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Volumn 35, Issue 2, 2010, Pages 113-119

Curcumin: Multiple molecular targets mediate multiple pharmacological actions - A review

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRASE INHIBITOR; INTERLEUKIN 1; INTERLEUKIN 6; LIPOXYGENASE; MESALAZINE; PHENYLBUTAZONE; PROTEIN BCL 2; SALAZOSULFAPYRIDINE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR;

EID: 84930541017     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2010.035.02.1426640     Document Type: Review
Times cited : (78)

References (44)
  • 1
    • 34548227773 scopus 로고    scopus 로고
    • From exotic spice to modern drug?
    • Singh, S. From exotic spice to modern drug? Cell 2007, 130(5): 765-8.
    • (2007) Cell , vol.130 , Issue.5 , pp. 765-768
    • Singh, S.1
  • 2
    • 38749109673 scopus 로고    scopus 로고
    • Curcumin as "curecumin" from kitchen to clinic
    • Goel, A., Kunnumakkara, A.B., Aggarwal, B.B. Curcumin as "curecumin" from kitchen to clinic. Biochem Pharm 2008, 75(4): 787-809.
    • (2008) Biochem Pharm , vol.75 , Issue.4 , pp. 787-809
    • Goel, A.1    Kunnumakkara, A.B.2    Aggarwal, B.B.3
  • 3
  • 4
    • 54949136123 scopus 로고    scopus 로고
    • Curcumin in cancer management: Recent results of analogue design and clinical studies and desirable future research
    • Steward, W.P., Gescher, AJ. Curcumin in cancer management: Recent results of analogue design and clinical studies and desirable future research. Mol Nutr Food Res 2008, 52(9): 1005-9.
    • (2008) Mol Nutr Food Res , vol.52 , Issue.9 , pp. 1005-1009
    • Steward, W.P.1    Gescher, A.J.2
  • 6
    • 0012598758 scopus 로고    scopus 로고
    • Evaluation of certain food additives
    • WHO Geneva
    • WHO Geneva. Evaluation of certain food additives. WHO Technical Report Series 891, 2000.
    • (2000) WHO Technical Report Series 891
  • 8
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • Aggarwal, B.B., Sung, B. Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets. Trends Pharmacol Sci 2009, 30(2): 85-94.
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.2 , pp. 85-94
    • Aggarwal, B.B.1    Sung, B.2
  • 9
    • 84934444448 scopus 로고    scopus 로고
    • Modulation of transcription factors by curcumin
    • Shishodia, S., Singh, T., Chaturvedi, M.M. Modulation of transcription factors by curcumin. Adv Exp Med Biol 2007, 595: 127-48.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 127-148
    • Shishodia, S.1    Singh, T.2    Chaturvedi, M.M.3
  • 11
    • 45849088463 scopus 로고    scopus 로고
    • Curcumin - Biological and medicinal properties
    • Ravindran, P.N., K.N. Babu, Sivaraman. K. (Eds.). CRC Press: Florida
    • Aggarwal, B.B., Bhatt, I.D., Ichikawa, H. et al. Curcumin - Biological and medicinal properties. In: Turmeric: The Genus Curcuma. Ravindran, P.N., K.N. Babu, Sivaraman. K. (Eds.). CRC Press: Florida, 2006, 297-368.
    • (2006) Turmeric: The Genus Curcuma , pp. 297-368
    • Aggarwal, B.B.1    Bhatt, I.D.2    Ichikawa, H.3
  • 12
    • 18844481997 scopus 로고    scopus 로고
    • Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53
    • Park, M.J., Kim, E.H., Park, I.C. et al. Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Int J Oncol 2002, 21(2): 379-83.
    • (2002) Int J Oncol , vol.21 , Issue.2 , pp. 379-383
    • Park, M.J.1    Kim, E.H.2    Park, I.C.3
  • 13
    • 0036195104 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: Its suppression by ectopic expression of Bcl-2 and Bcl-xl
    • Anto, R.J., Mukhopadhyay, A., Denning, K., Aggarwal, B.B. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: Its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 2002, 23(1): 143-50.
