메뉴 건너뛰기




Volumn 15, Issue 1, 2005, Pages 102-111

Cellular abnormalities of blood vessels as targets in cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; GROWTH FACTOR; PLASMA PROTEIN;

EID: 12344312042     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2004.12.005     Document Type: Review
Times cited : (660)

References (56)
  • 1
    • 0034662621 scopus 로고    scopus 로고
    • Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy
    • N. Hansen-Algenstaedt, B.R. Stoll, T.P. Padera, D.E. Dolmans, D.J. Hicklin, D. Fukumura, and R.K. Jain Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy Cancer Res 60 2000 4556 4560
    • (2000) Cancer Res , vol.60 , pp. 4556-4560
    • Hansen-Algenstaedt, N.1    Stoll, B.R.2    Padera, T.P.3    Dolmans, D.E.4    Hicklin, D.J.5    Fukumura, D.6    Jain, R.K.7
  • 2
    • 1542436704 scopus 로고    scopus 로고
    • Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: Better than commonly perceived - But they can be improved
    • R.S. Kerbel Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived - but they can be improved Cancer Biol Ther 2 2003 S134 S139
    • (2003) Cancer Biol Ther , vol.2
    • Kerbel, R.S.1
  • 3
    • 0029328266 scopus 로고
    • Intratumor microvessel density as a prognostic factor in cancer
    • N. Weidner Intratumor microvessel density as a prognostic factor in cancer Am J Pathol 147 1995 9 19
    • (1995) Am J Pathol , vol.147 , pp. 9-19
    • Weidner, N.1
  • 4
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • P. Carmeliet, and R.K. Jain Angiogenesis in cancer and other diseases Nature 407 2000 249 257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 7
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • D. Lyden, K. Hattori, S. Dias, C. Costa, P. Blaikie, L. Butros, A. Chadburn, B. Heissig, W. Marks, and L. Witte Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth Nat Med 7 2001 1194 1201
    • (2001) Nat Med , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3    Costa, C.4    Blaikie, P.5    Butros, L.6    Chadburn, A.7    Heissig, B.8    Marks, W.9    Witte, L.10
  • 8
    • 0036831559 scopus 로고    scopus 로고
    • Vascular and haematopoietic stem cells: Novel targets for anti-angiogenesis therapy?
    • S. Rafii, D. Lyden, R. Benezra, K. Hattori, and B. Heissig Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat Rev Cancer 2 2002 826 835
    • (2002) Nat Rev Cancer , vol.2 , pp. 826-835
    • Rafii, S.1    Lyden, D.2    Benezra, R.3    Hattori, K.4    Heissig, B.5
  • 9
    • 0242667873 scopus 로고    scopus 로고
    • Minor contribution of bone marrow-derived endothelial progenitors to the vascularization of murine gliomas
    • M.R. Machein, S. Renninger, E. de Lima-Hahn, and K.H. Plate Minor contribution of bone marrow-derived endothelial progenitors to the vascularization of murine gliomas Brain Pathol 13 2003 582 597
    • (2003) Brain Pathol , vol.13 , pp. 582-597
    • MacHein, M.R.1    Renninger, S.2    De Lima-Hahn, E.3    Plate, K.H.4
  • 10
    • 4644295385 scopus 로고    scopus 로고
    • Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells
    • I. Rajantie, M. Ilmonen, A. Alminaite, U. Ozerdem, K. Alitalo, and P. Salven Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells Blood 104 2004 2084 2086 This paper, together with [9], presents evidence against the widely held concept of the recruitment of circulating endothelial progenitor cells to blood vessels in tumors. This is a controversial area still awaiting definitive information on the conditions in which these cells are or are not recruited, their abundance and their fate. Evidence in favor of the concept is reviewed in [8].
