Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones

Biochemical Journal

Volumn 353, Issue 2, 2001, Pages 333-338

  Franklin, T J ^a   Morris, W P ^a   Edwards, P N ^a   Large, M S ^a   Stephenson, R ^a  

^a NONE   (United Kingdom)

Author keywords

Collagen accumulation; Fibrosis; Hydroxylation; Turnover

Indexed keywords

1,4 DIHYDROPHENANTHROLIN 4 ONE 3 CARBOXYLIC ACID; 8 (N BUTYL N ETHYLCARBAMOYL) 1,4 DIHYDROPHENANTHROLIN 4 ONE CARBOXYLIC ACID; COLLAGEN; ESTRADIOL; HYDROXYPROLINE; PHENANTHROLINE DERIVATIVE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COLLAGEN DISEASE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME RELEASE; FEMALE; FIBROSIS; HUMAN; HUMAN CELL; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; RAT;

ANIMALIA; AVES;

EID: 0035863065     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3530333     Document Type: Article

References (14)

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4. Heterogeneous distribution of the precursor of type I and type III collagen and fibronectin in the rough endoplasmic reticulum of palatal mesenchymal cells of the mouse embryo cultured in ascorbate-depleted medium
5. Remodelling of the rough endoplasmic reticulum during stimulation of procollagen secretion by ascorbic acid in cultured chondrocytes
6. Role of molecular conformation on secretion of chick tendon collagen
7. Inhibition of prolyl hydroxylation and procollagen processing in chick embryo calvaria by a derivative of pyridine-2, 4-dicarboxylate
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11. 14C]succinic acid on ion-exchange minicolumns
12. Inhibition of collagen hydroxylation by 2,7,8-trihydroxyanthraquinone in embryonic-chick tendon cells
13. Rapid method for the determination of the 4-hydroxylation of proline in vivo
14. Regulation of the production of secretory proteins: Intracellular degradation of newly synthesised "defective" collagen