Chiral mutagenesis of insulin's hidden receptor-binding surface: Structure of an allo-isoleucineA2 analogue

Journal of Molecular Biology

Volumn 316, Issue 3, 2002, Pages 435-441

  Xu, Bin ^a   Hua, Qing Xin ^a   Nakagawa, Satoe H ^b   Jia, Wenhua ^a   Chu, Ying Chi ^c   Katsoyannis, Panayotis G ^c   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

Insulin; Insulin analogues; Insulin chain combination; Insulin receptor; Protein folding

Indexed keywords

ALANINE; ALLOISOLEUCINE; ALLOISOLEUCINE A2; INSULIN; INSULIN RECEPTOR; MONOMER; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHIRALITY; HYDROPHOBICITY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR BINDING; THERMODYNAMICS; THERMOSTABILITY;

VERTEBRATA;

EID: 0036300570     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5377     Document Type: Article

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