The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients

Clinical Rheumatology

Volumn 29, Issue 11, 2010, Pages 1251-1258

  Ma, Jilin ^a   Yu, Jianning ^a   Tao, Xiaojuan ^a   Cai, Long ^a   Wang, Julie ^b   Zheng, Song Guo ^b  

^a Western Medicine Hospital   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Foxp3; Lupus; Regulatory T cells; Th17 cells

Indexed keywords

INTERLEUKIN 17; PREDNISONE; TRANSCRIPTION FACTOR FOXP3;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADRENAL CORTEX HORMONES; ADULT; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-17; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED;

EID: 77957690846     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-010-1510-7     Document Type: Article

References (48)

1. AB Gottlieb RG Lahita N Chiorazzi HG Kunkel 1979 Immune function in systemic lupus erythematosus. Impairment of in vitro T-cell proliferation and in vivo antibody response to exogenous antigen J Clin Invest 63 885 892 1:STN:280:DyaE1M7psVCrsw%3D%3D 10.1172/JCI109388 312809
2. W Kolowos US Gaipl RE Voll C Frank JP Haas TD Beyer JR Kalden M Herrmann 2001 CD4 positive peripheral T cells from patients with systemic lupus erythematosus (SLE) are clonally expanded Lupus 10 321 331 1:CAS:528: DC%2BD3MXkslKrtbc%3D 10.1191/096120301671176280 11403262
3. SL Reiner 2007 Development in motion: helper T cell at work Cell 129 33 36 1:CAS:528:DC%2BD2sXkvVelt7c%3D 10.1016/j.cell.2007.03.019 17418783
4. TR Mosmann RL Coffman 1989 Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties Annu Rev Immunol 7 145 173 1:CAS:528:DyaL1MXit12lsbk%3D 10.1146/annurev.iy.07.040189.001045 2523712
5. RL Coffman 2006 Origins of the Th1-Th2 model: a personal perspective Nat Immunol 7 539 541 1:CAS:528:DC%2BD28Xksleks7k%3D 10.1038/ni0606-539 16715060
6. S Sakaguchi 2000 Regulatory T cells: key controllers of immunologic self-tolerance Cell 101 455 458 1:CAS:528:DC%2BD3cXjvFWntL4%3D 10.1016/S0092-8674(00)80856-9 10850488
7. + regulatory T cells in immunological tolerance to self and non-self Nat Immunol 6 345 352 1:CAS:528:DC%2BD2MXisVyitLY%3D 10.1038/ni1178 15785760
8. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat Immunol 6 1123 1132 1:CAS:528:DC%2BD2MXhtFamsb7J 10.1038/ni1254 16200070
9. + T cells regulates tissue inflammation by producing interleukin 17 Nat Immunol 6 1133 1141 1:CAS:528:DC%2BD2MXhtFamsb%2FO 10.1038/ni1261 16200068
10. + T cells in peripheral blood of patients with systemic lupus erythematosus Scan J Immunol 59 198 202 10.1111/j.0300-9475.2004.01370.x
11. JC Crispin A Martinez J Alcocer-Varela 2003 Quantification of regulatory T cells in patients with systemic lupus erythematosus J Autoimmun 21 273 276 10.1016/S0896-8411(03)00121-5 14599852
12. M Miyara Z Amoura C Parizot C Badoual K Dorgham S Trad D Nochy P Debré JC Piette G Gorochov 2005 Global natural regulatory T cell depletion in active systemic lupus erythematosus J Immunol 175 8392 8400 1:CAS:528:DC%2BD2MXht12jt7vO 16339581
13. high T regulatory cell function in patients with active systemic lupus erythematosus J Immunol 178 2579 2588 1:CAS:528: DC%2BD2sXht1Cntrw%3D 17277168
