Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds

European Journal of Medicinal Chemistry

Volumn 42, Issue 1, 2007, Pages 71-80

  Das, Umashankar ^a   Alcorn, Jane ^a   Shrivastav, Anuraag ^b   Sharma, Rajendra K ^b   De Clercq, Erik ^c   Balzarini, Jan ^c   Dimmock, Jonathan R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

, Unsaturated ketones; Apoptosis; N Acyl 4 piperidones; Structure cytotoxicity relationships

Indexed keywords

1 (4 METHOXYBENZOYL) 3,5 BIS(PHENYLMETHYLENE) 4 PIPERIDONE; 1 BENZOYL 3,5 BIS(PHENYLMETHYLENE) 4 PIPERIDONE; 3,5 BIS(4 METHYLPHENYLMETHYLENE) 4 PIPERIDONE; FLUOROURACIL; MELPHALAN; PIPERIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NICK END LABELING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; T LYMPHOCYTE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; PIPERIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846666546     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.08.002     Document Type: Article

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