-
1
-
-
33344476395
-
Survival of the fittest: In vivo selection and stem cell gene therapy
-
DOI 10.1182/blood-2005-06-2335
-
Neff T, Beard BC, Kiem H-P. Survival of the fittest: in vivo selection and stem cell gene therapy (review). Blood. 2006;107:1751-1760. (Pubitemid 43289350)
-
(2006)
Blood
, vol.107
, Issue.5
, pp. 1751-1760
-
-
Neff, T.1
Beard, B.C.2
Kiem, H.-P.3
-
2
-
-
0037129435
-
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
-
DOI 10.1056/NEJMoa012616
-
Hacein-Bey-Abina S, Le Deist F, Carlier F, et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med. 2002;346:1185-1193. (Pubitemid 34984579)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.16
, pp. 1185-1193
-
-
Hacein-Bey-Abina, S.1
Le Deist, F.2
Carlier, F.3
Bouneaud, C.4
Hue, C.5
De Villartay, J.-P.6
Thrasher, A.J.7
Wulffraat, N.8
Sorensen, R.9
Dupuis-Girod, S.10
Fischer, A.11
Graham Davies, E.12
Kuis, W.13
Leiva, L.14
Cavazzana-Calvo, M.15
-
3
-
-
0037189401
-
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning
-
DOI 10.1126/science.1070104
-
Aiuti A, Slavin S, Aker M, et al. Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science. 2002;296:2410-2413. (Pubitemid 34734219)
-
(2002)
Science
, vol.296
, Issue.5577
, pp. 2410-2413
-
-
Aiuti, A.1
Slavin, S.2
Aker, M.3
Ficara, F.4
Deola, S.5
Mortellaro, A.6
Morecki, S.7
Andolfi, G.8
Tabucchi, A.9
Carlucci, F.10
Marinello, E.11
Cattaneo, F.12
Vai, S.13
Servida, P.14
Miniero, R.15
Roncarolo, M.G.16
Bordignon, C.17
-
4
-
-
33645734405
-
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
-
Ott MG, Schmidt M, Schwarzwaelder K, et al. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med. 2006;12:401-409.
-
(2006)
Nat Med
, vol.12
, pp. 401-409
-
-
Ott, M.G.1
Schmidt, M.2
Schwarzwaelder, K.3
-
5
-
-
29244441185
-
Hematopoietic stem cell transduction and amplification in large animal models
-
DOI 10.1089/hum.2005.16.1355
-
Trobridge G, Beard BC, Kiem H-P. Hematopoietic stem cell transduction and amplification in large animal models. Hum Gene Ther. 2005;16:1355-1366. (Pubitemid 41829011)
-
(2005)
Human Gene Therapy
, vol.16
, Issue.12
, pp. 1355-1366
-
-
Trobridge, G.1
Beard, B.C.2
Kiem, H.-P.3
-
6
-
-
0036594445
-
Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs
-
(review)
-
Sorrentino BP. Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs (review). Nat Rev Cancer. 2002;2:431-441.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 431-441
-
-
Sorrentino, B.P.1
-
7
-
-
0032227546
-
Retroviral vectors containing a variant dihydrofolate reductase gene for drug protection and in vivo selection of hematopoietic cells
-
Allay JA, Galipeau J, Blakley RL, Sorrentino BP. Retroviral vectors containing a variant dihydrofolate reductase gene for drug protection and in vivo selection of hematopoietic cells. Stem Cells. 1998;16(suppl 1):223-233.
-
(1998)
Stem Cells
, vol.16
, Issue.SUPPL. 1
, pp. 223-233
-
-
Allay, J.A.1
Galipeau, J.2
Blakley, R.L.3
Sorrentino, B.P.4
-
8
-
-
0026637623
-
Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1
-
Sorrentino BP, Brandt SJ, Bodine D, et al. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science. 1992;257:99-103.