    • (2004) Blood , vol.104 , pp. 2084-2086
    • Rajantie, I.1    Ilmonen, M.2    Alminaite, A.3    Ozerdem, U.4    Alitalo, K.5    Salven, P.6
  • 12
    • 0036548794 scopus 로고    scopus 로고
    • Dissecting tumour pathophysiology using intravital microscopy
    • R.K. Jain, L.L. Munn, and D. Fukumura Dissecting tumour pathophysiology using intravital microscopy Nat Rev Cancer 2 2002 266 276
    • (2002) Nat Rev Cancer , vol.2 , pp. 266-276
    • Jain, R.K.1    Munn, L.L.2    Fukumura, D.3
  • 13
    • 1542320497 scopus 로고    scopus 로고
    • Pathology: Cancer cells compress intratumour vessels
    • T.P. Padera, B.R. Stoll, J.B. Tooredman, D. Capen, E. di Tomaso, and R.K. Jain Pathology: cancer cells compress intratumour vessels Nature 427 2004 695 The Jain laboratory is systematically investigating barriers to effective delivery of drugs to tumors. This is one of a series of multidisciplinary papers that describe the high interstitial fluid pressure within tumors, tumor vascular abnormalities and the normalization of tumor vessels after treatment. The concept of blood vessel normalization in tumors is set out in [49].
    • (2004) Nature , vol.427 , pp. 695
    • Padera, T.P.1    Stoll, B.R.2    Tooredman, J.B.3    Capen, D.4    Di Tomaso, E.5    Jain, R.K.6
  • 14
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 19
    • 0038376001 scopus 로고    scopus 로고
    • Imaging of angiogenesis: From microscope to clinic
    • D.M. McDonald, and P.L. Choyke Imaging of angiogenesis: from microscope to clinic Nat Med 9 2003 713 725
    • (2003) Nat Med , vol.9 , pp. 713-725
    • McDonald, D.M.1    Choyke, P.L.2
  • 20
    • 0036892284 scopus 로고    scopus 로고
    • Probing the structural and molecular diversity of tumor vasculature
    • R. Pasqualini, W. Arap, and D.M. McDonald Probing the structural and molecular diversity of tumor vasculature Trends Mol Med 8 2002 563 571
    • (2002) Trends Mol Med , vol.8 , pp. 563-571
    • Pasqualini, R.1    Arap, W.2    McDonald, D.M.3
  • 21
    • 3142767799 scopus 로고    scopus 로고
    • Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas
    • B. Streubel, A. Chott, D. Huber, M. Exner, U. Jager, O. Wagner, and I. Schwarzinger Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas N Engl J Med 351 2004 250 259
    • (2004) N Engl J Med , vol.351 , pp. 250-259
    • Streubel, B.1    Chott, A.2    Huber, D.3    Exner, M.4    Jager, U.5    Wagner, O.6    Schwarzinger, I.7
  • 23
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • L.E. Benjamin, I. Hemo, and E. Keshet A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF Development 125 1998 1591 1598
    • (1998) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 24
    • 0242405617 scopus 로고    scopus 로고
    • Endothelial-pericyte interactions in angiogenesis
    • H. Gerhardt, and C. Betsholtz Endothelial-pericyte interactions in angiogenesis Cell Tissue Res 314 2003 15 23
    • (2003) Cell Tissue Res , vol.314 , pp. 15-23
    • Gerhardt, H.1    Betsholtz, C.2
  • 25
    • 0035015517 scopus 로고    scopus 로고
    • Pericytes: Cell biology and pathology
    • G. Allt, and J.G. Lawrenson Pericytes: cell biology and pathology Cells Tissues Organs 169 2001 1 11
    • (2001) Cells Tissues Organs , vol.169 , pp. 1-11
    • Allt, G.1    Lawrenson, J.G.2
  • 26
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • S. Morikawa, P. Baluk, T. Kaidoh, A. Haskell, R.K. Jain, and D.M. McDonald Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors Am J Pathol 160 2002 985 1000
    • (2002) Am J Pathol , vol.160 , pp. 985-1000
    • Morikawa, S.1    Baluk, P.2    Kaidoh, T.3    Haskell, A.4    Jain, R.K.5    McDonald, D.M.6
  • 29
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    • A. Abramsson, P. Lindblom, and C. Betsholtz Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors J Clin Invest 112 2003 1142 1151
    • (2003) J Clin Invest , vol.112 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 30
    • 16544382996 scopus 로고    scopus 로고
    • Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
    • M. Furuhashi, T. Sjoblom, A. Abramsson, J. Ellingsen, P. Micke, H. Li, E. Bergsten-Folestad, U. Eriksson, R. Heuchel, and C. Betsholtz Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate Cancer Res 64 2004 2725 2733
    • (2004) Cancer Res , vol.64 , pp. 2725-2733
    • Furuhashi, M.1    Sjoblom, T.2    Abramsson, A.3    Ellingsen, J.4    Micke, P.5    Li, H.6    Bergsten-Folestad, E.7    Eriksson, U.8    Heuchel, R.9    Betsholtz, C.10
  • 31
    • 2942682933 scopus 로고    scopus 로고
    • Insight into the physiological functions of PDGF through genetic studies in mice
    • C. Betsholtz Insight into the physiological functions of PDGF through genetic studies in mice Cytokine Growth Factor Rev 15 2004 215 228 This review summarizes important work from the Betsholtz laboratory on the significance of pericytes in the maturation and stabilization of the microvasculature, and the key role of PDGF and its receptors in regulating the relationship between pericytes and endothelial cells and thereby normal vascular structure and function.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 215-228
    • Betsholtz, C.1
  • 33
    • 0037805549 scopus 로고    scopus 로고
    • Basement membranes: Structure, assembly and role in tumour angiogenesis
    • R. Kalluri Basement membranes: structure, assembly and role in tumour angiogenesis Nat Rev Cancer 3 2003 422 433 This review provides a broad framework for understanding the importance of the vascular basement membrane in tumor angiogenesis.
