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Volumn 37, Issue 8, 2010, Pages 759-772

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

Author keywords

Antibiotic biosynthesis; BAC vector; ermEp; Heterologous expression; Insertion vector; promoter; Saccharopolyspora; Streptomyces

Indexed keywords

BACTERIAL STRAIN; BIOSYNTHESIS; CLONING; EXPERIMENTAL STUDY; GENE CLUSTER; HETEROLOGOUS EXPRESSION; HOST; NONRIBOSOMAL PEPTIDE SYNTHESIS; REVIEW; SACCHAROPOLYSPORA; SCALE UP; STREPTOMYCES; STREPTOMYCES ALBUS; STREPTOMYCES AMBOFACIENS; STREPTOMYCES AVERMITILIS; STREPTOMYCES COELICOLOR; STREPTOMYCES FRADIAE; STREPTOMYCES GRISEOFUSCUS; STREPTOMYCES LIVIDANS; STREPTOMYCES ROSEOSPORUS; STREPTOMYCES TOYOCAENSIS; STREPTOMYCETACEAE;

EID: 77956468890     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-010-0730-9     Document Type: Review
Times cited : (178)

References (130)
  • 2
    • 15244341383 scopus 로고    scopus 로고
    • Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens
    • 15774892
    • B Aigle X Pang B Decaris P Leblond 2005 Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens J Bacteriol 187:2491-2500 15774892
    • (2005) J Bacteriol , vol.187 , pp. 2491-2500
    • Aigle, B.1    Pang, X.2    Decaris, B.3    Leblond, P.4
  • 3
    • 77956489067 scopus 로고    scopus 로고
    • Development of genetic system for lipopeptide combinatorial biosynthesis in Streptomyces fradiae and heterologous expression of the A54145 biosynthetic gene cluster
    • submitted
    • Alexander D, Rock J, He X, Brian P, Miao V, and Baltz RH (2010) Development of genetic system for lipopeptide combinatorial biosynthesis in Streptomyces fradiae and heterologous expression of the A54145 biosynthetic gene cluster. Appl Environ Microbiol (submitted)
    • (2010) Appl Environ Microbiol
    • Alexander, D.1    Rock, J.2    He, X.3    Brian, P.4    Miao, V.5    Baltz, R.H.6
  • 4
    • 64249084052 scopus 로고    scopus 로고
    • Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data
    • BO Bachmann J Ravel 2010 Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data Methods Enzymol 458 181 217
    • (2010) Methods Enzymol , vol.458 , pp. 181-217
    • Bachmann, B.O.1    Ravel, J.2
  • 5
    • 0017895562 scopus 로고
    • Genetic recombination in Streptomyces fradiae by protoplast fusion and cell regeneration
    • 731205
    • RH Baltz 1978 Genetic recombination in Streptomyces fradiae by protoplast fusion and cell regeneration J Gen Microbiol 107:93-102 731205
    • (1978) J Gen Microbiol , vol.107 , pp. 93-102
    • Baltz, R.H.1
  • 6
    • 0020017143 scopus 로고
    • Genetics and biochemistry of tylosin production: A model for genetic engineering in antibiotic-producing Streptomyces
    • 6950720
    • RH Baltz 1982 Genetics and biochemistry of tylosin production: a model for genetic engineering in antibiotic-producing Streptomyces Basic Life Sci 19:431-444 6950720
    • (1982) Basic Life Sci , vol.19 , pp. 431-444
    • Baltz, R.H.1
  • 7
    • 33744536067 scopus 로고    scopus 로고
    • Antibiotic discovery from actinomycetes: Will a renaissance follow the decline and fall?
    • RH Baltz 2005 Antibiotic discovery from actinomycetes: will a renaissance follow the decline and fall? SIM News 55 186 196
    • (2005) SIM News , vol.55 , pp. 186-196
    • Baltz, R.H.1
  • 8
    • 33845713556 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of novel antibiotics and other secondary metabolites in actinomycetes
    • RH Baltz 2006 Combinatorial biosynthesis of novel antibiotics and other secondary metabolites in actinomycetes SIM News 56 148 160
    • (2006) SIM News , vol.56 , pp. 148-160
    • Baltz, R.H.1
  • 9
    • 33845709126 scopus 로고    scopus 로고
    • Molecular engineering approaches to peptide, polyketide and other antibiotics
    • 17160059
    • RH Baltz 2006 Molecular engineering approaches to peptide, polyketide and other antibiotics Nat Biotechnol 24:1533-1540 17160059
    • (2006) Nat Biotechnol , vol.24 , pp. 1533-1540
    • Baltz, R.H.1
  • 10
    • 33745019553 scopus 로고    scopus 로고
    • Marcel Faber roundtable: Is our antibiotic pipeline unproductive because of starvation, constipation, or lack of inspiration?
