EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression

Journal of Biological Chemistry

Volumn 282, Issue 39, 2007, Pages 28609-28618

  Selvendiran, Karuppaiyah ^a   Tong, Liyue ^a   Vishwanath, Shilpa ^a   Bratasz, Anna ^a   Trigg, Nancy J ^a   Kutala, Vijay K ^a   Hideg, Kalman ^b   Kuppusamy, Periannan ^a,c  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PÉCS   (Hungary)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELLS; FASL EXPRESSION;

GENE EXPRESSION; GENETIC ENGINEERING; ONCOLOGY; PHOSPHORYLATION;

CELL PROLIFERATION;

3,5 BIS(2 FLUOROBENZYLIDINE)PIPERIDIN 4 ONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE INHIBITOR; CHECKPOINT KINASE 1; CISPLATIN; EF 24; FAS LIGAND; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIPERIDINE DERIVATIVE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; PROTEIN PP53; SERINE; THREONINE; UBIQUITIN; UNCLASSIFIED DRUG; 3,5 BIS(2 FLUOROBENZYLIDENE)PIPERIDIN 4 ONE; 3,5-BIS(2-FLUOROBENZYLIDENE)PIPERIDIN-4-ONE; ANTINEOPLASTIC AGENT; BENZYLIDENE DERIVATIVE; CASPASE; CYSTEINE PROTEINASE INHIBITOR; FASLG PROTEIN, HUMAN; MDM2 PROTEIN, HUMAN; PIPERIDONE DERIVATIVE; PTEN PROTEIN, HUMAN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; BIOSYNTHESIS; CELL DIVISION; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; FEMALE; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; NUDE MOUSE; OVARY TUMOR; PHOSPHORYLATION; TIME; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZYLIDENE COMPOUNDS; CASPASES; CELL DIVISION; CELL SURVIVAL; CISPLATIN; CYSTEINE PROTEINASE INHIBITORS; DRUG RESISTANCE, NEOPLASM; FAS LIGAND PROTEIN; FEMALE; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; OVARIAN NEOPLASMS; PHOSPHORYLATION; PIPERIDONES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MDM2; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 35348930988     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703796200     Document Type: Article

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