Separation of populations of antibody variants by fine tuning of hydrophobic-interaction chromatography operating conditions

Journal of Chromatography A

Volumn 1214, Issue 1-2, 2008, Pages 81-89

  Valliere Douglass, John ^a   Wallace, Alison ^a   Balland, Alain ^a  

^a AMGEN INC   (United States)

Author keywords

Aggregation; Amidation; Antibodies; Clipping; Hydrophobic interaction chromatography (HIC); Isomerization; Oxidation; Potency; Succinimide

Indexed keywords

AGGLOMERATION; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DRUG INTERACTIONS; DRUG PRODUCTS PLANTS; FLOW INTERACTIONS; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; ISOMERS; MONOCLONAL ANTIBODIES; SURFACE PLASMON RESONANCE; THEOREM PROVING;

AGGREGATION; AMIDATION; CLIPPING; HYDROPHOBIC-INTERACTION CHROMATOGRAPHY (HIC); POTENCY; SUCCINIMIDE;

ANTIBODIES;

ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; PAPAIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL MODIFICATION; CHROMATOGRAPHY; CONFORMATION; MOLECULE; PRIORITY JOURNAL; SEPARATION TECHNIQUE;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY; HYDROPHOBICITY; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; ISOMERISM; PAPAIN; PROTEIN STABILITY; SUCCINIMIDES;

EID: 56549110132     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.10.078     Document Type: Article

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