Identification, cloning and characterization of an aldo-keto reductase from Trypanosoma cruzi with quinone oxido-reductase activity

Molecular and Biochemical Parasitology

Volumn 173, Issue 2, 2010, Pages 132-141

  Garavaglia, Patricia A ^a   Cannata, Joaquín J B ^b,c   Ruiz, Andrés M ^a   Maugeri, Dante ^c   Duran, Rosario ^d   Galleano, Mónica ^e   García, Gabriela A ^a  

^a Administracion Nacional de Laboratorios E Institutos de Salud Dr Carlos G Malbran   (Argentina)

^b Centre de Estudios Farmacologicos y Botanicos   (Argentina)

^c INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

^d INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

^e UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Aldo keto reductase; Chagas' disease; Drug metabolism; Free radicals; Quinone; Trypanosoma cruzi

Indexed keywords

1,2 NAPHTHOQUINONE; 2 (3,3 DICHLOROALLYL) 3 HYDROXY 1,4 NAPHTHOQUINONE; 2 DIHYDROXYACETONE; 4 NITROBENZALDEHYDE; 9,10 PHENANTHRENQUINONE; ALDO KETO REDUCTASE; ALPHA LAPACHONE; ANTINEOPLASTIC AGENT; BENZALDEHYDE DERIVATIVE; BETA LAPACHONE; CIBACRON BLUE F3GA; DIHYDROXYACETONE; JUGLONE; MENADIONE; NAPHTHOQUINONE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; SEPHAROSE; UNCLASSIFIED DRUG; 4-NITROBENZALDEHYDE; ALCOHOL DEHYDROGENASE; ALDEHYDE REDUCTASE; BENZOQUINONE; BENZOQUINONE DERIVATIVE; CARBONYL REDUCTASE; COENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROTOZOAL DNA; PROTOZOAL PROTEIN;

AMASTIGOTE; ANIMAL EXPERIMENT; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL LYSATE; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ANALYSIS; GEL CHROMATOGRAPHY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR CLONING; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; COENZYME; DNA SEQUENCE; ENZYMOLOGY; GENETICS; HUMAN; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION; PROCEDURES; PROTEIN MULTIMERIZATION;

ALCOHOL OXIDOREDUCTASES; ANIMALS; BENZALDEHYDES; BENZOQUINONES; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, LIQUID; CLONING, MOLECULAR; COENZYMES; DIHYDROXYACETONE; DNA, PROTOZOAN; HUMANS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NADP; OXIDATION-REDUCTION; PROTEIN MULTIMERIZATION; PROTOZOAN PROTEINS; SEQUENCE ANALYSIS, DNA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRYPANOSOMA CRUZI; ALDEHYDE REDUCTASE;

TRYPANOSOMA CRUZI;

EID: 77954761645     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.05.019     Document Type: Article

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