-
(1992)
Science
, vol.257
, pp. 99-103
-
-
Sorrentino, B.P.1
Brandt, S.J.2
Bodine, D.3
-
9
-
-
33751184381
-
Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model
-
DOI 10.1182/blood-2006-03-011734
-
Rattmann I, Kleff V, Sorg UR, et al. Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model. Blood. 2006;108:2965-2971. (Pubitemid 44776933)
-
(2006)
Blood
, vol.108
, Issue.9
, pp. 2965-2971
-
-
Rattmann, I.1
Kleff, V.2
Sorg, U.R.3
Bardenheuer, W.4
Brueckner, A.5
Hilger, R.A.6
Opalka, B.7
Seeber, S.8
Flasshove, M.9
Moritz, T.10
-
10
-
-
12844249961
-
Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy
-
DOI 10.1182/blood-2004-08-3169
-
Neff T, Beard BC, Peterson LJ, Anandakumar P, Thompson J, Kiem H-P. Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. Blood. 2005;105:997-1002. (Pubitemid 40170867)
-
(2005)
Blood
, vol.105
, Issue.3
, pp. 997-1002
-
-
Neff, T.1
Beard, B.C.2
Peterson, L.J.3
Anandakumar, P.4
Thompson, J.5
Kiem, H.-P.6
-
11
-
-
0347086142
-
Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model
-
DOI 10.1172/JCI200318782
-
Neff T, Horn PA, Peterson LJ, et al. Methylguanine methyltransferase- mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model. J Clin Invest. 2003;112:1581-1588. (Pubitemid 38056284)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.10
, pp. 1581-1588
-
-
Neff, T.1
Horn, P.A.2
Peterson, L.J.3
Thomasson, B.M.4
Thompson, J.5
Williams, D.A.6
Schmidt, M.7
Georges, G.E.8
Von Kalle, C.9
Kiem, H.-P.10
-
12
-
-
0034990304
-
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector
-
Sawai N, Zhou S, Vanin EF, Houghton P, Brent TP, Sorrentino BP. Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector. Mol Ther. 2001;3:78-87.
-
(2001)
Mol Ther
, vol.3
, pp. 78-87
-
-
Sawai, N.1
Zhou, S.2
Vanin, E.F.3
Houghton, P.4
Brent, T.P.5
Sorrentino, B.P.6
-
13
-
-
0034657950
-
Limiting numbers of G156AO6-methylguanine-DNA methyltransferase- transduced marrow progenitors repopulate nonmyeloablated mice after drug selection
-
Davis BM, Koc ON, Gerson SL. Limiting numbers of G156AO6-methylguanine- DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection. Blood. 2000;95:3078-3084.
-
(2000)
Blood
, vol.95
, pp. 3078-3084
-
-
Davis, B.M.1
Koc, O.N.2
Gerson, S.L.3
-
14
-
-
0030613767
-
6-benzylguanine and 1,3-bis(2-chloroethyl)-1- nitrosourea
-
Davis BM, Reese JS, Koc ON, Lee K, Schupp JE, Gerson SL. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 1997;57:5093-5099. (Pubitemid 27498125)
-
(1997)
Cancer Research
, vol.57
, Issue.22
, pp. 5093-5099
-
-
Davis, B.M.1
Reese, J.S.2
Koc, O.N.3
Lee, K.4
Schupp, J.E.5
Gerson, S.L.6
-
15
-
-
0037448352
-
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency [1]
-
DOI 10.1056/NEJM200301163480314
-
Hacein-Bey-Abina S, von Kalle C, Schmidt M, et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med. 2003;348:255-256. (Pubitemid 36077924)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.3
, pp. 255-256
-
-
Hacein-Bey-Abina, S.1
Von Kalle, C.2
Schmidt, M.3
Le Deist, F.4
Wulffraat, N.5
McIntyre, E.6
Radford, I.7
Villeval, J.-L.8
Fraser, C.C.9
Cavazzana-Calvo, M.10
Fischer, A.11
-
16
-
-
38649091006
-
Case of leukemia associated with X-linked severe combined immunodeficiency gene therapy trial in London
-
Board of the European Society of Gene and Cell Therapy, Executive Committee of the Clinigene Network of Excellence, Executive of the Consert Integrated Project [commentary]
-
Board of the European Society of Gene and Cell Therapy, Executive Committee of the Clinigene Network of Excellence, Executive of the Consert Integrated Project. Case of leukemia associated with X-linked severe combined immunodeficiency gene therapy trial in London [commentary]. Hum Gene Ther. 2008;19:3-4.
-
(2008)
Hum Gene Ther
, vol.19
, pp. 3-4
-
-
-
17
-
-
41849142699
-
High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector
-
Zhang X-B, Beard BC, Trobridge GD, et al. High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector. J Clin Invest. 2008;118:1502-1510.
