Synthesis and pharmacology of site specific cocaine abuse treatment agents: A new synthetic methodology for methylphenidate analogs based on the Blaise reaction

European Journal of Medicinal Chemistry

Volumn 36, Issue 4, 2001, Pages 303-311

  Deutsch, Howard M ^a   Ye, Xiaocong ^b   Shi, Qing ^c   Liu, Zhanzhu ^d   Schweri, Margaret M ^e  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b ELAN PHARMACEUTICALS   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d Hebei Institute of Marteria Medica   (China)

^e MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cocaine; Discrimination ratio; Dopamine; Drug abuse; Methylphenidate; Uptake inhibitor

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; ALPHA BROMOPHENYLACETIC ACID ESTER DERIVATIVE; ALPHA CYANO OMEGA MESYLATE DERIVATIVE; BORANE DERIVATIVE; COCAINE; CYANOBOROHYDRIDE SODIUM; DOPAMINE; DOPAMINE UPTAKE INHIBITOR; ESTER DERIVATIVE; MESYLIC ACID DERIVATIVE; METHYLPHENIDATE DERIVATIVE; NAPHTHYL GROUP; THREO 4 TRIFLUOROMETHYLMETHYLPHENIDATE; THREO METHYL 2 PHENYL 2 (2 AZACYCLOPENTYL)ACETATE; THREO METHYL 2 PIPERIDYL 2 (2 NAPHTHYL)ACETATE; TRITIUM; UNCLASSIFIED DRUG; ZINC;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CHEMICAL REACTION; COCAINE DEPENDENCE; CONTROLLED STUDY; CORPUS STRIATUM; CYCLIZATION; DOPAMINE UPTAKE; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR SIZE; NONHUMAN; PHARMACOLOGICAL BLOCKING; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOCHEMISTRY; COCAINE; COCAINE-RELATED DISORDERS; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; METHYLPHENIDATE; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034917341     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(01)01230-2     Document Type: Article

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