    • (2002) Carcinogenesis , vol.23 , Issue.1 , pp. 143-150
    • Anto, R.J.1    Mukhopadhyay, A.2    Denning, K.3    Aggarwal, B.B.4
  • 14
    • 45849149639 scopus 로고    scopus 로고
    • Curcumin and cancer: An "old-age" disease with an "age-old" solution
    • Anand, P., Sundaram, C., Jhurani, S., Kunnumakkara A.B., Aggarwal B.B. Curcumin and cancer: An "old-age" disease with an "age-old" solution. Cancer Lett 2008, 267(1): 133-64.
    • (2008) Cancer Lett , vol.267 , Issue.1 , pp. 133-164
    • Anand, P.1    Sundaram, C.2    Jhurani, S.3    Kunnumakkara, A.B.4    Aggarwal, B.B.5
  • 15
    • 0037236792 scopus 로고    scopus 로고
    • Anticancer potential of curcumin: Preclinical and clinical studies
    • Aggarwal, B.B., Kumar, A., Bharti, A.C. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res 2003, 23(1A): 363-98.
    • (2003) Anticancer Res , vol.23 , Issue.1 A , pp. 363-398
    • Aggarwal, B.B.1    Kumar, A.2    Bharti, A.C.3
  • 16
    • 4043111378 scopus 로고    scopus 로고
    • Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling
    • Aggarwal, S., Takada, Y., Singh, S., Myers, J.N., Aggarwal, B.B. Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. Int J Cancer 2004, 111(5): 679-92.
    • (2004) Int J Cancer , vol.111 , Issue.5 , pp. 679-692
    • Aggarwal, S.1    Takada, Y.2    Singh, S.3    Myers, J.N.4    Aggarwal, B.B.5
  • 17
    • 28844479049 scopus 로고    scopus 로고
    • Curcumin inhibits phorbolester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells
    • Lee, K.W., Kim, J.H., Lee, H.J., Surh, Y.J. Curcumin inhibits phorbolester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells. Antioxid Redox Signal 2005, 7(11-12): 1612-20.
    • (2005) Antioxid Redox Signal , vol.7 , Issue.11-12 , pp. 1612-1620
    • Lee, K.W.1    Kim, J.H.2    Lee, H.J.3    Surh, Y.J.4
  • 18
    • 33845292957 scopus 로고    scopus 로고
    • Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial
    • Hanai, H., Iida, T., Takeuchi, K. et al. Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2006; 4(12): 1502-6.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , Issue.12 , pp. 1502-1506
    • Hanai, H.1    Iida, T.2    Takeuchi, K.3
  • 19
    • 42249112650 scopus 로고    scopus 로고
    • The effect of curcumin (turmeric) on alzheimers disease
    • Mishra, S., Pelanalvenu, K. The effect of curcumin (turmeric) on alzheimers disease. Ann Indian Acad Neurol 2008, 11(1): 13-9.
    • (2008) Ann Indian Acad Neurol , vol.11 , Issue.1 , pp. 13-19
    • Mishra, S.1    Pelanalvenu, K.2
  • 20
    • 9744229172 scopus 로고    scopus 로고
    • Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor
    • Giri, R.K., Rajagopal, V., Kalra, V.K. Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor. J Neurochem 2004, 91(5): 1199-210.
    • (2004) J Neurochem , vol.91 , Issue.5 , pp. 1199-1210
    • Giri, R.K.1    Rajagopal, V.2    Kalra, V.K.3
  • 21
    • 20444402292 scopus 로고    scopus 로고
    • Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets
    • Kim, C.Y, Kim, K.H., Lee, S.H. et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol 2005, 174(12): 8116-24.
    • (2005) J Immunol , vol.174 , Issue.12 , pp. 8116-8124
    • Kim, C.Y.1    Kim, K.H.2    Lee, S.H.3
  • 22
    • 48349145010 scopus 로고    scopus 로고
    • Curcuma oil: Reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain
    • Rathore, P., Dohare, P., Varma, S., Ray, A., Sharma, U., Jagannathan, N.R., Ray, M. Curcuma oil: Reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem Res 2008, 33(9): 1672-82.
