A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues

Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2001, Pages 586-593

  Dimmock, J R ^a   Padmanilayam, M P ^a   Puthucode, R N ^a   Nazarali, A J ^a   Motaganahalli, N L ^a   Zello, G A ^a   Quail, J W ^a   Oloo, E O ^a   Kraatz, H B ^a   Prisciak, J S ^a   Allen, T M ^b   Santos, C L ^b   Balzarini, J ^c   De Clercq, E ^c   Manavathu, E K ^d  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; MELPHALAN; PIPERIDONE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DRUG CONFORMATION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; LEUKEMIA L 1210; LEUKEMIA P 388; MOLECULAR MODEL; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PROTEIN SYNTHESIS; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACRYLATES; ANIMALS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MODELS, MOLECULAR; OXIDATION-REDUCTION; PIPERIDINES; RNA; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035865786     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0002580     Document Type: Article

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