Synthesis of 2β-acyl-3β-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites

Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2001, Pages 1509-1515

  Davies, H M L ^a   Gilliatt, V ^b   Kuhn, L A ^b   Saikali, E ^b   Ren, P ^a   Hammond, P S ^c   Sexton, T ^c   Childers, S R ^c  

^a UNIVERSITY AT BUFFALO   (United States)

^b WAKE FOREST UNIVERSITY   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2BETA ACYL 3BETA NAPHTHYLTROPANE 8 AZABICYCLO[3.2.1]OCTANE DERIVATIVE; DOPAMINE; DOPAMINE TRANSPORTER; SEROTONIN; SEROTONIN TRANSPORTER; TROPANE DERIVATIVE; UNCLASSIFIED DRUG; CARRIER PROTEIN; COTRANSPORTER; MEMBRANE PROTEIN; NERVE PROTEIN; NORADRENALIN; NORADRENALIN TRANSPORTER; SLC6A2 PROTEIN, RAT; SLC6A4 PROTEIN, RAT;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; MOLECULAR MODEL; NEUROTRANSMISSION; ANIMAL; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; CORPUS STRIATUM; FRONTAL LOBE; IN VITRO STUDY; METABOLISM; RADIOASSAY; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FRONTAL LOBE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS; TROPANES;

EID: 0035837029     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000363+     Document Type: Article

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