    • (2003) Nat Rev Cancer , vol.3 , pp. 422-433
    • Kalluri, R.1
  • 34
    • 0038236716 scopus 로고    scopus 로고
    • The basement membrane matrix in malignancy
    • J.A. Engbring, and H.K. Kleinman The basement membrane matrix in malignancy J Pathol 200 2003 465 470
    • (2003) J Pathol , vol.200 , pp. 465-470
    • Engbring, J.A.1    Kleinman, H.K.2
  • 35
    • 0142151097 scopus 로고    scopus 로고
    • Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    • P. Baluk, S. Morikawa, A. Haskell, M. Mancuso, and D.M. McDonald Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors Am J Pathol 163 2003 1801 1815 This report, together with [11,19,26], describes abnormalities in endothelial cells, pericytes and vascular basement membrane in tumors, and methods to image them, including a novel use of scanning electron microscopy to analyze abnormalities in the luminal surface of the endothelium of tumor vessels.
    • (2003) Am J Pathol , vol.163 , pp. 1801-1815
    • Baluk, P.1    Morikawa, S.2    Haskell, A.3    Mancuso, M.4    McDonald, D.M.5
  • 36
    • 0035802109 scopus 로고    scopus 로고
    • Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
    • J. Xu, D. Rodriguez, E. Petitclerc, J.J. Kim, M. Hangai, Y.S. Moon, G.E. Davis, P.C. Brooks, and S.M. Yuen Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo J Cell Biol 154 2001 1069 1079
    • (2001) J Cell Biol , vol.154 , pp. 1069-1079
    • Xu, J.1    Rodriguez, D.2    Petitclerc, E.3    Kim, J.J.4    Hangai, M.5    Moon, Y.S.6    Davis, G.E.7    Brooks, P.C.8    Yuen, S.M.9
  • 38
    • 3242762087 scopus 로고    scopus 로고
    • Increased angiogenic response in aortic explants of collagen XVIII/endostatin-null mice
    • Q. Li, and B.R. Olsen Increased angiogenic response in aortic explants of collagen XVIII/endostatin-null mice Am J Pathol 165 2004 415 424
    • (2004) Am J Pathol , vol.165 , pp. 415-424
    • Li, Q.1    Olsen, B.R.2
  • 40
    • 0036792466 scopus 로고    scopus 로고
    • Inhibition of endothelial cell survival and angiogenesis by protein kinase a
    • S. Kim, M. Bakre, H. Yin, and J.A. Varner Inhibition of endothelial cell survival and angiogenesis by protein kinase A J Clin Invest 110 2002 933 941
    • (2002) J Clin Invest , vol.110 , pp. 933-941
    • Kim, S.1    Bakre, M.2    Yin, H.3    Varner, J.A.4
  • 42
    • 0034255151 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases
    • C.J. Bruns, W. Liu, D.W. Davis, R.M. Shaheen, D.J. McConkey, M.R. Wilson, C.D. Bucana, D.J. Hicklin, and L.M. Ellis Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases Cancer 89 2000 488 499
    • (2000) Cancer , vol.89 , pp. 488-499
    • Bruns, C.J.1    Liu, W.2    Davis, D.W.3    Shaheen, R.M.4    McConkey, D.J.5    Wilson, M.R.6    Bucana, C.D.7    Hicklin, D.J.8    Ellis, L.M.9
  • 44
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • G. Bergers, S. Song, N. Meyer-Morse, E. Bergsland, and D. Hanahan Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors J Clin Invest 111 2003 1287 1295 Based on studies of spontaneous pancreatic islet tumors in RIP-Tag2 transgenic mice, this report provides the first evidence for the complementary action of VEGF inhibitors on endothelial cells and PDGF inhibitors on pericytes.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 45
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • C.G. Willett, Y. Boucher, E. di Tomaso, D.G. Duda, L.L. Munn, R.T. Tong, D.C. Chung, D.V. Sahani, S.P. Kalva, and S.V. Kozin Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer Nat Med 10 2004 145 147 This report from the Jain laboratory describes effects of anti-VEGF antibody on human cancers. Changes include a reduction in tumor interstitial fluid pressure measured in vivo, as well as decreased tumor vascularity assessed histologically. Complementary studies in preclinical models are described in [50].
