Changes in solvent exposure reveal the kinetics and equilibria of adsorbed protein unfolding in hydrophobic interaction chromatography

Journal of Chromatography A

Volumn 1217, Issue 35, 2010, Pages 5571-5583

  Deitcher, R W ^a   O'Connell, J P ^a   Fernandez, E J ^a  

^a University of Virginia   (United States)

Author keywords

Hydrophobic interaction chromatography; Kinetics; Protein adsorption; Protein folding; Thermodynamics

Indexed keywords

BULK PHASE; BULK SOLUTIONS; CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC TECHNIQUES; CONFORMATIONAL STABILITIES; CONFORMATIONAL STATE; DEUTERIUM LABELING; EQUILIBRIUM PARTITIONING; EXPERIMENTAL PROTOCOLS; HYDROGEN EXCHANGE; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IRREVERSIBLE ADSORPTION; ISOCRATIC; LACTOGLOBULIN; LIGAND CHEMISTRY; MOLECULAR PROPERTIES; PHYSICALLY BASED MODELS; PROTEIN ADSORPTION; PROTEIN RECOVERY; PROTEIN UNFOLDING; PSEUDO FIRST ORDER RATE CONSTANTS; RESIN PROPERTIES; SALT CONCENTRATION; SOLVENT EXPOSURE; SURFACE UNFOLDING; THREE MODELS;

ADSORPTION; CHROMATOGRAPHIC ANALYSIS; DEUTERIUM; EQUILIBRIUM CONSTANTS; GEL PERMEATION CHROMATOGRAPHY; HYDROGEN; HYDROPHOBICITY; MASS SPECTROMETRY; PROTEIN FOLDING; RATE CONSTANTS; RESINS; SOLVENTS; THERMODYNAMICS;

HYDROPHOBIC CHROMATOGRAPHY;

ALPHA LACTALBUMIN; BETA LACTOGLOBULIN; CHYMOTRYPSINOGEN; SODIUM CHLORIDE; LACTOGLOBULIN; SOLVENT;

ADSORPTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; ELUTION; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; STOICHIOMETRY; THERMODYNAMICS; ANIMAL; BOVINAE; CHEMICAL PHENOMENA; CHEMISTRY; CHROMATOGRAPHY; KINETICS;

ADSORPTION; ANIMALS; CATTLE; CHROMATOGRAPHY; CHYMOTRYPSINOGEN; HYDROPHOBICITY; KINETICS; LACTOGLOBULINS; PROTEIN FOLDING; SOLVENTS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;

EID: 77955428025     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.06.051     Document Type: Article

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