Quantitative structure-activity relationship studies of threo-methylphenidate analogs

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 20, 2010, Pages 7221-7238

  Misra, Milind ^a   Shi, Qing ^b   Ye, Xiaocong ^b   Gruszecka Kowalik, Ewa ^b   Bu, Wei ^b   Liu, Zhanzhu ^b   Schweri, Margaret M ^c   Deutsch, Howard M ^b   Venanzi, Carol A ^a  

^a NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Comparative molecular field analysis; Dopamine transporter; Methylphenidate; Molecular descriptors

Indexed keywords

DOPAMINE TRANSPORTER; METHYLPHENIDATE; THREO 3',5' DICHLOROMETHYLMETHYLPHENIDATE; THREO 3',5' DIMETHYLMETHYLPHENIDATE; THREO N (2 CHLOROBENZYL)METHYLPHENIDATE; THREO N (2 METHYLFURAN)METHYLPHENIDATE; THREO N (2 METHYLPYRIDINE)METHYLPHENIDATE; THREO N (2 METHYLTHIOPENE)METHYLPHENIDATE; THREO N (2 PHENYLETHYL)METHYLPHENIDATE; THREO N (2 PHENYLETHYL)RITALINOL; THREO N (3 CHLOROBENZYL)METHYLPHENIDATE; THREO N (3 METHYLFURAN)METHYLPHENIDATE; THREO N (3 METHYLPYRIDINE)METHYLPHENIDATE; THREO N (3 METHYLTHIOPENE)METHYLPHENIDATE; THREO N (3 PHENYLPROPYL)METHYLPHENIDATE; THREO N (3 PHENYLPROPYL)RITALINOL; THREO N (4 CHLOROBENZYL)METHYLPHENIDATE; THREO N (4 ISOTHIOCYANANTOBENZYL)METHYLPHENIDATE; THREO N (4 METHOXYBENZYL)METHYLPHENIDATE; THREO N (4 METHYLPYRIDINE)METHYLPHENIDATE; THREO N (4 NITROBENZYL)METHYLPHENIDATE; THREO N (4 PHENYLBUTYL)METHYLPHENIDATE; THREO N (4 PHENYLBUTYL)RITALINOL; THREO N (5 PHENYLPENTYL)METHYLPHENIDATE; THREO N (6 PHENYLHEXYL)METHYLPHENIDATE; THREO N [(5 CHLOROTHIOPHENE 2 YL)METHYL]METHYLPHENIDATE; THREO N ALLYLMETHYLPHENIDATE; THREO N ETHYLRITALINOL; THREO N PROPARGYLMETHYLPHENIDATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG BINDING; ELECTRON; MALE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; SUBSTITUTION REACTION;

DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ISOMERISM; METHYLPHENIDATE; MODELS, MOLECULAR; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957608631     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.034     Document Type: Article

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