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Volumn 21, Issue 8, 2010, Pages 943-956

Analysis of self-inactivating lentiviral vector integration sites and flanking gene expression in human peripheral blood progenitor cells after alkylator chemotherapy

Author keywords

[No Author keywords available]

Indexed keywords

CARMUSTINE; LENTIVIRUS VECTOR; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

EID: 77955506450     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2009.116     Document Type: Article
Times cited : (5)

References (85)
  • 4
    • 34248670400 scopus 로고    scopus 로고
    • The Zinc Finger Proteins ZXDA and ZXDC Form a Complex that Binds CIITA and Regulates MHC II Gene Transcription
    • DOI 10.1016/j.jmb.2007.04.033, PII S0022283607004950
    • Al-Kandari, W., Koneni, R., Navalgund, V., Aleksandrova, A., Jambunathan, S., and Fontes, J.D. (2007). The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. J. Mol. Biol. 369, 1175-1187. (Pubitemid 46770777)
    • (2007) Journal of Molecular Biology , vol.369 , Issue.5 , pp. 1175-1187
    • Al-Kandari, W.1    Koneni, R.2    Navalgund, V.3    Aleksandrova, A.4    Jambunathan, S.5    Fontes, J.D.6
  • 6
    • 0037443457 scopus 로고    scopus 로고
    • Side effects of retroviral gene transfer into hematopoietic stem cells
    • DOI 10.1182/blood-2002-07-2314
    • Baum, C., Dullmann, J., Li, Z., Fehse, B., Meyer, J., Williams, D.A., and von Kalle, C. (2003). Side effects of retroviral gene transfer into hematopoietic stem cells. Blood 101, 2099-2114. (Pubitemid 36302043)
    • (2003) Blood , vol.101 , Issue.6 , pp. 2099-2114
    • Baum, C.1    Dullmann, J.2    Li, Z.3    Fehse, B.4    Meyer, J.5    Williams, D.A.6    Von Kalle, C.7
  • 8
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y., and Hochberg, Y. (1995). Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J. R. Stat. Soc. 57, 289-300.
    • (1995) J. R. Stat. Soc. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 10
    • 34547834963 scopus 로고    scopus 로고
    • The use of coded PCR primers enables high-throughput sequencing of multiple ho-molog amplification products by 454 parallel sequencing
    • Binladen, J., Gilbert, M.T., Bollback, J.P., Panitz, F., Bendixen, C., Nielsen, R., and Willerslev, E. (2007). The use of coded PCR primers enables high-throughput sequencing of multiple ho-molog amplification products by 454 parallel sequencing. PLoS One 2, e197.
    • (2007) PLoS One , vol.2
    • Binladen, J.1    Gilbert, M.T.2    Bollback, J.P.3    Panitz, F.4    Bendixen, C.5    Nielsen, R.6    Willerslev, E.7
  • 11
    • 33750020601 scopus 로고    scopus 로고
    • Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome
    • Boztug, K., Dewey, R.A., and Klein, C. (2006). Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome. Curr. Opin. Mol. Ther. 8, 390-395.
    • (2006) Curr. Opin. Mol. Ther. , vol.8 , pp. 390-395
    • Boztug, K.1    Dewey, R.A.2    Klein, C.3
  • 12
    • 4344571581 scopus 로고    scopus 로고
    • Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
    • Breitling, R., Armengaud, P., Amtmann, A., and Herzyk, P. (2004). Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett. 573, 83-92.
    • (2004) FEBS Lett. , vol.573 , pp. 83-92
    • Breitling, R.1    Armengaud, P.2    Amtmann, A.3    Herzyk, P.4
  • 15
    • 0344668735 scopus 로고    scopus 로고
    • n repeat element within the 5 untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter
    • n repeat element within the 5 untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter. Hum. Mol. Genet. 12, 3067-3074.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 3067-3074
    • Chen, L.S.1    Tassone, F.2    Sahota, P.3    Hagerman, P.J.4
  • 18
    • 0001072895 scopus 로고
    • The use of confidence or fiducial limits illustrated in the case of the binomial
    • Clopper, C.J., and Pearson, E.S. (1934). The use of confidence or fiducial limits illustrated in the case of the binomial. Biome-trika 26, 404-413.
    • (1934) Biome-trika , vol.26 , pp. 404-413
    • Clopper, C.J.1    Pearson, E.S.2
  • 21