    • 16418869
    • RH Baltz 2006 Marcel Faber roundtable: is our antibiotic pipeline unproductive because of starvation, constipation, or lack of inspiration? J Ind Microbiol Biotechnol 33:507-513 16418869
    • (2006) J Ind Microbiol Biotechnol , vol.33 , pp. 507-513
    • Baltz, R.H.1
  • 11
    • 35448957251 scopus 로고    scopus 로고
    • Natural products from actinomycetes: Back to the future
    • RH Baltz 2007 Natural products from actinomycetes: back to the future Microbe 2 125 131
    • (2007) Microbe , vol.2 , pp. 125-131
    • Baltz, R.H.1
  • 12
    • 54849405130 scopus 로고    scopus 로고
    • Renaissance in antibacterial discovery from actinomycetes
    • RH Baltz 2008 Renaissance in antibacterial discovery from actinomycetes Curr Opin Pharmacol 8 1 7
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 1-7
    • Baltz, R.H.1
  • 13
    • 47249150183 scopus 로고    scopus 로고
    • Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin
    • 18473888
    • RH Baltz 2008 Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin Curr Top Med Chem 8:618-638 18473888
    • (2008) Curr Top Med Chem , vol.8 , pp. 618-638
    • Baltz, R.H.1
  • 14
    • 64249100988 scopus 로고    scopus 로고
    • Biosynthesis and genetic engineering of lipopeptides in Streptomyces rosesporus
    • 19374996
    • RH Baltz 2009 Biosynthesis and genetic engineering of lipopeptides in Streptomyces rosesporus Methods Enzymol 458:511-531 19374996
    • (2009) Methods Enzymol , vol.458 , pp. 511-531
    • Baltz, R.H.1
  • 15
    • 0019832103 scopus 로고
    • Protoplast fusion in Streptomyces: Conditions for efficient genetic recombination and cell regeneration
    • 7338732
    • RH Baltz P Matsushima 1981 Protoplast fusion in Streptomyces: conditions for efficient genetic recombination and cell regeneration J Gen Microbiol 127:137-146 7338732
    • (1981) J Gen Microbiol , vol.127 , pp. 137-146
    • Baltz, R.H.1    Matsushima, P.2
  • 16
    • 0019418152 scopus 로고
    • Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin
    • 7283418
    • RH Baltz ET Seno 1981 Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin Antimicrob Agents Chemother 20:214-225 7283418
    • (1981) Antimicrob Agents Chemother , vol.20 , pp. 214-225
    • Baltz, R.H.1    Seno, E.T.2
  • 17
    • 0024154171 scopus 로고
    • Genetics of Streptomyces fradiae and tylosin biosynthesis
    • RH Baltz ET Seno 1988 Genetics of Streptomyces fradiae and tylosin biosynthesis Ann Rev Microbiol 42 547 574
    • (1988) Ann Rev Microbiol , vol.42 , pp. 547-574
    • Baltz, R.H.1    Seno, E.T.2
  • 18
    • 77956243492 scopus 로고    scopus 로고
    • Genetic engineering of acidic lipopeptide antibiotics
    • R.H. Baltz J.E. Davies A.L. Demain (eds). American Society for Microbiology Washington, DC
    • Baltz RH, Nguyen KT, Alexander DC (2010) Genetic engineering of acidic lipopeptide antibiotics. In: Baltz RH, Davies JE, Demain AL (eds) Manual of industrial microbiology and biotechnology. American Society for Microbiology, Washington, DC, pp 391-410
    • (2010) Manual of Industrial Microbiology and Biotechnology , pp. 391-410
    • Baltz, R.H.1    Nguyen, K.T.2    Alexander, D.C.3
  • 19
    • 60349101699 scopus 로고    scopus 로고
    • Investigations into viomycin biosynthesis using heterologous production in Streptomyces lividans
    • 19105177
    • JJ Barkei BM Kevany EA Felnagle MG Thomas 2009 Investigations into viomycin biosynthesis using heterologous production in Streptomyces lividans ChemBioChem 10:366-376 19105177
    • (2009) ChemBioChem , vol.10 , pp. 366-376
    • Barkei, J.J.1    Kevany, B.M.2    Felnagle, E.A.3    Thomas, M.G.4
  • 20
    • 0000161630 scopus 로고
    • A cluster of tylosin biosynthetic genes is interrupted by a structurally unstable segment containing four repeated sequences
    • C.L. Hershberger S.W. Queener G. Hegeman (eds). American Society for Microbiology Washington, DC
    • Beckman RJ, Cox K, Seno ET (1989) A cluster of tylosin biosynthetic genes is interrupted by a structurally unstable segment containing four repeated sequences. In: Hershberger CL, Queener SW, Hegeman G (eds) Genetics and molecular biology of industrial microorganisms. American Society for Microbiology, Washington, DC, pp 176-186
    • (1989) Genetics and Molecular Biology of Industrial Microorganisms , pp. 176-186
    • Beckman, R.J.1    Cox, K.2    Seno, E.T.3
  • 22
    • 15744383448 scopus 로고    scopus 로고
    • Regulation of secondary metabolism in streptomycetes
    • 15802254
    • MJ Bibb 2005 Regulation of secondary metabolism in streptomycetes Curr Opin Microbiol 8:208-215 15802254
    • (2005) Curr Opin Microbiol , vol.8 , pp. 208-215
    • Bibb, M.J.1
  • 23
    • 64249095577 scopus 로고    scopus 로고
    • Analyzing the regulation of antibiotic production in streptomycetes
    • 19374980
    • MJ Bibb A Hesketh 2009 Analyzing the regulation of antibiotic production in streptomycetes Methods Enzymol 458:93-116 19374980
    • (2009) Methods Enzymol , vol.458 , pp. 93-116
    • Bibb, M.J.1    Hesketh, A.2
  • 24
    • 0026645203 scopus 로고
    • Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp
    • 1628843
    • M Bierman R Logan K O'Brien ET Seno RN Rao BE Schoner 1992 Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp Gene 116:43-49 1628843
    • (1992) Gene , vol.116 , pp. 43-49
    • Bierman, M.1    Logan, R.2    O'Brien, K.3    Seno, E.T.4    Rao, R.N.5    Schoner, B.E.6
  • 25
    • 0024504498 scopus 로고
    • Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis
    • 2914874
    • C Binnie M Warren MJ Butler 1989 Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis J Bacteriol 171:887-895 2914874
    • (1989) J Bacteriol , vol.171 , pp. 887-895
    • Binnie, C.1    Warren, M.2    Butler, M.J.3
  • 26
    • 0022780876 scopus 로고
    • Cloning and expression of a tylosin resistance gene from a tylosin-producing strain of Streptomyces fradiae
    • 3020383
