-
1
-
-
37749008710
-
Real-time definition of non-randomness in the distribution of genomic events
-
Abel, U., Deichmann, A., Bartholomae, C., Schwarzwaelder, K., Glimm, H., Howe, S., Thrasher, A., Garrigue, A., Hacein-Bey-Abina, S., Cavazzana-Calvo, M., Fischer, A., Jaeger, D., von Kalle, C., and Schmidt, M. (2007). Real-time definition of non-randomness in the distribution of genomic events. PloS One 2, e570.
-
(2007)
PloS One
, vol.2
-
-
Abel, U.1
Deichmann, A.2
Bartholomae, C.3
Schwarzwaelder, K.4
Glimm, H.5
Howe, S.6
Thrasher, A.7
Garrigue, A.8
Hacein-Bey-Abina, S.9
Cavazzana-Calvo, M.10
Fischer, A.11
Jaeger, D.12
Von Kalle, C.13
Schmidt, M.14
-
2
-
-
0037189401
-
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning
-
Aiuti, A., Slavin, S., Aker, M., Ficara, F., Deola, S., Mortellaro, A., Morecki, S., Andolfi, G., Tabucchi, A., Carlucci, F., Marinello, E., Cattaneo, F., Vai, S., Servida, P., Miniero, R., Roncarolo, M.G., and Bordignon, C. (2002). Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science 296, 2410-2413.
-
(2002)
Science
, vol.296
, pp. 2410-2413
-
-
Aiuti, A.1
Slavin, S.2
Aker, M.3
Ficara, F.4
Deola, S.5
Mortellaro, A.6
Morecki, S.7
Andolfi, G.8
Tabucchi, A.9
Carlucci, F.10
Marinello, E.11
Cattaneo, F.12
Vai, S.13
Servida, P.14
Miniero, R.15
Roncarolo, M.G.16
Bordignon, C.17
-
3
-
-
0345863840
-
RTCGD: Retroviral tagged cancer gene database
-
Akagi, K., Suzuki, T., Stephens, R.M., Jenkins, N.A., and Cope-land, N.G. (2004). RTCGD: Retroviral tagged cancer gene database. Nucleic Acids Res. 32, D523-D527.
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Akagi, K.1
Suzuki, T.2
Stephens, R.M.3
Jenkins, N.A.4
Cope-Land, N.G.5
-
4
-
-
34248670400
-
The Zinc Finger Proteins ZXDA and ZXDC Form a Complex that Binds CIITA and Regulates MHC II Gene Transcription
-
DOI 10.1016/j.jmb.2007.04.033, PII S0022283607004950
-
Al-Kandari, W., Koneni, R., Navalgund, V., Aleksandrova, A., Jambunathan, S., and Fontes, J.D. (2007). The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. J. Mol. Biol. 369, 1175-1187. (Pubitemid 46770777)
-
(2007)
Journal of Molecular Biology
, vol.369
, Issue.5
, pp. 1175-1187
-
-
Al-Kandari, W.1
Koneni, R.2
Navalgund, V.3
Aleksandrova, A.4
Jambunathan, S.5
Fontes, J.D.6
-
5
-
-
67749139463
-
QuickMap: A public tool for large-scale gene therapy vector insertion site mapping and analysis
-
Appelt, J.U., Giordano, F.A., Ecker, M., Roeder, I., Grund, N., Hotz-Wagenblatt, A., Opelz, G., Zeller, W.J., Allgayer, H., Fruehauf, S., and Laufs, S. (2009). QuickMap: A public tool for large-scale gene therapy vector insertion site mapping and analysis. Gene Ther. 16, 885-893.
-
(2009)
Gene Ther.
, vol.16
, pp. 885-893
-
-
Appelt, J.U.1
Giordano, F.A.2
Ecker, M.3
Roeder, I.4
Grund, N.5
Hotz-Wagenblatt, A.6
Opelz, G.7
Zeller, W.J.8
Allgayer, H.9
Fruehauf, S.10
Laufs, S.11
-
6
-
-
0037443457
-
Side effects of retroviral gene transfer into hematopoietic stem cells
-
DOI 10.1182/blood-2002-07-2314
-
Baum, C., Dullmann, J., Li, Z., Fehse, B., Meyer, J., Williams, D.A., and von Kalle, C. (2003). Side effects of retroviral gene transfer into hematopoietic stem cells. Blood 101, 2099-2114. (Pubitemid 36302043)
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2099-2114
-
-
Baum, C.1
Dullmann, J.2
Li, Z.3
Fehse, B.4
Meyer, J.5
Williams, D.A.6
Von Kalle, C.7
-
7
-
-
67149106145
-
P140K gene-modified dog hematopoietic cells in primary and secondary recipients
-
P140K gene-modified dog hematopoietic cells in primary and secondary recipients. Blood 113, 5094-5103.
-
(2009)
Blood
, vol.113
, pp. 5094-5103
-
-
Beard, B.C.1
Sud, R.2
Keyser, K.A.3
Ironside, C.4
Neff, T.5
Gerull, S.6
Trobridge, G.D.7
Kiem, H.P.8
-
8
-
-
0001677717
-
Controlling the false discovery rate: A practical and powerful approach to multiple testing
-
Benjamini, Y., and Hochberg, Y. (1995). Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J. R. Stat. Soc. 57, 289-300.
-
(1995)
J. R. Stat. Soc.
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
9
-
-
33745225238
-
Fragile sites are preferential targets for integrations of MLV vectors in gene therapy
-
Bester, A.C., Schwartz, M., Schmidt, M., Garrigue, A., Hacein-Bey-Abina, S., Cavazzana-Calvo, M., Ben-Porat, N., von Kalle, C., Fischer, A., and Kerem, B. (2006). Fragile sites are preferential targets for integrations of MLV vectors in gene therapy. Gene Ther. 13, 1057-1059.
-
(2006)
Gene Ther.
, vol.13
, pp. 1057-1059
-
-
Bester, A.C.1
Schwartz, M.2
Schmidt, M.3
Garrigue, A.4
Hacein-Bey-Abina, S.5
Cavazzana-Calvo, M.6
Ben-Porat, N.7
Von Kalle, C.8
Fischer, A.9
Kerem, B.10
-
10
-
-
34547834963
-
The use of coded PCR primers enables high-throughput sequencing of multiple ho-molog amplification products by 454 parallel sequencing
-
Binladen, J., Gilbert, M.T., Bollback, J.P., Panitz, F., Bendixen, C., Nielsen, R., and Willerslev, E. (2007). The use of coded PCR primers enables high-throughput sequencing of multiple ho-molog amplification products by 454 parallel sequencing. PLoS One 2, e197.
-
(2007)
PLoS One
, vol.2
-
-
Binladen, J.1
Gilbert, M.T.2
Bollback, J.P.3
Panitz, F.4
Bendixen, C.5
Nielsen, R.6
Willerslev, E.7
-
11
-
-
33750020601
-
Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome
-
Boztug, K., Dewey, R.A., and Klein, C. (2006). Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome. Curr. Opin. Mol. Ther. 8, 390-395.
-
(2006)
Curr. Opin. Mol. Ther.
