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Volumn 8, Issue , 2009, Pages

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; FANCONI ANEMIA GROUP D2 PROTEIN; HYDROXYUREA; MITOMYCIN C; ATM PROTEIN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; DRUG DERIVATIVE; FANCD2 PROTEIN, HUMAN; KETONE; MITOMYCIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

EID: 74549187963     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-8-133     Document Type: Article
Times cited : (39)

References (51)
  • 1
    • 58149216953 scopus 로고    scopus 로고
    • Fanconi anemia: causes and consequences of genetic instability
    • full_text, 18724063
    • Kalb R, Neveling K, Nanda I, Schindler D, Hoehn H. Fanconi anemia: causes and consequences of genetic instability. Genome Dyn 2006, 1:218-242. full_text, 18724063.
    • (2006) Genome Dyn , vol.1 , pp. 218-242
    • Kalb, R.1    Neveling, K.2    Nanda, I.3    Schindler, D.4    Hoehn, H.5
  • 2
    • 66949142402 scopus 로고    scopus 로고
    • The genetic and molecular basis of Fanconi anemia
    • de Winter JP, Joenje H. The genetic and molecular basis of Fanconi anemia. Mutat Res 2008,
    • (2008) Mutat Res
    • de Winter, J.P.1    Joenje, H.2
  • 3
    • 34548759123 scopus 로고    scopus 로고
    • Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
    • 10.1038/nrg2159, 17768402
    • Wang W. Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat Rev Genet 2007, 8:735-748. 10.1038/nrg2159, 17768402.
    • (2007) Nat Rev Genet , vol.8 , pp. 735-748
    • Wang, W.1
  • 4
    • 34547785606 scopus 로고    scopus 로고
    • Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players
    • 10.1093/hmg/ddm026, 17613548
    • Rahman N, Scott RH. Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players. Hum Mol Genet 2007, 16(Spec No 1):R60-66. 10.1093/hmg/ddm026, 17613548.
    • (2007) Hum Mol Genet , vol.16 , Issue.SPEC NO 1
    • Rahman, N.1    Scott, R.H.2
  • 6
    • 58149457080 scopus 로고    scopus 로고
    • A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway
    • 10.1002/ijc.24039, 19048618
    • Landais I, Sobeck A, Stone S, LaChapelle A, Hoatlin ME. A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway. Int J Cancer 2009, 124:783-792. 10.1002/ijc.24039, 19048618.
    • (2009) Int J Cancer , vol.124 , pp. 783-792
    • Landais, I.1    Sobeck, A.2    Stone, S.3    LaChapelle, A.4    Hoatlin, M.E.5
  • 7
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • 10.1200/JCO.2008.16.0812, 18591545
    • Ashworth A. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 2008, 26:3785-3790. 10.1200/JCO.2008.16.0812, 18591545.
    • (2008) J Clin Oncol , vol.26 , pp. 3785-3790
    • Ashworth, A.1
  • 9
    • 70349240709 scopus 로고    scopus 로고
    • PARP inhibitors: will the new class of drugs match the hype?
    • 10.1093/jnci/djp315, 19738163
    • Tuma RS. PARP inhibitors: will the new class of drugs match the hype?. J Natl Cancer Inst 2009, 101:1230-1232. 10.1093/jnci/djp315, 19738163.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1230-1232
    • Tuma, R.S.1
  • 10
    • 65849111219 scopus 로고    scopus 로고
    • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
    • 10.1016/j.cell.2009.03.017, 19490892
    • Scholl C, Frohling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 2009, 137:821-834. 10.1016/j.cell.2009.03.017, 19490892.
    • (2009) Cell , vol.137 , pp. 821-834
    • Scholl, C.1    Frohling, S.2    Dunn, I.F.3    Schinzel, A.C.4    Barbie, D.A.5    Kim, S.Y.6    Silver, S.J.7    Tamayo, P.8    Wadlow, R.C.9    Ramaswamy, S.10
  • 11
    • 66149091940 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    • 10.1016/j.cell.2009.05.006, 2768667, 19490893
    • Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 2009, 137:835-848. 10.1016/j.cell.2009.05.006, 2768667, 19490893.
    • (2009) Cell , vol.137 , pp. 835-848
    • Luo, J.1    Emanuele, M.J.2    Li, D.3    Creighton, C.J.4    Schlabach, M.R.5    Westbrook, T.F.6    Wong, K.K.7    Elledge, S.J.8
  • 12
    • 34248184445 scopus 로고    scopus 로고
    • Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated
    • 10.1172/JCI31245, 1847538, 17431503
    • Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest 2007, 117:1440-1449. 10.1172/JCI31245, 1847538, 17431503.