    • VA Birmingham KL Cox JL Larson SE Fishman CL Hershberger ET Seno 1986 Cloning and expression of a tylosin resistance gene from a tylosin-producing strain of Streptomyces fradiae Mol Gen Genet 204:532-539 3020383
    • (1986) Mol Gen Genet , vol.204 , pp. 532-539
    • Birmingham, V.A.1    Cox, K.L.2    Larson, J.L.3    Fishman, S.E.4    Hershberger, C.L.5    Seno, E.T.6
  • 27
    • 0022972007 scopus 로고
    • A47934, a novel glycopeptide-aglycone antibiotic produced by a strain of Streptomyces toyocaensis: Taxonomy and fermentation studies
    • 3793622
    • LD Boeck FP Mertz 1986 A47934, a novel glycopeptide-aglycone antibiotic produced by a strain of Streptomyces toyocaensis: taxonomy and fermentation studies J Antibiot 39:1533-1540 3793622
    • (1986) J Antibiot , vol.39 , pp. 1533-1540
    • Boeck, L.D.1    Mertz, F.P.2
  • 29
    • 0030029880 scopus 로고    scopus 로고
    • Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans
    • 8576062
    • C Bormann V Möhrle C Bruntner 1996 Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans J Bacteriol 178:1216-1218 8576062
    • (1996) J Bacteriol , vol.178 , pp. 1216-1218
    • Bormann, C.1    Möhrle, V.2    Bruntner, C.3
  • 30
    • 48449098635 scopus 로고    scopus 로고
    • Mining microbial genomes for new natural products and biosynthetic pathways
    • 18524911
    • GL Challis 2008 Mining microbial genomes for new natural products and biosynthetic pathways Microbiology 154:1555-1569 18524911
    • (2008) Microbiology , vol.154 , pp. 1555-1569
    • Challis, G.L.1
  • 31
    • 0017201026 scopus 로고
    • Restriction of a bacteriophage of Streptomyces albus G involving endonuclease SalI
    • 977549
    • KF Chater LC Wilde 1976 Restriction of a bacteriophage of Streptomyces albus G involving endonuclease SalI J Bacteriol 128:644-650 977549
    • (1976) J Bacteriol , vol.128 , pp. 644-650
    • Chater, K.F.1    Wilde, L.C.2
  • 32
    • 49449102829 scopus 로고    scopus 로고
    • Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts
    • 18556785
    • Y Chen E Wendt-Pienkowski B Shen 2008 Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts J Bacteriol 190:5587-5596 18556785
    • (2008) J Bacteriol , vol.190 , pp. 5587-5596
    • Chen, Y.1    Wendt-Pienkowski, E.2    Shen, B.3
  • 34
    • 33749607080 scopus 로고    scopus 로고
    • Complementation of daptomycin dptA and dptD deletion mutations in-trans and production of hybrid lipopeptide antibiotics
    • 17005980
    • M-F Coëffet-Le Gal L Thurson P Rich V Miao RH Baltz 2006 Complementation of daptomycin dptA and dptD deletion mutations in-trans and production of hybrid lipopeptide antibiotics Microbiology 152:2993-3001 17005980
    • (2006) Microbiology , vol.152 , pp. 2993-3001
    • Coëffet-Le Gal, M.-F.1    Thurson, L.2    Rich, P.3    Miao, V.4    Baltz, R.H.5
  • 35
    • 68149179629 scopus 로고    scopus 로고
    • New natural product biosynthetic chemistry discovered by genome mining
    • 19636446
    • C Corre GL Challis 2009 New natural product biosynthetic chemistry discovered by genome mining Nat Prod Rep 26:977-986 19636446
    • (2009) Nat Prod Rep , vol.26 , pp. 977-986
    • Corre, C.1    Challis, G.L.2
  • 36
    • 0021223023 scopus 로고
    • Restriction of bacteriophage plaque formation in Streptomyces spp
    • 6086574
    • KL Cox RH Baltz 1984 Restriction of bacteriophage plaque formation in Streptomyces spp J Bacteriol 159:499-504 6086574
    • (1984) J Bacteriol , vol.159 , pp. 499-504
    • Cox, K.L.1    Baltz, R.H.2
  • 38
    • 56649114287 scopus 로고    scopus 로고
    • Control of tylosin biosynthesis in Streptomyces fradiae
    • 18852501
    • E Cundliffe 2008 Control of tylosin biosynthesis in Streptomyces fradiae J Microbiol Biotechnol 18:1485-1491 18852501
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 1485-1491
    • Cundliffe, E.1
  • 39
    • 0027368792 scopus 로고
    • Large genomic rearrangements of the unstable region in Streptomyces ambofaciens are associated with major changes in global gene expression
    • 7934838
    • A Dary P Kaiser N Bourget CJ Thompson J-M Simonet B Decaris 1993 Large genomic rearrangements of the unstable region in Streptomyces ambofaciens are associated with major changes in global gene expression Mol Microbiol 10:759-769 7934838
    • (1993) Mol Microbiol , vol.10 , pp. 759-769
    • Dary, A.1    Kaiser, P.2    Bourget, N.3    Thompson, C.J.4    Simonet, J.-M.5    Decaris, B.6
  • 40
    • 0033961234 scopus 로고    scopus 로고
    • DNA rearrangements at the extremities of the Streptomyces ambofaciens linear chromosome: Evidence for developmental control
    • 10717384
    • A Dary P Martin T Wenner B Decaris P Leblond 2000 DNA rearrangements at the extremities of the Streptomyces ambofaciens linear chromosome: evidence for developmental control Biochimie 82:29-34 10717384
    • (2000) Biochimie , vol.82 , pp. 29-34
    • Dary, A.1    Martin, P.2    Wenner, T.3    Decaris, B.4    Leblond, P.5
  • 41
    • 75749105024 scopus 로고    scopus 로고
    • Daptomycin: From the mountain to the clinic, with the essential help of Francis Tally, MD
    • BI Eisenstein FB Oleson Jr RH Baltz 2010 Daptomycin: from the mountain to the clinic, with the essential help of Francis Tally, MD Clin Inf Dis 50 S10 S15
    • (2010) Clin Inf Dis , vol.50
    • Eisenstein, B.I.1    Oleson Jr., F.B.2    Baltz, R.H.3
  • 42
    • 0023254801 scopus 로고
    • Cloning and nucleotide sequence of a carbomycin-resistance gene from Streptomyces thermotolerans
    • 3036668
    • JK Epp SG Burgett BE Schoner 1987 Cloning and nucleotide sequence of a carbomycin-resistance gene from Streptomyces thermotolerans Gene 53:73-83 3036668
    • (1987) Gene , vol.53 , pp. 73-83
    • Epp, J.K.1    Burgett, S.G.2    Schoner, B.E.3
  • 43
    • 0024796844 scopus 로고
    • Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans
    • 2628170
    • JK Epp ML Huber JR Turner T Goodson BE Schoner 1989 Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans Gene 85:293-301 2628170
