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Volumn 31, Issue 10, 2010, Pages 1774-1786

A role for p53 in the β-amyloid-mediated regulation of the lysosomal system

Author keywords

Amyloid; Apoptosis; Lysosome; P53

Indexed keywords

AMYLOID BETA PROTEIN; CATHEPSIN L; PIFITHRIN ALPHA; PROTEIN BAX; PROTEIN P53; SMALL INTERFERING RNA;

EID: 77955841088     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.09.018     Document Type: Article
Times cited : (27)

References (48)
  • 1
    • 0034721509 scopus 로고    scopus 로고
    • Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease
    • Adamec E., Mohan P.S., Cataldo A.M., Vonsattel J.P., Nixon R.A. Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease. Neuroscience 2000, 100:663-675.
    • (2000) Neuroscience , vol.100 , pp. 663-675
    • Adamec, E.1    Mohan, P.S.2    Cataldo, A.M.3    Vonsattel, J.P.4    Nixon, R.A.5
  • 3
    • 0037216189 scopus 로고    scopus 로고
    • β-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase
    • Boland B., Campbell V. β-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase. Neurobiol. Aging 2003, 24:179-186.
    • (2003) Neurobiol. Aging , vol.24 , pp. 179-186
    • Boland, B.1    Campbell, V.2
  • 4
    • 0346850963 scopus 로고    scopus 로고
    • Aβ-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L Neurobiol
    • Boland B., Campbell V. Aβ-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L Neurobiol. Aging 2004, 25:83-91.
    • (2004) Aging , vol.25 , pp. 83-91
    • Boland, B.1    Campbell, V.2
  • 6
    • 0038677510 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine
    • Boya P., Gonzalez-Polo R.A., Poncet D., Andreau K., Vieira H.L., Roumier T., Perfettini J.L., Kroemer G. Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene 2003, 22:3927-3936.
    • (2003) Oncogene , vol.22 , pp. 3927-3936
    • Boya, P.1    Gonzalez-Polo, R.A.2    Poncet, D.3    Andreau, K.4    Vieira, H.L.5    Roumier, T.6    Perfettini, J.L.7    Kroemer, G.8
  • 7
    • 0032988381 scopus 로고    scopus 로고
    • Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak
    • Brunk U.T., Svensson I. Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak. Redox Rep. 1999, 4:3-11.
    • (1999) Redox Rep. , vol.4 , pp. 3-11
    • Brunk, U.T.1    Svensson, I.2
  • 8
    • 0033955920 scopus 로고    scopus 로고
    • Probing the cathepsins using a BODIPY FL-pepstatin A: applications in florescence polarization and microscopy
    • Chen C.S., Chen W.N., Zhou M., Arttamangkul S., Haugland R.P. Probing the cathepsins using a BODIPY FL-pepstatin A: applications in florescence polarization and microscopy. J. Biochem. Biophys. Meth. 2000, 42:137-151.
    • (2000) J. Biochem. Biophys. Meth. , vol.42 , pp. 137-151
    • Chen, C.S.1    Chen, W.N.2    Zhou, M.3    Arttamangkul, S.4    Haugland, R.P.5
  • 10
    • 33744943247 scopus 로고    scopus 로고
    • Multiple actions of pifithrin-α on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells A
    • Chua C.C., Liu X., Gao J., Hamdy R.C., Chua B.H.L. Multiple actions of pifithrin-α on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells A. J. Physiol. Heart Circ. Physiol. 2006, 290:H2606-H2613.
    • (2006) J. Physiol. Heart Circ. Physiol. , vol.290
    • Chua, C.C.1    Liu, X.2    Gao, J.3    Hamdy, R.C.4    Chua, B.H.L.5
  • 11
    • 0035085210 scopus 로고    scopus 로고
    • A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β-peptide
    • Culmsee C., Zhu X., Yu Q.-S., Chan S.L., Camandola S., Guo Z., Greig N.H., Mattson M.P. A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β-peptide. J. Neurochem. 2001, 77:220-228.
    • (2001) J. Neurochem. , vol.77 , pp. 220-228
    • Culmsee, C.1    Zhu, X.2    Yu, Q.-S.3    Chan, S.L.4    Camandola, S.5    Guo, Z.6    Greig, N.H.7    Mattson, M.P.8
  • 12
    • 0033593230 scopus 로고    scopus 로고
    • Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xl
    • Finucane D.M., Bossy-Wetzel E., Waterhouse N.J., Cotter T.G., Green D.R. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xl. J. Biol. Chem. 1999, 274:2225-2233.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2225-2233
    • Finucane, D.M.1    Bossy-Wetzel, E.2    Waterhouse, N.J.3    Cotter, T.G.4    Green, D.R.5
  • 13
    • 0038584865 scopus 로고    scopus 로고
    • A role for c-jun N terminal kinase 1 (JNK1), but not JNK2, in the β-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neuron