, vol.8
, pp. 390-395
-
-
Boztug, K.1
Dewey, R.A.2
Klein, C.3
-
12
-
-
4344571581
-
Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
-
Breitling, R., Armengaud, P., Amtmann, A., and Herzyk, P. (2004). Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett. 573, 83-92.
-
(2004)
FEBS Lett.
, vol.573
, pp. 83-92
-
-
Breitling, R.1
Armengaud, P.2
Amtmann, A.3
Herzyk, P.4
-
13
-
-
70449427834
-
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
-
Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C.C., Veres, G., Schmidt, M., Kutschera, I., Vidaud, M., Abel, U., Dal-Cortivo, L., Caccavelli, L., Mahlaoui, N., Kiermer, V., Mittelstaedt, D., Bellesme, C., Lahlou, N., Lefrere, F., Blanche, S., Audit, M., Payen, E., Leboulch, P., l'Homme, B., Bougneres, P., von Kalle, C., Fischer, A., Cavazzana-Calvo, M., and Aubourg, P. (2009). Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 326, 818-823.
-
(2009)
Science
, vol.326
, pp. 818-823
-
-
Cartier, N.1
Hacein-Bey-Abina, S.2
Bartholomae, C.C.3
Veres, G.4
Schmidt, M.5
Kutschera, I.6
Vidaud, M.7
Abel, U.8
Dal-Cortivo, L.9
Caccavelli, L.10
Mahlaoui, N.11
Kiermer, V.12
Mittelstaedt, D.13
Bellesme, C.14
Lahlou, N.15
Lefrere, F.16
Blanche, S.17
Audit, M.18
Payen, E.19
Leboulch, P.20
L'Homme, B.21
Bougneres, P.22
Von Kalle, C.23
Fischer, A.24
Cavazzana-Calvo, M.25
Aubourg, P.26
more..
-
14
-
-
70350770506
-
Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy
-
Cassani, B., Montini, E., Maruggi, G., Ambrosi, A., Mirolo, M., Selleri, S., Biral, E., Frugnoli, I., Hernandez-Trujillo, V., Di Serio, C., Roncarolo, M.G., Naldini, L., Mavilio, F., and Aiuti, A. (2009). Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy. Blood 114, 3546-3556.
-
(2009)
Blood
, vol.114
, pp. 3546-3556
-
-
Cassani, B.1
Montini, E.2
Maruggi, G.3
Ambrosi, A.4
Mirolo, M.5
Selleri, S.6
Biral, E.7
Frugnoli, I.8
Hernandez-Trujillo, V.9
Di Serio, C.10
Roncarolo, M.G.11
Naldini, L.12
Mavilio, F.13
Aiuti, A.14
-
15
-
-
0344668735
-
n repeat element within the 5 untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter
-
n repeat element within the 5 untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter. Hum. Mol. Genet. 12, 3067-3074.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 3067-3074
-
-
Chen, L.S.1
Tassone, F.2
Sahota, P.3
Hagerman, P.J.4
-
16
-
-
4143145142
-
6- benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide
-
6-benzylguanine and 1,3-bis(2-chloroethyl)- nitrosourea or temozolomide. Hum. Gene Ther. 15, 758-769.
-
(2004)
Hum. Gene Ther.
, vol.15
, pp. 758-769
-
-
Chinnasamy, D.1
Fairbairn, L.J.2
Neuenfeldt, J.3
Treisman, J.S.4
Hanson Jr., J.P.5
Margison, G.P.6
Chinnasamy, N.7
-
17
-
-
34248198326
-
6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide
-
6-methylguanine- DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide. J. Clin. Oncol. 25, 1470-1475.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1470-1475
-
-
Chinot, O.L.1
Barrie, M.2
Fuentes, S.3
Eudes, N.4
Lancelot, S.5
Metellus, P.6
Muracciole, X.7
Braguer, D.8
Ouafik, L.9
Martin, P.M.10
Dufour, H.11
Figarella-Branger, D.12
-
18
-
-
0001072895
-
The use of confidence or fiducial limits illustrated in the case of the binomial
-
Clopper, C.J., and Pearson, E.S. (1934). The use of confidence or fiducial limits illustrated in the case of the binomial. Biome-trika 26, 404-413.
-
(1934)
Biome-trika
, vol.26
, pp. 404-413
-
-
Clopper, C.J.1
Pearson, E.S.2
-
20
-
-
34249906359
-
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
-
Deichmann, A., Hacein-Bey-Abina, S., Schmidt, M., Garrigue, A., Brugman, M.H., Hu, J., Glimm, H., Gyapay, G., Prum, B., Fraser, C.C., Fischer, N., Schwarzwaelder, K., Siegler, M.L., de Ridder, D., Pike-Overzet, K., Howe, S.J., Thrasher, A.J., Wagemaker, G., Abel, U., Staal, F.J., Delabesse, E., Villeval, J.L., Aronow, B., Hue, C., Prinz, C., Wissler, M., Klanke, C., Weissenbach, J., Alexander, I., Fischer, A., von Kalle, C., and Cavazzana-Calvo, M. (2007). Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J. Clin. Invest. 117, 2225-2232.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2225-2232
-
-
Deichmann, A.1
Hacein-Bey-Abina, S.2
Schmidt, M.3
Garrigue, A.4
Brugman, M.H.5
Hu, J.6
Glimm, H.7
Gyapay, G.8
Prum, B.9
Fraser, C.C.10
Fischer, N.11
Schwarzwaelder, K.12
Siegler, M.L.13
De Ridder, D.14
Pike-Overzet, K.15
Howe, S.J.16
Thrasher, A.J.17
Wagemaker, G.18
Abel, U.19
Staal, F.J.20
Delabesse, E.21
Villeval, J.L.22
Aronow, B.23
Hue, C.24
Prinz, C.25
Wissler, M.26
Klanke, C.27
Weissenbach, J.28
Alexander, I.29
Fischer, A.30
Von Kalle, C.31
Cavazzana-Calvo, M.32
more..
-
21
-
-
0036252492
-
High-level transduction and gene expression in hematopoietic re-populating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
-
Demaison, C., Parsley, K., Brouns, G., Scherr, M., Battmer, K., Kinnon, C., Grez, M., and Thrasher, A.J. (2002). High-level transduction and gene expression in hematopoietic re-populating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum. Gene Ther. 13, 803-813.
-
(2002)
Hum. Gene Ther.
, vol.13
, pp. 803-813
-
-
Demaison, C.1
Parsley, K.2
Brouns, G.3
Scherr, M.4
Battmer, K.5
Kinnon, C.6
Grez, M.7
Thrasher, A.J.8
-
22
-
-
0038005018
-
DAVID: Database for annotation, visualization, and integrated discovery
-
Dennis, G., Jr., Sherman, B.T., Hosack, D.A., Yang, J., Gao, W., Lane, H.C., and Lempicki, R.A. (2003). DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, 3.
-
(2003)
Genome Biol.
, vol.4
, pp. 3
-
-
Dennis Jr., G.1
Sherman, B.T.2
Hosack, D.A.3
Yang, J.4
Gao, W.5
Lane, H.C.6
Lempicki, R.A.7
-
23
-
-
0025571828
-
6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
-
6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. Cancer Commun. 2, 371-377.
