Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells

European Journal of Medicinal Chemistry

Volumn 43, Issue 1, 2008, Pages 1-7

  Pati, Hari N ^a   Das, Umashankar ^a   Quail, J Wilson ^b   Kawase, Masami ^c   Sakagami, Hiroshi ^d   Dimmock, Jonathan R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c MATSUYAMA UNIVERSITY   (Japan)

^d MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

Cytotoxicity; Enones; Mesna; Molecular modeling; Piperidin 4 ones; Selective cytotoxicity; Sodium 2 mercaptoethanesulfonate; X ray crystallography

Indexed keywords

1 ACRYLOYL 3,5 BIS(BENZYLIDENE)PIPERIDIN 4 ONE; 3,5 BIS(BENZYLIDENE)PIPERIDIN 4 ONE; CYTOTOXIC AGENT; MESNA; PIPERIDONE DERIVATIVE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HL 60; CELL STRAIN HSC 2; CELL STRAIN HSC 4; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICHAEL ADDITION; MOLECULAR MODEL; STATISTICAL ANALYSIS; X RAY CRYSTALLOGRAPHY;

BENZYLIDENE COMPOUNDS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOTOXINS; HUMANS; HYDROPHOBICITY; MODELS, BIOLOGICAL; NEOPLASMS; PIPERIDONES; SENSITIVITY AND SPECIFICITY;

EID: 38149093408     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.03.010     Document Type: Article

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