    • 0036252492 scopus 로고    scopus 로고
    • High-level transduction and gene expression in hematopoietic re-populating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
    • Demaison, C., Parsley, K., Brouns, G., Scherr, M., Battmer, K., Kinnon, C., Grez, M., and Thrasher, A.J. (2002). High-level transduction and gene expression in hematopoietic re-populating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum. Gene Ther. 13, 803-813.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 803-813
    • Demaison, C.1    Parsley, K.2    Brouns, G.3    Scherr, M.4    Battmer, K.5    Kinnon, C.6    Grez, M.7    Thrasher, A.J.8
  • 23
    • 0025571828 scopus 로고
    • 6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
    • 6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. Cancer Commun. 2, 371-377.
    • (1990) Cancer Commun. , vol.2 , pp. 371-377
    • Dolan, M.E.1    Stine, L.2    Mitchell, R.B.3    Moschel, R.C.4    Pegg, A.E.5
  • 24
    • 0037105522 scopus 로고    scopus 로고
    • Development of virus vectors for gene therapy of b chain hemoglobinopathies: Flanking with a chromatin insulator reduces g-globin gene silencing in vivo
    • Emery, D.W., Yannaki, E., Tubb, J., Nishino, T., Li, Q., and Stamatoyannopoulos, G. (2002). Development of virus vectors for gene therapy of b chain hemoglobinopathies: Flanking with a chromatin insulator reduces g-globin gene silencing in vivo. Blood 100, 2012-2019.
    • (2002) Blood , vol.100 , pp. 2012-2019
    • Emery, D.W.1    Yannaki, E.2    Tubb, J.3    Nishino, T.4    Li, Q.5    Stamatoyannopoulos, G.6
  • 26
    • 19144361831 scopus 로고    scopus 로고
    • Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123
    • Fruehauf, S., Breems, D.A., Knaan-Shanzer, S., Brouwer, K.B., Haas, R., Lowenberg, B., Nooter, K., Ploemacher, R.E., Valerio, D., and Boesen, J.J. (1996). Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123. Hum. Gene Ther. 7, 1219-1231.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1219-1231
    • Fruehauf, S.1    Breems, D.A.2    Knaan-Shanzer, S.3    Brouwer, K.B.4    Haas, R.5    Lowenberg, B.6    Nooter, K.7    Ploemacher, R.E.8    Valerio, D.9    Boesen, J.J.10
  • 29
    • 0022272291 scopus 로고
    • 6-alkylguanine-DNA alkyltransferase activity in human myeloid cells
    • 6- alkylguanine-DNA alkyltransferase activity in human myeloid cells. J. Clin. Invest. 76, 2106-2114.
    • (1985) J. Clin. Invest. , vol.76 , pp. 2106-2114
    • Gerson, S.L.1    Miller, K.2    Berger, N.A.3
  • 30
    • 0027339636 scopus 로고
    • 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone
    • 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochem. Pharmacol. 45, 483-491.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 483-491
    • Gerson, S.L.1    Zborowska, E.2    Norton, K.3    Gordon, N.H.4    Willson, J.K.5
  • 35
    • 39849094315 scopus 로고    scopus 로고
    • Globin lentiviral vector insertions can perturb the expression of endogenous genes in b-thalassemic hematopoietic cells
    • Hargrove, P.W., Kepes, S., Hanawa, H., Obenauer, J.C., Pei, D., Cheng, C., Gray, J.T., Neale, G., and Persons, D.A. (2008). Globin lentiviral vector insertions can perturb the expression of endogenous genes in b-thalassemic hematopoietic cells. Mol. Ther. 16, 525-533.
    • (2008) Mol. Ther. , vol.16 , pp. 525-533
    • Hargrove, P.W.1    Kepes, S.2    Hanawa, H.3    Obenauer, J.C.4    Pei, D.5    Cheng, C.6    Gray, J.T.7    Neale, G.8    Persons, D.A.9
  • 37
    • 0002294347 scopus 로고
    • A simple sequentially rejective multiple test procedure
    • Holm, S. (1979). A simple sequentially rejective multiple test procedure. Scand. J. Stat. 6, 65-70.
    • (1979) Scand. J. Stat. , vol.6 , pp. 65-70
    • Holm, S.1
  • 39
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, D.W., Sherman, B.T., and Lempicki, R.A. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57.
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 41
    • 0036226603 scopus 로고    scopus 로고
    • BLAT: The BLAST-like alignment tool
    • Kent, W.J. (2002). BLAT: The BLAST-Like Alignment Tool. Genome Res. 12, 656-664.