    • (2008) Neurochem Res , vol.33 , Issue.9 , pp. 1672-1682
    • Rathore, P.1    Dohare, P.2    Varma, S.3    Ray, A.4    Sharma, U.5    Jagannathan, N.R.6    Ray, M.7
  • 23
    • 33947201665 scopus 로고    scopus 로고
    • Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage
    • Jiang, J., Wang, W., Sun, Y.J., Hu, M., Li, F., Zhu, D.Y. Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. Eur J Pharmacol 2007, 561(1-3): 54-62.
    • (2007) Eur J Pharmacol , vol.561 , Issue.1-3 , pp. 54-62
    • Jiang, J.1    Wang, W.2    Sun, Y.J.3    Hu, M.4    Li, F.5    Zhu, D.Y.6
  • 24
    • 0036191276 scopus 로고    scopus 로고
    • Inhibition of human low density lipoprotein oxidation by active principles from spices
    • Naidu, K.A., Thippeswamy, N.B. Inhibition of human low density lipoprotein oxidation by active principles from spices. Mol Cell Biochem 2002, 229(1-2): 19-23.
    • (2002) Mol Cell Biochem , vol.229 , Issue.1-2 , pp. 19-23
    • Naidu, K.A.1    Thippeswamy, N.B.2
  • 25
    • 11144355340 scopus 로고    scopus 로고
    • Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects
    • Egan, M.E., Pearson, M., Weiner S.A. et al. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science 2004, 304(5670): 600-2.
    • (2004) Science , vol.304 , Issue.5670 , pp. 600-602
    • Egan, M.E.1    Pearson, M.2    Weiner, S.A.3
  • 26
    • 40549117477 scopus 로고    scopus 로고
    • Curcumin prevents and reverses murine cardiac hypertrophy
    • Li, H.L., Liu, C., de Couto, G. et al. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2008, 118(3): 879-93.
    • (2008) J Clin Invest , vol.118 , Issue.3 , pp. 879-893
    • Li, H.L.1    Liu, C.2    De Couto, G.3
  • 27
    • 0036007614 scopus 로고    scopus 로고
    • Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rots
    • Arun, N., Nalini, N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rots. Plant Foods Hum Nutr 2002, 57(1): 41-52.
    • (2002) Plant Foods Hum Nutr , vol.57 , Issue.1 , pp. 41-52
    • Arun, N.1    Nalini, N.2
  • 28
    • 46349088791 scopus 로고    scopus 로고
    • Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity
    • Weisberg, S.P., Leibel, R., Tortoriello, D.V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008, 149(7): 3549-58.
    • (2008) Endocrinology , vol.149 , Issue.7 , pp. 3549-3558
    • Weisberg, S.P.1    Leibel, R.2    Tortoriello, D.V.3
  • 29
    • 8044223405 scopus 로고    scopus 로고
    • Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats
    • Babu, P.S., Srinivasan, K. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol Cell Biochem 1997, 166(1-2): 169-75.
    • (1997) Mol Cell Biochem , vol.166 , Issue.1-2 , pp. 169-175
    • Babu, P.S.1    Srinivasan, K.2
  • 31
    • 0036252640 scopus 로고    scopus 로고
    • Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kB) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
    • Liacini, A., Sylvester, J., Li, W.Q., Zafarullah, M. Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kB) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes. Matrix Biol 2002, 21(3): 251-62.
    • (2002) Matrix Biol , vol.21 , Issue.3 , pp. 251-262
    • Liacini, A.1    Sylvester, J.2    Li, W.Q.3    Zafarullah, M.4
  • 34
    • 0037663778 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth
    • Xu, J., Fu, Y., Chen, A. Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am J Physiol Gastrointest Liver Physiol 2003, 285(1): G20-30.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285 , Issue.1
    • Xu, J.1    Fu, Y.2    Chen, A.3
  • 35
    • 35649005988 scopus 로고    scopus 로고
    • Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells
    • Fahey, A.J., Adrian, Robins, R., Constantinescu, C.S. Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells. J Cell Mol Med 2007, 11(5): 1129-37.
