Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism

Journal of Biological Chemistry

Volumn 284, Issue 25, 2009, Pages 17352-17363

  Anandatheerthavarada, Hidupur K ^a   Sepuri, Naresh Babu V ^a   Avadhani, Narayan G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOSOL; CYTOSOLIC; ENDOPLASMIC RETICULUM; MITOCHONDRIAL IMPORT; MITOCHONDRIAL TRANSLOCATION; OUTER MEMBRANE; SEQUENTIAL INTERACTIONS; TRANSLOCASES; UNDERLYING MECHANISM; UNIMODAL;

AMINES; AMINO ACIDS; ORGANIC ACIDS; PROTEINS;

ABERRATIONS;

CHOLESTANETRIOL 26 MONOOXYGENASE; CYPMT2A; CYPMT2B; CYPMT4; CYPMT5; CYTOCHROME; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 2E1; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20; TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 22; TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 40; TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 70; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; MITOCHONDRION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CYTOCHROME P-450 ENZYME SYSTEM; GENES, FUNGAL; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; MUTATION; PROTEIN SORTING SIGNALS; RABBITS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 67650559448     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.007492     Document Type: Article

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