    • (2002) Genome Res. , vol.12 , pp. 656-664
    • Kent, W.J.1
  • 43
    • 40549111908 scopus 로고    scopus 로고
    • Retroviral integration site analysis in hematopoietic stem cells
    • Kustikova, O.S., Baum, C., and Fehse, B. (2008). Retroviral integration site analysis in hematopoietic stem cells. Methods Mol. Biol. 430, 255-267.
    • (2008) Methods Mol. Biol. , vol.430 , pp. 255-267
    • Kustikova, O.S.1    Baum, C.2    Fehse, B.3
  • 47
    • 63949083133 scopus 로고    scopus 로고
    • Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator
    • Li, C.L., Xiong, D., Stamatoyannopoulos, G., and Emery, D.W. (2009). Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol. Ther. 17, 716-724.
    • (2009) Mol. Ther. , vol.17 , pp. 716-724
    • Li, C.L.1    Xiong, D.2    Stamatoyannopoulos, G.3    Emery, D.W.4
  • 55
    • 33750624015 scopus 로고    scopus 로고
    • Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
    • Modlich, U., Bohne, J., Schmidt, M., von Kalle, C., Knoss, S., Schambach, A., and Baum, C. (2006). Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood 108, 2545-2553.
    • (2006) Blood , vol.108 , pp. 2545-2553
    • Modlich, U.1    Bohne, J.2    Schmidt, M.3    Von Kalle, C.4    Knoss, S.5    Schambach, A.6    Baum, C.7
  • 58
    • 12844249961 scopus 로고    scopus 로고
    • Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy
    • Neff, T., Beard, B.C., Peterson, L.J., Anandakumar, P., Thompson, J., and Kiem, H.P. (2005). Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. Blood 105, 997-1002.
    • (2005) Blood , vol.105 , pp. 997-1002
    • Neff, T.1    Beard, B.C.2    Peterson, L.J.3    Anandakumar, P.4    Thompson, J.5    Kiem, H.P.6
  • 61
    • 0025195404 scopus 로고
    • 6-alkylguanine-DNA alkyl-transferase: Regulation and importance in response to alky-lating carcinogenic and therapeutic agents
    • 6-alkylguanine-DNA alkyl-transferase: Regulation and importance in response to alky-lating carcinogenic and therapeutic agents. Cancer Res. 50, 6119-6129.
    • (1990) Cancer Res. , vol.50 , pp. 6119-6129
    • Pegg, A.E.1
  • 62
    • 0021016737 scopus 로고
    • Intensive 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), NSC #4366650 and cryopreserved autologous marrow transplantation for refractory cancer: A phase I-II study
    • Phillips, G.L., Fay, J.W., Herzig, G.P., Herzig, R.H., Weiner, R.S., Wolff, S., Lazarus, H.M., Karanes, C., Ross, W.E., and Kramer, B.S. (1983). Intensive 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), NSC #4366650 and cryopreserved autologous marrow transplantation for refractory cancer: A phase I-II study. Cancer 52, 1792-1802.
    • (1983) Cancer , vol.52 , pp. 1792-1802
    • Phillips, G.L.1    Fay, J.W.2    Herzig, G.P.3    Herzig, R.H.4    Weiner, R.S.5    Wolff, S.6    Lazarus, H.M.7    Karanes, C.8    Ross, W.E.9    Kramer, B.S.10
  • 63
    • 0022628253 scopus 로고
    • Intensive 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma
    • Phillips, G.L., Wolff, S.N., Fay, J.W., Herzig, R.H., Lazarus, H.M., Schold, C., and Herzig, G.P. (1986). Intensive 1,3-bis (2-chloroethyl)-1- nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma. J. Clin. Oncol. 4, 639-645.
    • (1986) J. Clin. Oncol. , vol.4 , pp. 639-645
    • Phillips, G.L.1    Wolff, S.N.2    Fay, J.W.3    Herzig, R.H.4    Lazarus, H.M.5    Schold, C.6    Herzig, G.P.7
  • 64
    • 0037456621 scopus 로고    scopus 로고
    • Genetic alterations in cancer as a result of breakage at fragile sites
    • Popescu, N.C. (2003). Genetic alterations in cancer as a result of breakage at fragile sites. Cancer Lett. 192, 1-17.
    • (2003) Cancer Lett. , vol.192 , pp. 1-17
    • Popescu, N.C.1
  • 67
    • 0034665336 scopus 로고    scopus 로고
    • Direct reversal of DNA damage by mutant methyl-transferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells
    • Ragg, S., Xu-Welliver, M., Bailey, J., D'Souza, M., Cooper, R., Chandra, S., Seshadri, R., Pegg, A.E., and Williams, D.A. (2000). Direct reversal of DNA damage by mutant methyl-transferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells. Cancer Res. 60, 5187-5195.
