A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5598-5601

  Warshakoon, Namal C ^a   Wu, Shengde ^a   Boyer, Angelique ^a   Kawamoto, Richard ^a   Sheville, Justin ^a   Renock, Sean ^a   Xu, Kevin ^a   Pokross, Matthew ^a   Evdokimov, Artem G ^a   Walter, Richard ^a   Mekel, Marlene ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

HIF 1 prolyl hydroxylase inhibitors; Imidazo 1,2 a pyridines

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1BETA; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

HUMANS; PROCOLLAGEN-PROLINE DIOXYGENASE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748786038     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.089     Document Type: Article

References (14)

1. Mack C.A., Magovern C.J., Budenbender K.T., Patel S.R., Schwatz E.A., Zanzonico P., Ferris B., Sanborn T., Isom O.W., Crystal R.G., and Rosengart T.K. J. Vasc. Surg. 27 (1998) 699
2. Bruick R.K., and McKnight S.L. Genes Dev. 15 (2001) 2497
3. Safran M., and Kaelin Jr. W.G. J. Clin. Invest. 111 (2003) 779
4. Semenza G.L. J. Appl. Physiol. 88 (2000) 1474
5. Semenza G.L. Cell 107 (2001) 1
6. Kondo K., and Kaelin Jr. W.G. Exp. Cell. Res. 264 (2001) 117
7. Semenza G. Biochem. Pharmacol. 64 (2002) 993
8. McDonough M.A., McNeill L.A., Tilliet M., Papamicaël C.A., Chen Q.-Y., Benerji B., Hewitson K.S., and Schofield C.J. J. Am. Chem. Soc. 127 (2005) 7680
9. Mole D.R., Schlemminger I., McNeill L.A., Hewitson K.S., Pugh C.W., Ratcliffe P.J., and Schofield C.J. Bioorg. Med. Chem. Lett. 13 (2003) 2677
10. Schlemminger I., Mole R., McNeill L.A., Dhanda A., Hewitson K.S., Tian Y.-M., Ratcliffe P.J., Pugh C.W., and Schofield C.J. Bioorg. Med. Chem. Lett. 13 (2003) 1451
11. Guenzler, P.; Volkmar, K.; Stephen, J.; Liu, D. Y.; Todd, W. PCT. Int. Appl. WO 2005007192, 2005.
12. Evodokimov, Nat. Struct. Mol. Biol. 2006, submitted for publication.
13. Kaizerman J.A., Gross M.I., Ge Y., White S., Hu W., Duan J.-X., Eldon E., and Johnson K.W. J. Med. Chem. 46 (2003) 3914
14. Warshakoon N.C., Sheville J., and Gardner J.H. Tetrahedron Lett. (2006)