Bimodal targeting of microsomal cytochrome P450s to mitochondria: Implications in drug metabolism and toxicity

Expert Opinion on Drug Metabolism and Toxicology

Volumn 6, Issue 10, 2010, Pages 1231-1251

  Sangar, Michelle C ^a   Bansal, Seema ^a   Avadhani, Narayan G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Mitochondrial targeting of CYP; Requirement for electron transfer systems; ROS production and oxidative stress; Structure function of mitochondrial P450

Indexed keywords

BENZO[A]PYRENE; BUTHIONINE SULFOXIMINE; CHOLESTANETRIOL 26 MONOOXYGENASE; CYTOCHROME P450; CYTOCHROME P450 11A; CYTOCHROME P450 11B; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 24A; CYTOCHROME P450 27A; CYTOCHROME P450 2B1; CYTOCHROME P450 2C11; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A2; CYTOCHROME P450 4A1; FERREDOXIN; FLAVODOXIN; GLUTATHIONE; HYDROGEN PEROXIDE; IRON; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SEMIQUINONE; SUPEROXIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XENOBIOTIC AGENT;

AMINO ACID METABOLISM; CALCIUM HOMEOSTASIS; CELL DEATH; CELL STRAIN HEPG2; CYTOSOL; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CLEARANCE; DRUG MECHANISM; DRUG METABOLISM; DRUG TARGETING; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME DEGRADATION; ESTROGEN METABOLISM; FATTY ACID OXIDATION; GENETIC POLYMORPHISM; GENETIC TOXICOLOGY; GENETIC VARIABILITY; HUMAN; LIVER MICROSOME; LIVER MICROSOME METABOLISM; LIVER MITOCHONDRION; MICROSOME MEMBRANE; MITOCHONDRIAL RESPIRATION; MUTATIONAL ANALYSIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PHARMACOGENETICS; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REDOX STRESS; REVIEW; TOXICOLOGICAL PARAMETERS; XENOBIOTIC METABOLISM;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENDOPLASMIC RETICULUM; HUMANS; MICROSOMES; MITOCHONDRIA; OXIDATIVE STRESS; PHARMACEUTICAL PREPARATIONS; RODENTIA;

RODENTIA;

EID: 77956861090     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2010.503955     Document Type: Review

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