-
(1990)
Cancer Commun.
, vol.2
, pp. 371-377
-
-
Dolan, M.E.1
Stine, L.2
Mitchell, R.B.3
Moschel, R.C.4
Pegg, A.E.5
-
24
-
-
0037105522
-
Development of virus vectors for gene therapy of b chain hemoglobinopathies: Flanking with a chromatin insulator reduces g-globin gene silencing in vivo
-
Emery, D.W., Yannaki, E., Tubb, J., Nishino, T., Li, Q., and Stamatoyannopoulos, G. (2002). Development of virus vectors for gene therapy of b chain hemoglobinopathies: Flanking with a chromatin insulator reduces g-globin gene silencing in vivo. Blood 100, 2012-2019.
-
(2002)
Blood
, vol.100
, pp. 2012-2019
-
-
Emery, D.W.1
Yannaki, E.2
Tubb, J.3
Nishino, T.4
Li, Q.5
Stamatoyannopoulos, G.6
-
25
-
-
0034668064
-
6-benzylguanine for patients with recurrent or progressive malignant glioma
-
6-benzylguanine for patients with recurrent or progressive malignant glioma. J. Clin. Oncol. 18, 3522-3528.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 3522-3528
-
-
Friedman, H.S.1
Pluda, J.2
Quinn, J.A.3
Ewesuedo, R.B.4
Long, L.5
Friedman, A.H.6
Cokgor, I.7
Colvin, O.M.8
Haglund, M.M.9
Ashley, D.M.10
Rich, J.N.11
Sampson, J.12
Pegg, A.E.13
Moschel, R.C.14
McLendon, R.E.15
Provenzale, J.M.16
Stewart, E.S.17
Tourt-Uhlig, S.18
Garcia-Turner, A.M.19
Herndon, J.E.20
Bigner, D.D.21
Dolan, M.E.22
more..
-
26
-
-
19144361831
-
Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123
-
Fruehauf, S., Breems, D.A., Knaan-Shanzer, S., Brouwer, K.B., Haas, R., Lowenberg, B., Nooter, K., Ploemacher, R.E., Valerio, D., and Boesen, J.J. (1996). Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123. Hum. Gene Ther. 7, 1219-1231.
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 1219-1231
-
-
Fruehauf, S.1
Breems, D.A.2
Knaan-Shanzer, S.3
Brouwer, K.B.4
Haas, R.5
Lowenberg, B.6
Nooter, K.7
Ploemacher, R.E.8
Valerio, D.9
Boesen, J.J.10
-
27
-
-
1542515338
-
A census of human cancer genes
-
Futreal, P.A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N., and Stratton, M.R. (2004). A census of human cancer genes. Nat. Rev. Cancer 4, 177-183.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 177-183
-
-
Futreal, P.A.1
Coin, L.2
Marshall, M.3
Down, T.4
Hubbard, T.5
Wooster, R.6
Rahman, N.7
Stratton, M.R.8
-
28
-
-
77955482073
-
Assessing the genome accessibility of viral integration sites
-
[abstract]
-
Gabriel, R., Paruzynski, A., Eckenberg, R., Bartholomae, C.C., Nowrouzu, A., Wang, W., Schwarzwaelder, K., Arens, A., Kirsten, R., Deichmann, A., Ball, C.R., Howe, S.J., Recchia, A., Cattoglio, C., Balaggan, K.S., Yáñez-Muñ oz, R., Ali, R.R., Mavilio, F., Gaspar, H.B., Thrasher, A., Glimm, H., von Kalle, C., Saurin, W., and Schmidt, M. (2008) Assessing the genome accessibility of viral integration sites [abstract]. Hum. Gene Ther. 19, 1085.
-
(2008)
Hum. Gene Ther.
, vol.19
, pp. 1085
-
-
Gabriel, R.1
Paruzynski, A.2
Eckenberg, R.3
Bartholomae, C.C.4
Nowrouzu, A.5
Wang, W.6
Schwarzwaelder, K.7
Arens, A.8
Kirsten, R.9
Deichmann, A.10
Ball, C.R.11
Howe, S.J.12
Recchia, A.13
Cattoglio, C.14
Balaggan, K.S.15
Yáñez-Muñ Oz, R.16
Ali, R.R.17
Mavilio, F.18
Gaspar, H.B.19
Thrasher, A.20
Glimm, H.21
Von Kalle, C.22
Saurin, W.23
Schmidt, M.24
more..
-
29
-
-
0022272291
-
6-alkylguanine-DNA alkyltransferase activity in human myeloid cells
-
6- alkylguanine-DNA alkyltransferase activity in human myeloid cells. J. Clin. Invest. 76, 2106-2114.
-
(1985)
J. Clin. Invest.
, vol.76
, pp. 2106-2114
-
-
Gerson, S.L.1
Miller, K.2
Berger, N.A.3
-
30
-
-
0027339636
-
6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone
-
6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochem. Pharmacol. 45, 483-491.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 483-491
-
-
Gerson, S.L.1
Zborowska, E.2
Norton, K.3
Gordon, N.H.4
Willson, J.K.5
-
31
-
-
35348872062
-
New bioinformatic strategies to rapidly characterize retroviral integration sites of gene therapy vectors
-
Giordano, F.A., Hotz-Wagenblatt, A., Lauterborn, D., Appelt, J.U., Fellenberg, K., Nagy, K.Z., Zeller, W.J., Suhai, S., Frue-hauf, S., and Laufs, S. (2007). New bioinformatic strategies to rapidly characterize retroviral integration sites of gene therapy vectors. Methods Inf. Med. 46, 542-547.
-
(2007)
Methods Inf. Med.
, vol.46
, pp. 542-547
-
-
Giordano, F.A.1
Hotz-Wagenblatt, A.2
Lauterborn, D.3
Appelt, J.U.4
Fellenberg, K.5
Nagy, K.Z.6
Zeller, W.J.7
Suhai, S.8
Frue-Hauf, S.9
Laufs, S.10
-
32
-
-
33749054952
-
\+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor
-
\+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. Stem Cells 24, 1822-1830.
-
(2006)
Stem Cells
, vol.24
, pp. 1822-1830
-
-
Gordon, M.Y.1
Levicar, N.2
Pai, M.3
Bachellier, P.4
Dimarakis, I.5
Al-Allaf, F.6
M'Hamdi, H.7
Thalji, T.8
Welsh, J.P.9
Marley, S.B.10
Davies, J.11
Dazzi, F.12
Marelli-Berg, F.13
Tait, P.14
Playford, R.15
Jiao, L.16
Jensen, S.17
Nicholls, J.P.18
Ayav, A.19
Nohandani, M.20
Farza-Neh, F.21
Gaken, J.22
Dodge, R.23
Alison, M.24
Apperley, J.F.25
Lechler, R.26
Habib, N.A.27
more..
