Glycosylated derivatives of steffimycin: Insights into the role of the sugar moieties for the biological activity

ChemBioChem

Volumn 9, Issue 4, 2008, Pages 624-633

  Olano, Carlos ^a   Abdelfattah, Mohammed S ^b   Gullón, Sonia ^a   Braña, Alfredo F ^a   Rohr, Jürgen ^b   Méndez, Carmen ^a   Salas, José A ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b University of Kentucky   (United States)

Author keywords

Anthracyclines; Antitumor agents; Biological activity; Combinatorial biosynthesis; Deoxyhexoses

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BIOVIONOSYL 8 DEMETHOXYSTEFFIMYCIN; BOIVINOSYL 8 DEMETHOXY 10 DEOXYSTEFFIMYCIN; DEOXYSUGAR; DIGITOXOSYL 8 DEMETHOXY 10 DEOXYSTEFFIMYCIN; DIGITOXOSYL 8 DEMETHOXYSTEFFIMYCIN; PLASMID VECTOR; STEFFIMYCIN DERIVATIVE; UNCLASSIFIED DRUG; ANTHRACYCLINE; CARBOHYDRATE; STEFFIMYCIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; GENE EXPRESSION; GENE TRANSFER; GLYCOSYLATION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; STREPTOMYCES ALBUS; STRUCTURE ACTIVITY RELATION; AMINATION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; OXIDATION REDUCTION REACTION; PLASMID; STREPTOMYCES; TUMOR CELL LINE;

STREPTOMYCES; STREPTOMYCES STEFFISBURGENSIS;

AMINATION; ANTHRACYCLINES; CARBOHYDRATES; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLYCOSYLATION; HUMANS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PLASMIDS; STREPTOMYCES;

EID: 40949145314     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700610     Document Type: Article

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