    • (2007) J Cell Mol Med , vol.11 , Issue.5 , pp. 1129-1137
    • Fahey, A.J.1    Adrian, R.R.2    Constantinescu, C.S.3
  • 36
    • 0036953772 scopus 로고    scopus 로고
    • Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing
    • Mani, H., Sidhu, G.S., Kumari, R., Gaddipati, J.P., Seth, P., Maheshwari, R.K. Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing. Biofactors 2002, 16(1-2): 29-43.
    • (2002) Biofactors , vol.16 , Issue.1-2 , pp. 29-43
    • Mani, H.1    Sidhu, G.S.2    Kumari, R.3    Gaddipati, J.P.4    Seth, P.5    Maheshwari, R.K.6
  • 37
    • 33749170318 scopus 로고    scopus 로고
    • Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species
    • Panchatcharam, M., Miriyala, S., Gayathri, V.S., Suguna, L. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem 2006, 290(1-2): 87-96.
    • (2006) Mol Cell Biochem , vol.290 , Issue.1-2 , pp. 87-96
    • Panchatcharam, M.1    Miriyala, S.2    Gayathri, V.S.3    Suguna, L.4
  • 38
    • 0035212813 scopus 로고    scopus 로고
    • Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing
    • Phan, T.T., See, P., Lee, S.T., Chan, S.Y. Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing. J Trauma 2001, 51(5): 927-31.
    • (2001) J Trauma , vol.51 , Issue.5 , pp. 927-931
    • Phan, T.T.1    See, P.2    Lee, S.T.3    Chan, S.Y.4
  • 39
    • 0027792308 scopus 로고
    • Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes
    • Sui, Z., Salto, R., Li, J., Craik, C., Ortiz de Montellano, P.R. Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes. Bioorg Med Chem 1993, 1(6): 415-22.
    • (1993) Bioorg Med Chem , vol.1 , Issue.6 , pp. 415-422
    • Sui, Z.1    Salto, R.2    Li, J.3    Craik, C.4    Ortiz De Montellano, P.R.5
  • 40
    • 0030805998 scopus 로고    scopus 로고
    • Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action
    • Mazumder, A., Neamati, N., Sunder, S., Schulz, J., Pertz, H., Eich, E., Pommier, Y. Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. J Med Chem 1997, 40(19): 3057-63.
    • (1997) J Med Chem , vol.40 , Issue.19 , pp. 3057-3063
    • Mazumder, A.1    Neamati, N.2    Sunder, S.3    Schulz, J.4    Pertz, H.5    Eich, E.6    Pommier, Y.7
  • 41
    • 0031976901 scopus 로고    scopus 로고
    • Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat
    • Barthelemy, S., Vergnes, L., Moynier, M., Guyot, D., Labidalle, S., Bahraoui, E. Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat. Res Virol 1998, 149(1): 43-52.
    • (1998) Res Virol , vol.149 , Issue.1 , pp. 43-52
    • Barthelemy, S.1    Vergnes, L.2    Moynier, M.3    Guyot, D.4    Labidalle, S.5    Bahraoui, E.6
  • 43
    • 77953496318 scopus 로고    scopus 로고
    • Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways
    • In press
    • Chen, M., Hu, D.N., Pan, Z., Lu, C.W., Xue, C.Y., Aass, I. Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways. Exp Eye Res 2009, In press.
    • (2009) Exp Eye Res
    • Chen, M.1    Hu, D.N.2    Pan, Z.3    Lu, C.W.4    Xue, C.Y.5    Aass, I.6
  • 44
    • 4644364745 scopus 로고    scopus 로고
    • Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2
    • Syng-Ai, C., Kumari, A.L., Khar, A. Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2. Mol Cancer Ther 2004, 3(9): 1101-8.
    • (2004) Mol Cancer Ther , vol.3 , Issue.9 , pp. 1101-1108
    • Syng-Ai, C.1    Kumari, A.L.2    Khar, A.3


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