Heterologous production of daptomycin in Streptomyces lividans

Journal of Industrial Microbiology and Biotechnology

Volumn 33, Issue 2, 2006, Pages 121-128

  Penn, Julia ^a   Li, Xiang ^b   Whiting, Andrew ^a   Latif, Mohammed ^a   Gibson, Trevor ^a   Silva, Christopher J ^b   Brian, Paul ^b   Davies, Julian ^b,c   Miao, Vivian ^b   Wrigley, Stephen K ^a   Baltz, Richard H ^b  

^a Cubist Pharmaceuticals (UK) Ltd   (United Kingdom)

^b CUBIST PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

A21978C; Actinorhodin; Calcium dependent antibiotic (CDA); Daptomycin; Streptomyces lividans

Indexed keywords

A 21978C; ACTINORHODINE; ANTIBIOTIC AGENT; BACTERIAL DNA; CALCIUM; CALCIUM DEPENDENT ANTIBIOTIC; DAPTOMYCIN; GENOMIC DNA; PHOSPHATE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONTROLLED STUDY; DRUG SYNTHESIS; FERMENTATION; FERMENTATION MEDIUM; GENE CLUSTER; GENE DELETION; GENE INSERTION; GENETIC CODE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PHOSPHORYLATION; SPECIES COMPARISON; STREPTOMYCES; STREPTOMYCES LIVIDANS; STREPTOMYCES ROSEOSPORUS;

ANTHRAQUINONES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CALCIUM; CULTURE MEDIA; DAPTOMYCIN; FERMENTATION; GENE DELETION; MULTIGENE FAMILY; PEPTIDES; RECOMBINANT PROTEINS; STREPTOMYCES; STREPTOMYCES LIVIDANS;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES FILAMENTOSUS; STREPTOMYCES LIVIDANS;

EID: 30844464361     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-005-0033-8     Document Type: Conference Paper

References (21)

1. Bibb MJ, Janssen GR, Ward JM (1985) Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeus. Gene 38:215-226
2. Bierman M, Logan R, O'Brien K, Seno ET, Rao RN, Schoner BE (1992) Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp . Gene 116:43-49
3. Chouayekh H, Virolle M-J (2002) The polyphosphate kinase plays a negative role in the control of antibiotic production in Streptomyces lividans. Mol Microbiol 43:919-930
4. Debono M, Barnhart M, Carrell CB, Hoffman JA, Occolowitz JL, Abbott BJ, Fukuda DS, Hamill RL (1987) A21978C, a complex of new acidic peptide antibiotics: isolation, chemistry, and mass spectral structure elucidation. J Antibiot 40:761-777
5. Debono M, Abbott BJ, Molloy RM, Fukuda DS, Hunt AH, Daupert VM, Counter FT, Ott JL, Carrell CB, Howard LC, Boeck LD, Hamill RL (1988) Enzymatic and chemical modifications of lipopetide antibiotic A21978C: the synthesis and evaluation of daptomycin (LY146032). J Antibiot 41:1093-1105
6. Eisenstein BI (2004) Lipopeptides, focusing on daptomycin, for the treatment of Gram-positive infections. Expert Opin Investig Drugs 13:1159-1169
7. Gorst-Allman CP, Rudd BAM, Chang C, Floss HG (1981) Biosynthesis of actinorhodin. Determination of the point of dimerization. J Org Chem 46:455-456
8. Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BAM, Hayes MA, Smith CP, Micklefield J (2002) Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor. Chem Biol 9:1-13
9. Hu H, Zhang Q, Ochi K (2002) Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase β subunit) of Streptomyces lividans. J Bacteriol 184:3984-3991
10. Huber FM, Pieper RL, Tietz AJ (1988) The formation of daptomycin by supplying decanoic acid to Streptomyces roseosporus cultures producing the antibiotic complex A21978C. J Biotechnol 7:283-292
11. Jung D, Rozek A, Okon M, Hancock REW (2004) Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol 11:949-957
12. Keiser T, Bibb M, Buttner MJ, Chater KF, Hopwood D (2000) Practical Streptomycete genetics. John Innes Foundation, Norwich
13. Kempter C, Kaiser D, Haag S, Nicholson G, Gnau V, Walk T, Gierling KH, Decker H, Zahner H, Jung G, Metzger JW (1997) CDA: calcium-dependent peptide antibiotics from Streptomyces coelicolor A3(2) containing unusual residues. Angew Chem Int Ed Engl 36:498-501
14. LaPlante KL, Rybak MJ (2004) Daptomycin - a novel antibiotic against Gram-positive pathogens. Expert Opin Pharmacother 5:2321-2331
15. Malpartida F, Hopwood DA (1984) Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host. Nature 309: 462-464
16. Malpartida F, Hopwood DA (1986) Physical and genetic characterisation of the gene cluster for the antibiotic actinorhodin in Streptomyces coelicolor A3(2). Mol Gen Genet 205:66-73
17. Miao V, Coeffet-LeGal M-F, Brian P, Brost R, Penn J, Whiting A, Martin S, Ford R, Parr I, Bouchard M, Silva CJ, Wrigley SK, Baltz RH (2005) Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry. Microbiology 151:1507-1523
18. Raja A, LaBonte J, Lebbos J, Kirkpatrick P (2003) Fresh from the pipeline: daptomycin. Nat Rev Drug Disc 2:943-944
19. Shima J, Hesketh A, Okamoto S, Kawamoto S, Ochi K (1996) Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2). J Bacteriol 178:7276-7284
20. Silverman JA, Perlmutter NG, Shapiro HM (2003) Correlation of daptomycin bactericidal activity and membrane depolarization in Staphylococcus aureus. Antimicrob Agent Chemother 47:2538-2544
21. Zeeck A, Christiansen P (1969). Konformation and Konfiguration des Actinorhodins. Liebigs Ann Chem 724:172-182