-
33
-
-
0037129435
-
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
-
DOI 10.1056/NEJMoa012616
-
Hacein-Bey-Abina, S., Le Deist, F., Carlier, F., Bouneaud, C., Hue, C., De Villartay, J.P., Thrasher, A.J., Wulffraat, N., Sor-ensen, R., Dupuis-Girod, S., Fischer, A., Davies, E.G., Kuis, W., Leiva, L., and Cavazzana-Calvo, M. (2002). Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N. Engl. J. Med. 346, 1185-1193. (Pubitemid 34984579)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.16
, pp. 1185-1193
-
-
Hacein-Bey-Abina, S.1
Le Deist, F.2
Carlier, F.3
Bouneaud, C.4
Hue, C.5
De Villartay, J.-P.6
Thrasher, A.J.7
Wulffraat, N.8
Sorensen, R.9
Dupuis-Girod, S.10
Fischer, A.11
Graham Davies, E.12
Kuis, W.13
Leiva, L.14
Cavazzana-Calvo, M.15
-
34
-
-
51349090473
-
Insertional on-cogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
-
Hacein-Bey-Abina, S., Garrigue, A., Wang, G.P., Soulier, J., Lim, A., Morillon, E., Clappier, E., Caccavelli, L., Delabesse, E., Beldjord, K., Asnafi, V., Macintyre, E., Dal, C.L., Radford, I., Brousse, N., Sigaux, F., Moshous, D., Hauer, J., Borkhardt, A., Belohradsky, B.H., Wintergerst, U., Velez, M.C., Leiva, L., Sorensen, R., Wulffraat, N., Blanche, S., Bushman, F.D., Fischer, A., and Cavazzana-Calvo, M. (2008). Insertional on-cogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J. Clin. Invest. 118, 3132-3142.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3132-3142
-
-
Hacein-Bey-Abina, S.1
Garrigue, A.2
Wang, G.P.3
Soulier, J.4
Lim, A.5
Morillon, E.6
Clappier, E.7
Caccavelli, L.8
Delabesse, E.9
Beldjord, K.10
Asnafi, V.11
MacIntyre, E.12
Dal, C.L.13
Radford, I.14
Brousse, N.15
Sigaux, F.16
Moshous, D.17
Hauer, J.18
Borkhardt, A.19
Belohradsky, B.H.20
Wintergerst, U.21
Velez, M.C.22
Leiva, L.23
Sorensen, R.24
Wulffraat, N.25
Blanche, S.26
Bushman, F.D.27
Fischer, A.28
Cavazzana-Calvo, M.29
more..
-
35
-
-
39849094315
-
Globin lentiviral vector insertions can perturb the expression of endogenous genes in b-thalassemic hematopoietic cells
-
Hargrove, P.W., Kepes, S., Hanawa, H., Obenauer, J.C., Pei, D., Cheng, C., Gray, J.T., Neale, G., and Persons, D.A. (2008). Globin lentiviral vector insertions can perturb the expression of endogenous genes in b-thalassemic hematopoietic cells. Mol. Ther. 16, 525-533.
-
(2008)
Mol. Ther.
, vol.16
, pp. 525-533
-
-
Hargrove, P.W.1
Kepes, S.2
Hanawa, H.3
Obenauer, J.C.4
Pei, D.5
Cheng, C.6
Gray, J.T.7
Neale, G.8
Persons, D.A.9
-
36
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi, M.E., Diserens, A.C., Gorlia, T., Hamou, M.F., de Tribolet, N., Weller, M., Kros, J.M., Hainfellner, J.A., Mason, W., Mar-iani, L., Bromberg, J.E., Hau, P., Mirimanoff, R.O., Cairncross, J.G., Janzer, R.C., and Stupp, R. (2005). MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352, 997-1003.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
Hamou, M.F.4
De Tribolet, N.5
Weller, M.6
Kros, J.M.7
Hainfellner, J.A.8
Mason, W.9
Mar-Iani, L.10
Bromberg, J.E.11
Hau, P.12
Mirimanoff, R.O.13
Cairncross, J.G.14
Janzer, R.C.15
Stupp, R.16
-
37
-
-
0002294347
-
A simple sequentially rejective multiple test procedure
-
Holm, S. (1979). A simple sequentially rejective multiple test procedure. Scand. J. Stat. 6, 65-70.
-
(1979)
Scand. J. Stat.
, vol.6
, pp. 65-70
-
-
Holm, S.1
-
38
-
-
51349158298
-
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
-
Howe, S.J., Mansour, M.R., Schwarzwaelder, K., Bartholomae, C., Hubank, M., Kempski, H., Brugman, M.H., Pike-Overzet, K., Chatters, S.J., de Ridder, D., Gilmour, K.C., Adams, S., Thornhill, S.I., Parsley, K.L., Staal, F.J., Gale, R.E., Linch, D.C., Bayford, J., Brown, L., Quaye, M., Kinnon, C., Ancliff, P., Webb, D.K., Schmidt, M., von Kalle, C., Gaspar, H.B., and Thrasher, A.J. (2008). Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J. Clin. Invest. 118, 3143-3150.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3143-3150
-
-
Howe, S.J.1
Mansour, M.R.2
Schwarzwaelder, K.3
Bartholomae, C.4
Hubank, M.5
Kempski, H.6
Brugman, M.H.7
Pike-Overzet, K.8
Chatters, S.J.9
De Ridder, D.10
Gilmour, K.C.11
Adams, S.12
Thornhill, S.I.13
Parsley, K.L.14
Staal, F.J.15
Gale, R.E.16
Linch, D.C.17
Bayford, J.18
Brown, L.19
Quaye, M.20
Kinnon, C.21
Ancliff, P.22
Webb, D.K.23
Schmidt, M.24
Von Kalle, C.25
Gaspar, H.B.26
Thrasher, A.J.27
more..
-
39
-
-
61449172037
-
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
-
Huang, D.W., Sherman, B.T., and Lempicki, R.A. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 44-57
-
-
Huang, D.W.1
Sherman, B.T.2
Lempicki, R.A.3
-
40
-
-
0036708229
-
P140K into hematopoietic stem cells
-
P140K into hematopoietic stem cells. Cancer Gene Ther. 9, 737-746.
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 737-746
-
-
Jansen, M.1
Sorg, U.R.2
Ragg, S.3
Flasshove, M.4
Seeber, S.5
Williams, D.A.6
Moritz, T.7
-
41
-
-
0036226603
-
BLAT: The BLAST-like alignment tool
-
Kent, W.J. (2002). BLAT: The BLAST-Like Alignment Tool. Genome Res. 12, 656-664.
-
(2002)
Genome Res.
, vol.12
, pp. 656-664
-
-
Kent, W.J.1
-
42
-
-
21044448037
-
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking
-
Kustikova, O., Fehse, B., Modlich, U., Yang, M., Dullmann, J., Kamino, K., von Neuhoff, N., Schlegelberger, B., Li, Z., and Baum, C. (2005). Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science 308, 1171-1174.
-
(2005)
Science
, vol.308
, pp. 1171-1174
-
-
Kustikova, O.1
Fehse, B.2
Modlich, U.3
Yang, M.4
Dullmann, J.5
Kamino, K.6
Von Neuhoff, N.7
Schlegelberger, B.8
Li, Z.9
Baum, C.10
-
43
-
-
40549111908
-
Retroviral integration site analysis in hematopoietic stem cells
-
Kustikova, O.S., Baum, C., and Fehse, B. (2008). Retroviral integration site analysis in hematopoietic stem cells. Methods Mol. Biol. 430, 255-267.