-
(2008)
J Clin Invest
, vol.118
, pp. 1502-1510
-
-
Zhang, X.-B.1
Beard, B.C.2
Trobridge, G.D.3
-
18
-
-
33646594123
-
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque
-
DOI 10.1182/blood-2005-10-4108
-
Seggewiss R, Pittaluga S, Adler RL, et al. Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood. 2006;107:3865-3867. (Pubitemid 43726789)
-
(2006)
Blood
, vol.107
, Issue.10
, pp. 3865-3867
-
-
Seggewiss, R.1
Pittaluga, S.2
Adler, R.L.3
Javier Guenaga, F.4
Ferguson, C.5
Pilz, I.H.6
Ryu, B.7
Sorrentino, B.P.8
Young III, W.S.9
Donahue, R.E.10
Von Kalle, C.11
Nienhuis, A.W.12
Dunbar, C.E.13
-
19
-
-
34249789022
-
In vivo selection and chemoprotection after drug resistance gene therapy in a nonmyeloablative allogeneic transplantation setting in dogs
-
Gerull S, Beard BC, Peterson LJ, Neff T, Kiem H-P. In vivo selection and chemoprotection after drug resistance gene therapy in a nonmyeloablative allogeneic transplantation setting in dogs. Hum Gene Ther. 2007;18:451-456.
-
(2007)
Hum Gene Ther
, vol.18
, pp. 451-456
-
-
Gerull, S.1
Beard, B.C.2
Peterson, L.J.3
Neff, T.4
Kiem, H.-P.5
-
20
-
-
0037108189
-
Polyclonal long-term repopulating stem cell clones in a primate model
-
Schmidt M, Zickler P, Hoffmann G, et al. Polyclonal long-term repopulating stem cell clones in a primate model. Blood. 2002;100:2737-2743.
-
(2002)
Blood
, vol.100
, pp. 2737-2743
-
-
Schmidt, M.1
Zickler, P.2
Hoffmann, G.3
-
21
-
-
0037841763
-
Transcription start regions in the human genome are favored targets for MLV integration
-
DOI 10.1126/science.1083413
-
Wu X, Li Y, Crise B, Burgess SM. Transcription start regions in the human genome are favored targets for MLV integration. Science. 2003;300:1749-1751. (Pubitemid 36712571)
-
(2003)
Science
, vol.300
, Issue.5626
, pp. 1749-1751
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
-
23
-
-
34249804819
-
Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, and foamy virus
-
Beard BC, Keyser KA, Trobridge GD, et al. Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, and foamy virus. Hum Gene Ther. 2007;18:423-434.
-
(2007)
Hum Gene Ther
, vol.18
, pp. 423-434
-
-
Beard, B.C.1
Keyser, K.A.2
Trobridge, G.D.3
-
24
-
-
31944444349
-
Foamy virus vector integration sites in normal human cells
-
DOI 10.1073/pnas.0510046103
-
Trobridge GD, Miller DG, Jacobs MA, et al. Foamy virus vector integration sites in normal human cells. Proc Natl Acad Sci U S A. 2006;103:1498-1503. (Pubitemid 43191194)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.5
, pp. 1498-1503
-
-
Trobridge, G.D.1
Miller, D.G.2
Jacobs, M.A.3
Allen, J.M.4
Kiem, H.-P.5
Kaul, R.6
Russell, D.W.7
-
25
-
-
10744233606
-
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences
-
DOI 10.1016/j.ymthe.2003.10.013
-
Baum C, von Kalle C, Staal FJ, et al. Chance or necessity? Insertional mutagenesis in gene therapy and its consequences (review). Mol Ther. 2004;9:5-13. (Pubitemid 38208322)
-
(2004)
Molecular Therapy
, vol.9
, Issue.1
, pp. 5-13
-
-
Baum, C.1
Von Kalle, C.2
Staal, F.J.T.3
Li, Z.4
Fehse, B.5
Schmidt, M.6
Weerkamp, F.7
Karlsson, S.8
Wagemaker, G.9
Williams, D.A.10
-
26
-
-
34249727198
-
Insertional mutagenesis in gene therapy and stem cell biology
-
DOI 10.1097/MOH.0b013e3281900f01, PII 0006275220070700000006
-
Baum C. Insertional mutagenesis in gene therapy and stem cell biology (review). Curr Opin Hematol. 2007;14:337-342. (Pubitemid 46842807)
-
(2007)
Current Opinion in Hematology
, vol.14
, Issue.4
, pp. 337-342
-
-
Baum, C.1
-
29
-
-
0031684399
-
Mortality in beagles irradiated during prenatal and postnatal development, II: Contribution of benign and malignant neoplasia
-
Benjamin SA, Lee AC, Angleton GM, Saunders WJ, Keefe TJ, Mallinckrodt CH. Mortality in beagles irradiated during prenatal and postnatal development, II: contribution of benign and malignant neoplasia. Radiat Res. 1998;150:330-348.