    • (1989) Gene , vol.85 , pp. 293-301
    • Epp, J.K.1    Huber, M.L.2    Turner, J.R.3    Goodson, T.4    Schoner, B.E.5
  • 44
    • 8844224923 scopus 로고    scopus 로고
    • Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered Streptomyces coelicolor strains
    • 15556007
    • AS Eustáquio B Gust S-M Li S Pelzer W Wohlleben KF Chater L Heide 2004 Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered Streptomyces coelicolor strains Chem Biol 11:1561-1572 15556007
    • (2004) Chem Biol , vol.11 , pp. 1561-1572
    • Eustáquio, A.S.1    Gust, B.2    Li, S.-M.3    Pelzer, S.4    Wohlleben, W.5    Chater, K.F.6    Heide, L.7
  • 46
    • 34447527903 scopus 로고    scopus 로고
    • Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin
    • 17496129
    • EA Felnagle MR Rondon AD Berti HA Crosby MG Thomas 2007 Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin Appl Environ Microbiol 73:4162-4170 17496129
    • (2007) Appl Environ Microbiol , vol.73 , pp. 4162-4170
    • Felnagle, E.A.1    Rondon, M.R.2    Berti, A.D.3    Crosby, H.A.4    Thomas, M.G.5
  • 47
  • 48
    • 0029840323 scopus 로고    scopus 로고
    • An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus
    • 8757400
    • E Fernández F Lombó C Méndez JA Salas 1996 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus Mol Gen Genet 251:692-698 8757400
    • (1996) Mol Gen Genet , vol.251 , pp. 692-698
    • Fernández, E.1    Lombó, F.2    Méndez, C.3    Salas, J.A.4
  • 49
    • 0025119344 scopus 로고
    • Selection for Streptomyces ambofaciens mutants that produce large quantities of spiramycin and determination of optimal conditions for spiramycin production
    • Ford LM, Eaton TE, Godfrey OW (1990) Selection for Streptomyces ambofaciens mutants that produce large quantities of spiramycin and determination of optimal conditions for spiramycin production. Appl Environ Microbiol 56:3511-3514
    • (1990) Appl Environ Microbiol , vol.56 , pp. 3511-3514
    • Ford, L.M.1    Eaton, T.E.2    Godfrey, O.W.3
  • 50
    • 34447524208 scopus 로고    scopus 로고
    • Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis
    • U Galm B Shen 2006 Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis Expert Opin Drug Discov 1 409 437
    • (2006) Expert Opin Drug Discov , vol.1 , pp. 409-437
    • Galm, U.1    Shen, B.2
  • 51
    • 34249907531 scopus 로고    scopus 로고
    • Strategies to unravel the function of orphan biosynthesis pathways: Recent examples and future prospects
    • 17340107
    • H Gross 2007 Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects Appl Microbiol Biotechnol 75:267-277 17340107
    • (2007) Appl Microbiol Biotechnol , vol.75 , pp. 267-277
    • Gross, H.1
  • 52
    • 62149089979 scopus 로고    scopus 로고
    • Genomic-mining-a concept for the discovery of new bioactive natural products
    • 19333866
    • H Gross 2009 Genomic-mining-a concept for the discovery of new bioactive natural products Curr Opin Drug Discov Devel 12:207-219 19333866
    • (2009) Curr Opin Drug Discov Devel , vol.12 , pp. 207-219
    • Gross, H.1
  • 53
    • 33745143939 scopus 로고    scopus 로고
    • Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin
    • 16751529
    • S Gullón C Olano MS Abdelfattah AF Braňa J Rohr C Méndez JA Salas 2006 Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin Appl Environ Microbiol 72:4172-4183 16751529
    • (2006) Appl Environ Microbiol , vol.72 , pp. 4172-4183
    • Gullón, S.1    Olano, C.2    Abdelfattah, M.S.3    Braňa, A.F.4    Rohr, J.5    Méndez, C.6    Salas, J.A.7
  • 54
    • 0025953664 scopus 로고
    • Tn5099, a xylE promoter probe transposon for Streptomyces spp
    • 1653213
    • DR Hahn PJ Solenberg RH Baltz 1991 Tn5099, a xylE promoter probe transposon for Streptomyces spp J Bacteriol 173:5573-5577 1653213
    • (1991) J Bacteriol , vol.173 , pp. 5573-5577
    • Hahn, D.R.1    Solenberg, P.J.2    Baltz, R.H.3
  • 55
    • 0031036748 scopus 로고    scopus 로고
    • Use of rpsL for dominance selection and gene replacement in Streptomyces roseosporus
    • TJ Hosted RH Baltz 1996 Use of rpsL for dominance selection and gene replacement in Streptomyces roseosporus J Bacteriol 179 180 186
    • (1996) J Bacteriol , vol.179 , pp. 180-186
    • Hosted, T.J.1    Baltz, R.H.2
  • 58
    • 34548042564 scopus 로고    scopus 로고
    • Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans
    • 17623098
    • KP Jayapal W Lian F Glod DH Sherman W Hu 2007 Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans BMC Genomics 8 229 17623098
    • (2007) BMC Genomics , vol.8 , pp. 229
    • Jayapal, K.P.1    Lian, W.2    Glod, F.3    Sherman, D.H.4    Hu, W.5
  • 59
    • 70349231218 scopus 로고    scopus 로고
    • Bioinformatic perspectives on NRPS/PKS megasynthases: Advances and challenges
    • 19554239
    • H Jenke-Kodama E Dittmann 2009 Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges Nat Prod Rep 26:874-883 19554239
    • (2009) Nat Prod Rep , vol.26 , pp. 874-883
    • Jenke-Kodama, H.1    Dittmann, E.2
  • 60
    • 67650034392 scopus 로고    scopus 로고
    • Genome mining in Streptomyces avermitilis: A biochemical Baeyer-Villiger reaction and discovery of a new branch of the pentalenolactone family tree
    • 19485417
    • J Jiang CN Tetzlaff S Takamatsu M Iwatsuki M Komatsu H Ikeda DE Cane 2009 Genome mining in Streptomyces avermitilis: a biochemical Baeyer-Villiger reaction and discovery of a new branch of the pentalenolactone family tree Biochemistry 48:6431-6440 19485417
    • (2009) Biochemistry , vol.48 , pp. 6431-6440
    • Jiang, J.1    Tetzlaff, C.N.2    Takamatsu, S.3    Iwatsuki, M.4    Komatsu, M.5    Ikeda, H.6    Cane, D.E.7
  • 61
    • 0027932534 scopus 로고
    • Engineered biosynthesis of a complete macrolactone in a heterologous host
    • 8036492
    • CM Kao L Katz C Khosla 1994 Engineered biosynthesis of a complete macrolactone in a heterologous host Science 265:509-512 8036492
    • (1994) Science , vol.265 , pp. 509-512
