Structural and mutational analysis of Trypanosoma brucei prostaglandin H 2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases

Journal of Biological Chemistry

Volumn 280, Issue 28, 2005, Pages 26371-26382

  Kilunga, Kubata Bruno ^a,c   Inoue, Tsuyoshi ^b,g   Okano, Yousuke ^b,g   Kabututu, Zakayi ^a,b   Martin, Samuel K ^c   Lazarus, Michael ^a,h   Duszenko, Michael ^d   Sumii, Yuichi ^b   Kusakari, Yukiko ^b   Matsumura, Hiroyoshi ^b   Kai, Yasushi ^b   Sugiyama, Shigeru ^e   Inaka, Kouji ^e   Inui, Takashi ^a,f   Urade, Yoshihiro ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e MARUWA Foods Industries Inc   (Japan)

^f Tsu City College   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^h HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID CATALYSTS; CATALYTIC MECHANISMS; HYDROPHOBIC CORE ACTIVE SITE; TRYPANOSOMA BRUCEI PROSTAGLANDIN SYNTHASE;

CATALYSIS; CRYSTAL STRUCTURE; ELECTROSTATICS; HYDROGEN BONDS; KINETIC THEORY; MOLECULES; MUTAGENESIS;

STRUCTURAL ANALYSIS;

ALDEHYDE KETONE REDUCTASE; ALDEHYDE REDUCTASE; ASPARTIC ACID; HISTIDINE; LYSINE; OXIDOREDUCTASE; PHENANTHRENE DERIVATIVE; PHENANTHRENEQUINONE; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN F2 ALPHA SYNTHASE; PROSTAGLANDIN H2; PROSTAGLANDIN H2 REDUCTASE; PROSTAGLANDIN SYNTHASE; PROTOZOAL PROTEIN; QUINONE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYST; CRYSTAL STRUCTURE; ELECTRICITY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTON TRANSPORT; REDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CATALYTIC DOMAIN; CIRCULAR DICHROISM; CITRATES; CRYSTALLOGRAPHY, X-RAY; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYPROSTAGLANDIN DEHYDROGENASES; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDOREDUCTASES; PROSTAGLANDIN H2; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTONS; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; TRYPANOSOMA BRUCEI BRUCEI; TYROSINE; ULTRAVIOLET RAYS;

TRYPANOSOMA BRUCEI;

EID: 22644436552     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413884200     Document Type: Article

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