-
(2008)
Methods Mol. Biol.
, vol.430
, pp. 255-267
-
-
Kustikova, O.S.1
Baum, C.2
Fehse, B.3
-
44
-
-
68849096855
-
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene
-
Larochelle, A., Choi, U., Shou, Y., Naumann, N., Loktionova, N.A., Clevenger, J.R., Krouse, A., Metzger, M., Donahue, R.E., Kang, E., Stewart, C., Persons, D., Malech, H.L., Dunbar, C.E., and Sorrentino, B.P. (2009). In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. J. Clin. Invest. 119, 1952-1963.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1952-1963
-
-
Larochelle, A.1
Choi, U.2
Shou, Y.3
Naumann, N.4
Loktionova, N.A.5
Clevenger, J.R.6
Krouse, A.7
Metzger, M.8
Donahue, R.E.9
Kang, E.10
Stewart, C.11
Persons, D.12
Malech, H.L.13
Dunbar, C.E.14
Sorrentino, B.P.15
-
45
-
-
0037443442
-
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells
-
Laufs, S., Gentner, B., Nagy, K.Z., Jauch, A., Benner, A., Naun-dorf, S., Kuehlcke, K., Schiedlmeier, B., Ho, A.D., Zeller, W.J., and Fruehauf, S. (2003). Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells. Blood 101, 2191-2198.
-
(2003)
Blood
, vol.101
, pp. 2191-2198
-
-
Laufs, S.1
Gentner, B.2
Nagy, K.Z.3
Jauch, A.4
Benner, A.5
Naun-Dorf, S.6
Kuehlcke, K.7
Schiedlmeier, B.8
Ho, A.D.9
Zeller, W.J.10
Fruehauf, S.11
-
46
-
-
33750532541
-
Lentiviral vector integration sites in human NOD/SCID repopulating cells
-
Laufs, S., Guenechea, G., Gonzalez-Murillo, A., Zsuzsanna, N.K., Luz Lozano, M., del Val, C., Jonnakuty, S., Hotz-Wagenblatt, A., Jens, Z.W., Bueren, J.A., and Fruehauf, S. (2006). Lentiviral vector integration sites in human NOD/SCID repopulating cells. J. Gene Med. 8, 1197-1207.
-
(2006)
J. Gene Med.
, vol.8
, pp. 1197-1207
-
-
Laufs, S.1
Guenechea, G.2
Gonzalez-Murillo, A.3
Zsuzsanna, N.K.4
Luz Lozano, M.5
Del Val, C.6
Jonnakuty, S.7
Hotz-Wagenblatt, A.8
Jens, Z.W.9
Bueren, J.A.10
Fruehauf, S.11
-
47
-
-
63949083133
-
Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator
-
Li, C.L., Xiong, D., Stamatoyannopoulos, G., and Emery, D.W. (2009). Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol. Ther. 17, 716-724.
-
(2009)
Mol. Ther.
, vol.17
, pp. 716-724
-
-
Li, C.L.1
Xiong, D.2
Stamatoyannopoulos, G.3
Emery, D.W.4
-
48
-
-
0037134031
-
Murine leukemia induced by retroviral gene marking
-
Li, Z., Dullmann, J., Schiedlmeier, B., Schmidt, M., von Kalle, C., Meyer, J., Forster, M., Stocking, C., Wahlers, A., Frank, O., Ostertag, W., Kuhlcke, K., Eckert, H.G., Fehse, B., and Baum, C. (2002). Murine leukemia induced by retroviral gene marking. Science 296, 497.
-
(2002)
Science
, vol.296
, pp. 497
-
-
Li, Z.1
Dullmann, J.2
Schiedlmeier, B.3
Schmidt, M.4
Von Kalle, C.5
Meyer, J.6
Forster, M.7
Stocking, C.8
Wahlers, A.9
Frank, O.10
Ostertag, W.11
Kuhlcke, K.12
Eckert, H.G.13
Fehse, B.14
Baum, C.15
-
49
-
-
41649115450
-
\+ hematopoietic progenitor cells
-
\+ hematopoietic progenitor cells. Radiat. Res. 169, 301-310.
-
(2008)
Radiat. Res.
, vol.169
, pp. 301-310
-
-
Maier, P.1
Herskind, C.2
Fleckenstein, K.3
Spier, I.4
Laufs, S.5
Zeller, W.J.6
Fruehauf, S.7
Wenz, F.8
-
50
-
-
77949424638
-
P140K
-
P140K. Gene Ther. 17, 389-399.
-
(2010)
Gene Ther.
, vol.17
, pp. 389-399
-
-
Maier, P.1
Spier, I.2
Laufs, S.3
Veldwijk, M.R.4
Fruehauf, S.5
Wenz, F.6
Zeller, W.J.7
-
51
-
-
24044455869
-
Genome sequencing in microfabricated high-density picolitre reactors
-
Margulies, M., Egholm, M., Altman, W.E., Attiya, S., Bader, J.S., Bemben, L.A., Berka, J., Braverman, M.S., Chen, Y.J., Chen, Z., Dewell, S.B., Du, L., Fierro, J.M., Gomes, X.V., Godwin, B.C., He, W., Helgesen, S., Ho, C.H., Irzyk, G.P., Jando, S.C., Alenquer, M.L., Jarvie, T.P., Jirage, K.B., Kim, J.B., Knight, J.R., Lanza, J.R., Leamon, J.H., Lefkowitz, S.M., Lei, M., Li, J., Lohman, K.L., Lu, H., Makhijani, V.B., McDade, K.E., McKenna, M.P., Myers, E.W., Nickerson, E., Nobile, J.R., Plant, R., Puc, B.P., Ronan, M.T., Roth, G.T., Sarkis, G.J., Simons, J.F., Simpson, J.W., Srinivasan, M., Tartaro, K.R., Tomasz, A., Vogt, K.A., Volkmer, G.A., Wang, S.H., Wang, Y., Weiner, M.P., Yu, P., Begley, R.F., and Rothberg, J.M. (2005). Genome sequencing in microfabricated high-density picolitre reactors. Nature 437, 376-380.
-
(2005)
Nature
, vol.437
, pp. 376-380
-
-
Margulies, M.1
Egholm, M.2
Altman, W.E.3
Attiya, S.4
Bader, J.S.5
Bemben, L.A.6
Berka, J.7
Braverman, M.S.8
Chen, Y.J.9
Chen, Z.10
Dewell, S.B.11
Du, L.12
Fierro, J.M.13
Gomes, X.V.14
Godwin, B.C.15
He, W.16
Helgesen, S.17
Ho, C.H.18
Irzyk, G.P.19
Jando, S.C.20
Alenquer, M.L.21
Jarvie, T.P.22
Jirage, K.B.23
Kim, J.B.24
Knight, J.R.25
Lanza, J.R.26
Leamon, J.H.27
Lefkowitz, S.M.28
Lei, M.29
Li, J.30
Lohman, K.L.31
Lu, H.32
Makhijani, V.B.33
McDade, K.E.34
McKenna, M.P.35
Myers, E.W.36
Nickerson, E.37
Nobile, J.R.38
Plant, R.39
Puc, B.P.40
Ronan, M.T.41
Roth, G.T.42
Sarkis, G.J.43
Simons, J.F.44
Simpson, J.W.45
Srinivasan, M.46
Tartaro, K.R.47
Tomasz, A.48
Vogt, K.A.49
Volkmer, G.A.50
Wang, S.H.51
Wang, Y.52
Weiner, M.P.53
Yu, P.54
Begley, R.F.55
Rothberg, J.M.56
more..