-
(1998)
Radiat Res
, vol.150
, pp. 330-348
-
-
Benjamin, S.A.1
Lee, A.C.2
Angleton, G.M.3
Saunders, W.J.4
Keefe, T.J.5
Mallinckrodt, C.H.6
-
30
-
-
0023250381
-
Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow
-
DOI 10.1084/jem.166.1.210
-
Williams DA, Hsieh K, DeSilva A, Mulligan RC. Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow. J Exp Med. 1987;166:210-218. (Pubitemid 17101901)
-
(1987)
Journal of Experimental Medicine
, vol.166
, Issue.1
, pp. 210-218
-
-
Williams, D.A.1
Hsieh, K.2
Desilva, A.3
Mulligan, R.C.4
-
31
-
-
0025939045
-
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: Efficacy, potency, and toxicity
-
Mickisch GH, Licht T, Merlino GT, Gottesman MM, Pastan I. Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity. Cancer Res. 1991;51:5417-5424.
-
(1991)
Cancer Res
, vol.51
, pp. 5417-5424
-
-
Mickisch, G.H.1
Licht, T.2
Merlino, G.T.3
Gottesman, M.M.4
Pastan, I.5
-
32
-
-
0029967966
-
Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine
-
Neff T, Blau CA. Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine. Exp Hematol. 1996;24:1340-1346. (Pubitemid 26348932)
-
(1996)
Experimental Hematology
, vol.24
, Issue.11
, pp. 1340-1346
-
-
Neff, T.1
Blau, C.A.2
-
33
-
-
0034985885
-
Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene
-
DOI 10.1006/mthe.2000.0236
-
Takebe N, Zhao SC, Adhikari D, et al. Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene. Mol Ther. 2001;3:88-96. (Pubitemid 32509809)
-
(2001)
Molecular Therapy
, vol.3
, Issue.1
, pp. 88-96
-
-
Takebe, N.1
Zhao, S.-C.2
Adhikari, D.3
Mineishi, S.4
Sadelain, M.5
Hilton, J.6
Colvin, M.7
Banerjee, D.8
Bertino, J.R.9
-
34
-
-
14844320795
-
Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan
-
DOI 10.1081/CNV-200046508
-
Harkey MA, Czerwinski M, Slattery J, Kiem H-P. Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan. Cancer Invest. 2005;23:19-25. (Pubitemid 40344196)
-
(2005)
Cancer Investigation
, vol.23
, Issue.1
, pp. 19-25
-
-
Harkey, M.A.1
Czerwinski, M.2
Slattery, J.3
Kiem, H.-P.4
-
35
-
-
10744232285
-
In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations
-
Pollok KE, Hartwell JR, Braber A, et al. In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. Hum Gene Ther. 2003;14:1703-1714.
-
(2003)
Hum Gene Ther
, vol.14
, pp. 1703-1714
-
-
Pollok, K.E.1
Hartwell, J.R.2
Braber, A.3
-
36
-
-
0018096492
-
Multisystem stem cell failure after apparent recovery from alkylating agents
-
Botnick LE, Hannon EC, Hellman S. Multisystem stem cell failure after apparent recovery from alkylating agents. Cancer Res. 1978;38:1942-1947. (Pubitemid 8375074)
-
(1978)
Cancer Research
, vol.38
, Issue.7
, pp. 1942-1947
-
-
Botnick, L.E.1
Hannon, E.C.2
Hellman, S.3
-
37
-
-
0018759437
-
Nature of the hemopoietic stem cell compartment and its proliferative potential
-
Botnick LE, Hannon EC, Hellman S. Nature of the hemopoietic stem cell compartment and its proliferative potential. Blood Cells. 1979;5:195-210. (Pubitemid 9233314)
-
(1979)
Blood Cells
, vol.5
, Issue.2
, pp. 195-210
-
-
Botnick, L.E.1
Hannon, E.C.2
Hellman, S.3
-
38
-
-
0019411617
-
Differential effects of cytotoxic agents on hematopoietic progenitors
-
Botnick LE, Hannon EC, Vigneulle R, Hellman S. Differential effects of cytotoxic agents on hematopoietic progenitors. Cancer Res. 1981;41:2338-2342. (Pubitemid 11111439)
-
(1981)
Cancer Research
, vol.41
, Issue.6
, pp. 2338-2342
-
-
Botnick, L.E.1
Hannon, E.C.2
Vigneulle, R.3
Hellman, S.4
-
39
-
-
0024426850
-
6-alkylguanine-DNA alkyltransferase
-
Dumenco LL, Warman B, Hatzoglou M, Lim IK, Abboud SL, Gerson SL. Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase. Cancer Res. 1989;49:6044-6051. (Pubitemid 19274168)
-
(1989)
Cancer Research
, vol.49
, Issue.21
, pp. 6044-6051
-
-
Dumenco, L.L.1
Warman, B.2
Hatzoglou, M.3
Lin, I.K.4
Abboud, S.L.5
Gerson, S.L.6
-
40
-
-
0029056481
-
Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells
-
Allay JA, Dumenco LL, Koc ON, Liu L, Gerson SL. Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells. Blood. 1995;85:3342-3351.
