Quantitative structure-activity relationship modeling of dopamine D1 antagonists using comparative molecular field analysis, genetic algorithms- partial least-squares, and K nearest neighbor methods

Journal of Medicinal Chemistry

Volumn 42, Issue 17, 1999, Pages 3217-3226

  Hoffman, Brian ^a   Cho, Sung Jin ^a   Zheng, Weifan ^a   Wyrick, Steven ^a   Nichols, David E ^c   Mailman, Richard B ^a,b   Tropsha, Alexander ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 1 RECEPTOR BLOCKING AGENT;

ALGORITHM; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; MOLECULAR MODEL; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ANIMALS; CORPUS STRIATUM; DOPAMINE ANTAGONISTS; LEAST-SQUARES ANALYSIS; LIGANDS; MODELS, MOLECULAR; RATS; RECEPTORS, DOPAMINE D1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 13044300880     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980415j     Document Type: Article

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