-
52
-
-
67349120266
-
Tran-scriptional enhancers induce insertional gene deregulation independently from the vector type and design
-
Maruggi, G., Porcellini, S., Facchini, G., Perna, S. K., Cattoglio, C., Sartori, D., Ambrosi, A., Schambach, A., Baum, C., Bonini, C., Bovolenta, C., Mavilio, F., and Recchia, A. (2009). Tran-scriptional enhancers induce insertional gene deregulation independently from the vector type and design. Mol. Ther. 17, 851-856.
-
(2009)
Mol. Ther.
, vol.17
, pp. 851-856
-
-
Maruggi, G.1
Porcellini, S.2
Facchini, G.3
Perna, S.K.4
Cattoglio, C.5
Sartori, D.6
Ambrosi, A.7
Schambach, A.8
Baum, C.9
Bonini, C.10
Bovolenta, C.11
Mavilio, F.12
Recchia, A.13
-
53
-
-
51049094440
-
6-methylguanine-DNA methyltransferase P140K expression level and chemoprotec-tion of hematopoietic stem cells
-
6-methylguanine-DNA methyltransferase P140K expression level and chemoprotec-tion of hematopoietic stem cells. Cancer Res. 68, 6171-6180.
-
(2008)
Cancer Res.
, vol.68
, pp. 6171-6180
-
-
Milsom, M.D.1
Jerabek-Willemsen, M.2
Harris, C.E.3
Schambach, A.4
Broun, E.5
Bailey, J.6
Jansen, M.7
Schleimer, D.8
Nattamai, K.9
Wilhelm, J.10
Watson, A.11
Geiger, H.12
Margison, G.P.13
Moritz, T.14
Baum, C.15
Thomale, J.16
Williams, D.A.17
-
54
-
-
19344375031
-
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
-
Mitchell, R.S., Beitzel, B.F., Schroder, A.R., Shinn, P., Chen, H., Berry, C.C., Ecker, J.R., and Bushman, F.D. (2004). Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol. 2, e234.
-
(2004)
PLoS Biol.
, vol.2
-
-
Mitchell, R.S.1
Beitzel, B.F.2
Schroder, A.R.3
Shinn, P.4
Chen, H.5
Berry, C.C.6
Ecker, J.R.7
Bushman, F.D.8
-
55
-
-
33750624015
-
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
-
Modlich, U., Bohne, J., Schmidt, M., von Kalle, C., Knoss, S., Schambach, A., and Baum, C. (2006). Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood 108, 2545-2553.
-
(2006)
Blood
, vol.108
, pp. 2545-2553
-
-
Modlich, U.1
Bohne, J.2
Schmidt, M.3
Von Kalle, C.4
Knoss, S.5
Schambach, A.6
Baum, C.7
-
56
-
-
49449084991
-
Leukemia induction after a single ret-roviral vector insertion in Evi1 or Prdm16
-
Modlich, U., Schambach, A., Brugman, M.H., Wicke, D.C., Knoess, S., Li, Z., Maetzig, T., Rudolph, C., Schlegelberger, B., and Baum, C. (2008). Leukemia induction after a single ret-roviral vector insertion in Evi1 or Prdm16. Leukemia 22, 1519-1528.
-
(2008)
Leukemia
, vol.22
, pp. 1519-1528
-
-
Modlich, U.1
Schambach, A.2
Brugman, M.H.3
Wicke, D.C.4
Knoess, S.5
Li, Z.6
Maetzig, T.7
Rudolph, C.8
Schlegelberger, B.9
Baum, C.10
-
57
-
-
65249101260
-
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
-
Montini, E., Cesana, D., Schmidt, M., Sanvito, F., Bartholomae, C.C., Ranzani, M., Benedicenti, F., Sergi, L.S., Ambrosi, A., Ponzoni, M., Doglioni, C., Di Serio, C., von Kalle, C., and Naldini, L. (2009). The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. J. Clin. Invest. 119, 964-975.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 964-975
-
-
Montini, E.1
Cesana, D.2
Schmidt, M.3
Sanvito, F.4
Bartholomae, C.C.5
Ranzani, M.6
Benedicenti, F.7
Sergi, L.S.8
Ambrosi, A.9
Ponzoni, M.10
Doglioni, C.11
Di Serio, C.12
Von Kalle, C.13
Naldini, L.14
-
58
-
-
12844249961
-
Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy
-
Neff, T., Beard, B.C., Peterson, L.J., Anandakumar, P., Thompson, J., and Kiem, H.P. (2005). Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. Blood 105, 997-1002.
-
(2005)
Blood
, vol.105
, pp. 997-1002
-
-
Neff, T.1
Beard, B.C.2
Peterson, L.J.3
Anandakumar, P.4
Thompson, J.5
Kiem, H.P.6
-
59
-
-
0026513077
-
Phase i trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856
-
Newlands, E.S., Blackledge, G.R., Slack, J.A., Rustin, G.J., Smith, D.B., Stuart, N.S., Quarterman, C.P., Hoffman, R., Stevens, M.F., Brampton, M.H., and Gibson, A.C. (1992). Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856). Br. J. Cancer 65, 287-291.
-
(1992)
Br. J. Cancer
, vol.65
, pp. 287-291
-
-
Newlands, E.S.1
Blackledge, G.R.2
Slack, J.A.3
Rustin, G.J.4
Smith, D.B.5
Stuart, N.S.6
Quarterman, C.P.7
Hoffman, R.8
Stevens, M.F.9
Brampton, M.H.10
Gibson, A.C.11
-
60
-
-
33645734405
-
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
-
Ott, M.G., Schmidt, M., Schwarzwaelder, K., Stein, S., Siler, U., Koehl, U., Glimm, H., Kuhlcke, K., Schilz, A., Kunkel, H., Naundorf, S., Brinkmann, A., Deichmann, A., Fischer, M., Ball, C., Pilz, I., Dunbar, C., Du, Y., Jenkins, N.A., Copeland, N.G., Luthi, U., Hassan, M., Thrasher, A.J., Hoelzer, D., von Kalle, C., Seger, R., and Grez, M. (2006). Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat. Med. 12, 401-409.
-
(2006)
Nat. Med.
, vol.12
, pp. 401-409
-
-
Ott, M.G.1
Schmidt, M.2
Schwarzwaelder, K.3
Stein, S.4
Siler, U.5
Koehl, U.6
Glimm, H.7
Kuhlcke, K.8
Schilz, A.9
Kunkel, H.10
Naundorf, S.11
Brinkmann, A.12
Deichmann, A.13
Fischer, M.14
Ball, C.15
Pilz, I.16
Dunbar, C.17
Du, Y.18
Jenkins, N.A.19
Copeland, N.G.20
Luthi, U.21
Hassan, M.22
Thrasher, A.J.23
Hoelzer, D.24
Von Kalle, C.25
Seger, R.26
Grez, M.27
more..