    • Kao, C.M.1    Katz, L.2    Khosla, C.3
  • 63
    • 43149117260 scopus 로고    scopus 로고
    • Conjugal transfer using the bacteriophage φc31 att/int system and properties of the attB site in Streptomyces ambofaciens
    • 17989926
    • M-K Kim H-S Ha S-U Choi 2008 Conjugal transfer using the bacteriophage φC31 att/int system and properties of the attB site in Streptomyces ambofaciens Biotechnol Lett 30:695-699 17989926
    • (2008) Biotechnol Lett , vol.30 , pp. 695-699
    • Kim, M.-K.1    Ha, H.-S.2    Choi, S.-U.3
  • 64
    • 0031040356 scopus 로고    scopus 로고
    • Macrolide antibiotics in food-animal health
    • 15989594
    • HA Kirst 1997 Macrolide antibiotics in food-animal health Expert Opin Investig Drugs 6:103-118 15989594
    • (1997) Expert Opin Investig Drugs , vol.6 , pp. 103-118
    • Kirst, H.A.1
  • 65
    • 44949176042 scopus 로고    scopus 로고
    • Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol
    • 18492804
    • M Komatsu M Tsuda S Omura H Oikawa H Ikeda 2008 Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol Proc Nat Acad Sci USA 105:7422-7427 18492804
    • (2008) Proc Nat Acad Sci USA , vol.105 , pp. 7422-7427
    • Komatsu, M.1    Tsuda, M.2    Omura, S.3    Oikawa, H.4    Ikeda, H.5
  • 66
    • 77249153701 scopus 로고    scopus 로고
    • Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
    • 20133795
    • M Komatsu T Uchiyama S Omura DE Cane H Ikeda 2010 Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism Proc Nat Acad Sci USA 107:2646-2651 20133795
    • (2010) Proc Nat Acad Sci USA , vol.107 , pp. 2646-2651
    • Komatsu, M.1    Uchiyama, T.2    Omura, S.3    Cane, D.E.4    Ikeda, H.5
  • 67
    • 0024552527 scopus 로고
    • Site-specific integration in Streptomyces ambofaciens: Localization of integration functions in S. ambofaciens plasmid pSAM2
    • 2536654
    • S Kuhstoss MA Richardson RN Rao 1989 Site-specific integration in Streptomyces ambofaciens: localization of integration functions in S. ambofaciens plasmid pSAM2 J Bacteriol 171:16-23 2536654
    • (1989) J Bacteriol , vol.171 , pp. 16-23
    • Kuhstoss, S.1    Richardson, M.A.2    Rao, R.N.3
  • 68
    • 0026318809 scopus 로고
    • Analysis of the integration function of the streptomycete bacteriophage φc31
    • S Kustoss RN Rao 1991 Analysis of the integration function of the streptomycete bacteriophage φC31 J Mol Biol 222 897 908
    • (1991) J Mol Biol , vol.222 , pp. 897-908
    • Kustoss, S.1    Rao, R.N.2
  • 69
    • 0025967413 scopus 로고
    • Plasmid cloning vectors that integrate site-specifically in Streptomyces spp
    • 1995427
    • S Kuhstoss MA Richardson RN Rao 1991 Plasmid cloning vectors that integrate site-specifically in Streptomyces spp Gene 97:143-146 1995427
    • (1991) Gene , vol.97 , pp. 143-146
    • Kuhstoss, S.1    Richardson, M.A.2    Rao, R.N.3
  • 70
    • 0030445331 scopus 로고    scopus 로고
    • Production of a novel polyketide through the construction of a hybrid polyketide synthase
    • 8996112
    • S Kuhstoss M Huber JR Turner JW Paschal RN Rao 1996 Production of a novel polyketide through the construction of a hybrid polyketide synthase Gene 183:231-236 8996112
    • (1996) Gene , vol.183 , pp. 231-236
    • Kuhstoss, S.1    Huber, M.2    Turner, J.R.3    Paschal, J.W.4    Rao, R.N.5
  • 71
    • 0034830337 scopus 로고    scopus 로고
    • Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein
    • 11457082
    • H-J Kwon WC Smith L Xiang B Shen 2001 Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein J Am Chem Soc 123:3385-3386 11457082
    • (2001) J Am Chem Soc , vol.123 , pp. 3385-3386
    • Kwon, H.-J.1    Smith, W.C.2    Xiang, L.3    Shen, B.4
  • 72
    • 0026556522 scopus 로고
    • Cloning of the complete biosynthetic gene cluster for an aminonucleoside antibiotic, puromycin, and its regulated expression in heterologous hosts
    • 1537349
    • RA Lacalle JA Tercera J Jimenez 1992 Cloning of the complete biosynthetic gene cluster for an aminonucleoside antibiotic, puromycin, and its regulated expression in heterologous hosts EMBO J 11:785-792 1537349
    • (1992) EMBO J , vol.11 , pp. 785-792
    • Lacalle, R.A.1    Tercera, J.A.2    Jimenez, J.3
  • 73
    • 0029007928 scopus 로고
    • DNA processing reactions in bacterial conjugation
    • 7574478
    • E Lanka BM Wilkins 1995 DNA processing reactions in bacterial conjugation Annu Rev Biochem 64:141-169 7574478
    • (1995) Annu Rev Biochem , vol.64 , pp. 141-169
    • Lanka, E.1    Wilkins, B.M.2
  • 74
    • 0021351979 scopus 로고
    • Shuttle vectors for cloning recombinant DNA in Escherichia coli and Streptomyces griseofuscus C581
    • 6317655
    • JL Larson CL Hershberger 1984 Shuttle vectors for cloning recombinant DNA in Escherichia coli and Streptomyces griseofuscus C581 J Bacteriol 157:314-317 6317655
    • (1984) J Bacteriol , vol.157 , pp. 314-317
    • Larson, J.L.1    Hershberger, C.L.2
  • 75
    • 0022721552 scopus 로고
    • The minimal replicon of a streptomycete plasmid produces an ultrahigh level of plasmid DNA
    • 3012613
    • JL Larson CL Hershberger 1986 The minimal replicon of a streptomycete plasmid produces an ultrahigh level of plasmid DNA Plasmid 15:199-209 3012613
    • (1986) Plasmid , vol.15 , pp. 199-209
    • Larson, J.L.1    Hershberger, C.L.2
  • 76
    • 0024505121 scopus 로고
    • Hypervariability, a new phenomenon of genetic instability, related to DNA amplification in Streptomyces ambofaciens
    • 2914852
    • P Leblond P Demuyter L Moutier M Laakel B Decaris J-M Simonet 1989 Hypervariability, a new phenomenon of genetic instability, related to DNA amplification in Streptomyces ambofaciens J Bacteriol 171:419-423 2914852
    • (1989) J Bacteriol , vol.171 , pp. 419-423
    • Leblond, P.1    Demuyter, P.2    Moutier, L.3    Laakel, M.4    Decaris, B.5    Simonet, J.-M.6
  • 77
    • 0025297469 scopus 로고
    • Genetic instability and hypervariability in Streptomyces ambofaciens: Towards an understanding of a mechanism of genome plasticity
