Mapping the functional surface of insulin by design: Structure and function of a novel A-chain analogue

Journal of Molecular Biology

Volumn 264, Issue 2, 1996, Pages 390-403

  Hua, Qing Xin ^a   Hu, Shi Quan ^b   Frank, Bruce H ^c   Jia, Wenhua ^a   Chu, Ying Chi ^b   Wang, Shu Hua ^b   Burke, G Thompson ^b   Katsoyannis, Panayotis G ^b   Weiss, Michael A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Disulphide bond; NMR spectroscopy; Protein dynamics; Protein engineering; Protein folding

Indexed keywords

CYSTEINE; DISULFIDE; INSULIN; MUTANT PROTEIN; SERINE;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENETIC ENGINEERING; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN FOLDING; RAT; RECEPTOR BINDING; X RAY CRYSTALLOGRAPHY;

ANIMALIA;

EID: 0030606309     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0648     Document Type: Article

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