    • Fogarty M.P., Downer E.J., Campbell V. A role for c-jun N terminal kinase 1 (JNK1), but not JNK2, in the β-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neuron. Biochem. J. 2003, 371:789-798.
    • (2003) Biochem. J. , vol.371 , pp. 789-798
    • Fogarty, M.P.1    Downer, E.J.2    Campbell, V.3
  • 14
    • 0034697299 scopus 로고    scopus 로고
    • E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase-3
    • Giovanni A., Keramaris E., Morris E.J., Hou S.T., O'Hare M., Dyson N., Robertson G.S., Slack R.S., Park D.S. E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase-3. J. Biol. Chem. 2000, 275(16):11553-11560.
    • (2000) J. Biol. Chem. , vol.275 , Issue.16 , pp. 11553-11560
    • Giovanni, A.1    Keramaris, E.2    Morris, E.J.3    Hou, S.T.4    O'Hare, M.5    Dyson, N.6    Robertson, G.S.7    Slack, R.S.8    Park, D.S.9
  • 15
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner G.G., Wong C.W. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Comm. 1984, 122:1131-1135.
    • (1984) Biochem. Biophys. Res. Comm. , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 16
    • 42549128696 scopus 로고    scopus 로고
    • A role for p53 in the regulation of lysosomal permeability by Δ9-tetrahydrocannabinol in rat cortical neurones: implications for neurodegeneration
    • Gowran A., Campbell V.A. A role for p53 in the regulation of lysosomal permeability by Δ9-tetrahydrocannabinol in rat cortical neurones: implications for neurodegeneration. J. Neurochem. 2008, 105:1513-1524.
    • (2008) J. Neurochem. , vol.105 , pp. 1513-1524
    • Gowran, A.1    Campbell, V.A.2
  • 17
    • 18144428775 scopus 로고    scopus 로고
    • Prospective therapeutic applications of p53 inhibitors
    • Gudkov A.V., Komarova E.A. Prospective therapeutic applications of p53 inhibitors. Biochem. Biophys. Res. Commun. 2005, 331:726-736.
    • (2005) Biochem. Biophys. Res. Commun. , vol.331 , pp. 726-736
    • Gudkov, A.V.1    Komarova, E.A.2
  • 20
    • 0028169925 scopus 로고
    • Visualization of Aβ42 and Aβ40 in senile plaques with end-specific β monoclonals: evidence that an initially deposited species is Aβ42
    • Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of Aβ42 and Aβ40 in senile plaques with end-specific β monoclonals: evidence that an initially deposited species is Aβ42. Neuron 1994, 13:45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 21
    • 0037077284 scopus 로고    scopus 로고
    • Apolipoprotein E4 potentiates amyloid β peptide-induced lysosomal leakage and apoptosis in neuronal cells
    • Ji Z.-S., Miranda R.D., Newhouse Y.M., Weisgraber K.H., Hunag Y., Mahley R.W. Apolipoprotein E4 potentiates amyloid β peptide-induced lysosomal leakage and apoptosis in neuronal cells. J. Biol. Chem. 2002, 277:21821-21828.
    • (2002) J. Biol. Chem. , vol.277 , pp. 21821-21828
    • Ji, Z.-S.1    Miranda, R.D.2    Newhouse, Y.M.3    Weisgraber, K.H.4    Hunag, Y.5    Mahley, R.W.6
  • 22
    • 33645553416 scopus 로고    scopus 로고
    • Reactivity of apolipoprotein E4 and β-amyloid: lysosomal stability and neurodegeneration
    • Ji Z.S., Mullendorff K., Cheng I.H., Miranda R.D., Huang Y., Mahley R.W. reactivity of apolipoprotein E4 and β-amyloid: lysosomal stability and neurodegeneration. J. Biol. Chem. 2006, 281(5):2683-2692.
    • (2006) J. Biol. Chem. , vol.281 , Issue.5 , pp. 2683-2692
    • Ji, Z.S.1    Mullendorff, K.2    Cheng, I.H.3    Miranda, R.D.4    Huang, Y.5    Mahley, R.W.6
  • 26
    • 0037507247 scopus 로고    scopus 로고
    • P53 inhibior, PFT-alpha can suppress heat shock and glucocorticold signalling pathways
    • Komarova E.A., Neznanov N., Komarov P.G., Gudkov A. p53 inhibior, PFT-alpha can suppress heat shock and glucocorticold signalling pathways. J. Biol. Chem. 2003, 278:15465-15468.
    • (2003) J. Biol. Chem. , vol.278 , pp. 15465-15468
    • Komarova, E.A.1    Neznanov, N.2    Komarov, P.G.3    Gudkov, A.4
  • 27
    • 0029823454 scopus 로고    scopus 로고
    • Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice
    • Laferla F.M., Hall C.K., Ngo L., Jay G. Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J. Clin. Invest. 1996, 98:1232-1626.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1232-1626
    • Laferla, F.M.1    Hall, C.K.2    Ngo, L.3    Jay, G.4
  • 28
    • 37048999377 scopus 로고    scopus 로고
    • Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis
    • Lin N., Zheng Y., Chen W., Wang C., Lui X., He W., Xu H., Cao X. Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer Res. 2007, 67:11176-11185.