14. S Mellor-Pita MJ Citores R Castejon P Tutor-Ureta M Yebra-Bango JL Andreu JA Vargas 2006 Decrease of regulatory T cells in patients with systemic lupus erythematosus Ann Rheum Dis 65 553 554 1:STN:280:DC%2BD287ktFKjuw%3D%3D 10.1136/ard.2005.044974 16531555
15. B Alvarado-Sánchez B Hernández-Castro D Portales-Pérez L Baranda E Layseca-Espinosa C Abud-Mendoza AC Cubillas-Tejeda R González-Amaro 2006 Regulatory T cells in patients with systemic lupus erythematosus J Autoimmun 27 110 118 10.1016/j.jaut.2006.06.005 16890406
16. H Kebir K Kreymborg I Ifergan A Dodelet-Devillers R Cayrol M Bernard F Giuliani N Arbour B Becher A Prat 2007 Human Th17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation Nat Med 13 1173 1175 1:CAS:528:DC%2BD2sXhtFagsbzK 10.1038/nm1651 17828272
17. T Aarvak M Chabaud P Miossec JB Natvig 1999 IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells J Immunol 162 1246 1251 1:CAS:528:DyaK1MXhtVSmt70%3D 9973376
18. AJ van Beelen MB Teunissen ML Kapsenberg EC de Jong 2007 Interleukin-17 in inflammatory skin disorders Curr Opin Allergy Clin Immunol 7 374 381 10.1097/ACI.0b013e3282ef869e 17873575
19. E Bettelli M Oukka VK Kuchroo 2007 Th17 cells in the circle of immunity and autoimmunity Nat Immunol 8 345 350 1:CAS:528:DC%2BD2sXjt1Sqs7c%3D 10.1038/ni0407-345 17375096
20. AT Masi DJ McShane NF Rothfield JG Schaller N Talal RJ Winchester 1982 The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 25 1271 1277 10.1002/art.1780251101 7138600
21. C Bombardier DD Gladman MB Urowitz D Caron CH Chang 1992 Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE Arthritis Rheum 35 630 640 1:STN:280: DyaK383oslWrtg%3D%3D 10.1002/art.1780350606 1599520
22. high regulatory cells in human peripheral blood J Immunol 167 1245 1253 1:CAS:528:DC%2BD3MXls1Wktbk%3D 11466340
23. + Treg cells J Exp Med 203 1701 1711 1:CAS:528:DC%2BD28XntVCgs70%3D 10.1084/jem.20060772 16818678
24. N Seddiki B Santner-Nanan J Martinson J Zaunders S Sasson A Landay M Solomon W Selby SI Alexander R Nanan A Kelleher B Fazekas de St Groth 2006 Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells J Exp Med 203 1693 1700 1:CAS:528: DC%2BD28XntVCgs7w%3D 10.1084/jem.20060468 16818676
25. + T cells by an IL-10-dependent mechanism J Allergy Clin Immunol 114 296 301 10.1016/j.jaci.2004.04.048
26. C Karagiannidis M Akdis P Holopainen NJ Woolley G Hense B Rückert PY Mantel G Menz CA Akdis K Blaser CB Schmidt-Weber 2004 Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma J Allergy Clin Immunol 114 1425 1433 1:CAS:528:DC%2BD2cXhtVCnsrzM 10.1016/j.jaci.2004.07.014 15577848
27. + regulatory T cells (TREG) in systemic lupus erythematosus (SLE) patients: the possible influence of treatment with corticosteroids Clin Immunol 127 151 157 1:CAS:528:DC%2BD1cXks1alu78%3D 10.1016/j.clim.2007.12.010 18299252
28. II Ivanov BS McKenzie L Zhou CE Tadokoro A Lepelley JJ Lafaille DJ Cua DR Littman 2006 The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 1121 1133 1:CAS:528:DC%2BD28XhtVCnsrrE 10.1016/j.cell.2006.07.035 16990136
29. E Gambineri TR Torgerson HD Ochs 2003 Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis Curr Opin Rheumatol 15 430 435 1:CAS:528:DC%2BD3sXltFKjsb8%3D 10.1097/00002281-200307000-00010 12819471
30. + T regulatory cells Nat Immunol 4 337 342 1:CAS:528:DC%2BD3sXitlyqs7s%3D 10.1038/ni909 12612581