    • (2007) J Clin Invest , vol.117 , pp. 1440-1449
    • Kennedy, R.D.1    Chen, C.C.2    Stuckert, P.3    Archila, E.M.4    De la Vega, M.A.5    Moreau, L.A.6    Shimamura, A.7    D'Andrea, A.D.8
  • 13
    • 56649088073 scopus 로고    scopus 로고
    • Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair
    • Czornak K, Chughtai S, Chrzanowska KH. Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair. J Appl Genet 2008, 49:383-396.
    • (2008) J Appl Genet , vol.49 , pp. 383-396
    • Czornak, K.1    Chughtai, S.2    Chrzanowska, K.H.3
  • 14
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    • 10.1038/nrm2514, 18813293
    • Lavin MF. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol 2008, 9:759-769. 10.1038/nrm2514, 18813293.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 15
    • 36849045647 scopus 로고    scopus 로고
    • Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion
    • 10.1200/JCO.2007.11.2649, 17968022
    • Austen B, Skowronska A, Baker C, Powell JE, Gardiner A, Oscier D, Majid A, Dyer M, Siebert R, Taylor AM, et al. Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J Clin Oncol 2007, 25:5448-5457. 10.1200/JCO.2007.11.2649, 17968022.
    • (2007) J Clin Oncol , vol.25 , pp. 5448-5457
    • Austen, B.1    Skowronska, A.2    Baker, C.3    Powell, J.E.4    Gardiner, A.5    Oscier, D.6    Majid, A.7    Dyer, M.8    Siebert, R.9    Taylor, A.M.10
  • 19
    • 20044389847 scopus 로고    scopus 로고
    • EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism
    • 10.1097/00001813-200503000-00005, 15711178
    • Adams BK, Cai J, Armstrong J, Herold M, Lu YJ, Sun A, Snyder JP, Liotta DC, Jones DP, Shoji M. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anticancer Drugs 2005, 16:263-275. 10.1097/00001813-200503000-00005, 15711178.
    • (2005) Anticancer Drugs , vol.16 , pp. 263-275
    • Adams, B.K.1    Cai, J.2    Armstrong, J.3    Herold, M.4    Lu, Y.J.5    Sun, A.6    Snyder, J.P.7    Liotta, D.C.8    Jones, D.P.9    Shoji, M.10
  • 20
    • 33744815937 scopus 로고    scopus 로고
    • Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system
    • 10.1021/jm051141k, 16722634
    • Sun A, Shoji M, Lu YJ, Liotta DC, Snyder JP. Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system. J Med Chem 2006, 49:3153-3158. 10.1021/jm051141k, 16722634.
    • (2006) J Med Chem , vol.49 , pp. 3153-3158
    • Sun, A.1    Shoji, M.2    Lu, Y.J.3    Liotta, D.C.4    Snyder, J.P.5
  • 21
    • 41549086576 scopus 로고    scopus 로고
    • Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa
    • 10.1080/10611860801890093, 18365880
    • Shoji M, Sun A, Kisiel W, Lu YJ, Shim H, McCarey BE, Nichols C, Parker ET, Pohl J, Mosley CA, et al. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. J Drug Target 2008, 16:185-197. 10.1080/10611860801890093, 18365880.
    • (2008) J Drug Target , vol.16 , pp. 185-197
    • Shoji, M.1    Sun, A.2    Kisiel, W.3    Lu, Y.J.4    Shim, H.5    McCarey, B.E.6    Nichols, C.7    Parker, E.T.8    Pohl, J.9    Mosley, C.A.10
  • 22
    • 48849095626 scopus 로고    scopus 로고
    • EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1
    • 2573855, 18682687
    • Thomas SL, Zhong D, Zhou W, Malik S, Liotta D, Snyder JP, Hamel E, Giannakakou P. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle 2008, 7:2409-2417. 2573855, 18682687.
    • (2008) Cell Cycle , vol.7 , pp. 2409-2417
    • Thomas, S.L.1    Zhong, D.2    Zhou, W.3    Malik, S.4    Liotta, D.5    Snyder, J.P.6    Hamel, E.7    Giannakakou, P.8
  • 23
    • 30644459206 scopus 로고    scopus 로고
    • Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks
    • 10.1128/MCB.26.2.425-437.2006, 1346898, 16382135
    • Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, et al. Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Mol Cell Biol 2006, 26:425-437. 10.1128/MCB.26.2.425-437.2006, 1346898, 16382135.
