpha to systemic treatment with STEALTH liposomal doxorubicin (Doxil) improved anti-tumor activity in osteosarcoma-bearing rats
    • Hoving S, Seynhaeve AL, van Tiel ST, et al. Addition of low-dose tumor necrosis factor-alpha to systemic treatment with STEALTH liposomal doxorubicin (Doxil) improved anti-tumor activity in osteosarcoma-bearing rats. Anticancer Drugs 2005;16(6):667-74
    • (2005) Anticancer Drugs , vol.16 , Issue.6 , pp. 667-74
    • Hoving, S.1    Seynhaeve, A.L.2    Van Tiel, S.T.3
  • 175
    • 0024390026 scopus 로고
    • Augmentation of antitumor efficacy by the combination of recombinant tumor necrosis factor and chemotherapeutic agents in vivo
    • KrosnickJA, Mule JJ, McIntoshJK, Rosenberg SA. Augmentation of antitumor efficacy by the combination of recombinant tumor necrosis factor and chemotherapeutic agents in vivo. Cancer Res 1989;49(14):3729-33
    • (1989) Cancer Res , vol.49 , Issue.14 , pp. 3729-33
    • Krosnickja Mule, J.J.1    McIntosh, J.K.2    Rosenberg, S.A.3
  • 176
    • 0025642580 scopus 로고
    • Augmentation for intratumoral accumulation and anti-tumor activity of liposome-encapsulated adriamycin by tumor necrosis factor-alpha in mice
    • Suzuki S, Ohta S, Takashio K, et al. Augmentation for intratumoral accumulation and anti-tumor activity of liposome-encapsulated adriamycin by tumor necrosis factor-alpha in mice. Int J Cancer 1990;46(6):1095-100
    • (1990) Int J Cancer , vol.46 , Issue.6 , pp. 1095-100
    • Suzuki, S.1    Ohta, S.2    Takashio, K.3
  • 177
    • 17444417500 scopus 로고    scopus 로고
    • Effect of low-dose tumor necrosis factor-alpha in combination with STEALTH liposomal cisplatin (SPI-077) on soft-tissue-and osteosarcoma-bearing rats
    • Hoving S, van Tiel ST, Eggermont AM, ten Hagen TL. Effect of low-dose tumor necrosis factor-alpha in combination with STEALTH liposomal cisplatin (SPI-077) on soft-tissue-and osteosarcoma-bearing rats. Anticancer Res 2005;25(2A):743-50
    • (2005) Anticancer Res , vol.25 , Issue.2 A , pp. 743-50
    • Hoving, S.1    Van Tiel, S.T.2    Eggermont, A.M.3    Ten Hagen, T.L.4
  • 178
    • 0036131963 scopus 로고    scopus 로고
    • Pegylated liposomal tumor necrosis factor-alpha results in reduced toxicity and synergistic antitumor activity after systemic administration in combination with liposomal doxorubicin (Doxil) in soft tissue sarcoma-bearing rats
    • Ten Hagen TL, Seynhaeve AL, van Tiel ST, et al. Pegylated liposomal tumor necrosis factor-alpha results in reduced toxicity and synergistic antitumor activity after systemic administration in combination with liposomal doxorubicin (Doxil) in soft tissue sarcoma-bearing rats. Int J Cancer 2002;97(1):115-20
    • (2002) Int J Cancer , vol.97 , Issue.1 , pp. 115-20
    • Ten Hagen, T.L.1    Seynhaeve, A.L.2    Van Tiel, S.T.3
  • 179
    • 0029001362 scopus 로고
    • Antitumor effects of liposomal IL1 alpha and TNF alpha against the pulmonary metastases of the B16F10 murine melanoma in syngeneic mice
    • Saito M, Fan D, Lachman LB. Antitumor effects of liposomal IL1 alpha and TNF alpha against the pulmonary metastases of the B16F10 murine melanoma in syngeneic mice. Clin Exp Metastasis 1995;13(4):249-59
    • (1995) Clin Exp Metastasis , vol.13 , Issue.4 , pp. 249-59
    • Saito, M.1    Fan, D.2    Lachman, L.B.3
  • 180
    • 0033764170 scopus 로고    scopus 로고
    • Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)
    • Curnis F, Sacchi A, Borgna L, et al. Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13). Nat Biotechnol 2000;18(11):1185-90
    • (2000) Nat Biotechnol , vol.18 , Issue.11 , pp. 1185-90
    • Curnis, F.1    Sacchi, A.2    Borgna, L.3
  • 181
    • 0036678474 scopus 로고    scopus 로고
    • Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
    • Curnis F, Sacchi A, Corti A. Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration. J Clin Invest 2002;110(4):475-82
    • (2002) J Clin Invest , vol.110 , Issue.4 , pp. 475-82
    • Curnis, F.1    Sacchi, A.2    Corti, A.3
  • 182
    • 39449095721 scopus 로고    scopus 로고
    • Synergistic damage of tumor vessels with ultra low-dose endothelial-monocyte activating polypeptide-II and neovasculature-targeted tumor necrosis factor-alpha
    • Crippa L, Gasparri A, Sacchi A, et al. Synergistic damage of tumor vessels with ultra low-dose endothelial-monocyte activating polypeptide-II and neovasculature-targeted tumor necrosis factor-alpha. Cancer Res 2008;68(4):1154-61
    • (2008) Cancer Res , vol.68 , Issue.4 , pp. 1154-61
    • Crippa, L.1    Gasparri, A.2    Sacchi, A.3
  • 183
    • 1642434101 scopus 로고    scopus 로고
    • Coupling tumor necrosis factor-alpha with alpha-V integrin ligands improves its antineoplastic activity
    • Curnis F, Gasparri A, Sacchi A, et al. Coupling tumor necrosis factor-alpha with alpha-V integrin ligands improves its antineoplastic activity. Cancer Res 2004;64(2):565-71
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 565-71
    • Curnis, F.1    Gasparri, A.2    Sacchi, A.3
  • 184
    • 33646118484 scopus 로고    scopus 로고
    • NPI-2358 is a tubulin-depolymerizing agent: In-vitro evidence for activity as a tumor vascular-disrupting agent
    • Nicholson B, Lloyd GK, Miller BR, et al. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs 2006;17(1):25-31
    • (2006) Anticancer Drugs , vol.17 , Issue.1 , pp. 25-31
    • Nicholson, B.1    Lloyd, G.K.2    Miller, B.R.3
  • 185
    • 34250859583 scopus 로고    scopus 로고
    • MPC-6827: A small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps
    • Kasibhatla S, Baichwal V, Cai SX, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res 2007;67(12):5865-71
    • (2007) Cancer Res , vol.67 , Issue.12 , pp. 5865-71
    • Kasibhatla, S.1    Baichwal, V.2    Cai, S.X.3


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