CLEFMA - An anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 6109-6120

  Lagisetty, Pallavi ^a   Vilekar, Prachi ^a   Sahoo, Kaustuv ^a   Anant, Shrikant ^b   Awasthi, Vibhudutta ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Autophagy; Bis(benzylidene) derivatives; Cell proliferation; CLEFMA; Curcuminoid; Lung adenocarcinoma

Indexed keywords

2 [3,5 BIS(2 FLUOROBENZYLIDENE 4 PIPERIDONE 1 YL)N(4 FLUOROBENZYL)ACETAMIDE]; 3 [3,5 BIS (2 FLUOROBENZYLIDENE) 4 OXO PIPERIDINE 1 CARBONYL]HENEICOS 4 ENOIC ACID; 3 [3,5 BIS (2 FLUOROBENZYLIDENE) 4 OXO PIPERIDINE 1 CARBONYL]HEPTADEC 4 ENOIC ACID; 3 [3,5 BIS (2 FLUOROBENZYLIDENE) 4 OXO PIPERIDINE 1 CARBONYL]PENTADEC 4 ENOIC ACID; 3 METHYLADENINE; 3,5 BIS(2 FLUOROBENZYL) 4 PIPERIDONE; 3,5 BIS(2 FLUOROBENZYLIDENE) 4 HYDROXY PIPERIDINE; 3,5 BIS(2 FLUOROBENZYLIDENE) 4 PIPERIDONE; 4 [3,5 BIS (2 CHLOROBENZYLIDENE) 4 OXO PIPERIDIN 1 YL] 4 OXO 2 BUTENOIC ACID; 4 [3,5 BIS(2 CHLOROBENZYLIDENE 4 OXO PIPERIDINE 1 YL) 4 OXO 2 BUTENOIC ACID]; 4 [3,5 BIS(2 FLUOROBENZYLIDENE) 4 OXO PIPERIDIN 1 YL]N HEXADECYL 4 OXO BUTYRAMIDE; 4 OXO 4 [3,5 BIS(2 FLUOROBENZYLIDENE 4 PIPERIDONE 1 YLCARBONYL)N HYDROXYSUCCINIMIDYL BUTANOIC ESTER]; 4 OXO 4 [3,5 BIS(2 FLUOROBENZYLIDENE 4 PIPERIDONYLCARBONYL) 2 GLUCOSE BUTANAMIDE]; ANTINEOPLASTIC AGENT; CASPASE; CURCUMIN; N (4 METHYLBENZENESULFONYL) 3,5 BIS(2 FLUOROBENZYLIDENE) 4 PIPERIDONE; N ACETYL 3,5 BIS(2 FLUOROBENZYLIDENE) 4 PIPERIDONE; N FORMYL 3,5 BIS(2 FLUOROBENZYLIDENE) 4 PIPERIDONE; N STEAROYL 3,5 BIS(2 FLUOROBENZYLIDENE) 4 PIPERIDONE; PIPERIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CELL DEATH; CELL KILLING; CELL POPULATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON MICROSCOPY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRANSMISSION ELECTRON MICROSCOPY; X RAY CRYSTALLOGRAPHY;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LUNG NEOPLASMS; PIPERIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955471499     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.055     Document Type: Article

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