-
(1995)
Blood
, vol.85
, pp. 3342-3351
-
-
Allay, J.A.1
Dumenco, L.L.2
Koc, O.N.3
Liu, L.4
Gerson, S.L.5
-
41
-
-
0029782310
-
Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors
-
Allay JA, Koc ON, Davis BM, Gerson SL. Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors. Clin Cancer Res. 1996;2:1353-1359.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1353-1359
-
-
Allay, J.A.1
Koc, O.N.2
Davis, B.M.3
Gerson, S.L.4
-
42
-
-
0025986145
-
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine
-
Dolan ME, Pegg AE, Dumenco LL, Moschel RC, Gerson SL. Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine. Carcinogenesis. 1991;12:2305-2309.
-
(1991)
Carcinogenesis
, vol.12
, pp. 2305-2309
-
-
Dolan, M.E.1
Pegg, A.E.2
Dumenco, L.L.3
Moschel, R.C.4
Gerson, S.L.5
-
43
-
-
0027339636
-
6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone
-
DOI 10.1016/0006-2952(93)90086-C
-
Gerson SL, Zborowska E, Norton K, Gordon NH, Willson JK. Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochem Pharmacol. 1993;45:483-491. (Pubitemid 23042649)
-
(1993)
Biochemical Pharmacology
, vol.45
, Issue.2
, pp. 483-491
-
-
Gerson, S.L.1
Zborowska, E.2
Norton, K.3
Gordon, N.H.4
Willson, J.K.V.5
-
44
-
-
0030445950
-
6-benzylguanine plus 1,3- Bis(2-chloroethyl)-1-nitrosourea
-
DOI 10.1073/pnas.93.24.14088
-
Reese JS, Koc ON, Lee KM, et al. Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea. Proc Natl Acad Sci U S A. 1996;93:14088-14093. (Pubitemid 26424250)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.24
, pp. 14088-14093
-
-
Reese, J.S.1
Koc, O.N.2
Keun Myoung, L.3
Liu, L.4
Allay, J.A.5
Phillips Jr., W.P.6
Gerson, S.L.7
-
45
-
-
0033589691
-
Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy
-
Davis BM, Roth JC, Liu L, Xu-Welliver M, Pegg AE, Gerson SL. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. Hum Gene Ther. 1999;10:2769-2778.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 2769-2778
-
-
Davis, B.M.1
Roth, J.C.2
Liu, L.3
Xu-Welliver, M.4
Pegg, A.E.5
Gerson, S.L.6
-
46
-
-
0035942239
-
Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells
-
Davis BM, Encell LP, Zielske SP, et al. Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells. Proc Natl Acad Sci U S A. 2001;98:4950-4954.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 4950-4954
-
-
Davis, B.M.1
Encell, L.P.2
Zielske, S.P.3
-
47
-
-
0032031010
-
Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis
-
Encell LP, Coates MM, Loeb LA. Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis. Cancer Res. 1998;58:1013-1020.
-
(1998)
Cancer Res
, vol.58
, pp. 1013-1020
-
-
Encell, L.P.1
Coates, M.M.2
Loeb, L.A.3
-
48
-
-
0030963146
-
Creation of human alkyltransferases resistant to O6-benzylguanine
-
Christians FC, Dawson BJ, Coates MM, Loeb LA. Creation of human alkyltransferases resistant to O6-benzylguanine. Cancer Res. 1997;57:2007-2012.
