Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles

Chemical Research in Toxicology

Volumn 15, Issue 4, 2002, Pages 483-489

  Kumagai, Yoshito ^a   Koide, Sachie ^a   Taguchi, Keiko ^a   Endo, Akiko ^a   Nakai, Yumi ^b   Yoshikawa, Toshikazu ^c   Shimojo, Nobuhiro ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b JEOL LTD   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BOVINE SERUM ALBUMIN; DIMERCAPROL; DITHIOL DERIVATIVE; DITHIOTHREITOL; N ETHYLMALEIMIDE; PHENANTHRAQUINONE; PHENANTHRENE DERIVATIVE; PROTEIN; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; UNITHIOL;

ANIMAL CELL; ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; ENDOTHELIUM CELL; EXHAUST GAS; MICROSOME; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; REDUCTION;

ANIMALS; CATTLE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ETHYLMALEIMIDE; FREE RADICAL SCAVENGERS; MICROSOMES; OXIDATION-REDUCTION; PHENANTHRENES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; VEHICLE EMISSIONS;

ANIMALIA; BOVINAE;

EID: 0036227531     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0100993     Document Type: Article

References (40)

1. Health effects of exposure to diesel exhaust particles
2. An association between air pollution and mortality in six U.S. cities
3. The role of particulate pollutants in pulmonary inflammation and asthma: Evidence for the involvement of organic chemicals and oxidative stress
4. Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse
5. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage
6. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages
7. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element
8. Sampling of vehicle emissions for chemical analysis and biological testing
9. The identification of polynuclear aromatic hydrocarbon (PAH) derivatives in mutagenic fractions of diesel particulate extracts
10. Quinone chemistry and toxicology
11. Molecular mechanisms of quinone cytotoxicity
12. Role of quinones in toxicology
13. Biological chemistry ofthiols in the vasculature and in vascular-related disease
14. Redox-dependent signal transduction
15. An efficient method for purification of cuprozinc superoxide dismutase from bovine erythrocytes
16. A rapid and sensitive method for the quantitation of protein utilizing the principle of protein-dye binding
17. A new metabolic pathway of morphine: In vivo and in vitro formation of morphinone and morphinone-glutathione adduct in guinea pig
18. On the protective mechanism of the thiol-specific antioxidant enzyme against the oxidative damage of biomacromolecules
19. Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes
20. Thiyl free radical metabolites of thiol drugs, glutathione, and proteins
21. Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry
22. Production of hydroxyl radical by decomposition of superoxide spin-trapped adducts
23. Diaziquinone-glutathione conjugates: Characterization and mechanisms of formation
24. Biochemistry of oxygen toxicity
25. Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical generating system
26. Current concepts concerning radioprotective and cryoprotective properties of dimethyl sulfoxide in cellular systems
27. An electron spin resonance study of o-semiquinones formed during the enzymatic and autoxidation of catechol estrogens
28. Proton NMR studies of bovine serum albumin. Assignment of spin systems
29. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide
30. Reduction potentials of one-electron couples involving free radicals in aqueous solution
31. Thioredoxin
32. Repression of gene expression by oxidative stress
33. Phnanthraquinone inhibits eNOS activity and suppresses vasorelaxation
34. Phenanthraquinone affects endothelial nitric oxide synthase activity through modification of the thiol groups: An alternative inhibition mechanism
35. Nitric oxide production by cultured aortic endothelial cells in response to thiol depletion and replenishment
36. Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiol suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase
37. Sulfhydryl-depleting agents, but not deferoxamine, modulated EDRF action in cultured pulmonary arterial cells
38. Sulfhydryl-disulfide modification and the role of disulfide oxidoreductases in regulation of the catalytic activity of nitric oxide synthase in pulmonary artery endothelial cells
39. Nitric oxide exposure and sulfhydryl modulation alter L-arginine transport in cultured pulmonary artery endothelial cells
40. Induction of oxidatives stress and dysfunction of nitric oxide-dependent vascular tone caused by quinones contained in diesel exhaust particles