-
61
-
-
0025195404
-
6-alkylguanine-DNA alkyl-transferase: Regulation and importance in response to alky-lating carcinogenic and therapeutic agents
-
6-alkylguanine-DNA alkyl-transferase: Regulation and importance in response to alky-lating carcinogenic and therapeutic agents. Cancer Res. 50, 6119-6129.
-
(1990)
Cancer Res.
, vol.50
, pp. 6119-6129
-
-
Pegg, A.E.1
-
62
-
-
0021016737
-
Intensive 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), NSC #4366650 and cryopreserved autologous marrow transplantation for refractory cancer: A phase I-II study
-
Phillips, G.L., Fay, J.W., Herzig, G.P., Herzig, R.H., Weiner, R.S., Wolff, S., Lazarus, H.M., Karanes, C., Ross, W.E., and Kramer, B.S. (1983). Intensive 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), NSC #4366650 and cryopreserved autologous marrow transplantation for refractory cancer: A phase I-II study. Cancer 52, 1792-1802.
-
(1983)
Cancer
, vol.52
, pp. 1792-1802
-
-
Phillips, G.L.1
Fay, J.W.2
Herzig, G.P.3
Herzig, R.H.4
Weiner, R.S.5
Wolff, S.6
Lazarus, H.M.7
Karanes, C.8
Ross, W.E.9
Kramer, B.S.10
-
63
-
-
0022628253
-
Intensive 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma
-
Phillips, G.L., Wolff, S.N., Fay, J.W., Herzig, R.H., Lazarus, H.M., Schold, C., and Herzig, G.P. (1986). Intensive 1,3-bis (2-chloroethyl)-1- nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma. J. Clin. Oncol. 4, 639-645.
-
(1986)
J. Clin. Oncol.
, vol.4
, pp. 639-645
-
-
Phillips, G.L.1
Wolff, S.N.2
Fay, J.W.3
Herzig, R.H.4
Lazarus, H.M.5
Schold, C.6
Herzig, G.P.7
-
64
-
-
0037456621
-
Genetic alterations in cancer as a result of breakage at fragile sites
-
Popescu, N.C. (2003). Genetic alterations in cancer as a result of breakage at fragile sites. Cancer Lett. 192, 1-17.
-
(2003)
Cancer Lett.
, vol.192
, pp. 1-17
-
-
Popescu, N.C.1
-
65
-
-
27244442921
-
6-benzylguanine for patients with recurrent or progressive malignant glioma
-
6-benzylguanine for patients with recurrent or progressive malignant glioma. J. Clin. Oncol. 23, 7178-7187.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 7178-7187
-
-
Quinn, J.A.1
Desjardins, A.2
Weingart, J.3
Brem, H.4
Dolan, M.E.5
Delaney, S.M.6
Vredenburgh, J.7
Rich, J.8
Friedman, A.H.9
Reardon, D.A.10
Sampson, J.H.11
Pegg, A.E.12
Moschel, R.C.13
Birch, R.14
McLendon, R.E.15
Provenzale, J.M.16
Gururangan, S.17
Dancey, J.E.18
Maxwell, J.19
Tourt-Uhlig, S.20
Herndon, J.E.21
Bigner, D.D.22
Friedman, H.S.23
more..
-
66
-
-
61349197634
-
6-benzylguanine in adults with recurrent glioblastoma multiforme
-
6-benzylguanine in adults with recurrent glioblastoma multiforme. Clin. Cancer Res. 15, 1064-1068.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 1064-1068
-
-
Quinn, J.A.1
Jiang, S.X.2
Carter, J.3
Reardon, D.A.4
Desjardins, A.5
Vredenburgh, J.J.6
Rich, J.N.7
Gururangan, S.8
Friedman, A.H.9
Bigner, D.D.10
Sampson, J.H.11
McLendon, R.E.12
Herndon, J.E.13
Threatt, S.14
Friedman, H.S.15
-
67
-
-
0034665336
-
Direct reversal of DNA damage by mutant methyl-transferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells
-
Ragg, S., Xu-Welliver, M., Bailey, J., D'Souza, M., Cooper, R., Chandra, S., Seshadri, R., Pegg, A.E., and Williams, D.A. (2000). Direct reversal of DNA damage by mutant methyl-transferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells. Cancer Res. 60, 5187-5195.
-
(2000)
Cancer Res.
, vol.60
, pp. 5187-5195
-
-
Ragg, S.1
Xu-Welliver, M.2
Bailey, J.3
D'Souza, M.4
Cooper, R.5
Chandra, S.6
Seshadri, R.7
Pegg, A.E.8
Williams, D.A.9
-
68
-
-
33645085569
-
6-alkylguanine-DNA- alkyltransferase: Phase i safety, phar-macodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors
-
6-alkylguanine-DNA-alkyltransferase: Phase I safety, phar-macodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors. Clin. Cancer Res. 12, 1577-1584.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 1577-1584
-
-
Ranson, M.1
Middleton, M.R.2
Bridgewater, J.3
Lee, S.M.4
Dawson, M.5
Jowle, D.6
Halbert, G.7
Waller, S.8
McGrath, H.9
Gumbrell, L.10
McElhinney, R.S.11
Donnelly, D.12
McMurry, T.B.13
Margison, G.P.14
-
69
-
-
31944440000
-
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells
-
Recchia, A., Bonini, C., Magnani, Z., Urbinati, F., Sartori, D., Muraro, S., Tagliafico, E., Bondanza, A., Stanghellini, M.T., Bernardi, M., Pescarollo, A., Ciceri, F., Bordignon, C., and Mavilio, F. (2006). Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells. Proc. Natl. Acad. Sci. U.S.A. 103, 1457-1462.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 1457-1462
-
-
Recchia, A.1
Bonini, C.2
Magnani, Z.3
Urbinati, F.4
Sartori, D.5
Muraro, S.6
Tagliafico, E.7
Bondanza, A.8
Stanghellini, M.T.9
Bernardi, M.10
Pescarollo, A.11
Ciceri, F.12
Bordignon, C.13
Mavilio, F.14
-
70
-
-
0034990304
-
6-benzylgua-nine, and an alkyltransferase-expressing retroviral vector
-
6-benzylgua-nine, and an alkyltransferase-expressing retroviral vector. Mol. Ther. 3, 78-87.
-
(2001)
Mol. Ther.
, vol.3
, pp. 78-87
-
-
Sawai, N.1
Zhou, S.2
Vanin, E.F.3
Houghton, P.4
Brent, T.P.5
Sorrentino, B.P.6
-
71
-
-
60649103432
-
Clinical application of lentiviral vectors: Concepts and practice
-
Schambach, A., and Baum, C. (2008). Clinical application of lentiviral vectors: Concepts and practice. Curr. Gene Ther. 8, 474-482.
-
(2008)
Curr. Gene Ther.
