Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter

Journal of Medicinal Chemistry

Volumn 50, Issue 2, 2007, Pages 219-232

  Froimowitz, Mark ^a   Gu, Yonghong ^a   Dakin, Les A ^a   Nagafuji, Pamela M ^a   Kelley, Charles J ^a   Parrish, Damon ^b   Deschamps, Jeffrey R ^b   Janowsky, Aaron ^c  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (CHLOROPHENYL) 3 METHYLBUTYL]PIPERIDIUM CHLORIDE; ALKYL GROUP; AMIDE; CARBON; CHLORINE DERIVATIVE; COCAINE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; FUNCTIONAL GROUP; KETONE DERIVATIVE; METHYL GROUP; METHYLPHENIDATE; PHENYL GROUP; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; CELL LINE; CONFORMATION; CONTROLLED STUDY; DIASTEREOISOMER; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN CELL; HYDROGENATION; LOCOMOTION; MALE; MONOAMINE TRANSPORTER ASSAY; MOUSE; NONHUMAN; PHARMACOPHORE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; HUMANS; KETONES; MALE; METHYLPHENIDATE; MICE; MOTOR ACTIVITY; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RADIOLIGAND ASSAY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846409863     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0608614     Document Type: Article

References (43)

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