Protein structure and the spandrels of San Marco: Insulin's receptor-binding surface is buttressed by an invariant leucine essential for its stability

Biochemistry

Volumn 41, Issue 3, 2002, Pages 809-819

  Weiss, Michael A ^a   Nakagawa, Satoe H ^b   Jia, Wenhua ^a   Xu, Bin ^a   Hua, Qing Xin ^a   Chu, Ying Chi ^c   Wang, Run Ying ^c   Katsoyannis, Panayotis G ^c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR-BINDING;

BIOCHEMISTRY; INSULIN; MACROMOLECULES; STABILITY;

PROTEINS;

INSULIN; INSULIN RECEPTOR; LEUCINE; SOMATOMEDIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; GENETIC CONSERVATION; HYDROPHOBICITY; MACROMOLECULE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR BINDING; SURFACE PROPERTY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; DRUG STABILITY; HUMANS; INSULIN; INVERTEBRATES; LEUCINE; MAMMALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTOR, INSULIN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; VERTEBRATES;

INVERTEBRATA; VERTEBRATA;

EID: 0037154126     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi011839+     Document Type: Article

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