Daptomycin biosynthesis in Streptomyces roseosporus: Cloning and analysis of the gene cluster and revision of peptide stereochemistry

Microbiology

Volumn 151, Issue 5, 2005, Pages 1507-1523

  Miao, Vivian ^a   Coëffet LeGal, Marie Françoise ^a   Brian, Paul ^a   Brost, Renee ^a   Penn, Julia ^b   Whiting, Andrew ^b   Martin, Steven ^b   Ford, Robert ^b   Parr, Ian ^a   Bouchard, Mario ^a   Silva, Christopher J ^a   Wrigley, Stephen K ^b   Baltz, Richard H ^a  

^a CUBIST PHARMACEUTICALS INC   (United States)

^b Cubist Pharmaceuticals UK Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DAPTOMYCIN; EPIMERASE; GENOMIC DNA; GLUTAMIC ACID DERIVATIVE; KYNURENINE; LIPOPEPTIDE; PEPTIDE SYNTHASE; PROTEIN SUBUNIT; SYNTHETIC PEPTIDE;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME MECHANISM; GENE CLUSTER; GENE EXPRESSION; GENE SEQUENCE; GENETIC CODE; MICROBIOLOGY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; STEREOCHEMISTRY; STEREOSPECIFICITY; STREPTOMYCES; STREPTOMYCES LIVIDANS; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; CLONING, MOLECULAR; CONSERVED SEQUENCE; DAPTOMYCIN; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OPEN READING FRAMES; PEPTIDE SYNTHASES; PEPTIDES, CYCLIC; PROTEIN SUBUNITS; SEQUENCE ANALYSIS, DNA; STEREOISOMERISM; STREPTOMYCES; STREPTOMYCES LIVIDANS;

STREPTOMYCES LIVIDANS; STREPTOMYCES ROSEOSPORUS;

EID: 21044448952     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.27757-0     Document Type: Article

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