    • (2007) Cancer Res. , vol.67 , pp. 11176-11185
    • Lin, N.1    Zheng, Y.2    Chen, W.3    Wang, C.4    Lui, X.5    He, W.6    Xu, H.7    Cao, X.8
  • 30
    • 0034681208 scopus 로고    scopus 로고
    • (1-40) in rat cortical synaptosomes and cultured cortical neurones: modulation by the proinflammatory cytokine interleukin-1β
    • (1-40) in rat cortical synaptosomes and cultured cortical neurones: modulation by the proinflammatory cytokine interleukin-1β. J. Biol. Chem. 2000, 275(5):4713-4718.
    • (2000) J. Biol. Chem. , vol.275 , Issue.5 , pp. 4713-4718
    • MacManus, A.1    Ramsden, M.2    Murray, M.3    Pearson, H.A.4    Campbell, V.5
  • 32
    • 0028883179 scopus 로고
    • Tumour suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T., Reed J.C. Tumour suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995, 80:293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 33
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by β-amyloid
    • Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by β-amyloid. Nature 2000, 403:98-103.
    • (2000) Nature , vol.403 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 34
    • 0029860523 scopus 로고    scopus 로고
    • Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates Bax expression in human neurons
    • Paradis E., Douillard H., Koutroumanis M., Goodyer C., LeBlanc A. Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates Bax expression in human neurons. J. Neurosci. 1996, 16:7533-7539.
    • (1996) J. Neurosci. , vol.16 , pp. 7533-7539
    • Paradis, E.1    Douillard, H.2    Koutroumanis, M.3    Goodyer, C.4    LeBlanc, A.5
  • 36
    • 0035206383 scopus 로고    scopus 로고
    • Mechanisms of p53-dependent apoptosis
    • Schuler M., Green D.R. Mechanisms of p53-dependent apoptosis. Biochem. Soc. Trans. 2001, 29:684-688.
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 684-688
    • Schuler, M.1    Green, D.R.2
  • 41
    • 0033566644 scopus 로고    scopus 로고
    • Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein
    • Uetsuki T., Takemoto K., Nishimura I., Okamoto M., Niinobe M., Momoi T., Miura M., Yoshikawa K. Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein. J. Neurosci. 1999, 19:6955-6964.
    • (1999) J. Neurosci. , vol.19 , pp. 6955-6964
    • Uetsuki, T.1    Takemoto, K.2    Nishimura, I.3    Okamoto, M.4    Niinobe, M.5    Momoi, T.6    Miura, M.7    Yoshikawa, K.8
  • 42
    • 34547107293 scopus 로고    scopus 로고
    • Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy
    • Wang S.Q., Du Q.S., Zhao K., Li A.X., Wei D.Q., Chou K.C. Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy. Amino Acids 2007, 33:129-135.
    • (2007) Amino Acids , vol.33 , pp. 129-135
    • Wang, S.Q.1    Du, Q.S.2    Zhao, K.3    Li, A.X.4    Wei, D.Q.5    Chou, K.C.6
  • 43
    • 0035029801 scopus 로고    scopus 로고
    • Sublethal concentration of prion peptide PrP106-126 or the amyloid peptide protein of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons
    • White A.R., Guirguis R., Brazier M.W., Jobling M.F., Hill A.F., Beyreuther K., Barrow C.J., Master C.L., Collins S.J., Cappai R. Sublethal concentration of prion peptide PrP106-126 or the amyloid peptide protein of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons. Neurobiol. Dis. 2001, 8:299-316.
    • (2001) Neurobiol. Dis. , vol.8 , pp. 299-316
    • White, A.R.1    Guirguis, R.2    Brazier, M.W.3    Jobling, M.F.4    Hill, A.F.5    Beyreuther, K.6    Barrow, C.J.7    Master, C.L.8    Collins, S.J.9    Cappai, R.10
  • 44
    • 0242539781 scopus 로고    scopus 로고
    • Sustained capain activation associated with lysosomal rupture executes necrosis of the postischemic CAI neurons in primates
    • Yamashima T., Tonchev A.B., Tsukada T., Saido T.C., Imajoh-Ohmi S., Momoi T., Kominami E. Sustained capain activation associated with lysosomal rupture executes necrosis of the postischemic CAI neurons in primates. Hippocampus 2003, 13(7):791-800.
    • (2003) Hippocampus , vol.13 , Issue.7 , pp. 791-800
    • Yamashima, T.1    Tonchev, A.B.2    Tsukada, T.3    Saido, T.C.4    Imajoh-Ohmi, S.5    Momoi, T.6    Kominami, E.7
  • 48
    • 0035861890 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis
    • Zhao M., Eaton J.W., Brunk U.T. Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis. FEBS Lett. 2001, 14:405-412.
    • (2001) FEBS Lett. , vol.14 , pp. 405-412
    • Zhao, M.1    Eaton, J.W.2    Brunk, U.T.3


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