Death attributed to the toxic interaction of triazolam, amitriptyline and other psychotropic drugs

Forensic Science International

Volumn 86, Issue 1-2, 1997, Pages 35-41

  Kudo, K ^a   Imamura, T ^a   Jitsufuchi, N ^a   Zhang, X X ^a   Tokunaga, H ^a   Nagata, T ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Amitriptyline; Fatal poisoning; Triazolam

Indexed keywords

AMITRIPTYLINE; BROMAZEPAM; CARBOXYHEMOGLOBIN; PENTOBARBITAL; PSYCHOTROPIC AGENT; TRIAZOLAM;

AGED; ALCOHOL BLOOD LEVEL; ARTICLE; AUTOPSY; CASE REPORT; DEPRESSION; FEMALE; HUMAN; INTOXICATION; MALE; PRIORITY JOURNAL; SUICIDE;

EID: 0030942322     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(97)02110-5     Document Type: Article

References (14)

1. B.P. Joynt, Triazolam blood concentrations in forensic cases in Canada. J. Anal. Toxicol., 17 (1993) 171-177.
2. A. Steentoft and K. Worm, Cases of fatal triazolam poisoning. J. Forensic Sci. Soc., 33 (1993) 45-48.
3. K. Uemura and S. Komura, Death caused by triazolam and ethanol intoxication. Am. J. Forensic Med. Pathol., 16 (1995) 66-68.
4. K. Kudo, T. Nagata, K. Kimura, T. Imamura and N. Urakawa, Postmortem changes of triazolam concentrations in body tissues. Jpn. J. Legal Med., 46 (1992) 293-296.
5. K. Kudo, T. Nagata, K. Kimura, T. Imamura and M. Noda, Sensitive determination of diazepam and N-desmethyldiazepam in human material using capillary gas chromatography-mass spectrometry. J. Chromatogr. Biomed. Appl., 431 (1988) 353-359.
6. K. Kudo, T. Nagata, K. Kimura, R. Uehori and M. Noda, Toxicological analysis of thiamylal in biological materials by gas chromatography/mass spectrometry. Forensic Sci. Int., 37 (1988) 193-200.
7. X.X. Zhang, K. Kudo, T. Imamura, N. Jitsufuchi and T. Nagata, Sensitive determination of bromazepam in human tissues using capillary gas chromatography-mass spectrometry. J. Chromatogr. Biomed. Appl., 677 (1996) 111-116.
8. R.C. Baselt and R.H. Cravey, Disposition of Toxic Drugs and Chemicals in Man, Fourth Edition, Chemical Toxicology Institute, Foster City, 1995, p. 749 and 595.
9. S.A. Kaplan, M.L. Jack, R.E. Weinfeld, W. Glover, L. Weissman and S. Cotler, Biopharmaceutical and clinical pharmacokinetic profile of bromazepam. J. Pharm. Biopharm. 4 (1976) 1-16.
10. S. Sun and A.H.C. Chun, Determination of pentobarbital in serum by electron-capture GLC. J. Pharm. Sci., 66 (1977) 477-480.
11. C.L. Winek, Drug and Chemical Blood-Level Data, Fisher Scientific, 1994.
12. T.B. Cooper, D. Allen and G.M. Simpson, A sensitive method for the determination of amitriptyline and nortriptyline in human plasma. Comm. Psychopharm., 2 (1976) 105-116.
13. G. Baktir, H.U. Fisch, P. Huguenin and J. Bircher, Triazolam concentration-effect relationship in healthy subjects. Clin. Pharmacol. Ther., 34 (1983) 195-201.
14. G. Koves and J. Wells, The quantitation of triazolam in postmortem blood by gas chromatography/negative ion chemical ionization mass spectrometry. J. Anal. Toxicol., 10 (1986) 241-244.