Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6- benzylguanine

Cancer Research

Volumn 59, Issue 7, 1999, Pages 1514-1519

  Xu Welliver, Meng ^a   Leitão, José ^a,b   Kanugula, Sreenivas ^a   Pegg, Anthony E ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALGARVE   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL PROTECTION; DNA ALKYLATION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; ESCHERICHIA COLI; HUMAN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; GUANINE; HISTIDINE; HUMANS; MUTAGENESIS, SITE-DIRECTED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 0033118477     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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