    • 2201867
    • P Leblond P Demuyter J-M Simonet B Decaris 1990 Genetic instability and hypervariability in Streptomyces ambofaciens: towards an understanding of a mechanism of genome plasticity Mol Microbiol 4:707-714 2201867
    • (1990) Mol Microbiol , vol.4 , pp. 707-714
    • Leblond, P.1    Demuyter, P.2    Simonet, J.-M.3    Decaris, B.4
  • 78
    • 0025864011 scopus 로고
    • Genetic instability and associated genome plasticity in Streptomyces ambofaciens: Pulsed-field gel electrophoresis evidence for large DNA alterations in a limited genomic region
    • 2061296
    • P Leblond P Demuyter J-M Simonet B Decaris 1991 Genetic instability and associated genome plasticity in Streptomyces ambofaciens: pulsed-field gel electrophoresis evidence for large DNA alterations in a limited genomic region J Bacteriol 173:4229-4233 2061296
    • (1991) J Bacteriol , vol.173 , pp. 4229-4233
    • Leblond, P.1    Demuyter, P.2    Simonet, J.-M.3    Decaris, B.4
  • 80
    • 32344437742 scopus 로고    scopus 로고
    • Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species
    • 16408310
    • F Lombo A Velasco A Castro F de la Calle AF Brana JM Sanchez-Puelles C Mendez JA Salas 2006 Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species ChemBioChem 7:366-376 16408310
    • (2006) ChemBioChem , vol.7 , pp. 366-376
    • Lombo, F.1    Velasco, A.2    Castro, A.3    De La Calle, F.4    Brana, A.F.5    Sanchez-Puelles, J.M.6    Mendez, C.7    Salas, J.A.8
  • 81
    • 0021802904 scopus 로고
    • Efficient plasmid transformation of Streptomyces ambofaciens and Streptomyces fradiae protoplasts
    • 4008440
    • P Matsushima RH Baltz 1985 Efficient plasmid transformation of Streptomyces ambofaciens and Streptomyces fradiae protoplasts J Bacteriol 163:180-185 4008440
    • (1985) J Bacteriol , vol.163 , pp. 180-185
    • Matsushima, P.1    Baltz, R.H.2
  • 82
    • 0028091150 scopus 로고
    • Transformation of Saccharopolyspora spinosa protoplasts with plasmid DNA modified in vitro to avoid host restriction
    • P Matsushima RH Baltz 1994 Transformation of Saccharopolyspora spinosa protoplasts with plasmid DNA modified in vitro to avoid host restriction Microbiology 140 139 143
    • (1994) Microbiology , vol.140 , pp. 139-143
    • Matsushima, P.1    Baltz, R.H.2
  • 83
    • 0030024771 scopus 로고    scopus 로고
    • A gene cloning system for 'Streptomyces toyocaensis'
    • 8932699
    • P Matsushima RH Baltz 1996 A gene cloning system for 'Streptomyces toyocaensis' Microbiology 142:261-267 8932699
    • (1996) Microbiology , vol.142 , pp. 261-267
    • Matsushima, P.1    Baltz, R.H.2
  • 84
    • 0023094741 scopus 로고
    • Highly transformable mutants of Streptomyces fradiae defective in several restriction systems
    • 3473276
    • P Matsushima KL Cox RH Baltz 1987 Highly transformable mutants of Streptomyces fradiae defective in several restriction systems Mol Gen Genet 206:393-400 3473276
    • (1987) Mol Gen Genet , vol.206 , pp. 393-400
    • Matsushima, P.1    Cox, K.L.2    Baltz, R.H.3
  • 85
    • 0024409436 scopus 로고
    • Transduction and transformation of plasmid DNA in Streptomyces fradiae strains that express different levels of restriction
    • 2542216
    • P Matsushima MA McHenney RH Baltz 1989 Transduction and transformation of plasmid DNA in Streptomyces fradiae strains that express different levels of restriction J Bacteriol 171:3080-3084 2542216
    • (1989) J Bacteriol , vol.171 , pp. 3080-3084
    • Matsushima, P.1    McHenney, M.A.2    Baltz, R.H.3
  • 86
    • 0028145059 scopus 로고
    • Conjugal transfer of cosmid DNA from Escherichia coli to Saccharopolyspora spinosa: Effects of chromosomal insertions on macrolide A83543 production
    • 8063103
    • P Matsushima MC Broughton JR Turner RH Baltz 1994 Conjugal transfer of cosmid DNA from Escherichia coli to Saccharopolyspora spinosa: effects of chromosomal insertions on macrolide A83543 production Gene 146:39-45 8063103
    • (1994) Gene , vol.146 , pp. 39-45
    • Matsushima, P.1    Broughton, M.C.2    Turner, J.R.3    Baltz, R.H.4
  • 87
    • 0024327340 scopus 로고
    • Intergeneric conjugation between Escherichia coli and Streptomyces species
    • 2656662
    • P Mazodier R Petter C Thompson 1989 Intergeneric conjugation between Escherichia coli and Streptomyces species J Bacteriol 171:3583-3585 2656662
    • (1989) J Bacteriol , vol.171 , pp. 3583-3585
    • Mazodier, P.1    Petter, R.2    Thompson, C.3
  • 88
    • 0023903160 scopus 로고
    • Transduction of plasmid DNA in Streptomyces spp. and related genera by bacteriophage FP43
    • 3360743
    • MA McHenney RH Baltz 1988 Transduction of plasmid DNA in Streptomyces spp. and related genera by bacteriophage FP43 J Bacteriol 170:2276-2282 3360743
    • (1988) J Bacteriol , vol.170 , pp. 2276-2282
    • McHenney, M.A.1    Baltz, R.H.2
  • 89
    • 0026056391 scopus 로고
    • Transposition of Tn5096 from a temperature-sensitive transducible plasmid in Streptomyces spp
    • 1653214
    • MA McHenney RH Baltz 1991 Transposition of Tn5096 from a temperature-sensitive transducible plasmid in Streptomyces spp J Bacteriol 173:5578-5581 1653214
    • (1991) J Bacteriol , vol.173 , pp. 5578-5581
    • McHenney, M.A.1    Baltz, R.H.2
  • 90
    • 0029768888 scopus 로고    scopus 로고
    • Gene transfer and transposition mutagenesis in Streptomyces roseosporus: Mapping of insertions that influence daptomycin or pigment production
    • 8828204
    • MA McHenney RH Baltz 1996 Gene transfer and transposition mutagenesis in Streptomyces roseosporus: mapping of insertions that influence daptomycin or pigment production Microbiology 142:2363-2373 8828204
    • (1996) Microbiology , vol.142 , pp. 2363-2373
    • McHenney, M.A.1    Baltz, R.H.2
  • 91
    • 0031963078 scopus 로고    scopus 로고
    • Molecular cloning and physical mapping of the daptomycin gene cluster from Streptomyces roseosporus
    • 9422604
