Conformational Analysis of Drug-Like Molecules Bound to Proteins: An Extensive Study of Ligand Reorganization upon Binding

Journal of Medicinal Chemistry

Volumn 47, Issue 10, 2004, Pages 2499-2510

  Perola, Emanuele ^a   Charifson, Paul S ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; ORGANIC COMPOUND; PROTEIN;

ANALYTIC METHOD; ARTICLE; CALCULATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENERGY; HUMAN; HYDROPHOBICITY; LIGAND BINDING; MOLECULE; NONHUMAN; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

DRUG DESIGN; ENDOPEPTIDASES; LIGANDS; MOLECULAR CONFORMATION; PHARMACEUTICAL PREPARATIONS; PHOSPHOTRANSFERASES; PROTEIN BINDING; PROTEIN FOLDING; PROTEINS; THERMODYNAMICS;

EID: 2342586724     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030563w     Document Type: Article

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