    • (2000) Cancer Res. , vol.60 , pp. 5187-5195
    • Ragg, S.1    Xu-Welliver, M.2    Bailey, J.3    D'Souza, M.4    Cooper, R.5    Chandra, S.6    Seshadri, R.7    Pegg, A.E.8    Williams, D.A.9
  • 71
    • 60649103432 scopus 로고    scopus 로고
    • Clinical application of lentiviral vectors: Concepts and practice
    • Schambach, A., and Baum, C. (2008). Clinical application of lentiviral vectors: Concepts and practice. Curr. Gene Ther. 8, 474-482.
    • (2008) Curr. Gene Ther. , vol.8 , pp. 474-482
    • Schambach, A.1    Baum, C.2
  • 73
    • 0037162715 scopus 로고    scopus 로고
    • HIV-1 integration in the human genome favors active genes and local hotspots
    • Schroder, A.R., Shinn, P., Chen, H., Berry, C., Ecker, J.R., and Bushman, F. (2002). HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110, 521-529.
    • (2002) Cell , vol.110 , pp. 521-529
    • Schroder, A.R.1    Shinn, P.2    Chen, H.3    Berry, C.4    Ecker, J.R.5    Bushman, F.6
  • 75
    • 0029937517 scopus 로고    scopus 로고
    • Carmustine and streptozocin in refractory melanoma: An attempt at modulation of O-alkylguanine-DNA-alkyltransferase
    • Smith, D.C., Gerson, S.L., Liu, L., Donnelly, S., Day, R., Trump, D.L., and Kirkwood, J.M. (1996). Carmustine and streptozocin in refractory melanoma: An attempt at modulation of O-alkylguanine-DNA-alkyltransferase. Clin. Cancer Res. 2, 1129-1134.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1129-1134
    • Smith, D.C.1    Gerson, S.L.2    Liu, L.3    Donnelly, S.4    Day, R.5    Trump, D.L.6    Kirkwood, J.M.7
  • 76
    • 0036594445 scopus 로고    scopus 로고
    • Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs
    • Sorrentino, B.P. (2002). Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs. Nat. Rev. Cancer 2, 431-441.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 431-441
    • Sorrentino, B.P.1
  • 77
    • 84950622021 scopus 로고
    • EDF statistics for goodness of fit and some comparisons
    • Stephens, M.A. (1974). EDF statistics for goodness of fit and some comparisons. J. Am. Stat. Assoc. 69, 730-737.
    • (1974) J. Am. Stat. Assoc. , vol.69 , pp. 730-737
    • Stephens, M.A.1
  • 79
    • 22144499640 scopus 로고    scopus 로고
    • Long-term persistence of a noninte-grated lentiviral vector in mouse hematopoietic stem cells
    • Terskikh, A.V., Ershler, M.A., Drize, N.J., Nifontova, I.N., and Chertkov, J.L. (2005). Long-term persistence of a noninte-grated lentiviral vector in mouse hematopoietic stem cells. Exp. Hematol. 33, 873-882.
    • (2005) Exp. Hematol. , vol.33 , pp. 873-882
    • Terskikh, A.V.1    Ershler, M.A.2    Drize, N.J.3    Nifontova, I.N.4    Chertkov, J.L.5
  • 80
    • 0021288515 scopus 로고
    • 6-Alkylguanine-DNA alkyltransferase activity in human brain and brain tumors
    • 6- Alkylguanine-DNA alkyltransferase activity in human brain and brain tumors. Carcinogenesis 5, 121-124.
    • (1984) Carcinogenesis , vol.5 , pp. 121-124
    • Wiestler, O.1    Kleihues, P.2    Pegg, A.E.3
  • 81
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • Wu, X., Li, Y., Crise, B., and Burgess, S.M. (2003). Transcription start regions in the human genome are favored targets for MLV integration. Science 300, 1749-1751.
    • (2003) Science , vol.300 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 83
    • 0036632178 scopus 로고    scopus 로고
    • RNA 3 readthrough of oncoretrovirus and lentivirus: Implications for vector safety and efficacy
    • Zaiss, A.K., Son, S., and Chang, L.J. (2002). RNA 3 readthrough of oncoretrovirus and lentivirus: Implications for vector safety and efficacy. J. Virol. 76, 7209-7219.
    • (2002) J. Virol. , vol.76 , pp. 7209-7219
    • Zaiss, A.K.1    Son, S.2    Chang, L.J.3
  • 84
    • 0036226607 scopus 로고    scopus 로고
    • \+ hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro
    • \+ hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro. Mol. Ther. 5, 381-387.
    • (2002) Mol. Ther. , vol.5 , pp. 381-387
    • Zielske, S.P.1    Gerson, S.L.2


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