    • MA McHenney TJ Hosted BS Dehoff PR Rosteck Jr RH Baltz 1998 Molecular cloning and physical mapping of the daptomycin gene cluster from Streptomyces roseosporus J Bacteriol 180:143-151 9422604
    • (1998) J Bacteriol , vol.180 , pp. 143-151
    • McHenney, M.A.1    Hosted, T.J.2    Dehoff, B.S.3    Rosteck Jr., P.R.4    Baltz, R.H.5
  • 95
    • 70350722394 scopus 로고    scopus 로고
    • Genomic basis for natural product biosynthetic diversity in the actinomycetes
    • 19844637
    • M Nett H Ikeda BS Moore 2009 Genomic basis for natural product biosynthetic diversity in the actinomycetes Nat Prod Rep 26:1362-1384 19844637
    • (2009) Nat Prod Rep , vol.26 , pp. 1362-1384
    • Nett, M.1    Ikeda, H.2    Moore, B.S.3
  • 96
    • 33747056235 scopus 로고    scopus 로고
    • A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus
    • 16879412
    • K Nguyen D Kau J-Q Gu P Brian SK Wrigley RH Baltz V Miao 2006 A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus Mol Microbiol 61:1294-1307 16879412
    • (2006) Mol Microbiol , vol.61 , pp. 1294-1307
    • Nguyen, K.1    Kau, D.2    Gu, J.-Q.3    Brian, P.4    Wrigley, S.K.5    Baltz, R.H.6    Miao, V.7
  • 99
    • 34347344063 scopus 로고    scopus 로고
    • From microbial differentiation to ribosome engineering
    • 17587668
    • K Ochi 2007 From microbial differentiation to ribosome engineering Biosci Biotechnol Biochem 71:1373-1386 17587668
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 1373-1386
    • Ochi, K.1
  • 101
    • 40949145314 scopus 로고    scopus 로고
    • Glycosylated derivatives of steffimycin: Insights into the role of sugar moieties for the biological activity
    • 18224649
    • C Olano MS Abdelfattah S Gullón AF Braňa J Rohr C Méndez JA Salas 2008 Glycosylated derivatives of steffimycin: insights into the role of sugar moieties for the biological activity ChemBioChem 9:624-633 18224649
    • (2008) ChemBioChem , vol.9 , pp. 624-633
    • Olano, C.1    Abdelfattah, M.S.2    Gullón, S.3    Braňa, A.F.4    Rohr, J.5    Méndez, C.6    Salas, J.A.7
  • 103
    • 0036952785 scopus 로고    scopus 로고
    • Cloning the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression on Streptomyces lividans
    • H Onaka S-I Taniguchi Y Igarashi T Furamai 2002 Cloning the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression on Streptomyces lividans J Antibiotics 55 1063 1071
    • (2002) J Antibiotics , vol.55 , pp. 1063-1071
    • Onaka, H.1    Taniguchi, S.-I.2    Igarashi, Y.3    Furamai, T.4
  • 106
    • 5444219634 scopus 로고    scopus 로고
    • Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts
    • 15489173
    • CD Reeves SL Ward WP Revill H Suzuki M Marcus OV Petrakovsky S Marquez H Fu SD Dong L Katz 2004 Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts Chem Biol 11:1465-1472 15489173
    • (2004) Chem Biol , vol.11 , pp. 1465-1472
    • Reeves, C.D.1    Ward, S.L.2    Revill, W.P.3    Suzuki, H.4    Marcus, M.5    Petrakovsky, O.V.6    Marquez, S.7    Fu, H.8    Dong, S.D.9    Katz, L.10
  • 107
    • 0023631193 scopus 로고
    • A new shuttle cosmid vector, pKC505, for streptomycetes: Its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofaciens library
    • 3328731
    • MA Richardson S Kuhstoss P Solenberg NA Schaus RN Rao 1987 A new shuttle cosmid vector, pKC505, for streptomycetes: its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofaciens library Gene 61:231-241 3328731
    • (1987) Gene , vol.61 , pp. 231-241
    • Richardson, M.A.1    Kuhstoss, S.2    Solenberg, P.3    Schaus, N.A.4    Rao, R.N.5
  • 108
    • 0025299084 scopus 로고
    • Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis
    • 2193916
    • MA Richardson S Kuhstoss MLB Huber L Ford O Godfrey JR Turner NR Rao 1990 Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis J Bacteriol 172:3790-3798 2193916
    • (1990) J Bacteriol , vol.172 , pp. 3790-3798
    • Richardson, M.A.1    Kuhstoss, S.2    Huber, M.L.B.3    Ford, L.4    Godfrey, O.5    Turner, J.R.6    Rao, N.R.7
  • 109
    • 0027214965 scopus 로고
    • Streptomyces antibioticus contains at least three oleandomycin-resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily
    • AM Rodríquez C Olano C Vilches C Méndez JA Salas 1993 Streptomyces antibioticus contains at least three oleandomycin-resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily Mol Microbiol 8 571 582
    • (1993) Mol Microbiol , vol.8 , pp. 571-582
    • Rodríquez, A.M.1    Olano, C.2    Vilches, C.3    Méndez, C.4    Salas, J.A.5
  • 112
    • 0020320421 scopus 로고
    • S-adenosyl-L-methionine: Macrocin O-methyltransferase activities in a series of Streptomyces fradiae mutants that produce different levels of the macrolide antibiotic tylosin
    • 7103455
    • ET Seno RH Baltz 1982 S-adenosyl-L-methionine: macrocin O-methyltransferase activities in a series of Streptomyces fradiae mutants that produce different levels of the macrolide antibiotic tylosin Antimicrob Agents Chemother 21:758-763 7103455
    • (1982) Antimicrob Agents Chemother , vol.21 , pp. 758-763
    • Seno, E.T.1    Baltz, R.H.2
  • 113
    • 76049095346 scopus 로고    scopus 로고
    • Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates
    • 20159569
    • S Siebenberg PM Bapat AE Lantz B Gust L Heide 2009 Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates J Biosci Bioeng 109:230-234 20159569
    • (2009) J Biosci Bioeng , vol.109 , pp. 230-234
    • Siebenberg, S.1    Bapat, P.M.2    Lantz, A.E.3    Gust, B.4    Heide, L.5
  • 114
    • 0026071001 scopus 로고
    • Transposition of Tn5096 and other IS493 derivatives in Streptomyces griseofuscus
    • 1846854
    • PJ Solenberg RH Baltz 1991 Transposition of Tn5096 and other IS493 derivatives in Streptomyces griseofuscus J Bacteriol 173:1096-1104 1846854
    • (1991) J Bacteriol , vol.173 , pp. 1096-1104
    • Solenberg, P.J.1    Baltz, R.H.2
  • 115
    • 0028030482 scopus 로고
    • Hypertransposing derivatives of the streptomycete insertion sequence IS493