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    Di Tomaso, E.3    Duda, D.G.4    Munn, L.L.5    Tong, R.T.6    Chung, D.C.7    Sahani, D.V.8    Kalva, S.P.9    Kozin, S.V.10
  • 46
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • T. Inai, M. Mancuso, H. Hashizume, F. Baffert, A. Haskell, P. Baluk, D.D. Hu-Lowe, D.R. Shalinsky, G. Thurston, and G.D. Yancopoulos Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts Am J Pathol 165 2004 35 52 By using two methods of inhibiting VEGF signaling in spontaneous and implanted tumors in mice, we and our colleagues describe the sequence of cellular changes in tumor blood vessels occurring from 24 hours to weeks after the onset of treatment.
    • (2004) Am J Pathol , vol.165 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3    Baffert, F.4    Haskell, A.5    Baluk, P.6    Hu-Lowe, D.D.7    Shalinsky, D.R.8    Thurston, G.9    Yancopoulos, G.D.10
  • 48
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • R. Erber, A. Thurnher, A.D. Katsen, G. Groth, H. Kerger, H.P. Hammes, M.D. Menger, A. Ullrich, and P. Vajkoczy Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms FASEB J 18 2004 338 340
    • (2004) FASEB J , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6    Menger, M.D.7    Ullrich, A.8    Vajkoczy, P.9
  • 49
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • R.K. Jain Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy Nat Med 7 2001 987 989
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 50
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • R.T. Tong, Y. Boucher, S.V. Kozin, F. Winkler, D.J. Hicklin, and R.K. Jain Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors Cancer Res 64 2004 3731 3736
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 52
    • 0035297541 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
    • K. Pietras, A. Ostman, M. Sjoquist, E. Buchdunger, R.K. Reed, C.H. Heldin, and K. Rubin Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors Cancer Res 61 2001 2929 2934
    • (2001) Cancer Res , vol.61 , pp. 2929-2934
    • Pietras, K.1    Ostman, A.2    Sjoquist, M.3    Buchdunger, E.4    Reed, R.K.5    Heldin, C.H.6    Rubin, K.7
  • 53
    • 1842830358 scopus 로고    scopus 로고
    • Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels
    • F. Baffert, G. Thurston, M. Rochon-Duck, T. Le, R. Brekken, and D.M. McDonald Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels Circ Res 94 2004 984 992
    • (2004) Circ Res , vol.94 , pp. 984-992
    • Baffert, F.1    Thurston, G.2    Rochon-Duck, M.3    Le, T.4    Brekken, R.5    McDonald, D.M.6
  • 54
    • 2542512275 scopus 로고    scopus 로고
    • Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis
    • Y. He, I. Rajantie, M. Ilmonen, T. Makinen, M.J. Karkkainen, P. Haiko, P. Salven, and K. Alitalo Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis Cancer Res 64 2004 3737 3740
    • (2004) Cancer Res , vol.64 , pp. 3737-3740
    • He, Y.1    Rajantie, I.2    Ilmonen, M.3    Makinen, T.4    Karkkainen, M.J.5    Haiko, P.6    Salven, P.7    Alitalo, K.8
  • 55
    • 3042826827 scopus 로고    scopus 로고
    • Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function
    • N. Isaka, T.P. Padera, J. Hagendoorn, D. Fukumura, and R.K. Jain Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function Cancer Res 64 2004 4400 4404
    • (2004) Cancer Res , vol.64 , pp. 4400-4404
    • Isaka, N.1    Padera, T.P.2    Hagendoorn, J.3    Fukumura, D.4    Jain, R.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.