Conformational and quantitative structure-activity relationship study of cytotoxic 2-arylidenebenzocycloalkanones

Journal of Medicinal Chemistry

Volumn 42, Issue 8, 1999, Pages 1358-1366

  Dimmock, Jonathan R ^a   Kandepu, N Murthi ^a   Nazarali, Adil J ^a   Kowalchuk, Travis P ^a   Motaganahalli, Narasimhan ^a   Quail, J Wilson ^a   Mykytiuk, Patricia A ^a   Audette, Gerald F ^a   Prasad, Lata ^a   Perjési, Pál ^b   Allen, Theresa M ^c   Santos, Cheryl L ^c   Szydlowski, Jen ^c   De Clercq, Erik ^d   Balzarini, Jan ^d  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF PÉCS   (Hungary)

^c UNIVERSITY OF ALBERTA   (Canada)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 METHOXYPHENYLMETHYLENE) 1 BENZOSUBERONE; ANTINEOPLASTIC AGENT; MELPHALAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOPATHOGENIC EFFECT; DRUG CONFORMATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LEUKEMIA L 1210; LEUKEMIA P 388; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANONES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES; TUMOR CELLS, CULTURED;

EID: 0033594531     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9806695     Document Type: Article

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