Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle

Molecular Pharmacology

Volumn 75, Issue 3, 2009, Pages 555-567

  Dong, Hongbin ^a   Dalton, Timothy P ^a   Miller, Marian L ^a   Ying, Chen ^a   Uno, Shigeyuki ^b   Shi, Zhanquan ^a   Shertzer, Howard G ^a   Bansal, Seema ^c   Avadhani, Narayan G ^c   Nebert, Daniel W ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BENZO[A]PYRENE; BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A1; DIOXIN; PEPTIDASE; SIGNAL RECOGNITION PARTICLE; MITOCHONDRIAL PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; DIET; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FEMALE; GENE MUTATION; MALE; MICROSOME; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TOXICITY; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHICKEN; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; GENE TARGETING; GENETICS; MOLECULAR GENETICS; MOUSE MUTANT; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMALS; BENZO(A)PYRENE; CHICKENS; CYTOCHROME P-450 CYP1A1; FEMALE; GENE KNOCK-IN TECHNIQUES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA;

EID: 62149113325     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.051888     Document Type: Article

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