    • 8088548
    • PJ Solenberg RH Baltz 1994 Hypertransposing derivatives of the streptomycete insertion sequence IS493 Gene 147:47-54 8088548
    • (1994) Gene , vol.147 , pp. 47-54
    • Solenberg, P.J.1    Baltz, R.H.2
  • 117
    • 57149112966 scopus 로고    scopus 로고
    • ClustScan: And integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures
    • 18978015
    • A Starcevic J Zucko J Simunkovic PF Long J Cullum D Hranueli 2008 ClustScan: and integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures Nucl Acids Res 36:6882-6892 18978015
    • (2008) Nucl Acids Res , vol.36 , pp. 6882-6892
    • Starcevic, A.1    Zucko, J.2    Simunkovic, J.3    Long, P.F.4    Cullum, J.5    Hranueli, D.6
  • 118
    • 0022575723 scopus 로고
    • High frequency conjugal transfer of tylosin genes and amplifiable DNA in Streptomyces fradiae
    • 3458997
    • J Stonesifer P Matsushima RH Baltz 1986 High frequency conjugal transfer of tylosin genes and amplifiable DNA in Streptomyces fradiae Mol Gen Genet 202:348-355 3458997
    • (1986) Mol Gen Genet , vol.202 , pp. 348-355
    • Stonesifer, J.1    Matsushima, P.2    Baltz, R.H.3
  • 119
    • 0036242736 scopus 로고    scopus 로고
    • Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae
    • 11986923
    • G Stratigopoulos E Cundliffe 2002 Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae J Ind Microbiol Biotechnol 28:219-224 11986923
    • (2002) J Ind Microbiol Biotechnol , vol.28 , pp. 219-224
    • Stratigopoulos, G.1    Cundliffe, E.2
  • 120
    • 63449126395 scopus 로고    scopus 로고
    • Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase
    • 19047343
    • A Talà G Wang M Zemanova S Okamoto K Ochi P Alifano 2009 Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase J Bacteriol 191:805-814 19047343
    • (2009) J Bacteriol , vol.191 , pp. 805-814
    • Talà, A.1    Wang, G.2    Zemanova, M.3    Okamoto, S.4    Ochi, K.5    Alifano, P.6
  • 122
    • 33646591928 scopus 로고    scopus 로고
    • A gene cluster for biosynthesis of the sequiterpine antibiotic pentalenolactone in Streptomyces avermitilis
    • 16681390
    • CN Tetzlaff Z You DE Cane S Takamatzu S Omura H Ikeda 2006 A gene cluster for biosynthesis of the sequiterpine antibiotic pentalenolactone in Streptomyces avermitilis Biochemistry 45:6179-6186 16681390
    • (2006) Biochemistry , vol.45 , pp. 6179-6186
    • Tetzlaff, C.N.1    You, Z.2    Cane, D.E.3    Takamatzu, S.4    Omura, S.5    Ikeda, H.6
  • 123
    • 33744533954 scopus 로고    scopus 로고
    • Microbial genomics for the improvement of natural product discovery
    • S Van Lanen B Shen 2006 Microbial genomics for the improvement of natural product discovery Curr Opin Microbiol 9 1 9
    • (2006) Curr Opin Microbiol , vol.9 , pp. 1-9
    • Van Lanen, S.1    Shen, B.2
  • 124
    • 64249163186 scopus 로고    scopus 로고
    • Applying the genetics of secondary metabolism in model actinomycetes to the discovery of new antibiotics
    • 19374981
    • GP van Wezel NL McKenzie JR Nodwell 2009 Applying the genetics of secondary metabolism in model actinomycetes to the discovery of new antibiotics Methods Enzymol 458:117-141 19374981
    • (2009) Methods Enzymol , vol.458 , pp. 117-141
    • Van Wezel, G.P.1    McKenzie, N.L.2    Nodwell, J.R.3
  • 125
    • 5444249226 scopus 로고    scopus 로고
    • Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: Novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae
    • SL Ward Z Hu A Schirmer R Reid P Revill CD Reeves OV Petrakowsky SD Dong L Katz 2004 Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae Antimicrob Agents Chemother 8 4703 4712
    • (2004) Antimicrob Agents Chemother , vol.8 , pp. 4703-4712
    • Ward, S.L.1    Hu, Z.2    Schirmer, A.3    Reid, R.4    Revill, P.5    Reeves, C.D.6    Petrakowsky, O.V.7    Dong, S.D.8    Katz, L.9
  • 126
    • 61649111711 scopus 로고    scopus 로고
    • CLUSTEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters
    • 19297688
    • T Weber C Rausch P Lopez I Hoof V Gaykova DH Huson W Wohlleben 2009 CLUSTEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters J Biotechnol 140:13-17 19297688
    • (2009) J Biotechnol , vol.140 , pp. 13-17
    • Weber, T.1    Rausch, C.2    Lopez, P.3    Hoof, I.4    Gaykova, V.5    Huson, D.H.6    Wohlleben, W.7
  • 127
    • 28444466613 scopus 로고    scopus 로고
    • Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus
    • 16305230
    • E Wendt-Pienkowski Y Huang J Zhang B Li H Jiang H Kwon CR Hutchinson B Shen 2005 Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus J Am Chem Soc 127:16442-16452 16305230
    • (2005) J Am Chem Soc , vol.127 , pp. 16442-16452
    • Wendt-Pienkowski, E.1    Huang, Y.2    Zhang, J.3    Li, B.4    Jiang, H.5    Kwon, H.6    Hutchinson, C.R.7    Shen, B.8
  • 128
    • 0142030053 scopus 로고    scopus 로고
    • End-to-end fusion of linear deleted chromosomes initiates a cycle of genome instability in Streptomyces ambofaciens
    • 14617168
    • T Wenner V Roth G Fischer C Fourrier B Aigle B Decaris P Leblond 2003 End-to-end fusion of linear deleted chromosomes initiates a cycle of genome instability in Streptomyces ambofaciens Mol Microbiol 50:411-425 14617168
    • (2003) Mol Microbiol , vol.50 , pp. 411-425
    • Wenner, T.1    Roth, V.2    Fischer, G.3    Fourrier, C.4    Aigle, B.5    Decaris, B.6    Leblond, P.7
  • 129
    • 34447558011 scopus 로고    scopus 로고
    • Molecular basis for chloronium-mediated meroterpene cyclization: Cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster
    • 17392281
    • JM Winter MC Moffitt E Zazopoulos JB McAlpine PC Dorrestein BS Moore 2007 Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster J Biol Chem 282:16362-16368 17392281
    • (2007) J Biol Chem , vol.282 , pp. 16362-16368
    • Winter, J.M.1    Moffitt, M.C.2    Zazopoulos, E.3    McAlpine, J.B.4    Dorrestein, P.C.5    Moore, B.S.6


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