Cytoskeletal changes in cell transformation and tumorigenesis

Current Opinion in Genetics and Development

Volumn 11, Issue 1, 2001, Pages 41-47

  Pawlak, G ^a   Helfman, D M ^a  

^a Simons Center for Quantitative Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; EZRIN; GUANOSINE TRIPHOSPHATASE; MOESIN; RADIXIN; RAS PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TROPOMYOSIN;

APOPTOSIS; CARCINOGENICITY; CELL ACTIVITY; CELL ADHESION; CELL GROWTH; CELL MOTILITY; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL TRANSFORMATION; CONTACT INHIBITION; HUMAN; MICROFILAMENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW;

EID: 0035253753     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00154-4     Document Type: Review

References (83)

1. Actin, its associated proteins and metastasis
2. Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with α-actinin
3. The human non-muscle α-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells
4. Gelsolin: A candidate for suppressor of human bladder cancer
5. Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1
6. Suppression of tumorigenicity in transformed cells after transfection with vinculin
7. Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene
8. Suppression of src-induced transformed phenotype by expression of tropomyosin-1
9. Restoration of microfilament bundle organization in v-raf-transformed NRK cells after transduction with tropomyosin 2 cDNA
10. Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects
11. Anti-oncogenic effects of tropomyosin: Isoform specificity and importance of protein coding sequences
12. Tropomyosin-2 cDNA lacking the 3′ untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts
13. Rho GTPases and the actin cytoskeleton
14. Bidirectional signaling between the cytoskeleton and integrins
15. The ras family of GTPases in cancer cell invasion
16. Rho family proteins in cell adhesion and cell migration
17. Understanding Ras: 'It ain't over 'til it's over'
18. Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation
19. Transformation mediated by RhoA requires activity of ROCK kinases
20. Functional properties of non-muscle tropomyosin isoforms
21. Tropomyosins of human mammary epithelial cells: Consistent defects of expression in mammary carcinoma cell lines
22. Expression of tropomyosin isoforms in benign and malignant human breast lesions
23. Two differentially expressed genes in normal human prostate tissue and in carcinoma
24. Genomic analysis of metastasis reveals an essential role for RhoC
25. Molecular classification of cutaneous malignant melanoma by gene expression profiling
26. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in cell growth, cell cycle, signaling, and adhesion
27. Ras- and Raf-induced down-modulation of non-muscle tropomyosin are MEK-independent
28. Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop
29. The TSC1 tumor suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
30. Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes
31. Deregulation of genes encoding microfilament-associated proteins during Fos-induced morphological transformation
32. Essential function of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts
33. High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential
34. Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion in endometrial cancer cells
35. ERM proteins in cell adhesion and membrane dynamics
36. An anti-ras function of neurofibromatosis type 2 gene product (NF2/Merlin)
37. The neurofibromatosis type 2 gene product, schwannomin, suppresses growth in NIH 3T3 cell
38. A role for rho in ras transformation
39. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins
40. Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
41. The role of ankyrin and spectrin in membrane transport and domain formation
42. The role of the cytoskeleton in adhesion-mediated signaling and gene expression
43. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
44. Rho GTPases and signaling networks
45. Regulation of myosin phosphatase by rho and rho-associated kinase (rho-kinase)
46. Involvement of microtubules in the control of adhesion-dependent signal transduction
47. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
48. Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through rho-dependent actin stress fiber formation and cell contraction
49. Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions
50. Focal adhesion assembly
51. Cell adhesions or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase
52. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
53. The essential role of tropomyosin in cooperative regulation of smooth muscle thin filament activity by caldesmon
54. Caldesmon
55. Signal transduction and regulation in smooth muscle
56. Stretch-dependent activation and desensitization of mitogen-activated protein kinase in carotid arteries
57. 2+-independent contraction of smooth muscle
58. Mammal-specific, ERK-dependent, caldesmon phosphorylation in smooth muscle
59. 2+ sensitivity of smooth muscle contraction
60. Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
61. A transformation-associated complex involving tyrosine kinase signal adaptor proteins and caldesmon links v-ErbB signaling to actin stress fiber disassembly
62. Tyrosine phosphorylation of caldesmon is required for the binding to the Shc-Grb2 complex
63. An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex
64. Extranuclear apoptosis: The role of the cytoplasm in the execution phase
65. Activation of ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix: A mechanism of ras-induced resistance to anoikis in intestinal epithelial cells
66. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
67. Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
68. Cleavage of the actin-capping protein alpha-adducin at asp-ser-asp633-ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells
69. Myosin heavy chain degradation during apoptosis in endothelial cells
70. Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation
71. CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: A novel regulatory mechanism of the CD95 apoptotic pathway
72. Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis
73. The extracellular matrix as a survival factor
74. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells
75. Integrins and anoikis
76. Control of adhesion-dependent cell survival by focal adhesion kinase
77. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis
78. 2-terminal kinase
79. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix
80. Integrin signalling: A new Cas(t) of characters enters the stage
81. Integrins and signal transduction pathways: The road taken
82. β-catenin signaling and cancer
83. Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest