3,5-bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties

ChemMedChem

Volumn 4, Issue 11, 2009, Pages 1831-1840

  Das, Swagatika ^a   Das, Umashankar ^a   Selvakumar, Ponniah ^b   Sharma, Rajendra K ^b   Balzarini, Jan ^c   De Clercq, Erik ^c   Molnár, Joseph ^d   Serly, Julianna ^d   Baráth, Zoltán ^d   Schatte, Gabriele ^e   Bandy, Brian ^a   Gorecki, Dennis K J ^a   Dimmock, Jonathan R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d UNIVERSITY OF SZEGED   (Hungary)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 BIS(2 NITROBENZYLIDENE) 1 PHOSPHONO 4 PIPERIDONE; 3,5 BIS(2 NITROBENZYLIDENE) 4 PIPERIDONE; 3,5 BIS(3 NITROBENZYLIDENE) 4 PIPERIDONE; 3,5 BIS(3,4 DIMETHOXYBENZYLIDENE) 4 PIPERIDONE; 3,5 BIS(3,4,5 TRIMETHOXYBENZYLIDENE) 4 PIPERIDONE; 3,5 BIS(BENZYLIDENE) 1 PHOSPHONO 4 PIPERIDONE DERIVATIVE; 3,5 BIS(BENZYLIDENE) 4 OXO 1 PHOSPHONOPIPERIDINE DERIVATIVE; 3,5 BIS(BENZYLIDENE) 4 PIPERIDONE DERIVATIVE; [3,5 BIS(2 NITROBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(2 NITROBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; [3,5 BIS(3 NITROBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(3 NITROBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; [3,5 BIS(3,4 DIMETHOXYBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(3,4 DIMETHOXYBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; [3,5 BIS(3,4,5 TRIMETHOXYBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(3,4,5 TRIMETHOXYBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; [3,5 BIS(4 CHLOROBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(4 CHLOROBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; [3,5 BIS(4 METHOXYBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(4 METHOXYBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; [3,5 BIS(4 METHYLBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(4 METHYLBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; [3,5 BIS(4 NITROBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(4 NITROBENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; [3,5 BIS(BENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID; [3,5 BIS(BENZYLIDENE) 4 OXO 1 YL]PHOSPHONIC ACID DIETHYL ESTER; ESTER DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL RESPIRATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROPHILICITY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYTOTOXINS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LEUKEMIA L1210; MICE; MOLECULAR CONFORMATION; PIPERIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 73449106470     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900288     Document Type: Article

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