    • (2006) Mol Cell Biol , vol.26 , pp. 425-437
    • Sobeck, A.1    Stone, S.2    Costanzo, V.3    de Graaf, B.4    Reuter, T.5    de Winter, J.6    Wallisch, M.7    Akkari, Y.8    Olson, S.9    Wang, W.10
  • 24
    • 34250189868 scopus 로고    scopus 로고
    • DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2
    • 10.1128/MCB.02196-06, 1900049, 17420278
    • Sobeck A, Stone S, Hoatlin ME. DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2. Mol Cell Biol 2007, 27:4283-4292. 10.1128/MCB.02196-06, 1900049, 17420278.
    • (2007) Mol Cell Biol , vol.27 , pp. 4283-4292
    • Sobeck, A.1    Stone, S.2    Hoatlin, M.E.3
  • 25
    • 69749095427 scopus 로고    scopus 로고
    • Checkpoint signaling from a single DNA interstrand crosslink
    • 10.1016/j.molcel.2009.08.014, 19748363
    • Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J. Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell 2009, 35:704-715. 10.1016/j.molcel.2009.08.014, 19748363.
    • (2009) Mol Cell , vol.35 , pp. 704-715
    • Ben-Yehoyada, M.1    Wang, L.C.2    Kozekov, I.D.3    Rizzo, C.J.4    Gottesman, M.E.5    Gautier, J.6
  • 26
    • 55149115113 scopus 로고    scopus 로고
    • Fanconi anemia proteins stabilize replication forks
    • 10.1016/j.dnarep.2008.08.005, 2596863, 18786657
    • Wang LC, Stone S, Hoatlin ME, Gautier J. Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst) 2008, 7:1973-1981. 10.1016/j.dnarep.2008.08.005, 2596863, 18786657.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1973-1981
    • Wang, L.C.1    Stone, S.2    Hoatlin, M.E.3    Gautier, J.4
  • 27
    • 0034892653 scopus 로고    scopus 로고
    • Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication
    • 10.1016/S1097-2765(01)00294-5, 11511367
    • Costanzo V, Robertson K, Bibikova M, Kim E, Grieco D, Gottesman M, Carroll D, Gautier J. Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol Cell 2001, 8:137-147. 10.1016/S1097-2765(01)00294-5, 11511367.
    • (2001) Mol Cell , vol.8 , pp. 137-147
    • Costanzo, V.1    Robertson, K.2    Bibikova, M.3    Kim, E.4    Grieco, D.5    Gottesman, M.6    Carroll, D.7    Gautier, J.8
  • 28
    • 70349850935 scopus 로고    scopus 로고
    • PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin
    • Di Virgilio M, Ying CY, Gautier J. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst) 2009,
    • (2009) DNA Repair (Amst)
    • Di Virgilio, M.1    Ying, C.Y.2    Gautier, J.3
  • 29
    • 0037106186 scopus 로고    scopus 로고
    • A requirement for replication in activation of the ATR-dependent DNA damage checkpoint
    • 10.1101/gad.1013502, 187437, 12231621
    • Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA. A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev 2002, 16:2327-2332. 10.1101/gad.1013502, 187437, 12231621.
    • (2002) Genes Dev , vol.16 , pp. 2327-2332
    • Lupardus, P.J.1    Byun, T.2    Yee, M.C.3    Hekmat-Nejad, M.4    Cimprich, K.A.5
  • 30
    • 34547628200 scopus 로고    scopus 로고
    • Proteasome function is required for DNA damage response and fanconi anemia pathway activation
    • 10.1158/0008-5472.CAN-07-1015, 17671210
    • Jacquemont C, Taniguchi T. Proteasome function is required for DNA damage response and fanconi anemia pathway activation. Cancer Res 2007, 67:7395-7405. 10.1158/0008-5472.CAN-07-1015, 17671210.
    • (2007) Cancer Res , vol.67 , pp. 7395-7405
    • Jacquemont, C.1    Taniguchi, T.2
  • 31
    • 1642564603 scopus 로고    scopus 로고
    • Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway
    • 10.1074/jbc.M310369200, 14701837
    • Jana NR, Dikshit P, Goswami A, Nukina N. Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J Biol Chem 2004, 279:11680-11685. 10.1074/jbc.M310369200, 14701837.