, vol.8
, pp. 474-482
-
-
Schambach, A.1
Baum, C.2
-
72
-
-
0034571820
-
MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions
-
Schilz, A.J., Schiedlmeier, B., Kuhlcke, K., Fruehauf, S., Linde-mann, C., Zeller, W.J., Grez, M., Fauser, A.A., Baum, C., and Eckert, H.G. (2000). MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions. Mol. Ther. 2, 609-618.
-
(2000)
Mol. Ther.
, vol.2
, pp. 609-618
-
-
Schilz, A.J.1
Schiedlmeier, B.2
Kuhlcke, K.3
Fruehauf, S.4
Linde-Mann, C.5
Zeller, W.J.6
Grez, M.7
Fauser, A.A.8
Baum, C.9
Eckert, H.G.10
-
73
-
-
0037162715
-
HIV-1 integration in the human genome favors active genes and local hotspots
-
Schroder, A.R., Shinn, P., Chen, H., Berry, C., Ecker, J.R., and Bushman, F. (2002). HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110, 521-529.
-
(2002)
Cell
, vol.110
, pp. 521-529
-
-
Schroder, A.R.1
Shinn, P.2
Chen, H.3
Berry, C.4
Ecker, J.R.5
Bushman, F.6
-
74
-
-
33646594123
-
Acute myeloid leukemia is associated with ret-roviral gene transfer to hematopoietic progenitor cells in a rhesus macaque
-
Seggewiss, R., Pittaluga, S., Adler, R.L., Guenaga, F.J., Ferguson, C., Pilz, I.H., Ryu, B., Sorrentino, B.P., Young, W.S., III, Donahue, R.E., von Kalle, C., Nienhuis, A.W., and Dunbar, C.E. (2006). Acute myeloid leukemia is associated with ret-roviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood 107, 3865-3867.
-
(2006)
Blood
, vol.107
, pp. 3865-3867
-
-
Seggewiss, R.1
Pittaluga, S.2
Adler, R.L.3
Guenaga, F.J.4
Ferguson, C.5
Pilz, I.H.6
Ryu, B.7
Sorrentino, B.P.8
Young, W.S.9
Iii Donahue, R.E.10
Von Kalle, C.11
Nienhuis, A.W.12
Dunbar, C.E.13
-
75
-
-
0029937517
-
Carmustine and streptozocin in refractory melanoma: An attempt at modulation of O-alkylguanine-DNA-alkyltransferase
-
Smith, D.C., Gerson, S.L., Liu, L., Donnelly, S., Day, R., Trump, D.L., and Kirkwood, J.M. (1996). Carmustine and streptozocin in refractory melanoma: An attempt at modulation of O-alkylguanine-DNA-alkyltransferase. Clin. Cancer Res. 2, 1129-1134.
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 1129-1134
-
-
Smith, D.C.1
Gerson, S.L.2
Liu, L.3
Donnelly, S.4
Day, R.5
Trump, D.L.6
Kirkwood, J.M.7
-
76
-
-
0036594445
-
Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs
-
Sorrentino, B.P. (2002). Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs. Nat. Rev. Cancer 2, 431-441.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 431-441
-
-
Sorrentino, B.P.1
-
77
-
-
84950622021
-
EDF statistics for goodness of fit and some comparisons
-
Stephens, M.A. (1974). EDF statistics for goodness of fit and some comparisons. J. Am. Stat. Assoc. 69, 730-737.
-
(1974)
J. Am. Stat. Assoc.
, vol.69
, pp. 730-737
-
-
Stephens, M.A.1
-
78
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp, R., Mason, W.P., van den Bent, M.J., Weller, M., Fisher, B., Taphoorn, M.J., Belanger, K., Brandes, A.A., Marosi, C., Bogdahn, U., Curschmann, J., Janzer, R.C., Ludwin, S.K., Gorlia, T., Allgeier, A., Lacombe, D., Cairncross, J.G., Ei-senhauer, E., and Mirimanoff, R.O. (2005). Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
Van Den Bent, M.J.3
Weller, M.4
Fisher, B.5
Taphoorn, M.J.6
Belanger, K.7
Brandes, A.A.8
Marosi, C.9
Bogdahn, U.10
Curschmann, J.11
Janzer, R.C.12
Ludwin, S.K.13
Gorlia, T.14
Allgeier, A.15
Lacombe, D.16
Cairncross, J.G.17
Ei-Senhauer, E.18
Mirimanoff, R.O.19
-
79
-
-
22144499640
-
Long-term persistence of a noninte-grated lentiviral vector in mouse hematopoietic stem cells
-
Terskikh, A.V., Ershler, M.A., Drize, N.J., Nifontova, I.N., and Chertkov, J.L. (2005). Long-term persistence of a noninte-grated lentiviral vector in mouse hematopoietic stem cells. Exp. Hematol. 33, 873-882.
-
(2005)
Exp. Hematol.
, vol.33
, pp. 873-882
-
-
Terskikh, A.V.1
Ershler, M.A.2
Drize, N.J.3
Nifontova, I.N.4
Chertkov, J.L.5
-
80
-
-
0021288515
-
6-Alkylguanine-DNA alkyltransferase activity in human brain and brain tumors
-
6- Alkylguanine-DNA alkyltransferase activity in human brain and brain tumors. Carcinogenesis 5, 121-124.
-
(1984)
Carcinogenesis
, vol.5
, pp. 121-124
-
-
Wiestler, O.1
Kleihues, P.2
Pegg, A.E.3
-
81
-
-
0037841763
-
Transcription start regions in the human genome are favored targets for MLV integration
-
Wu, X., Li, Y., Crise, B., and Burgess, S.M. (2003). Transcription start regions in the human genome are favored targets for MLV integration. Science 300, 1749-1751.
-
(2003)
Science
, vol.300
, pp. 1749-1751
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
-
83
-
-
0036632178
-
RNA 3 readthrough of oncoretrovirus and lentivirus: Implications for vector safety and efficacy
-
Zaiss, A.K., Son, S., and Chang, L.J. (2002). RNA 3 readthrough of oncoretrovirus and lentivirus: Implications for vector safety and efficacy. J. Virol. 76, 7209-7219.
-
(2002)
J. Virol.
, vol.76
, pp. 7209-7219
-
-
Zaiss, A.K.1
Son, S.2
Chang, L.J.3
-
84
-
-
0036226607
-
\+ hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro
-
\+ hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro. Mol. Ther. 5, 381-387.
-
(2002)
Mol. Ther.
, vol.5
, pp. 381-387
-
-
Zielske, S.P.1
Gerson, S.L.2
-
85
-
-
41149133413
-
Physiological promoters reduce the genotoxic risk of integrating gene vectors
-
Zychlinski, D., Schambach, A., Modlich, U., Maetzig, T., Meyer, J., Grassman, E., Mishra, A., and Baum, C. (2008). Physiological promoters reduce the genotoxic risk of integrating gene vectors. Mol. Ther. 16, 718-725.
-
(2008)
Mol. Ther.
, vol.16
, pp. 718-725
-
-
Zychlinski, D.1
Schambach, A.2
Modlich, U.3
Maetzig, T.4
Meyer, J.5
Grassman, E.6
Mishra, A.7
Baum, C.8
|