Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans

Journal of Bacteriology

Volumn 178, Issue 4, 1996, Pages 1216-1218

  Bormann, Christiane ^a   Möhrle, Volker ^a   Bruntner, Christina ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NIKKOMYCIN;

ARTICLE; DRUG ISOLATION; DRUG SYNTHESIS; GENE EXPRESSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES LIVIDANS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTIFUNGAL; BASE SEQUENCE; CLONING, MOLECULAR; COSMIDS; GENE EXPRESSION; GENES, BACTERIAL; GENETIC VECTORS; GENOMIC LIBRARY; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; RESTRICTION MAPPING; STREPTOMYCES; TRANSFORMATION, GENETIC;

EID: 0030029880     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.4.1216-1218.1996     Document Type: Article

References (19)

1. Bormann, C., W. Huhn, H. Zähner, R. Rathmann, H. Hahn, and W. A. König. 1985. Metabolic products of microorganisms 228. New nikkomycins produced by mutants of Streptomyces tendae. J. Antibiot. 38:9-16.
2. Bormann, C., S. Mattern, H. Schrempf, H.-P. Fiedler, and H. Zähner. 1989 Isolation of Streptomyces tendae mutants with an altered nikkomycin spectrum. J. Antibiot. 42:913-918.
3. Brillinger, G. U. 1979. Metabolic products of microorganisms 181 Chitin synthetase from fungi, a test model for substances with insecticidal properties Arch. Microbiol. 121:71-74.
4. Dähn, U., H. Hagenmaier, H. Höhne, W. A. König, G. Wolf, and H. Zahner. 1976. Stoffwechselprodukte von Mikroorganismen. 154. Mitteilung Nikkomycin, ein neuer Hemmstoff der Chitinsynthese bei Pilzen. Arch. Microbiol. 107:143-160.
5. Evans, D. R., R. B. Herbert, S. Baumberg, J. H. Cove, E. A. Southey, A. D. Buss, M. J. Dawson, D. Boble, and B. A. Rudd. 1995 The biosynthesis of nikkomycin X from histidine in Streptomyces tendae. Tetrahedron Lett 36: 2351-2354.
6. Fiedler, H.-P. 1984. Screening for new microbial products by high-performance liquid chromatography using a photodiode array detector. J. Chromatogr 316:487-494
7. Fiedler, H.-P., R. Kurth, J. Langhang, J. Delzer, and H. Zähner. 1982 Nikkomycins, microbial inhibitors of chitin synthetase. J. Chem Tech Biotechnol. 32:271-280.
8. Fiedler, H.-P., T. Sthüz, and H. Decker. 1993. An overview of nikkomycins: history, biochemistry, and applications, p. 325-352. In J. W. Rippon and R A. Fromtling (ed.), Cutaneous antifungal agents. Selected compoundsin clinical practice and development. Marcel Dekker, Inc., New York
9. Hagenmaier, H., A. Keckeisen, W. Dehler, H.-P. Fiedler, H. Zähner, and W. A. König. 1981. Stolfwechselprodukte von Mikroorganismen. 199 Konstitutionsaufklarung der Nikkomycine I, J,inund N. Liebigs Ann Chem 1981:1018-1024
10. Hagenmaier, H., A. Keckeisen, H. Zähner, and W. A. König. 1979 Stoffwechselprodukte von Mikroorganismen. 182. Aufklärung des Nucleosidantibiotikums Nikkomycin X. Liebigs Ann. Chem. 1979:1494-1502.
11. Hopwood, D. A., M. J. Bibb, K. F. Chater, T. Kieser, C. J. Bruton, H. M. Kieser, J. M. Ward, and H. Schrempf. 1985. Genetic manipulation of Streptomyces, a laboratory manual. John Innes Foundation, Norwich, United Kingdom.
12. Isono, K., T. Sato, K. Hirasawa, S. Funayama, and S. Suzuki. 1978. Biosynthesis of the nucleoside skeleton of polyoxins. J. Am. Chem. Soc. 100:3937-3939.
13. Isono, K., and S. Suzuki. 1979. The polyoxins: pyrimidine peptide antibiotics inhibiting fungal cell wall biosynthesis Heterocycles 13:333-351.
14. Martin, J.-F., and P. Liras. 1989. Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites Annu. Rev Microbiol. 43:173-206.
15. Möhrle, V., U. Roos, and C. Bormann. 1995. Identification of cellular proteins involved in nikkomycin production in Streptomyces tendae Tu901 Mol. Microbiol 15:561-571.
16. Müller, H., R. Further, H. Zähner, and D. M. Rast. 1981. Effect of nikkomycin Z, nikkomycin X and polyoxin A on chitosomal chitin synthetase Arch. Microbiol. 130:195-197.
17. Richardson, M. A., S. Kuhstoss, P. Solenberg, N. A. Schaus, and N. Rao. 1987. A new shuttle cosmid vector, pKC505, for streptomycetes: its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofaciens library. Gene 61:231-241.
18. Schmidt, R.-.M., and H. Pape. 1985. Biosynthesis of 4-formyl-4-imidazoline-2-one, the heterocyclic base of nikkomycin X Z. Naturforsch C41:135-140.
19. Sommer, U. 1983. Ph.D. thesis. University of Munster, Münster, Germany.