Design and synthesis of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5616-5620

  Warshakoon, Namal C ^a   Wu, Shengde ^a   Boyer, Angelique ^a   Kawamoto, Richard ^a   Sheville, Justin ^a   Bhatt, Ritu Tiku ^a   Renock, Sean ^a   Xu, Kevin ^a   Pokross, Matthew ^a   Zhou, Songtao ^a   Walter, Richard ^a   Mekel, Marlene ^a   Evdokimov, Artem G ^a   East, Stephen ^b  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b EVOTEC UK LTD   (United Kingdom)

Author keywords

Anemia; HIF 1 ; Hypoxia; Ischemia; Peripheral arterial disease (PAD); Prolyl hydroxylase inhibitors

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PYRIDINE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; SUBSTITUTION REACTION;

DRUG DESIGN; HUMANS; PROCOLLAGEN-PROLINE DIOXYGENASE; PYRIDINES;

EID: 33748786316     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.026     Document Type: Article

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