31. S Hori T Nomura S Sakaguchi 2003 Control of regulatory T cell development by the transcription factor Foxp3 Science 299 1057 1061 1:CAS:528: DC%2BD3sXhtFarsbw%3D 10.1126/science.1079490 12522256
32. SC Lin KH Chen CH Lin CC Kuo QD Ling CH Chan 2007 The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients Eur J Clin Investig 37 987 996 1:CAS:528:DC%2BD1cXlslCktw%3D%3D 10.1111/j.1365-2362.2007.01882.x
33. + T cells of patients with systemic lupus erythematosus (SLE): a comparative phenotypic analysis Ann Rheum Dis 67 664 671 1:STN:280:DC%2BD1c3ksVaksg%3D%3D 10.1136/ard.2007.074690 17728327
34. V Pillai SB Ortega CK Wang NJ Karandikar 2007 Transient regulatory T-cells: a state attained by all activated human T-cells Clin Immunol 123 18 29 1:CAS:528:DC%2BD2sXjtValtLo%3D 10.1016/j.clim.2006.10.014 17185041
35. + T cells Eur J Immunol 37 129 138 1:CAS:528:DC%2BD2sXhtFGitL4%3D 10.1002/eji.200636435 17154262
36. - regulatory T cells in vitro. A novel defect of T Cell regulation in systemic lupus erythematosus Arthritis Rheum 52 1180 1184 1:STN:280:DC%2BD2M7ptlWgug%3D%3D 10.1002/art.20976 15818683
37. S Baráth P Soltész E Kiss M Aleksza M Zeher G Szegedi S Sipka 2007 The severity of systemic lupus erythematosus negatively correlates with the increasing number of CD4(+)CD25(high)FoxP3(+) regulatory T cells during repeated plasmapheresis treatments of patients Autoimmunity 40 521 528 10.1080/08916930701610028 17966042
38. CK Wong CY Ho EK Li CW Lam 2000 Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus Lupus 9 589 593 1:CAS:528:DC%2BD3cXnsFCitbs%3D 10.1191/096120300678828703 11035433
39. HK Kang M Liu SK Datta 2007 Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells J Immunol 178 7849 7858 1:CAS:528:DC%2BD2sXmtVKnsrk%3D 17548623
40. - T cells through foxp3 induction and down regulation of Smad7 J Immunol 172 5149 5153 1:CAS:528:DC%2BD2cXjt1Cks7s%3D 15100250
41. E Bettelli Y Carrier W Gao T Korn TB Strom M Oukka HL Weiner VK Kuchroo 2006 Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells Nature 441 235 238 1:CAS:528:DC%2BD28XksVGns7g%3D 10.1038/nature04753 16648838
42. + T cell regulatory functions J Immunol 178 271 279 1:CAS:528:DC%2BD2sXnvVSq 17182564
43. E Tackey PE Lipsky GG Illei 2004 Rationale for interleukin-6 blockade in systemic lupus erythematosus Lupus 13 339 343 1:CAS:528:DC%2BD2cXlvVels78%3D 10.1191/0961203304lu1023oa 15230289
44. + regulatory T cells and for expansion of these cells J Immunol 178 2018 2027 1:CAS:528:DC%2BD2sXht1Cgtbs%3D 17277105
45. + regulatory T cell function J Exp Med 196 851 857 1:CAS:528:DC%2BD38Xnt1yhtLg%3D 10.1084/jem.20020190 12235217
46. + regulatory T cells by interleukin 2 and induction of autoimmune disease by IL-2 neutralization J Exp Med 201 723 735 1:CAS:528:DC%2BD2MXitl2rt78%3D 10.1084/jem.20041982 15753206
47. GM Kammer 2005 Altered regulation of IL-2 production in systemic lupus erythematosus: an evolving paradigm J Clin Invest 115 836 840 1:CAS:528:DC%2BD2MXjtFylsbY%3D 15841173
48. A Laurence CM Tato TS Davidson Y Kanno Z Chen Z Yao RB Blank F Meylan R Siegel L Hennighausen EM Shevach JJ O'shea 2007 Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation Immunity 26 371 381 1:CAS:528:DC%2BD2sXjvVSnsL8%3D 10.1016/j.immuni.2007.02.009 17363300