-
(1997)
Cancer Res
, vol.57
, pp. 2007-2012
-
-
Christians, F.C.1
Dawson, B.J.2
Coates, M.M.3
Loeb, L.A.4
-
49
-
-
0029929724
-
Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria
-
Christians FC, Loeb LA. Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria. Proc Natl Acad Sci U S A. 1996;93:6124-6128.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 6124-6128
-
-
Christians, F.C.1
Loeb, L.A.2
-
51
-
-
47049090397
-
Efficient transduction of pigtailed macaque hemtopoietic repopulating cells with HIV-based lentiviral vectors
-
Trobridge GD, Beard BC, Gooch C, et al. Efficient transduction of pigtailed macaque hemtopoietic repopulating cells with HIV-based lentiviral vectors. Blood. 2008;111:5537-5543.
-
(2008)
Blood
, vol.111
, pp. 5537-5543
-
-
Trobridge, G.D.1
Beard, B.C.2
Gooch, C.3
-
52
-
-
51049094440
-
Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells
-
Milsom MD, Jerabek-Willemsen M, Harris CE, et al. Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res. 2008;68:6171-6180.
-
(2008)
Cancer Res
, vol.68
, pp. 6171-6180
-
-
Milsom, M.D.1
Jerabek-Willemsen, M.2
Harris, C.E.3
-
53
-
-
25144490586
-
Recurrent retroviral vector integration at the Mds1-Evi1 locus in nonhuman primate hematopoietic cells
-
Calmels B, Ferguson C, Laukkanen MO, et al. Recurrent retroviral vector integration at the Mds1-Evi1 locus in nonhuman primate hematopoietic cells. Blood. 2005;106:2530-2533.
-
(2005)
Blood
, vol.106
, pp. 2530-2533
-
-
Calmels, B.1
Ferguson, C.2
Laukkanen, M.O.3
-
54
-
-
34250851635
-
Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells
-
DOI 10.1038/sj.mt.6300159, PII 6300159
-
Beard BC, Dickerson D, Beebe K, et al. Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells. Mol Ther. 2007;15:1356-1365. (Pubitemid 46969874)
-
(2007)
Molecular Therapy
, vol.15
, Issue.7
, pp. 1356-1365
-
-
Beard, B.C.1
Dickerson, D.2
Beebe, K.3
Gooch, C.4
Fletcher, J.5
Okbinoglu, T.6
Miller, D.G.7
Jacobs, M.A.8
Kaul, R.9
Kiem, H.-P.10
Trobridge, G.D.11
-
55
-
-
34548823473
-
Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression
-
DOI 10.1182/blood-2006-11-053710
-
Ball CR, Pilz IH, Schmidt M, et al. Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression. Blood. 2007;110:1779-1787. (Pubitemid 47443888)
-
(2007)
Blood
, vol.110
, Issue.6
, pp. 1779-1787
-
-
Ball, C.R.1
Pilz, I.H.2
Schmidt, M.3
Fessler, S.4
Williams, D.A.5
Von Kalle, C.6
Glimm, H.7
-
56
-
-
0028903635
-
Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy
-
Mauch P, Constine L, Greenberger J, et al. Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys. 1995;31:1319-1339.
-
(1995)
Int J Radiat Oncol Biol Phys
, vol.31
, pp. 1319-1339
-
-
Mauch, P.1
Constine, L.2
Greenberger, J.3
-
57
-
-
0027888222
-
Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents
-
[Published erratum appears in Exp Hematol. 1993;21:398]
-
Neben S, Hellman S, Montgomery M, Ferrara J, Mauch P. Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents. [Published erratum appears in Exp Hematol. 1993;21:398] Exp Hematol. 1993;21:156-162.
-
(1993)
Exp Hematol
, vol.21
, pp. 156-162
-
-
Neben, S.1
Hellman, S.2
Montgomery, M.3
Ferrara, J.4
Mauch, P.5
-
58
-
-
2342451325
-
Strategies to expand transduced hematopoietic stem cells in vivo
-
DOI 10.1016/j.ymthe.2004.01.014
-
Abkowitz JL, Golinelli D, Guttorp P, Abkowitz JL, Golinelli D, Guttorp P. Strategies to expand transduced hematopoietic stem cells in vivo. Mol Ther. 2004;9:566-576. (Pubitemid 38578807)
-
(2004)
Molecular Therapy
, vol.9
, Issue.4
, pp. 566-576
-
-
Abkowitz, J.L.1
Golinelli, D.2
Guttorp, P.3
|