    • (2004) J Biol Chem , vol.279 , pp. 11680-11685
    • Jana, N.R.1    Dikshit, P.2    Goswami, A.3    Nukina, N.4
  • 32
    • 50449099855 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin
    • 10.1124/mol.108.046201, 2638506, 18577686
    • Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, et al. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol 2008, 74:654-661. 10.1124/mol.108.046201, 2638506, 18577686.
    • (2008) Mol Pharmacol , vol.74 , pp. 654-661
    • Kasinski, A.L.1    Du, Y.2    Thomas, S.L.3    Zhao, J.4    Sun, S.Y.5    Khuri, F.R.6    Wang, C.Y.7    Shoji, M.8    Sun, A.9    Snyder, J.P.10
  • 34
    • 0037449711 scopus 로고    scopus 로고
    • BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice
    • 10.1074/jbc.M209677200, 12403772
    • Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW, Yang X, Iotzova VS, Clarke W, Strnad J, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 2003, 278:1450-1456. 10.1074/jbc.M209677200, 12403772.
    • (2003) J Biol Chem , vol.278 , pp. 1450-1456
    • Burke, J.R.1    Pattoli, M.A.2    Gregor, K.R.3    Brassil, P.J.4    MacMaster, J.F.5    McIntyre, K.W.6    Yang, X.7    Iotzova, V.S.8    Clarke, W.9    Strnad, J.10
  • 35
    • 0036785375 scopus 로고    scopus 로고
    • S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51
    • 10.1182/blood-2002-01-0278, 12239151
    • Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 2002, 100:2414-2420. 10.1182/blood-2002-01-0278, 12239151.
    • (2002) Blood , vol.100 , pp. 2414-2420
    • Taniguchi, T.1    Garcia-Higuera, I.2    Andreassen, P.R.3    Gregory, R.C.4    Grompe, M.5    D'Andrea, A.D.6
  • 36
    • 0021925626 scopus 로고
    • Identification of two complementation groups in Fanconi anemia
    • 10.1007/BF01534732, 3919452
    • Duckworth-Rysiecki G, Cornish K, Clarke CA, Buchwald M. Identification of two complementation groups in Fanconi anemia. Somat Cell Mol Genet 1985, 11:35-41. 10.1007/BF01534732, 3919452.
    • (1985) Somat Cell Mol Genet , vol.11 , pp. 35-41
    • Duckworth-Rysiecki, G.1    Cornish, K.2    Clarke, C.A.3    Buchwald, M.4
  • 37
    • 34247398807 scopus 로고    scopus 로고
    • DNA damage response: the players, the network and the role in tumor suppression
    • Rai R, Peng G, Li K, Lin SY. DNA damage response: the players, the network and the role in tumor suppression. Cancer Genomics Proteomics 2007, 4:99-106.
    • (2007) Cancer Genomics Proteomics , vol.4 , pp. 99-106
    • Rai, R.1    Peng, G.2    Li, K.3    Lin, S.Y.4
  • 38
    • 0030984490 scopus 로고    scopus 로고
    • PARP is important for genomic stability but dispensable in apoptosis
    • 10.1101/gad.11.18.2347, 316515, 9308963
    • Wang ZQ, Stingl L, Morrison C, Jantsch M, Los M, Schulze-Osthoff K, Wagner EF. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev 1997, 11:2347-2358. 10.1101/gad.11.18.2347, 316515, 9308963.
    • (1997) Genes Dev , vol.11 , pp. 2347-2358
    • Wang, Z.Q.1    Stingl, L.2    Morrison, C.3    Jantsch, M.4    Los, M.5    Schulze-Osthoff, K.6    Wagner, E.F.7
  • 39
    • 45849115079 scopus 로고    scopus 로고
    • Antioxidant and radical scavenging properties of curcumin
    • 10.1016/j.cbi.2008.05.003, 18547552
    • Ak T, Gulcin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact 2008, 174:27-37. 10.1016/j.cbi.2008.05.003, 18547552.
    • (2008) Chem Biol Interact , vol.174 , pp. 27-37
    • Ak, T.1    Gulcin, I.2
  • 40
    • 0037007177 scopus 로고    scopus 로고
    • Protective activities of some phenolic 1,3-diketones against lipid peroxidation: possible involvement of the 1,3-diketone moiety
    • 10.1002/1439-7633(20020402)3:4<364::AID-CBIC364>3.0.CO;2-S, 11933238
    • Patro BS, Rele S, Chintalwar GJ, Chattopadhyay S, Adhikari S, Mukherjee T. Protective activities of some phenolic 1,3-diketones against lipid peroxidation: possible involvement of the 1,3-diketone moiety. Chembiochem 2002, 3:364-370. 10.1002/1439-7633(20020402)3:4<364::AID-CBIC364>3.0.CO;2-S, 11933238.
