The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease

Science

Volumn 309, Issue 5733, 2005, Pages

  El Sayed, Najib M ^a,b   Myler, Peter J ^c,d,e   Bartholomeu, Daniella C ^a   Nilsson, Daniel ^f   Aggarwal, Gautam ^c   Tran, Anh Nhi ^f   Ghedin, Elodie ^a,b   Worthey, Elizabeth A ^c   Delcher, Arthur L ^a   Blandin, Gaëlle ^a   Westenberger, Scott J ^a,g   Caler, Elisabet ^a   Cerqueira, Gustavo C ^a,h   Branche, Carole ^f   Haas, Brian ^a   Anupama, Atashi ^c   Arner, Erik ^f   Åslund, Lena ⁱ   Attipoe, Philip ^c   Bontempi, Esteban ^f,j   Bringaud, Frédéric ^k   Burton, Peter ^l   Cadag, Eithon ^c   Campbell, David A ^g   Carrington, Mark ^m   Crabtree, Jonathan ^a   Darban, Hamid ^f   Da Silveira, Jose Franco ⁿ   De Jong, Pieter ^o   Edwards, Kimberly ^f   Englund, Paul T ^p   Fazelina, Gholam ^c   Feldblyum, Tamara ^a   Ferella, Marcela ^f   Frasch, Alberto Carlos ^q   Gull, Keith ^r   Horn, David ^s   Hou, Lihua ^a   Huang, Yiting ^c   Kindlund, Ellen ^f   Klingbeil, Michele ^t   Kluge, Sindy ^f   Koo, Hean ^a   Lacerda, Daniela ^a,u   Levin, Mariano J ^v   Lorenzi, Hernan ^v   Louie, Tin ^c   Machado, Carlos Renato ^h   McCulloch, Richard ^l   McKenna, Alan ^f   Mizuno, Yumi ^f   Mottram, Jeremy C ^l   Nelson, Siri ^c   Ochaya, Stephen ^f   Osoegawa, Kazutoyo ^o   Pai, Grace ^a   Parsons, Marilyn ^c,d   Pentony, Martin ^c   Pettersson, Ulf ⁱ   Pop, Mihai ^a   Ramirez, Jose Luis ^w   Rinta, Joel ^c   Robertson, Laura ^c   Salzberg, Steven L ^a   Sanchez, Daniel O ^q   Seyler, Amber ^c   Sharma, Reuben ^m   Shetty, Jyoti ^a   Simpson, Anjana J ^a   Sisk, Ellen ^c   Tammi, Martti T ^f,x   Tarleton, Rick ^y   Teixeira, Santuza ^h   Van Aken, Susan ^a   Vogt, Christy ^c   Ward, Pauline N ^l   Wickstead, Bill ^r   Wortman, Jennifer ^a   White, Owen ^a   Fraser, Claire M ^a   Stuart, Kenneth D ^c,d   Andersson, Björn ^f   more..

^a J CRAIG VENTER INSTITUTE   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f KAROLINSKA INSTITUTE   (Sweden)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

ⁱ UPPSALA UNIVERSITY   (Sweden)

^j Administracion Nacional de Laboratorios E Institutos de Salud Dr Carlos G Malbran   (Argentina)

^k CNRS   (France)

^l UNIVERSITY OF GLASGOW   (United Kingdom)

^m UNIVERSITY OF CAMBRIDGE   (United Kingdom)

ⁿ FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^o CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^p JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^q INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

^r UNIVERSITY OF OXFORD   (United Kingdom)

^s LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^t UNIVERSITY OF MASSACHUSETTS   (United States)

^u INSTITUTO OSWALDO CRUZ   (Brazil)

^v UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^w FACULTAD DE CIENCIAS   (Venezuela)

^x NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^y UNIVERSITY OF GEORGIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; DNA; GENES; PROTEINS;

CHAGAS DISEASES; SURFACE MOLECULES; TRYPANOSOMA CRUZI;

PROTOZOA;

GENE PRODUCT; MEMBRANE PROTEIN; MITOCHONDRIAL DNA; MUCIN; PHOSPHATASE; PROTEIN KINASE; PROTOZOAL PROTEIN; SIALIDASE;

GENOME;

ALLELE; ARTICLE; CHAGAS DISEASE; DIPLOIDY; DNA REPAIR; DNA REPLICATION; EUKARYOTE; GENE SEQUENCE; GENOME ANALYSIS; LEISHMANIA MAJOR; MOLECULAR SIZE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; RETROPOSON; SIGNAL TRANSDUCTION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; CHAGAS DISEASE; DNA REPAIR; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA, PROTOZOAN; GENES, PROTOZOAN; GENOME, PROTOZOAN; HUMANS; MEIOSIS; MEMBRANE PROTEINS; MULTIGENE FAMILY; PROTOZOAN PROTEINS; RECOMBINATION, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; RETROELEMENTS; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TELOMERE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EUKARYOTA; LEISHMANIA MAJOR; PROTOZOA; TRYPANOSOMA CRUZI;

EID: 22244453726     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1112631     Document Type: Article

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69. We thank our colleagues in the T. cruzi Genome Network (TcGN) and the trypanosomatid research community for their continued support and encouragement. In particular, we thank the members of the Tritryp Sequencing Consortium for their help with comparative genome annotation; J. Donelson and S. Melville for a critical review of this manuscript; A. Kerhornou for his help with GPI anchor predictions; as well as O. Campetella, I. Dorso, V. Campo, G. Montagna, and F. Aguero for their help with the surface protein analyses. Funding for this project was provided by grants from the National Institute for Allergy and Infectious Diseases (NIAID) to N.M.E.-S. (AI45038), K.D.S. and P.J.M. (AI045039), and B.A. (AI45061); the M. J. Murdoch Charitable Trust to the Seattle Biomedical Research Institute; the Beijer Foundation to B.A. M.J.L and A.C.F. are Howard Hughes Medical Institute International Research Scholars. G.C.C. is supported in part by CNPq, Brazil. We also express our gratitude to NIAID, Burroughs Wellcome Fund (BWF), the Wellcome Trust, and WHO (Tropical Disease Research) for providing funds for several TcGN and Tritryp meetings. Special thanks to C. Hertz-Fowler and P. Mooney at the Wellcome Trust Sanger Institute (WTSI) for coordinating data exchange with The Institute for Cenomic Research (TICR), and to A. Tivey and M. Aslett for loading and updating the T. cruzi data in GeneDB at WTSI. This Whole-Genome Shotgun project has been deposited at the DNA Databank of japan (DDBJ), the European Molecular Biology Laboratory (EMBL), and GenBank under the project accession AAHK00000000. The version described in this paper is the first version, AAHK01000000. All data sets and genome annotations are also available through GeneDB at www.genedb.org.