    • (2002) Chembiochem , vol.3 , pp. 364-370
    • Patro, B.S.1    Rele, S.2    Chintalwar, G.J.3    Chattopadhyay, S.4    Adhikari, S.5    Mukherjee, T.6
  • 42
    • 33744958660 scopus 로고    scopus 로고
    • The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly
    • 10.1074/jbc.M511411200, 16474167
    • Gurtan AM, Stuckert P, D'Andrea AD. The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. J Biol Chem 2006, 281:10896-10905. 10.1074/jbc.M511411200, 16474167.
    • (2006) J Biol Chem , vol.281 , pp. 10896-10905
    • Gurtan, A.M.1    Stuckert, P.2    D'Andrea, A.D.3
  • 43
    • 33749482993 scopus 로고    scopus 로고
    • Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis
    • 10.1158/0008-5472.CAN-06-0702, 16982768
    • Aleo E, Henderson CJ, Fontanini A, Solazzo B, Brancolini C. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res 2006, 66:9235-9244. 10.1158/0008-5472.CAN-06-0702, 16982768.
    • (2006) Cancer Res , vol.66 , pp. 9235-9244
    • Aleo, E.1    Henderson, C.J.2    Fontanini, A.3    Solazzo, B.4    Brancolini, C.5
  • 44
    • 70350007132 scopus 로고    scopus 로고
    • The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways
    • 10.1074/jbc.M109.007690, 19633289
    • Sobeck A, Stone S, Landais I, de Graaf B, Hoatlin ME. The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways. J Biol Chem 2009, 284:25560-25568. 10.1074/jbc.M109.007690, 19633289.
    • (2009) J Biol Chem , vol.284 , pp. 25560-25568
    • Sobeck, A.1    Stone, S.2    Landais, I.3    de Graaf, B.4    Hoatlin, M.E.5
  • 45
    • 17644432403 scopus 로고    scopus 로고
    • Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
    • 10.1101/gad.840500, 316686, 10859164
    • Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000, 14:1448-1459. 10.1101/gad.840500, 316686, 10859164.
    • (2000) Genes Dev , vol.14 , pp. 1448-1459
    • Liu, Q.1    Guntuku, S.2    Cui, X.S.3    Matsuoka, S.4    Cortez, D.5    Tamai, K.6    Luo, G.7    Carattini-Rivera, S.8    DeMayo, F.9    Bradley, A.10
  • 46
    • 33748656748 scopus 로고    scopus 로고
    • Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance
    • 10.1128/MCB.02018-05, 1592857, 16943440
    • Ho GP, Margossian S, Taniguchi T, D'Andrea AD. Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol 2006, 26:7005-7015. 10.1128/MCB.02018-05, 1592857, 16943440.
    • (2006) Mol Cell Biol , vol.26 , pp. 7005-7015
    • Ho, G.P.1    Margossian, S.2    Taniguchi, T.3    D'Andrea, A.D.4
  • 50
    • 55549101279 scopus 로고    scopus 로고
    • Finding multiple target optimal intervention in disease-related molecular network
    • 10.1038/msb.2008.60, 2673713, 18985027
    • Yang K, Bai H, Ouyang Q, Lai L, Tang C. Finding multiple target optimal intervention in disease-related molecular network. Mol Syst Biol 2008, 4:228. 10.1038/msb.2008.60, 2673713, 18985027.
    • (2008) Mol Syst Biol , vol.4 , pp. 228
    • Yang, K.1    Bai, H.2    Ouyang, Q.3    Lai, L.4    Tang, C.5
  • 51
    • 0035913157 scopus 로고    scopus 로고
    • Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress
    • 10.1038/sj.onc.1204509, 11466609
    • Gage BM, Alroy D, Shin CY, Ponomareva ON, Dhar S, Sharma GG, Pandita TK, Thayer MJ, Turker MS. Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress. Oncogene 2001, 20:4291-4297. 10.1038/sj.onc.1204509, 11466609.
    • (2001) Oncogene , vol.20 , pp. 4291-4297
    • Gage, B.M.1    Alroy, D.2    Shin, C.Y.3    Ponomareva, O.N.4    Dhar, S.5    Sharma, G.G.6    Pandita, T.K.7    Thayer, M.J.8    Turker, M.S.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.